Navigation Links
Mouse studies reveal promising vitamin D-based treatment for MS
Date:9/27/2013

MADISON -- A diagnosis of multiple sclerosis (MS) is a hard lot. Patients typically get the diagnosis around age 30 after experiencing a series of neurological problems such as blurry vision, wobbly gait or a numb foot. From there, this neurodegenerative disease follows an unforgiving course.

Many people with MS start using some kind of mobility aid -- cane, walker, scooter or wheelchair -- by 45 or 50, and those with the most severe cases are typically bed-bound by 60. The medications that are currently available don't do much to slow the relentless march of the disease.

In search of a better option for MS patients, a team of University of Wisconsin-Madison biochemists has discovered a promising vitamin D-based treatment that can halt -- and even reverse -- the course of the disease in a mouse model of MS. The treatment involves giving mice that exhibit MS symptoms a single dose of calcitriol, the active hormone form of vitamin D, followed by ongoing vitamin D supplements through the diet. The protocol is described in a scientific article that was published online in August in the Journal of Neuroimmunology.

"All of the animals just got better and better, and the longer we watched them, the more neurological function they regained," says biochemistry professor Colleen Hayes, who led the study.

MS afflicts around 400,000 people nationwide, with 200 new cases diagnosed each week. Early on, this debilitating autoimmune disease, in which the immune system attacks the myelin coating that protects the brain's nerve cells, causes symptoms including weakness, loss of dexterity and balance, disturbances to vision, and difficulty thinking and remembering. As it progresses, people can lose the ability to walk, sit, see, eat, speak and think clearly.

Current FDA-approved treatments only work for some MS patients and, even among them, the benefits are modest. "And in the long term they don't halt the disease process
'/>"/>

Contact: Colleen Hayes
cehayes@wisc.edu
608-263-6387
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Elevated levels of copper in amyloid plaques associated with neurodegeneration in mouse models of AD
2. New agent inhibits HCV replication in mouse models -- No resistance seen
3. Cat and mouse: A single gene matters
4. New mouse viruses could aid hepatitis research
5. Omega-3s from fish vs. fish oil pills better at maintaining blood pressure in mouse model
6. UT Southwestern scientists make mouse model of human cancer, demonstrate cure
7. Researchers generate a mutant mouse model useful in the treatment of neuromuscular diseases
8. Transplanted neural stem cells slows als onset and progression in mouse models
9. Early menopause: A genetic mouse model of human primary ovarian insufficiency
10. NPointer from Neurotechnology Uses Hand Gestures to Control and Navigate Computer Programs Without a Mouse or Touchpad
11. Stem cell transplantation into mouse cochlea may impact future hearing loss therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... and Mary,s Virginia Institute of Marine Science have ... Protection Agency to identify the streams and wetlands ... tools to help local governments and citizens conserve ... on a dataset of tidal-marsh observations first gathered ... this historical baseline can today,s researchers accurately map ...
(Date:10/16/2014)... – Post-menopausal women experienced improvements in vaginal atrophy, ... genital bleeding, after 12 weeks of daily 10 ... germ-based nutritional supplement previously shown to help relieve ... pilot study reported in a poster at the ... , "These data documented improved vaginal epithelium, ...
(Date:10/15/2014)... Gutenberg University Mainz (JGU) as a full member, ... maintain a significant nationwide standing in the field ... Johannes Gutenberg University Mainz as a full member ... national and international competition for the best minds ... be proud that Mainz University has been recognized ...
Breaking Biology News(10 mins):EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
... brain and squeeze it into a special chamber the size of ... cerebral spinal fluid and thread both of them with artificial blood ... and other brain cells behave as if they were in a ... that monitor how the cells respond when exposed to minute quantities ...
... Geology: researchers experience an earthquake while studying ... as tooth crown height, is used to track aridity ... terrestrial ecosystem is presented; researchers chronicle the discovery of ... highest wave-energy environments on Earth; and a change in ...
... on the University of California, Berkeley, campus has remained surprisingly ... to create a green wildlife haven within a dense urban ... survey conducted over a six-month period covering the winter of ... journal The Condor . The study, conducted during the ...
Cached Biology News:Vanderbilt-led team to develop 'microbrain' to improve drug testing 2Vanderbilt-led team to develop 'microbrain' to improve drug testing 3Vanderbilt-led team to develop 'microbrain' to improve drug testing 4Vanderbilt-led team to develop 'microbrain' to improve drug testing 5Rubbing boulders, fossil mammal teeth, barrier islands, and a change in volcanic behavior 2Rubbing boulders, fossil mammal teeth, barrier islands, and a change in volcanic behavior 3Rubbing boulders, fossil mammal teeth, barrier islands, and a change in volcanic behavior 4Rubbing boulders, fossil mammal teeth, barrier islands, and a change in volcanic behavior 5Rubbing boulders, fossil mammal teeth, barrier islands, and a change in volcanic behavior 6Rubbing boulders, fossil mammal teeth, barrier islands, and a change in volcanic behavior 7Rubbing boulders, fossil mammal teeth, barrier islands, and a change in volcanic behavior 8Rubbing boulders, fossil mammal teeth, barrier islands, and a change in volcanic behavior 9UC Berkeley survey shows college campuses can make good bird havens 2UC Berkeley survey shows college campuses can make good bird havens 3UC Berkeley survey shows college campuses can make good bird havens 4
(Date:10/22/2014)... and BOSTON , Oct. ... ), a leading global specialty pharmaceutical company, and Rhythm, ... granted an exclusive option to acquire Rhythm,s wholly owned ... a peptide ghrelin agonist, for the treatment of diabetic ... Rhythm has completed a successful Phase 2 trial of ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 WriteResult, ... services – has been working with a team of ... New Haven Farms Community Farming Collaborative to provide electronic ... solution. The study, which started in May, aims ... that provides participants weekly exposure to and participation in ...
(Date:10/22/2014)... Md. , Oct. 22, 2014   Synthetic ... developing novel pathogen-specific therapies for serious infections and diseases, ... has issued a Notice of Allowance for a composition ... its C. difficile program, SYN-004. This is ... SYN-004 in the U.S. and adds to the Company,s ...
(Date:10/20/2014)... The report “Pharmacy Automation Systems ... and Labeling Systems, Table-top Counters) by End-user (Inpatient ... & Trends to 2019” analyzes and studies the ... America, Europe, Asia-Pacific, and the Rest of the ... 30 figures spread through 300 pages and in-depth ...
Breaking Biology Technology:Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4
... Inc. (Nasdaq: IDIX ) announced today that ... Bank of America 2008 Specialty,Pharmaceuticals Conference on Friday, ... Inn, Long Island, NY., The live and ... under "Calendar of Events" in the Idenix Investor ...
... Partners announced today,that it has updated coverage on ... dollar markets, are progressing through,the clinic at a ... results for,Convivia(TM) sometime in the 3rd quarter of ... (DR) Cysteamine for the treatment of cystinosis in,2010," ...
... July 31 /PRNewswire-FirstCall/ - iNutrition, Inc., (http://www.inutrition.com ) ... its,new all natural line of nutrition bars. Fission ... come in three varieties; Fission Fruit, Fission,Energy, and ... delicious fruits, Fission Bars have no refined sugar, ...
Cached Biology Technology:Vista Partners Updates Coverage on Raptor Pharmaceuticals Corp. (OTC Bulletin Board: RPTP) 2iNutrition Launches New Fission Fruit Nutrition Bars 2
... inL10 Workstation from Caliper represents a revolutionary ... the first time the ability to generate ... to changing conditions. In addition, each ... due to changes in temperature, and offers ...
... fully automated systems for a broad range ... for applications ranging from compound logistics, over ... screening, which means it has fully automated ... and follow up studies all at your ...
ID clarifier: non-treated with lid...
... Building on over 20 years of experience ... the Life Sciences, the Freedom EVO platform ... expansion according to future needs. Together with ... system is equipped to successfully operate genomics, ...
Biology Products: