Navigation Links
Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
Date:8/17/2007

In an upcoming issue of G&D, Drs. Maria Divina Deato and Robert Tjian (HHMI, UC Berkeley) reveal that the formation of an alternative transcriptional core promoter complex directs cell-type specific differentiation during myogenesis. The article uncovers a whole new level of transcriptional control of terminal cell differentiation, and will be published online ahead of its September 1 print date at www.genesdev.org.

For nearly 30 years, we have assumed that the basal transcription machinery, particularly the highly conserved TBP and TFIID complex, would be invariant and universal for all cell types in eukaryotes. It seems that this simplistic model will need to be revised with significant implications for mechanisms controlling multi-cellular differentiation, explains Dr. Tjian.

Skeletal muscle differentiation, or myogenesis, involves a multi-step transition from muscle precursor cells (myoblasts) to myotubes that ultimately comprise the contractile myofibers of the muscle tissue. Drs. Deato and Tjian show that during myogenesis, a component of the canonical transcription initiation machinery a multi-subunit transcription factor called TFIID is disassembled and replaced with an alternative core promoter recognition complex. The researchers determined that this alternative complex contains both TAF3 and TRF3, and is required for successful myogenesis.


'/>"/>
Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related biology news :

1. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
2. X-Ray Beams And Fruit Fly Flight Simulator Aid Scientists View Of Muscle Power
3. Heart repair gets new muscle
4. Young Blood Revives Aging Muscles, Stanford Researchers Find
5. Small worm yields big clue on muscle receptor action
6. New complete muscle grown in the lab
7. Spiders help scientists discover how muscles relax
8. Cant serve an ace? Could be muscle fatigue
9. Lance Armstrong through a physiological lens: hard training boosts muscle power 8%
10. Muscle repair: Making a good system better, faster; implications for aging, disease
11. Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, Stanford study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2019)... ... October 30, 2019 , ... ... Convergence in Nashville, TN from Tuesday, November 5, 2019, to Thursday, November 7, ... (chemical, biological, radiological, nuclear) and IED (explosive) threats. Delegates and experts from over ...
(Date:10/29/2019)... ... October 29, 2019 , ... Fujirebio Diagnostics, Inc., ... Administration (FDA) clearance of the company’s Lumipulse® G whole PTH Assay for testing ... secreted by the parathyroid glands; which are four small glands located behind the ...
(Date:10/26/2019)... (PRWEB) , ... October 23, ... ... significant workflow advances to the ImageXpress® Pico Automated Cell Imaging System including ... , The Digital Confocal option allows scientists to decrease exposure ...
Breaking Biology News(10 mins):
(Date:10/10/2019)... ROCKVILLE, Md. (PRWEB) , ... October 09, 2019 ... ... Thursday, October 10th, groups of Montgomery County middle school and high school students ... to handle stressors, utilize relaxation techniques and physical fitness, and apply lifelong social/interpersonal, ...
(Date:10/8/2019)... (PRWEB) , ... October 08, 2019 , ... ... Project (TMP), Madhumita Suresh and Leslie Maurer presented company executives with a set ... and Science (MBS) graduates will offer insights from their TMP to a wider ...
(Date:10/3/2019)... ... 2019 , ... Today Cereset®, the only proven non-invasive technology ... its randomized research trial for individuals with persisting symptoms following mild-Traumatic Brain Injury ... non-invasive technology which compares tones delivered to a subject’s brain guided by the ...
(Date:10/3/2019)... ... October 02, 2019 , ... Murrieta Genomics , the launch pad ... capital companies in Silicon Valley at a special Life Science showcase event ... held at the JJ Lake Business Center located at 340 E. Middlefield Road in ...
Breaking Biology Technology: