Navigation Links
Mouse work: New insights on a fundamental DNA repair mechanism
Date:3/4/2010

Adding a new link to our understanding of the complex chain of chemistry that keeps living cells alive, a team of researchers from the University of Vermont (UVM), the University of Utah, Vanderbilt University and the National Institute of Standards and Technology (NIST) has demonstrated for the first time the specific activity of the protein NEIL3, one of a group responsible for maintaining the integrity of DNA in humans and other mammals. Their work reported last week* sheds new light on a potentially important source of harmful DNA mutations.

Since it first was identified about eight years ago, NEIL3 has been believed to be a basic DNA-maintenance enzyme of a type called a glycosylase. These proteins patrol the long, twisted strands of DNA looking for lesionsplaces where one of the four DNA bases has been damaged by radiation or chemical activity. They cut the damaged bases free from the DNA backbone, kicking off follow-on mechanisms that link in the proper undamaged base. The process is critical to cell health, says NIST biochemist and Senior Research Fellow Miral Dizdaroglu, "DNA is damaged all the time. About one to two percent of oxygen in the body becomes toxic in cells, for example, creating free radicals that damage DNA. Without these DNA repair mechanisms there wouldn't be any life on this planet, really."

The glycosylases seem to be highly specific; each responds to only a few unique cases of the many potential DNA base lesions. Figuring out exactly which ones can be challenging. NEIL3 and its kin NEIL1 and NEIL2 are mammalian versions of an enzyme found in the bacterium E. coli, which first was identified in work at UVM. The lesion targets of NEIL1 and NEIL2 have been known for some time, but NEIL3, a much more complicated protein twice the size of the others, had resisted several attempts to purify it and determine just what it does. In a significant advance, a research team at UVM managed to clone the house mouse version of NEIL
'/>"/>

Contact: Michael Baum
michael.baum@nist.gov
301-975-2763
National Institute of Standards and Technology (NIST)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stem cells restore sight in mouse model of retinitis pigmentosa
2. Penn biologists determine microRNA activity is suppressed in mouse ovum
3. CCNY biologists identify new spiny pocket mouse species
4. Chloride increases response to pheromones and odors in mouse sensory neurons
5. New source of classical techniques for blood-based studies in the laboratory mouse
6. Caltech researchers show efficacy of gene therapy in mouse models of Huntingtons disease
7. Mouse brain rewires its neural circuits to recuperate from damaged neural function after stroke
8. Mouse model provides clues to human language development
9. Engineered pig stem cells bridge the mouse-human gap
10. Caffeic acid inhibits colitis in a mouse model -- is a drug-metabolizing gene crucial?
11. A new mouse model provides insight into genetic neurological disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... This news release is available in German . ... has evolved to recognize and respond to threats to ... disease. A detailed understanding of the mechanism underlying immunologic ... of research have converged to support the hypothesis that ... of immune cells with stem-cell-like potential. Until now, there ...
(Date:7/24/2014)... 2014 NXT-ID, Inc., (NXTD: OTCQB) a biometric authentication company ... smart wallet, Wocket™, was recently the topic of  an interview ... Gino Pereira , CEO of NXT-ID, on July ... Mr. Gino Pereira explains how the ... cards and walks host Anita Finley through ...
(Date:7/24/2014)... Odds are, theres a virus living inside your gut ... new study led by researchers at San Diego State ... population is host to a newly described virus, named ... of gut bacteria, Bacteroidetes . This phylum of ... and other gut-related diseases. The research appears today in ...
Breaking Biology News(10 mins):Experiments prove 'stemness' of individual immune memory cells 2Experiments prove 'stemness' of individual immune memory cells 3Boomer Times Gets to Know NXT-ID's Next Generation Wocket Smart Wallet; Practical, Secure and Easy to Use 2Boomer Times Gets to Know NXT-ID's Next Generation Wocket Smart Wallet; Practical, Secure and Easy to Use 3Boomer Times Gets to Know NXT-ID's Next Generation Wocket Smart Wallet; Practical, Secure and Easy to Use 4Newly discovered gut virus lives in half the world's population 2Newly discovered gut virus lives in half the world's population 3
... has destroyed 17 percent of the native vegetation in ... new study published by Conservation International sounds an alarm ... Continued deforestation at the current rate would cause all ... years, according to CI researchers in Brazil. , Overall, ...
... It's one of those unavoidable facts of life -- ... internal temperatures cause only temporary discomfort, but in some ... , These convulsions are "scary and very upsetting to ... chair of Neurology. They've also been something of an ...
... shows that robot assisted knee surgery is significantly ... of surgeons tested whether Acrobot, a robotic assistant, ... knee replacement. Acrobot works by helping the surgeon ... the existing bones. , The surgeons looked at ...
Cached Biology News:Report shows deforestation threatens Brazil's Pantanal 2Molecular mechanism may explain how fevers spark seizures 2Molecular mechanism may explain how fevers spark seizures 3Robot assisted surgery more accurate than conventional surgery 2
(Date:7/24/2014)... (PRWEB) July 24, 2014 2014 ... Sulphate Industry” is a professional and in-depth research ... introduces Potassium Sulphate basic information, including its ... industry overview. This research covers the international market ... global industry analysis covering macroeconomic environment & economic ...
(Date:7/24/2014)... 2014  Neogen Corporation (Nasdaq: NEOG ) ... potential revenue from new rodenticide research are premature. In ... on July 22, 2014, Neogen,s CEO commented about several ... "It was my intent Tuesday at our ... a new type of rodenticide, but certainly not to ...
(Date:7/24/2014)... 24, 2014 WIRB-Copernicus Group ® ... ethical review services for clinical research, announced today ... division of Richmond, VA -based ... and biosecurity consulting firm in the ... biosafety division – WCG Biosafety™ – will be ...
(Date:7/24/2014)... 1000 balances – 4 steps – One ... needs and expertly narrows down the mass of product ... even terminals. , First, select the working environment, ... readability instead) and define the accuracy – it’s really ... down the list to models that fit best with ...
Breaking Biology Technology:Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4Neogen comments on SenesTech 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 3
... Fund More Than Doubles Assets Under Management, UTRECHT, ... growing European venture capital firm, today announced,the closing of ... Gilde,Healthcare II (GHC II). The new fund, which is ... funds raised to invest in European,healthcare opportunities. GHC II ...
... Emerging Nanotechnologies will host the U.S. launch of ... Responsible Nanotechnology aimed principally at businesses and research ... Society and the United Kingdom government-sponsored Nanotechnology Knowledge ... Association, Insight Investment. , The event ...
... Genmab Antibody,Summary: Genmab,s Partner Roche has Filed a CTA With the ... ... COPENHAGEN, October 2 Genmab A/S (OMX: GEN),announced today that ... British Medicines and Healthcare products,Regulatory Agency (MHRA) for a Genmab antibody ...
Cached Biology Technology:Gilde Healthcare Partners Closes EUR 150 Million European Healthcare Venture Fund 2A new 'responsible nanocode' for business 2Genmab A/S - Company Announcement 2
Spectrolyse (pL) PAI kit is a two-stage indirect enzymatic assay for the quantitative determination of Plasminogen Activator Inhibitor (PAI-1) activity in plasma. Sample Type: plasma...
NAK/TBK1 (CT) Affinity Purified Polyclonal Antibody...
... human cardiac troponin subunit T, a 31kDa protein ... contraction of cardiac muscle. It reacts with subunit ... It also cross-reacts with human skeletal troponin T ... Highly purified human cardiac troponin T ...
... is pleased to offer the ATTO-TAG ... detection of primary amines. Developed by ... the ATTO-TAG reagents are similar to ... (NDA) and anthracene-2,3-dicarboxaldehyde, all of which ...
Biology Products: