Navigation Links
Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
Date:8/17/2007

In an upcoming issue of G&D, Drs. Maria Divina Deato and Robert Tjian (HHMI, UC Berkeley) reveal that the formation of an alternative transcriptional core promoter complex directs cell-type specific differentiation during myogenesis. The article uncovers a whole new level of transcriptional control of terminal cell differentiation, and will be published online ahead of its September 1 print date at www.genesdev.org.

For nearly 30 years, we have assumed that the basal transcription machinery, particularly the highly conserved TBP and TFIID complex, would be invariant and universal for all cell types in eukaryotes. It seems that this simplistic model will need to be revised with significant implications for mechanisms controlling multi-cellular differentiation, explains Dr. Tjian.

Skeletal muscle differentiation, or myogenesis, involves a multi-step transition from muscle precursor cells (myoblasts) to myotubes that ultimately comprise the contractile myofibers of the muscle tissue. Drs. Deato and Tjian show that during myogenesis, a component of the canonical transcription initiation machinery a multi-subunit transcription factor called TFIID is disassembled and replaced with an alternative core promoter recognition complex. The researchers determined that this alternative complex contains both TAF3 and TRF3, and is required for successful myogenesis.


'/>"/>
Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related biology news :

1. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
2. X-Ray Beams And Fruit Fly Flight Simulator Aid Scientists View Of Muscle Power
3. Heart repair gets new muscle
4. Young Blood Revives Aging Muscles, Stanford Researchers Find
5. Small worm yields big clue on muscle receptor action
6. New complete muscle grown in the lab
7. Spiders help scientists discover how muscles relax
8. Cant serve an ace? Could be muscle fatigue
9. Lance Armstrong through a physiological lens: hard training boosts muscle power 8%
10. Muscle repair: Making a good system better, faster; implications for aging, disease
11. Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, Stanford study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2014)... of subarctic forest moths in Finnish Lapland suggests that ... on animals and plants because much of the harm ... of 80 moth species and found that 90 percent ... study period, from 1978 to 2009. During that time, ... degrees Fahrenheit, and winter precipitation increased as well. , ...
(Date:4/14/2014)... climate over the past three decades have caused small ... national animal. UCLA biologists have found that not only ... has also become shorter and higher pitched. ... integrative biology and physiology and of ecology and evolutionary ... study examined 170 male coqui frogs ( Eleutherodactylus coqui ...
(Date:4/14/2014)... ( http://www.ucr.edu ) David Kisailus, the Winston ... University of California, Riverside,s Bourns College of Engineering, ... Fellows are young scientists selected by the advisory ... National Academy of Sciences and organizers of the ... series. The Kavli Foundation, which is based in ...
Breaking Biology News(10 mins):Moth study suggests hidden climate change impacts 2Moth study suggests hidden climate change impacts 3Climate change a likely culprit in coqui frog's altered calls, say UCLA biologists 2Professor receives young scientist honor 2
... permanently damaged their skin cells, causing them to overproduce ... uneven skin tone over time. But new research indicates ... arthritis ?can actually help stop the formation of new ... findings on glucosamine may impact the way dermatologists treat ...
... warm, sun-drenched, tropical seas; some species are found at ... waters throughout the world's oceans. Some cold-water coral reefs ... a diversity rivaling some better known tropical coral reefs. ... method in which vessels drag large, heavily weighted nets ...
... the rewarding effect of cocaine on mice by genetically ... animal's brain. , While the researchers aren't suggesting that ... brings to light the key protein that controls cocaine's ... medications that achieve the same results and therefore help ...
Cached Biology News:Science finds new fix for UV-damaged skin in arthritis treatment 2Science finds new fix for UV-damaged skin in arthritis treatment 3Ocean acidification threatens cold-water coral ecosystems 2Genetically altered mice no longer like cocaine 2Genetically altered mice no longer like cocaine 3
(Date:1/15/2014)... 15, 2014 Freeslate, Inc ... solutions, today announced that Lupin Limited, one of ... of Freeslate’s CM Protégé PharmD System ... Lupin, headquartered in Mumbai, India, is focused on ... branded formulations and Active Pharmaceutical Ingredients (APIs) for ...
(Date:1/14/2014)... San Diego, CA (PRWEB) January 14, 2014 ... developing solutions based on the products of cells ... they have entered into an international license agreement ... containing Histogen’s proprietary multipotent cell conditioned media (CCM). ... to the existing license between Histogen and Suneva ...
(Date:1/14/2014)... and BETHESDA, Md. , Jan. ... are joining together with two institutes from the ... develop more reliable tools for bringing safer, more ... Organovo is collaborating with the National Center for ... Institute (NEI) to develop better and more clinically ...
(Date:1/14/2014)... , Jan. 14, 2014   Kinaxis ®, ... management ( SCM ) and sales and operations planning ... gold sponsor of the Biomanufacturing Summit , which ... January 30 – 31, 2014.  At the conference, join ... Chain at Amgen, as she presents ,Supply Chain: Improving ...
Breaking Biology Technology:Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... Scientific,Corporation (NYSE: BSX ) is scheduled to participate ... being held September 10 and 11,in New York City. ... make a,25-minute presentation followed by a 25-minute question and ... a.m. ET. A live webcast of Mr. LaViolette,s ...
... Artery ... Disease - ... -, FREMONT, Calif., Aug. 28 Vermillion, Inc.,(Nasdaq: VRML ), formerly ... called beta-2,microglobulin may aid in the diagnosis of peripheral artery disease (PAD).,The findings, ...
... (Pink Sheets: BIEL), announced today that Astonix Life,Science, ... provide ActiPatch,Therapy to the healthcare market in Singapore. ... ActiPatch to the market has been warmly,received. ... the Healthcare providers,in Singapore has been strong enough ...
Cached Biology Technology:Vermillion and Collaborators Discover Protein Biomarker Associated with Peripheral Artery Disease 2Vermillion and Collaborators Discover Protein Biomarker Associated with Peripheral Artery Disease 3BioElectronics Corporation Announces Singapore and Malaysia Sales 2
Human Apolipoprotein B100 Affinity Purified Polyclonal Ab ENTREZ GeneID: 338...
hypertension-related calcium-regulated gene, mRNA...
Human PLUNC MAb (Clone 252512)...
... GRASP1 ( Abpromise for all ... Synthetic peptide corresponding to amino ... region of rat GRASP1, conjugated to ... Entrez GeneID: 56850 ...
Biology Products: