Navigation Links
NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
Date:4/18/2012

Researchers at the National Institute of Standards and Technology (NIST) and the University of Massachusetts Amherst (UMass) have provided the first evidence that engineered nanoparticles are able to accumulate within plants and damage their DNA. In a recent paper,* the team led by NIST chemist Bryant C. Nelson showed that under laboratory conditions, cupric oxide nanoparticles have the capacity to enter plant root cells and generate many mutagenic DNA base lesions.

The team tested the man-made, ultrafine particles between 1 and 100 nanometers in size on a human food crop, the radish, and two species of common groundcovers used by grazing animals, perennial and annual ryegrass. This research is part of NIST's work to help characterize the potential environmental, health and safety (EHS) risks of nanomaterials, and develop methods for identifying and measuring them.

Cupric oxide (also known as copper (II) oxide or CuO) is a compound that has been used for many years as a pigment for coloring glass and ceramics, as a polish for optics, and as a catalyst in the manufacture of rayon. Cupric oxide also is a strong conductor of electric current, a property enhanced at the nanoscale level, which makes the nanoparticle form useful to semiconductor manufacturers.

Because cupric oxide is an oxidizing agenta reactive chemical that removes electrons from other compoundsit may pose a risk. Oxidation caused by metal oxides has been shown to induce DNA damage in certain organisms. What Nelson and his colleagues wanted to learn was whether nanosizing cupric oxide made the generation and accumulation of DNA lesions more or less likely in plants. If the former, the researchers also wanted to find out if nanosizing had any substantial effects on plant growth and health.

To obtain the answers, the NIST/UMass researchers first exposed radishes and the two ryegrasses to both cupric oxide nanoparticles and larger sized cupric oxide particles (bigger than 100 nanometers) as well as to simple copper ions. They then used a pair of highly sensitive spectrographic techniques** to evaluate the formation and accumulation of DNA base lesions and to determine if and how much copper was taken up by the plants.

For the radishes, twice as many lesions were induced in plants exposed to nanoparticles as were in those exposed to the larger particles. Additionally, the cellular uptake of copper from the nanoparticles was significantly greater than the uptake of copper from the larger particles. The DNA damage profiles for the ryegrasses differed from the radish profiles, indicating that nanoparticle-induced DNA damage is dependent on the plant species and on the nanoparticle concentration.

Finally, the researchers showed that cupric oxide nanoparticles had a significant effect on growth, stunting the development of both roots and shoots in all three plant species tested. The nanoparticle concentrations used in this study were higher than those likely to be encountered by plants under a typical soil exposure scenario.

"To our knowledge, this is first evidence that there could be a 'nano-based effect' for cupric oxide in the environment where size plays a role in the increased generation and accumulation of numerous mutagenic DNA lesions in plants," Nelson says.

Next up for Nelson and his colleagues is a similar study looking at the impact of titanium dioxide nanoparticlessuch as those used in many sunscreenson rice plants.


'/>"/>

Contact: Michael E. Newman
michael.newman@nist.gov
301-975-3025
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Related biology news :

1. Long-term study shows effect of climate change on animal diversity
2. £2 million study to reveal workings of dementia genes
3. New study looks to define evangelicals and how they affect polling
4. CU-Boulder study suggests air quality regulations miss key pollutants
5. Researchers study acoustic communication in deep-sea fish
6. Study reveals homeowner perceptions in fire-prone areas
7. Researchers study how pistachios may improve heart health
8. Study: urban black bears live fast, die young
9. New study indicates link between weight gains during pregnancy and dieting history
10. Study reveals specific gene in adolescent men with delinquent peers
11. Sweat it out: UH study examines ability of sweat patches to monitor bone loss
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
(Date:5/16/2016)... YORK , May 16, 2016   EyeLock ... solutions, today announced the opening of an IoT Center ... to strengthen and expand the development of embedded iris ... an unprecedented level of convenience and security with unmatched ... authenticate one,s identity aside from DNA. EyeLock,s platform uses ...
(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
(Date:4/26/2016)... and LONDON , ... Finacle, part of EdgeVerve Systems, a product subsidiary ... Onegini today announced a partnership to integrate the ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... provide their customers enhanced security to access and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... and Mold) microbial test has received AOAC Research Institute approval 061601. , “This ... introduced last year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. ...
(Date:6/23/2016)... 23, 2016   EpiBiome , a precision microbiome ... in debt financing from Silicon Valley Bank (SVB). The ... to advance its drug development efforts, as well as ... "SVB has been an incredible strategic partner to ... traditional bank would provide," said Dr. Aeron Tynes ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published ... how a patient who developed lymphedema after being treated for breast cancer benefitted from ... the paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... June 23, 2016 ... 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published recently ... peer-reviewed journal from touchONCOLOGY, Andrew D Zelenetz ... of cancer care is placing an increasing burden ... expensive biologic therapies. With the patents on many ...
Breaking Biology Technology: