Navigation Links
Mouse work: New insights on a fundamental DNA repair mechanism
Date:3/4/2010

Adding a new link to our understanding of the complex chain of chemistry that keeps living cells alive, a team of researchers from the University of Vermont (UVM), the University of Utah, Vanderbilt University and the National Institute of Standards and Technology (NIST) has demonstrated for the first time the specific activity of the protein NEIL3, one of a group responsible for maintaining the integrity of DNA in humans and other mammals. Their work reported last week* sheds new light on a potentially important source of harmful DNA mutations.

Since it first was identified about eight years ago, NEIL3 has been believed to be a basic DNA-maintenance enzyme of a type called a glycosylase. These proteins patrol the long, twisted strands of DNA looking for lesionsplaces where one of the four DNA bases has been damaged by radiation or chemical activity. They cut the damaged bases free from the DNA backbone, kicking off follow-on mechanisms that link in the proper undamaged base. The process is critical to cell health, says NIST biochemist and Senior Research Fellow Miral Dizdaroglu, "DNA is damaged all the time. About one to two percent of oxygen in the body becomes toxic in cells, for example, creating free radicals that damage DNA. Without these DNA repair mechanisms there wouldn't be any life on this planet, really."

The glycosylases seem to be highly specific; each responds to only a few unique cases of the many potential DNA base lesions. Figuring out exactly which ones can be challenging. NEIL3 and its kin NEIL1 and NEIL2 are mammalian versions of an enzyme found in the bacterium E. coli, which first was identified in work at UVM. The lesion targets of NEIL1 and NEIL2 have been known for some time, but NEIL3, a much more complicated protein twice the size of the others, had resisted several attempts to purify it and determine just what it does. In a significant advance, a research team at UVM managed to clone the house mouse version of NEIL
'/>"/>

Contact: Michael Baum
michael.baum@nist.gov
301-975-2763
National Institute of Standards and Technology (NIST)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stem cells restore sight in mouse model of retinitis pigmentosa
2. Penn biologists determine microRNA activity is suppressed in mouse ovum
3. CCNY biologists identify new spiny pocket mouse species
4. Chloride increases response to pheromones and odors in mouse sensory neurons
5. New source of classical techniques for blood-based studies in the laboratory mouse
6. Caltech researchers show efficacy of gene therapy in mouse models of Huntingtons disease
7. Mouse brain rewires its neural circuits to recuperate from damaged neural function after stroke
8. Mouse model provides clues to human language development
9. Engineered pig stem cells bridge the mouse-human gap
10. Caffeic acid inhibits colitis in a mouse model -- is a drug-metabolizing gene crucial?
11. A new mouse model provides insight into genetic neurological disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... biophysics textbook and it describes how life functions and ... into biological systems and provides an understanding of the ... how our genes make proteins that control the dynamics ... an organism. It quantifies the principles of life and ... on both large and small scales. The book is ...
(Date:10/15/2014)... awarded the 44th Rosenstiel Award for Distinguished Work in ... exploring the mechanisms of genomic instability and its implications ... the second alumnus to win the Rosenstiel Award; the ... , Alt is the Charles A. Janeway Professor of ... and an investigator at the Howard Hughes Medical Institute ...
(Date:10/14/2014)... N.Y. – Scientists have sequenced the house fly genome ... one might expect from an insect that thrives in ... published Oct. 14 in the journal Genome Biology ... biology and of how flies quickly adapt to resist ... Adult house flies (Musca domestica) carry and transmit more ...
Breaking Biology News(10 mins):New book about life as seen from physics 2Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2House fly genome reveals expanded immune system 2
... opportunistic pathogens that were once thought to be very ... that are not only similar but also suggest that ... linked, according to a review published this week in ... mechanisms used by bacterial and fungal species to promote ...
... current issue of the Journal of the American ... a study of genetic variants that influence human ... leveraging electronic medical records (EMRs; also called EHRs or ... Mayo Clinic Divisions of Cardiovascular Diseases and Biomedical Informatics ...
... 2010 The world,s top scientists and clinicians in ... to present their latest research findings at the 60th ... from Tuesday, November 2, through Saturday, November 6, 2010, ... Founded in 1948, the American Society of Human ...
Cached Biology News:Linking microbial sex and virulence 2Use of informatics, EMRs enable genetic study of vascular disease 2American Society of Human Genetics to host 60th Annual Meeting in Washington, D.C. 2American Society of Human Genetics to host 60th Annual Meeting in Washington, D.C. 3
(Date:10/20/2014)... (PRWEB) October 20, 2014 ... Sidney Kimmel Cancer Center at Thomas Jefferson University ... , Through the Strategic Alliance Partnership program, the ... will collaborate to raise awareness of the Center’s ... and other projects. Clinicians and other health care ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Local veterinary ... in an investigational study of donor stem cells for ... stem cell therapy and has performed clinical stem cell ... study is to determine if a single injection of ... joints can help reduce pain and inflammation in the ...
(Date:10/19/2014)... OCTOBER 20-22, 2014: The 9th Annual ... take place at the Congress Center Basel, ... now available at http://www.abim.ch . ... from all over the globe will exchange ... products and developments on the world market. ...
(Date:10/19/2014)... The Asia-Pacific Bromine Market report defines and segments ... forecast of revenue. , Browse through the TOC ... get an idea of the in-depth analysis provided. ... in the Asia-Pacific bromine market, and is supported ... http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is a volatile and ...
Breaking Biology Technology:Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3
... off marginally legal fireworks, I was feeling a little guilty. ... phone was powered off most of the weekend. Here it ... felt anything but independent of my technologies. , ,Ignoring e-mail ... comes with a penalty of sorting through an over-loaded inbox, ...
... Metro-Goldwyn-Mayer Studios Inc. v. Grokster, Ltd. et al. ... technology providers will function in the future when their ... copyrighted content. , ,The court, in an unanimous decision, ... decision favoring defendants Grokster Ltd. and StreamCast Networks (providers ...
... Trademark law is becoming increasingly important as businesses seek ... that has built up as a result of the ... applications for trademark registration are filed, many of them ... are seen by some as a good leading indicator ...
Cached Biology Technology:Declaring independence from technology (sort of) 2Declaring independence from technology (sort of) 3Tech vendors could be liable for customer behavior - and not just file sharing 2Tech vendors could be liable for customer behavior - and not just file sharing 3Why file for trademark protection? 2Why file for trademark protection? 3Why file for trademark protection? 4
... a glycoprotein. distributed in colon and ... breast, lung and salivary gland tissues. ... MUC1 and MUC2. Epitope: Tandem ... Immunogen: MUC3 tandem repeat peptide ...
Rabbit polyclonal to GABA A Receptor gamma 2 ( Abpromise for all tested applications). entrezGeneID: 2566 SwissProtID: P18507...
Anti-GOSR2 Monoclonal AntibodyOther Sub-Family: not assigned-Other Applications: Immunocytochemistry, Immunoprecipitation, Western Blot...
... The 2/3D Waver Shaker combines shaking and rocking ... a 330 x 330 mm stainless steel or ... incubator and cold room operation. The platform angle ... for a vigorous with action and rotation speed ...
Biology Products: