Navigation Links
NIH supporting Arizona State University research to help in fight against kidney disease
Date:6/8/2012

Research led by an Arizona State University biomedical engineer and physicist to find more effective ways of detecting the onset of kidney disease is getting support from the National Institutes of Health.

The NIH has awarded $400,000 to Kevin Bennett, an assistant professor of the School of Biological and Health Systems Engineering, one of ASU's Ira A. Fulton Schools of Engineering.

The grant will support his team's research focusing on a common form of kidney disease called nephritis.

"A significant portion of the diabetic population and others will develop kidney disease. The earlier we can detect it, the more likely it is that we can effectively treat it," Bennett says.

The current method of identifying kidney disease is to perform a biopsy, which can be painful for patients and prone to errors. Bennett is working on a method using magnetic resonance imaging (MRI) technology that involves magnetic particles.

His team has engineered magnetic nanoparticles that stick to the glomerulus, a part of the kidney that is attached to the nephron. The nephron is a part of the kidney that regulates the level of water and soluble substances in the blood.

By doing an MRI scan on a kidney onto which magnetic nanoparticles have been bound, it creates a visible distortion in the image that enables researchers to extract information about the nephron.

The distortions in such images enable nephrons to be accurately located, their size can be determined and changes in their behavior can be revealed. "If we can detect changes in nephron function early, patients can be treated earlier and with better results," Bennett says.

Another application of the research is in examination of the relationship between the number of nephrons and the risk of cardiovascular and kidney diseases in humans, which is currently done by taking sections of body tissue.

Researchers are also looking at how nanoparticle uptake in the kidneys is affected by diabetes and the strain nanoparticle uptake puts on the kidneys.

"We are doing this with noninvasive imaging. We are developing ways to detect all of this without having to do biopsies or collect body tissue," Bennett explains.

Bennett's team includes: professor Teresa Wu, an industrial engineer and an associate professor in the School of Computing, Informatics, and Decision Systems Engineering in the Ira A. Fulton Schools of Engineering; Min Zhang, a doctoral student working under Wu; professor John Bertam, head of Anatomy and Developmental Biology at Monash University in Australia; and Scott Beeman, a biomedical engineering doctoral student working in Bennett's laboratory.

Beeman has taken a lead role in the kidney research project and recently presented a progress report at a meeting of the International Society for Magnetic Resonance Medicine in Melbourne, Australia.

"It's rare that a Ph.D. student can push a whole field of research forward, but that's what Scott has done," Bennett says.

The team is already in the preclinical stage of research. "We are moving the technique to clinical trials, and we have already developed better nanoparticles and more sensitive ways to detect them."

The next step will be working with human donor kidneys.


'/>"/>
Contact: Joe Kullman
joe.kullman@asu.edu
480-965-8122
Arizona State University
Source:Eurekalert

Related biology news :

1. UC Davis scientists find new role for P53 genetic mutation -- initiation of prostate cancer
2. SF State biology department receives $1.5 million to support science teaching
3. Could cap and trade for water solve problems facing the United States largest rivers?
4. Scientists identify prostate cancer stem cells among low-PSA cells
5. Beehive extract shows potential as prostate cancer treatment
6. Experiments may understate plant responses to climate
7. Syracuse University study finds autumn advantage for invasive plants in eastern United States
8. New diagnostic tool determines aggressiveness of prostate cancer
9. Ohio state hosts national energy conference
10. Study shows botanical formula fights prostate cancer
11. NRC authors brief federal agencies on the state of polar regions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/5/2020)... ... June 04, 2020 , ... Murrieta Genomics has ... patent application for simplified sample preparation for Next Generation Genomic Sequencing (NGS) . ... cost, time, and complexity of sample preparation. , “I have been at the bench ...
(Date:5/30/2020)... JOSE, Calif. (PRWEB) , ... May 29, 2020 ... ... and enabler of digital transformation for enterprises globally, has collaborated with EchoNous Inc. ... the FDA. It can measure systolic heart function, which has been clinically ...
(Date:5/28/2020)... and FORT WORTH, Texas (PRWEB) , ... May ... ... stage biopharmaceutical company, announced today that interim results from their 1801 Phase 1/2 ... of Clinical Oncology (ASCO) Annual Meeting which will take place virtually on May ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... June 22, 2020 , ... Dracen Pharmaceuticals Inc., ... presented June 22-24 during the American Association for Cancer Research Virtual meeting. One ... the potent, consistent single agent activity in KEAP1 mutant tumor models of NSCLC. ...
(Date:6/19/2020)... ... June 18, 2020 , ... The Vitaspace project was founded ... forces to radically prolong life and find a way (medicine or technology) that will ... was supported by various scientists from all over the world, doctors, and all people ...
(Date:6/11/2020)... ... 2020 , ... PathSensors Inc., a Baltimore biotechnology company, announced ... program funded by the National Institute of Food and Agriculture (NIFA) entitled “Food ... goal was to engineer and develop a field-deployable instrument for portable pathogen and ...
(Date:6/11/2020)... (PRWEB) , ... June 09, 2020 , ... Reducing carbon ... the world. From the Paris Agreement to stock market dips, ways to reduce CO2 ... adding biofuels to their portfolio. Most of the biofuels being produced today are created ...
Breaking Biology Technology: