Navigation Links
Mutation in gene associated with rare eye disease also contributes to bladder cancer growth
Date:11/1/2011

New Orleans, LA Research conducted by Dr. Jayne S. Weiss, Professor and Chair of Ophthalmology at LSU Health Sciences Center New Orleans, and colleagues has found that a defect in a gene involved in a rare disease of the cornea also contributes to the progression of invasive bladder cancer. The findings are published in the November 2011 issue of the peer-reviewed journal, DNA and Cell Biology. It is the featured research of the issue, selected for the cover.

Because earlier studies, including Dr. Weiss', showed a protein called TERE1 or UBIAD1 is associated with an eye disease involving excess cholesterol as well as invasive prostate cancer, the team investigated its role in both lipid metabolism and the progression of invasive bladder cancer. TERE1 interacts with a cholesterol carrier protein and Dr. Weiss' earlier research found a TERE1 mutation in Schnyder's corneal dystrophy, a rare disease characterized by abnormal deposits of cholesterol and other lipids, or fats, in the cornea leading to progressive loss of vision. An elevated level of cholesterol in cells has also been implicated in the development and progression of breast, colon, liver, head and neck, and melanoma cancers.

The objectives of this study were to confirm that TERE1 levels are reduced in advanced bladder cancer and that TERE1 inhibits the growth of bladder cancer cells. The researchers manipulated the proteins thought to control cell stress, growth signaling, and how cholesterol and other fats are handled in cells and tested them in human bladder cancer cells in a mouse model. They found that TERE1 was reduced in a third of the invasive specimens and that when added to cells, TERE1 dramatically inhibited the development of tumors. They also showed that altering the dosage of TERE1 and another protein implicated in disease associated with triglyceride metabolism, called TBL2, regulates cholesterol in cells and that mutations in TERE1 associated with Schnyder's corneal dys
'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study tracks mutations causing CDA II back to the Roman Empire
2. New mutations in leukemia: Researchers found mechanism that can help design future therapies
3. Scientists identify mutation in SIGMAR1 gene linked to juvenile ALS
4. Mutations not inherited from parents cause more than half the cases of schizophrenia
5. Research discovers frequent mutations of chromatin remodeling genes in TCC of the bladder
6. As new data wave begins, a gene study in one disease discovers mutations in an unrelated disease
7. UT Southwestern research reveals that significantly more genetic mutations lead to colon cancer
8. Evolution and domestication of seed structure shown to use same genetic mutation
9. Environs prompt advantageous gene mutations as plants grow; changes passed to progeny
10. Mutations can spur dangerous identity crisis in cells
11. Evolutionary kings of the hill use good, bad and ugly mutations to speed ahead of competition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ) ... Facial Recognition Market 2015-2019" report to their ... Facial recognition is a technology used ... measures the overall facial feature of a person ... distance between eyes. Facial recognition is used for ...
(Date:12/11/2014)... , Dec. 10, 2014  Data Sciences ... monitoring, has released a new series of digital ... preclinical toxicology researchers. M series, part of the ... collect the best possible physiologic data when incorporating ... Adding functional endpoints to toxicology studies has evolved ...
(Date:12/10/2014)... , Dec. 9, 2014 CIE San ... catalyst that provides the connective tissue that enhances care ... them to easily share client-level information; earned a second ... expand to organizations serving seniors aging in community and; ... partner on December 11 th 4-6p. ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... played a vital role in China,s agricultural scene ... allowing growers to produce more varieties of vegetables, ... published report Chinese scientists called solar greenhouses "the ... crops in China." The team of researchers from ...
... LA JOLLA, Calif. March 17, 2011 Dr. Daniel ... Medicine Award for his "pioneering efforts" in sequencing, or spelling ... Von Hoff,s research and clinical work advances the art of ... all 3 billion letters of their DNA, to help determine ...
... 17, 2011Simulated interactions in which adults with autism converse ... social interaction skills, according to a novel study presented ... peer-reviewed journal published by Mary Ann Liebert, Inc. ( ... http://www.liebertpub.com/cyber More than half of individuals ...
Cached Biology News:Solar greenhouses: China's winning solution to global energy crisis 2Dr. Daniel Von Hoff presented with top genomics award from Scripps 2
(Date:12/19/2014)... The empty capsules market is ... population and technological innovations in the empty capsules ... catalysing the growth of the empty capsules market. ... , Scope of Report , The report will ... entrants/smaller firms to gauge the pulse of the ...
(Date:12/19/2014)... N.Y. , Dec. 18, 2014 Egenix, Inc. ... has been elected Chairman of the Board, to succeed ... and CEO, but will continue as a member of the ... he has added to the company over almost twenty years, ... The Board of Directors has established a Search Committee ...
(Date:12/17/2014)... (PRWEB) December 16, 2014 The ... since 2013, which is why IBISWorld updated its original ... continues to benefit from an intensified focus on environmental ... for new emission standards for power plants and a ... According to IBISWorld Industry Analyst Sarah Kahn, “a range ...
(Date:12/17/2014)... 2014 Achim Noack has been named ... Group. In this position, Noack will assist Jerry Stoller, ... develop marketing strategy and supervise global marketing management and ... has tremendous knowledge and experience in the crop protection ... experience and innovative thinking will be a great asset ...
Breaking Biology Technology:Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 4Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2
... frequently,relapsing bipolar disorder had a significant delay in ... injection (RLAI) was combined,with standard treatment, according to ... RLAI and standard treatment to those who received,standard ... presented yesterday at the 14th Biennial Winter Workshop,on ...
... BioSciences, Inc. today,announced that the Company will present ... Dana Point, CA on Tuesday, February 19, 2008 ... live web cast of the presentation at, http://www.darabiosciences.com ... available at,the same location., About DARA BioSciences, ...
... 4 Amarin Corporation plc,(NASDAQ: AMRND ) ... established,the position of Lead Independent Director and has ... role. In his capacity as Lead,Independent Director, Dr. ... the independent directors, and will preside over those ...
Cached Biology Technology:Study Suggests Risperidone Long-Acting Injection Combined with Standard Treatment Helped Delay Time to Relapse in Patients with Bipolar Disorder 2Study Suggests Risperidone Long-Acting Injection Combined with Standard Treatment Helped Delay Time to Relapse in Patients with Bipolar Disorder 3Study Suggests Risperidone Long-Acting Injection Combined with Standard Treatment Helped Delay Time to Relapse in Patients with Bipolar Disorder 4Study Suggests Risperidone Long-Acting Injection Combined with Standard Treatment Helped Delay Time to Relapse in Patients with Bipolar Disorder 5DARA BioSciences to Present at the ROTH Growth Stock Conference 2Amarin Appoints Dr. William Mason as Lead Independent Director 2Amarin Appoints Dr. William Mason as Lead Independent Director 3
Coverslips for Microarrays, 1. *Category: MICROARRAY ACCESSORIES....
S. O'Hare & C.K. Atterwill • In vitro toxicity techniques for regular lab use. Ex vivo techniques are also covered with the aim of reducing and refining the use of animals in the future....
... The ScriptCap™ 2'-O-Methyltransferase converts Cap 0 ... mRNA. The Cap 1 structure has been ... by up to 50%. This improvement is ... the ScriptCap™ m7G Capping System as well ...
Form: Concentrated Applications: ELISA...
Biology Products: