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NIH to fund collaborations with industry to identify new uses for existing compounds
Date:6/18/2013

The National Institutes of Health has awarded $12.7 million to match nine academic research groups with a selection of pharmaceutical industry compounds to explore new treatments for patients in eight disease areas, including Alzheimer's disease, Duchenne muscular dystrophy and schizophrenia. The collaborative pilot initiative, called Discovering New Therapeutic Uses for Existing Molecules, is led by the National Center for Advancing Translational Sciences (NCATS) and funded by the NIH Common Fund.

The process of developing a new therapeutic is long and difficult. The average length of time from target discovery to approval of a new drug is more than 13 years, and the failure rate exceeds 95 percent. This failure rate means, however, that many existing partially developed compounds could be advanced to clinical trials more quickly than starting from scratch.

"With thousands of diseases remaining untreatable, there is a sense of urgency to accelerate the pace at which discoveries are transformed into therapies for patients," said Health and Human Services Secretary Kathleen Sebelius. "This program helps forge partnerships between the pharmaceutical industry and the biomedical research community to work together to tackle problems that are beyond the scope of any one organization or sector."

"Innovative, collaborative approaches that improve the therapeutic pipeline are crucial for success," said NIH Director Francis S. Collins, M.D., Ph.D. "This unique collaboration between academia and industry holds the promise of trimming years from the long and expensive process of drug development."

AbbVie (formerly Abbott); AstraZeneca; Bristol-Myers Squibb Company; Eli Lilly and Company; GlaxoSmithKline; Janssen Research & Development, LLC; Pfizer; and Sanofi are participating in the pilot phase of the program.

NCATS launched this initiative in 2012 to help re-engineer the research pipeline using an innovative strategy to identify new uses for compounds that have undergone significant research and development by industry, including safety testing in humans. The Center crowdsourced the industry compounds to academic researchers nationwide to gain ideas for new therapeutic uses with the ultimate goal of developing new treatments for patients.

The program also tested newly created template agreements, which enabled negotiations to be completed in fewer than 11 weeks, versus a typical timeline of a year or more.

"Public-private collaborations are crucial for successful translation; no one organization can succeed alone," said NCATS Director Christopher P. Austin, M.D. "This initiative has created a marketplace to connect academic researchers with potential new drugs, as well as template agreements that streamline the process by limiting the amount of negotiation required before a project can begin."

Each award recipient will test a selected compound for its effectiveness against a previously unexplored disease or condition. The eight disease areas represented are alcohol dependence, Alzheimer's disease, calcific aortic valve stenosis (a condition in which the heart valve hardens and makes it difficult to pump blood out of the heart), nicotine dependence, peripheral artery disease, schizophrenia and two rare diseases: Duchenne muscular dystrophy and the progressive lung disease lymphangioleiomyomatosis. For more details about each project, please visit http://www.ncats.nih.gov/therapeutics-projects.html.

The projects, award recipient principal investigators and industry partners are:

The efficacy and safety of a selective estrogen receptor beta agonist (LY500307)

Academic Partner: Alan Breier, M.D., Indiana University, Indianapolis

Industry Partner: Eli Lilly and Company

Fyn inhibition by AZD0530 for Alzheimer's disease

Academic Partners: Stephen M. Strittmatter, M.D., Ph.D.; Haakon Berge Nygaard, M.D., Ph.D.; and Christopher H. Van Dyck, M.D., Yale University, New Haven, Conn.

Industry Partner: AstraZeneca

Medication development of a novel therapeutic for smoking cessation

Academic Partners: Darlene H. Brunzell, Ph.D., Virginia Commonwealth University, Richmond and Kenneth Alan Perkins, Ph.D., University of Pittsburgh

Industry Partner: Janssen Research & Development, LLC

A novel compound for alcoholism treatment: A translational strategy

Academic Partner: Fatemeh Akhlaghi, Pharm.D., Ph.D., University of Rhode Island, Kingston

NIH Intramural Partner: Lorenzo Leggio, M.D., Ph.D., M.Sc., National Institute on Alcohol Abuse and Alcoholism; National Institute on Drug Abuse

Industry Partner: Pfizer

Partnering to treat an orphan disease: Duchenne muscular dystrophy

Academic Partners: Kathryn R. Wagner, M.D., Ph.D., Kennedy Krieger Institute, Baltimore and Stanley C. Froehner, Ph.D., University of Washington, Seattle

Industry Partner: Sanofi

Reuse of ZD4054 for patients with symptomatic peripheral artery disease (PAD)

Academic Partner: Brian H. Annex, M.D., University of Virginia, Charlottesville

Industry Partner: AstraZeneca

Therapeutic strategy for lymphangioleiomyomatosis (LAM)

Academic Partner: N. Tony Eissa, M.D., Baylor College of Medicine, Houston

Industry Partner: AstraZeneca

Therapeutic strategy to slow progression of calcific aortic valve stenosis

Academic Partners: Jordan D. Miller, Ph.D.; Maurice Enriquez-Sarano, M.D.; and Hartzell V. Schaff, M.D., Mayo Clinic, Rochester, Minn.

Industry Partner: Sanofi

Translational neuroscience optimization of GlyT1 inhibitor for cognitive impairments associated with schizophrenia

Academic Partner: John H. Krystal, M.D., Yale University, New Haven, Conn.

Industry Partner: Pfizer

These cooperative agreements will fund projects for researchers to conduct pre-clinical validation and additional safety studies as needed. If specific milestones are met, clinical feasibility studies or proof-of-concept clinical trials will be initiated to test whether the selected compounds may be effective as treatments for other diseases. The projects will be supported for up to three years.

NCATS leads this effort with additional scientific expertise provided by the National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institute on Alcohol Abuse and Alcoholism; National Institute on Drug Abuse; National Institute of Mental Health; and the National Institute of Neurological Disorders and Stroke.


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Contact: NCATS Office of Communications
ncatsinfo@mail.nih.gov
301-435-0888
NIH/National Center for Advancing Translational Sciences (NCATS)
Source:Eurekalert

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