Navigation Links
Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
Date:8/17/2007

In an upcoming issue of G&D, Drs. Maria Divina Deato and Robert Tjian (HHMI, UC Berkeley) reveal that the formation of an alternative transcriptional core promoter complex directs cell-type specific differentiation during myogenesis. The article uncovers a whole new level of transcriptional control of terminal cell differentiation, and will be published online ahead of its September 1 print date at www.genesdev.org.

For nearly 30 years, we have assumed that the basal transcription machinery, particularly the highly conserved TBP and TFIID complex, would be invariant and universal for all cell types in eukaryotes. It seems that this simplistic model will need to be revised with significant implications for mechanisms controlling multi-cellular differentiation, explains Dr. Tjian.

Skeletal muscle differentiation, or myogenesis, involves a multi-step transition from muscle precursor cells (myoblasts) to myotubes that ultimately comprise the contractile myofibers of the muscle tissue. Drs. Deato and Tjian show that during myogenesis, a component of the canonical transcription initiation machinery a multi-subunit transcription factor called TFIID is disassembled and replaced with an alternative core promoter recognition complex. The researchers determined that this alternative complex contains both TAF3 and TRF3, and is required for successful myogenesis.


'/>"/>
Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related biology news :

1. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
2. X-Ray Beams And Fruit Fly Flight Simulator Aid Scientists View Of Muscle Power
3. Heart repair gets new muscle
4. Young Blood Revives Aging Muscles, Stanford Researchers Find
5. Small worm yields big clue on muscle receptor action
6. New complete muscle grown in the lab
7. Spiders help scientists discover how muscles relax
8. Cant serve an ace? Could be muscle fatigue
9. Lance Armstrong through a physiological lens: hard training boosts muscle power 8%
10. Muscle repair: Making a good system better, faster; implications for aging, disease
11. Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, Stanford study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/25/2015)... , Feb. 25, 2015  ABC Financial Services ... in the Health and Fitness Industry, today announced ... to MYiCLUBonline.  The latest upgrade includes advances to ... of cardless check-in via Identity One fingerprint biometrics. ... time through interactive displays at the International Health, ...
(Date:2/19/2015)... , Feb .19, 2015 Research and Markets ... addition of the "Military Electro-Optical / Infrared ... Technology, by Platform - Forecast to 2020" ... military electro-optical/infrared systems market is expected to reach ... of 7.71%. This report segments the ...
(Date:2/11/2015)... February 11, 2015 ... "Access Control Market by Product (Cards and Readers, Biometrics, ... Defense, Government, Industrial, Healthcare, Education) and By Geography - Global ... MarketsandMarkets, the Access Control Market is expected ... at a CAGR of 10.6% between 2014 ...
Breaking Biology News(10 mins):ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4
... an artificial tumor-specific receptor to immune system cells ... improved the cells, ability to fight a form of ... of Medicine and Texas Children,s Hospital in a report ... Medicine . "This is a way to convert ...
... of the American Dietetic Association takes a closer look ... child,s risk for the disease. Other studies in the issue ... that counseling and increased physical activity have on children,s obesity. ... ,Children living in poverty have high levels of ...
... skeletons of organisms contain small amounts of impurity elements ... provide important clues to past environments, a considerable effort ... to the ancient environments in which an organism lived. ... Science magazine, Allison Stephenson, a Ph.D. candidate in ...
Cached Biology News:A double-barreled immune cell approach for neuroblastoma 2News from the November 2008 Journal of the American Dietetic Association 2Bare bones of crystal growth: Biomolecules enhance metal contents in calcite 2
(Date:3/3/2015)... GlobalStemCellsGroup.com has recruited Mario Camacho ... biomedical researcher and founding partner of Criogenix SA de ... biomedical professors who will teach the “Diplomat in Cell ... CV is a private company registered in the National ... Mexico (RENIECYT). , Camacho Alcocer will teach two-day, interactive ...
(Date:3/2/2015)... March 02, 2015 Resilinc ... annual report which summarizes and analyzes nearly 700 ... EventWatch™ 24X7 global event monitoring and alert ... to a free trial period of the email service ... incidents that can negatively impact revenue, market share, customer ...
(Date:3/2/2015)... , March 2, 2015 ... healthy whole food nutrition products reveal technological advancements ... related disorders such as hyperglycemia, obesity, insulin level ... Nutraceutical and Biotech Companies in focus today are: RiceBran ... Foods Ltd. (NYSE: ANFI ), CEL-SCI ...
(Date:3/2/2015)... 02, 2015 Global Stem ... alliance with Shenzhen HANK Bioengineering Co., Ltd. and ... alliance will establish a stem cells training course ... in September 2015. , Shenzhen HANK is a ... award-winning scientist, microbiologist and virologist, to integrate research, ...
Breaking Biology Technology:Mario Camacho Alcocer Joins Global Stem Cells Group Faculty 2Mario Camacho Alcocer Joins Global Stem Cells Group Faculty 3Resilinc Publishes 2014 EventWatch™ Supply Chain Disruption Annual Report 2Resilinc Publishes 2014 EventWatch™ Supply Chain Disruption Annual Report 3Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 2Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 3Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 4Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 5Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 6Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 7Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 2Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 3
... year in which some new investments were made, some old ... to prosper in some emerging sectors. , ,With luck, 2007 ... warm and state policymakers need to turn a cold shoulder ... the global marketplace. What's in store for the New Year? ...
... - The recommendations of a state technology organization ... the tax-credit program designed to encourage more investment in ... fiscal situation and philosophical disagreements about the act's purpose, ... white paper, the Wisconsin Technology Council called ...
... of two transitions; one in leadership, the other in mission. ... in both. Wittwer, who officially succeeded James Barr on New ... transformation from a phone company to a broadband provider. ... about the leadership transition. In part one, he explains the ...
Cached Biology Technology:Wisconsin's high-growth economy: '07 predictions 2Wisconsin's high-growth economy: '07 predictions 3Wisconsin's high-growth economy: '07 predictions 4Will there be more money for investment credits? 2New CEO at TDS on tech innovation and leadership (Part 1) 2New CEO at TDS on tech innovation and leadership (Part 1) 3New CEO at TDS on tech innovation and leadership (Part 1) 4
... In virtually every research laboratory, the ... of information accurately, inexpensively and in real ... compact lab analysis system includes the Luminex ... It utilizes xMAP technology which enables you ...
... Luminex 100 IS System is a compact analysis ... integrates lasers, optics, fluidics, a controller, advanced digital ... powerful, compact lab analysis system includes the Luminex ... it has a DMF file at the FDA, ...
... of amino acids and peptides produced ... It is recommended for laboratory media ... in antibiotics, toxins and enzyme productions. ... pH6.8 0.5 at 25 C, 2% ...
... Highly nutritious peptone, used ... production of bacterial toxins, ... of bacteria with high ... Haemophilus, Neisseria, Pasteurella, Salmonella ...
Biology Products: