Navigation Links
Mutation in gene associated with rare eye disease also contributes to bladder cancer growth
Date:11/1/2011

New Orleans, LA Research conducted by Dr. Jayne S. Weiss, Professor and Chair of Ophthalmology at LSU Health Sciences Center New Orleans, and colleagues has found that a defect in a gene involved in a rare disease of the cornea also contributes to the progression of invasive bladder cancer. The findings are published in the November 2011 issue of the peer-reviewed journal, DNA and Cell Biology. It is the featured research of the issue, selected for the cover.

Because earlier studies, including Dr. Weiss', showed a protein called TERE1 or UBIAD1 is associated with an eye disease involving excess cholesterol as well as invasive prostate cancer, the team investigated its role in both lipid metabolism and the progression of invasive bladder cancer. TERE1 interacts with a cholesterol carrier protein and Dr. Weiss' earlier research found a TERE1 mutation in Schnyder's corneal dystrophy, a rare disease characterized by abnormal deposits of cholesterol and other lipids, or fats, in the cornea leading to progressive loss of vision. An elevated level of cholesterol in cells has also been implicated in the development and progression of breast, colon, liver, head and neck, and melanoma cancers.

The objectives of this study were to confirm that TERE1 levels are reduced in advanced bladder cancer and that TERE1 inhibits the growth of bladder cancer cells. The researchers manipulated the proteins thought to control cell stress, growth signaling, and how cholesterol and other fats are handled in cells and tested them in human bladder cancer cells in a mouse model. They found that TERE1 was reduced in a third of the invasive specimens and that when added to cells, TERE1 dramatically inhibited the development of tumors. They also showed that altering the dosage of TERE1 and another protein implicated in disease associated with triglyceride metabolism, called TBL2, regulates cholesterol in cells and that mutations in TERE1 associated with Schnyder's corneal dys
'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study tracks mutations causing CDA II back to the Roman Empire
2. New mutations in leukemia: Researchers found mechanism that can help design future therapies
3. Scientists identify mutation in SIGMAR1 gene linked to juvenile ALS
4. Mutations not inherited from parents cause more than half the cases of schizophrenia
5. Research discovers frequent mutations of chromatin remodeling genes in TCC of the bladder
6. As new data wave begins, a gene study in one disease discovers mutations in an unrelated disease
7. UT Southwestern research reveals that significantly more genetic mutations lead to colon cancer
8. Evolution and domestication of seed structure shown to use same genetic mutation
9. Environs prompt advantageous gene mutations as plants grow; changes passed to progeny
10. Mutations can spur dangerous identity crisis in cells
11. Evolutionary kings of the hill use good, bad and ugly mutations to speed ahead of competition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/14/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/5whpxg/fingerprint ... Sensors Market in Smart Mobile Devices " report ... 2014 was a watershed year for fingerprint sensors in ... Pay,. Apple gave fingerprint sensors a raison d,etre in ... sensors are a must-have feature in flagship smartphones. ...
(Date:5/11/2015)... May 11, 2015  Through a well-rounded UAS delegation representing ... had a strong showing at AUVSI,s Unmanned 2015 conference last ... Ohio,s UAS industry met with over ... all points along the UAS ecosystem. "Our ... Vice President for Aerospace Rich Knoll . "If you ...
(Date:5/8/2015)... Calif. , May 8, 2015 Synaptics Inc. ... solutions, today announced that members of the executive management team ... Morgan 43rd Annual Technology, Media and Telecom Conference Date: ... Hotel in Boston, MA ... 27, 2015 Time: 2:45pm ET Location: The New York Palace ...
Breaking Biology News(10 mins):Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2Synaptics to Present at Upcoming Investor Conferences 2
... Most toxic pollution falling onto Puget Sound,s waters ... percent below earlier estimates, according to a region-wide ... industrial areas like Tacoma still have the Puget,s Sound,s ... the Department of Energy,s Pacific Northwest National Laboratory and ...
... Dana-Farber Cancer Institute in Boston have identified a new type ... protects the animal,s own cells from immune system attack. ... that can drive lupus and other autoimmune diseases in which ... tissues. The discovery, published in the September 16 ...
... of Environmental Health Sciences has awarded $2.27 million ... five-year study of how the environment alters genetic ... The project reflects a changing approach to environmental ... toxicology, computational sciences and information technology to learn ...
Cached Biology News:The sky is falling (less) onto Puget Sound 2The sky is falling (less) onto Puget Sound 3The sky is falling (less) onto Puget Sound 4Discovery of a cell that suppresses the immune system 2Researcher awarded $2.27 million to study environmental effects on gene copy number 2Researcher awarded $2.27 million to study environmental effects on gene copy number 3Researcher awarded $2.27 million to study environmental effects on gene copy number 4
(Date:5/28/2015)... May 28, 2015 Celsion Corporation (the "Company") ... received commitments from two institutional healthcare investors to purchase ... common stock in an at-the-market registered direct offering and ... stock. The Company entered into a definitive ... Company agreed to sell an aggregate of 3,000,000 shares ...
(Date:5/28/2015)... , May 28, 2015 RXi Pharmaceuticals Corporation ... discovering and developing innovative therapeutics, primarily in the areas ... a public offering of 26 million units at a ... gross proceeds of approximately $10.4 million. Each unit consists ... 13-month overallotment purchase right to purchase 0.50 of a ...
(Date:5/28/2015)... Glenn Keet, CEO of Clinovo , ... Clinical Data Integration with EDC Systems ” at the ... on June 14th-18th. , During the presentation, Glenn Keet ... EDC, and will examine the value of patient engagement, ... health records/electronic medical records integration. , The presentation ...
(Date:5/28/2015)... (PRWEB) May 28, 2015 In two ... James L. Sherley, M.D., Ph.D., will present the company’s ... In a conference talk, he will describe ... culture designs with computer simulation to produce the first-ever ... number and quality over time in culture. When ...
Breaking Biology Technology:Celsion Corporation Announces $8 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $8 Million At-The-Market Registered Direct Offering 3RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 3Clinovo Presents at the DIA 2015 51st Annual Meeting in Washington, DC on June 14th-18th 2Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 2Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 3
... Business Objects has agreed to buy La Crosse-based data ... cash. The deal is expected to close in the second ... software, services, education and consulting to help businesses make sure ... They serve 6,000 customers worldwide in places such as call ...
... Madison, Wis. Third Wave Technologies has settled ... genotyping patents. Third Wave will license hepatitis C virus ... ,The two companies' relationship goes back further. In Aril ... was an exclusive distributor of its proprietary Invader line ...
... Graphics, a printer of magazines, catalogs, books, direct mail ... for clients into a new business unit called ... who also serves as Quad Graphics' vice president of ... is backed by the capabilities of 260 corporate IT ...
Cached Biology Technology:
StemSep Anti-Phycoertherin Tetrameric Antibody Complexes, 2 mL for labeling 1x10 9 cells. Cross-linking Reagent for StemSep Separations of Cells Labeled with PE-conjugated Antibody....
Printer paper for Model 680 series readers is used with the thermal printers of the Model 680 and Model 680 XR microplate readers. Supplied as 2 rolls....
... is used for vertical electrophoresis applications. The cell accommodates ... L of running buffer. It includes the PROTEAN II ... kit, which contains accessories for use with 2.0 mm ... 2 sets of 20 x 20 cm glass plates, ...
Includes PROTEAN II xi Basic unit and IPG conversion kit PROTEAN II XL Cell, wide format, Compatible with ReadyStrip IPG Strips 1.0 mm 165-3188 1.5 mm 165-3189 2.0 mm 165-3190...
Biology Products: