Navigation Links
Multiple sclerosis study reveals how killer T cells learn to recognize nerve fiber insulators
Date:1/11/2013

Misguided killer T cells may be the missing link in sustained tissue damage in the brains and spines of people with multiple sclerosis, findings from the University of Washington reveal. Cytoxic T cells, also known as CD8+ T cells, are white blood cells that normally are in the body's arsenal to fight disease.

Multiple sclerosis is characterized by inflamed lesions that damage the insulation surrounding nerve fibers and destroy the axons, electrical impulse conductors that look like long, branching projections. Affected nerves fail to transmit signals effectively.

Intriguingly, the UW study, published this week in Nature Immunology, also raises the possibility that misdirected killer T cells might at other times act protectively and not add to lesion formation. Instead they might retaliate against the cells that tried to make them mistake the wrappings around nerve endings as dangerous.

Scientists Qingyong Ji and Luca Castelli performed the research with Joan Goverman, UW professor and chair of immunology. Goverman is noted for her work on the cells involved in autoimmune disorders of the central nervous system and on laboratory models of multiple sclerosis.

Multiple sclerosis generally first appears between ages 20 to 40. It is believed to stem from corruption of the body's normal defense against pathogens, so that it now attacks itself. For reasons not yet known, the immune system, which wards off cancer and infection, is provoked to vandalize the myelin sheath around nerve cells. The myelin sheath resembles the coating on an electrical wire. When it frays, nerve impulses are impaired.

Depending on which nerves are harmed, vision problems, an inability to walk, or other debilitating symptoms may arise. Sometimes the lesions heal partially or temporarily, leading to a see-saw of remissions and flare ups. In other cases, nerve damage is unrelenting.

The myelin sheaths on nerve cell projection
'/>"/>

Contact: Leila Gray
leilag@uw.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Nursing gerbils unravel benefit of multiple mothers in collective mammals
2. Medbox, Inc. Featured in Multiple Media Stories in Massachusetts and California
3. Combination of two pharmaceuticals proves effective in the treatment of multiple sclerosis
4. Multiple sclerosis immune exchange between brain and blood is uncovered
5. Under the right conditions, peptide blocks HIV infection at multiple points along the way
6. Researchers identify need to sample multiple tumor zones in breast cancer
7. New data improve understanding of breast cancers multiple varieties
8. Clinical trial launches to see whether vitamin D helps treat multiple sclerosis
9. New insights into how immune system fights atherosclerosis
10. Zebra fish point the way towards new therapies for amyotrophic lateral sclerosis
11. UMMS researchers isolate gene mutations in patients with inherited amyotrophic lateral sclerosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Multiple sclerosis study reveals how killer T cells learn to recognize nerve fiber insulators
(Date:4/24/2014)... that cells are more resilient in taking care of ... critical components, cells can adapt and make copies of ... study published in this week,s Cell Reports , ... that cells can grow normally without a crucial component ... is stored in DNA, which has to be continuously ...
(Date:4/24/2014)... the Scientific Reports journal. , CSIC researcher Carles ... of CSIC and Pompeu Fabra University-UPF), explains: "When the Y ... that it did not match with the DNA recovered from ... genome and to make a functional interpretation in order to ... , The functional genome analysis was based on two ...
(Date:4/24/2014)... Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have identified ... system to discriminate between viral and endogenous RNAs ... they take control of cellular metabolism and hijack ... This process is dependent on viral RNA molecules ... of RNA viruses) and/or newly synthesized in the ...
Breaking Biology News(10 mins):Cell resiliency surprises scientists 2The blood preserved in the pumpkin did not belong to Louis XVI 2Viral infections: Identifying the tell-tale patterns 2Viral infections: Identifying the tell-tale patterns 3
... is on track to become only the second disease ever ... The Journal of Infectious Diseases, now available online, scientists are ... gone. One study reduces concerns that people whose immune systems ... The other study looks at the how switching forms ...
... there has been great controversy about the ubiquitous vegetable's ... National Academies of Sciences, a team led by a ... has for the first time demonstrated a single origin ... scientists analyzed DNA markers in 261 wild and 98 ...
... into the chest to maintain circulation can significantly extend ... failure who are not candidates for heart transplantation, according ... Duke University Medical Center cardiologists. , The pumps, known ... the heart's left ventricle ?the chamber of the heart ...
Cached Biology News:Polio vaccination strategies assessed as eradication nears 2Polio vaccination strategies assessed as eradication nears 3Finding rewrites the evolutionary history of the origin of potatoes 2Implantable pumps extend lives of patients too sick for transplant 2Implantable pumps extend lives of patients too sick for transplant 3
(Date:1/15/2014)... January 15, 2014 A study has been ... the Formula 1 track could help to tackle the problem ... (MAT), Stowhealth (a GP surgery based in Stowmarket) and academics ... Simplyhealth. Telemetry technology, which is inspired by equipment ...
(Date:1/15/2014)... NY (PRWEB) January 15, 2014 The Microcompetition ... a major disease. One of these latent viruses is the ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic inflammatory ... theory, a study found that RA patients have high concentrations ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Freeslate, ... solutions, today announced that Lupin Limited, one of India’s ... CM Protégé PharmD System for high throughput ... India, is focused on a wide range of quality, ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 p.m. – ... Warrington, Pa. , Details: The Hepatitis B Foundation, ... cure for hepatitis B and improving the quality of life ... on Friday, April 11 at Warrington Country Club in Warrington, ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... Madison, Wis. - TomoTherapy, Inc. , producer ... reach to Germany. , , The University Clinic Heidelberg ... treat cancer patients with the Hi-Art System, a machine that ... cells with limited damage to healthy tissue. , ,Dr. Jrgen ...
... the third major storm of the 2006 Atlantic ... low-pressure system recently, apprehensions about impending natural and ... , ,A Wisconsin telecommunications company has been enlisted ... ,To address concerns of a large-scale crisis once ...
... tool that misrepresented something simple about more than 90 ... basing their health plan buying decisions on the often ... have to imagine such a scenario because they have ... ,Now a Wisconsin software developer believes it has come ...
Cached Biology Technology:Wisconsin firm leads testing of alerts by cell phone 2Wisconsin firm leads testing of alerts by cell phone 3Healthcare software addresses "90 million" misclassified Americans 2Healthcare software addresses "90 million" misclassified Americans 3
... and other fluid sources for 8 vessels ... of each individual pump is controlled electronically. ... exactly maintained. ,High-precision controlled miniature pumps ... which allows flow rates between 0 and ...
... excellent ion chromatography system . The ... from 0.01S to 5000S, houses the measuring cell ... CE 4715, is available. Data processing is ... Solvent delivery is by the high pressure CE ...
Fujifilm Pictro-Color Process for sharp, clear reproduction comparable to silver-halide photography. Photorealistic 400 dpi quality. A4 and A5 output....
... and other fluid sources for 4 vessels ... of each individual pump is controlled electronically. ... exactly maintained. ,High-precision controlled peristaltic pumps ... which allows flow rates between 0.01 to ...
Biology Products: