Navigation Links
Mouse studies reveal promising vitamin D-based treatment for MS
Date:9/27/2013

MADISON -- A diagnosis of multiple sclerosis (MS) is a hard lot. Patients typically get the diagnosis around age 30 after experiencing a series of neurological problems such as blurry vision, wobbly gait or a numb foot. From there, this neurodegenerative disease follows an unforgiving course.

Many people with MS start using some kind of mobility aid -- cane, walker, scooter or wheelchair -- by 45 or 50, and those with the most severe cases are typically bed-bound by 60. The medications that are currently available don't do much to slow the relentless march of the disease.

In search of a better option for MS patients, a team of University of Wisconsin-Madison biochemists has discovered a promising vitamin D-based treatment that can halt -- and even reverse -- the course of the disease in a mouse model of MS. The treatment involves giving mice that exhibit MS symptoms a single dose of calcitriol, the active hormone form of vitamin D, followed by ongoing vitamin D supplements through the diet. The protocol is described in a scientific article that was published online in August in the Journal of Neuroimmunology.

"All of the animals just got better and better, and the longer we watched them, the more neurological function they regained," says biochemistry professor Colleen Hayes, who led the study.

MS afflicts around 400,000 people nationwide, with 200 new cases diagnosed each week. Early on, this debilitating autoimmune disease, in which the immune system attacks the myelin coating that protects the brain's nerve cells, causes symptoms including weakness, loss of dexterity and balance, disturbances to vision, and difficulty thinking and remembering. As it progresses, people can lose the ability to walk, sit, see, eat, speak and think clearly.

Current FDA-approved treatments only work for some MS patients and, even among them, the benefits are modest. "And in the long term they don't halt the disease process
'/>"/>

Contact: Colleen Hayes
cehayes@wisc.edu
608-263-6387
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Elevated levels of copper in amyloid plaques associated with neurodegeneration in mouse models of AD
2. New agent inhibits HCV replication in mouse models -- No resistance seen
3. Cat and mouse: A single gene matters
4. New mouse viruses could aid hepatitis research
5. Omega-3s from fish vs. fish oil pills better at maintaining blood pressure in mouse model
6. UT Southwestern scientists make mouse model of human cancer, demonstrate cure
7. Researchers generate a mutant mouse model useful in the treatment of neuromuscular diseases
8. Transplanted neural stem cells slows als onset and progression in mouse models
9. Early menopause: A genetic mouse model of human primary ovarian insufficiency
10. NPointer from Neurotechnology Uses Hand Gestures to Control and Navigate Computer Programs Without a Mouse or Touchpad
11. Stem cell transplantation into mouse cochlea may impact future hearing loss therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... discovery of two additional coral communities showing signs of damage ... of the 2010 spill in the Gulf of Mexico. The ... professor of biology at Penn State University. A paper describing ... in the Gulf of Mexico will be published during the ... of the journal Proceedings of the National Academy of ...
(Date:7/28/2014)... TEMPE, Ariz. - Reactions among minerals and organic compounds ... deep carbon cycle, they provide energy for the deep ... life. However, very little is known about how minerals ... Arizona State University have demonstrated how a common mineral ... negating the need for toxic solvents or expensive ...
(Date:7/28/2014)... pennellii , a wild relative of the domestic tomato, ... including the labs headed by Professors Neelima Sinha and ... Biology. The new genome information may help breeders produce ... 27 in the journal Nature Genetics , was ... in Germany. The UC Davis labs carried out work ...
Breaking Biology News(10 mins):Impact of Deepwater Horizon oil spill on coral is deeper and broader than predicted 2Mineral magic? Common mineral capable of making and breaking bonds 2Mineral magic? Common mineral capable of making and breaking bonds 3
... the capacity for echolocation, although it does take time and ... hear more than one might think. The blind learn to ... make. This enables them to sense the locations of walls ... stick or making clicking sounds with the tongue, and analyzing ...
... 29, 2013 -- Medication poisonings among children are an ... of 1500 children under 6 years of age was ... exposure to buprenorphine. Ingestion of strong opioids, such ... depression, and death in young children. In a ...
... millimeters-long when they hatch, but can smell the presence of ... to navigate home. The results are reported August 28 in ... Paris from the University of Miami and colleagues from other ... arena to find that larvae of two families, damselfish and ...
Cached Biology News:Echolocation 2'1 pill can kill': Effects of unintentional opioid exposure in young children 2
(Date:7/28/2014)... July 28, 2014 Appistry, Inc. ... that bring the power of genomics to next-generation medicine, ... Appistry Pipeline Challenge . , Two Appistry staff ... the National Center for Genome Resources, and Mr. Neil ... Clinics of Kansas City. Rounding out the panel are ...
(Date:7/28/2014)... BRYAN, Texas and COLLEGE STATION, Texas ... hotel theatlashotel.com will be a 177-key, 4-star ... Traditions in Bryan , Texas.  ... As the first hotel within ... will include 177 rooms, a mixture of standard rooms and suites, ...
(Date:7/25/2014)... Albany, NY (PRWEB) July 26, 2014 ... Trials Review, H2, 2014" provides data on the ... This report provides elemental information and data relating ... Cerebral Stroke. , View full global Ischemic Stroke ... It includes an overview of the trial numbers ...
(Date:7/25/2014)... 25, 2014 Research and Markets ... Metabolomics Market 2014-2018" report to their offering. ... Metabolomics or Metabonomics is the scientific study ... a new experimental technique that is being widely ... Metabolites are small molecules that are present in ...
Breaking Biology Technology:Appistry Names Industry Experts from the National Center for Genome Resources and Mercy Children's, Kansas City, to Judge Pipeline Challenge Competition 2Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 2Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 3Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 4Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2
... 28 , - New ... , Bial-Portela & CA, S.A., ... Portela), and Eisai Europe Limited (London; Chairman & CEO ... President &,CEO: Haruo Naito), today announced that the novel ...
... scientists have unlocked the physics of the perfect pizza ... generation of micro motors thinner that a human hair. ... by Associate Professor James Friend and Senior Lecturer Leslie ... team from Monash,s Micro/Nanophysics Research Laboratory, then calculated how ...
... -- Encorium Group, Inc. (Nasdaq: ... (CRO) that provides design, development, and management capabilities ... of the world,s leading pharmaceutical companies, today announced ... Annual Vaccine Industry Excellence Award for Best Contract ...
Cached Biology Technology:Novel Once Daily Anti-Epileptic Zebinix(R) Approved in the European Union 2Novel Once Daily Anti-Epileptic Zebinix(R) Approved in the European Union 3Novel Once Daily Anti-Epileptic Zebinix(R) Approved in the European Union 4Novel Once Daily Anti-Epileptic Zebinix(R) Approved in the European Union 5Novel Once Daily Anti-Epileptic Zebinix(R) Approved in the European Union 6Novel Once Daily Anti-Epileptic Zebinix(R) Approved in the European Union 7Novel Once Daily Anti-Epileptic Zebinix(R) Approved in the European Union 8Novel Once Daily Anti-Epileptic Zebinix(R) Approved in the European Union 9Pizza tossing art unlocks secrets of tiny motors 2Encorium Named as Finalist for the Second Annual Vaccine Industry Excellence Award 2Encorium Named as Finalist for the Second Annual Vaccine Industry Excellence Award 3Encorium Named as Finalist for the Second Annual Vaccine Industry Excellence Award 4
... Optimal Microdissection , CapSure HS and CapSure ... rapid extraction of populations of pure cells ... Laser Capture Microdissection., Ensure the Integrity ... , All CapSure LCM Caps have a ...
... The Chromo4 real-time PCR detector is ... interchangeably on a DNA Engine or Dyad ... system includes a compact scanning photonics shuttle ... (450-490 nm, 500-535 nm, 555-585 nm, 620-650 ...
... Laser Capture Microdissection (LCM) is the method ... Veritas Microdissection is the only instrument to ... unmatched flexibility., UV Laser Cutting ... for non-soft tissues and capturing large numbers ...
... VersArray ChipReader systems are highly sensitive laser ... microarrays. These are advanced scanners that meet ... and background level, and optimizing the signal ... top end of the range for increased ...
Biology Products: