Navigation Links
Mouse brain seen in sharpest detail ever
Date:10/25/2010

an take the reference brain apart and put it back together, because we have the 3-D data set intact, and any section will have the same excellent resolution," said Johnson, who is also a professor of biomedical engineering and physics at Duke. "It eliminates the Humpty Dumpty problem that researchers used to face when they made 3-D measurements of brain structures."

For example, a geneticist might want to alter a mouse's genotype in an experiment and learn what happens when the animal becomes highly responsive to fear challenges. "It would be interesting to see if the amygdala, (a brain center related to emotional arousal), is really smaller or larger in the animal," Johnson said. "However, if you do conventional histology, the animal brain shrinks when it is dried or prepared in alcohol, sometimes by about 40 percent. Because of variability, that would make it challenging to measure. This atlas provides a reference to measure against."

The team was also able to digitally segment 37 unique brain structures using the three different data acquisition strategies.

Scientists obtained images of brains from eight mice of the most frequently used strain of laboratory mice (C57BL), aged 66-78 days old. They registered the images together and created both an average and a probabilistic brain for reference. The average and probabilistic brains provide quantitative measure of variability. "It was truly remarkable how alike these structures were from brain to brain," he said.

All of the data is available on the web: www.civm.duhs.duke.edu/neuro201001.

As new data is gathered from other sources, researchers will be able to register it to the same coordinate system, which will promote data sharing, Johnson said. For example the Duke group has recently added data also at the highest resolution yet attained that allows definition of fiber tracts connecting different part
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Exposure to low doses of BPA alters gene expression in the fetal mouse ovary
2. Scientists reprogram mouse fat cells into clinically useful stem cells
3. Mouse stem cell study offers new insights into body fat distribution
4. Scientists create 3-D models of whole mouse organs
5. UCSF transgenic mouse mimics Parkinsons earliest symptoms
6. Intentional variation increases result validity in mouse testing
7. Mouse work: New insights on a fundamental DNA repair mechanism
8. Stem cells restore sight in mouse model of retinitis pigmentosa
9. Penn biologists determine microRNA activity is suppressed in mouse ovum
10. CCNY biologists identify new spiny pocket mouse species
11. Chloride increases response to pheromones and odors in mouse sensory neurons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mouse brain seen in sharpest detail ever
(Date:8/6/2015)... Germany , August 6, 2015 /PRNewswire/ ... SensoMotoric Instruments (SMI) shows the world,s first ... based on Epson,s Moverio BT-200 see-through head mounted display ... new solution, unprecedented quality and efficiency is brought to ... displays. For the first time, professionals and researchers can ...
(Date:8/5/2015)... , Aug. 5, 2015 The biosensors ... growth in applications, penetration into newer sectors, and development ... The global biosensors space has seen the entry of ... market so far. (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ... Sullivan, Analysis of the Global Biosensors Market ...
(Date:7/31/2015)... SHENZHEN , Kina, 31. juli 2015 ... ) bliver afholdt af BGI fra den 22. - 25. ... Konferencen fejrer sin 10-års fødselsdag i år. ... verdens mest indflydelsesrige årlige møder på ,omik,-feltet, og er ... forsamlinger. ICG-10 fokuserer på nylige gennembrud ...
Breaking Biology News(10 mins):SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2
... Early snow melt in the Colorado Rocky Mountains initiates two ... fritillary butterfly, Speyeria mormonia . One effect of snow ... required an understanding of the butterfly,s biology. "This suggests ... will be difficult in some cases due to lack of ...
... resources, published today by the Joint Research Centre (JRC), reveals ... average less than 200 mm freshwater available every year while ... The report ,Current Water Resources in Europe and Africa, shows ... 500 mm for Europe and from less than 0.1 mm ...
... A simple, inexpensive dip-and-dry treatment can convert ordinary ... even the armor-coated spores of microbes like anthrax ... Applied Materials & Interfaces . They describe a ... including make-shift curtains and other protective coatings that protect ...
Cached Biology News:An early spring drives butterfly population declines 2Current water resources in Europe and Africa 2
(Date:9/1/2015)... ... September 01, 2015 , ... Leading ... neuro and pain management space join prominent academics and key investors for Neuro ... Harvard Medical School in Boston. , Neuro Advance Boston focuses on the ...
(Date:9/1/2015)... ... 01, 2015 , ... Research conducted by Synedgen Inc.’s Director ... School of Medicine, Frederick National Laboratory for Cancer Research, and the Centers for ... Access journal. , Christopher Ryan PhD, of Synedgen, and Aparajita Chatterjee, Daniel ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... because of its properties such as low carbon footprints and compostability. These properties ... of petroleum based plastics. On the basis of applications, the market for biodegradable ...
(Date:8/31/2015)... 31, 2015 Research and Markets ( http://www.researchandmarkets.com/research/cbgl72/middle_east_and ... East & Africa Biomedical Sensors Market - Growth, Trends ... The Middle East ... billion by 2018 at a CAGR of 3.26% over ... bring Biomedical sensors that are adaptable to the genetic ...
Breaking Biology Technology:Neuro Advance Boston Brings Together Leading Neuroscience Experts on October 14 at Harvard Medical School 2Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 2Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 4Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 5Middle East & Africa Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts to 2020 2
... Silence Therapeutics plc (AIM: SLN) ("Silence" or the ... Ph.D., to the position of vice president of research. ... as senior director, technologies at Silence, will play a ... RNA interference (RNAi) research activities, including those focused on ...
... ... in innocent man spending 22 years in prison for murder; guilty man kills again. ... Rochester, NY (PRWEB) May 5, ... to reevaluate the polygraph’s role in criminal investigations. A recent WHEC.com story concerns ...
... 2010) Endoscopic radiofrequency ablation is an effective treatment ... fast and effective way to detect inflammatory bowel disease, ... tissue that is removed, and researchers find that endoscopic ... duct) is more precise than surgery with fewer side ...
Cached Biology Technology:Silence Therapeutics Appoints New Vice President of Research 2Silence Therapeutics Appoints New Vice President of Research 3NACVSA Points out Perils of Polygraph: Killer Passes Polygraph, Innocent Man Fails, Killer Goes On To Kill Again 2NACVSA Points out Perils of Polygraph: Killer Passes Polygraph, Innocent Man Fails, Killer Goes On To Kill Again 3NACVSA Points out Perils of Polygraph: Killer Passes Polygraph, Innocent Man Fails, Killer Goes On To Kill Again 4Latest breakthroughs in technology expand options for diagnosing and treating disease 2Latest breakthroughs in technology expand options for diagnosing and treating disease 3Latest breakthroughs in technology expand options for diagnosing and treating disease 4Latest breakthroughs in technology expand options for diagnosing and treating disease 5Latest breakthroughs in technology expand options for diagnosing and treating disease 6Latest breakthroughs in technology expand options for diagnosing and treating disease 7Latest breakthroughs in technology expand options for diagnosing and treating disease 8Latest breakthroughs in technology expand options for diagnosing and treating disease 9Latest breakthroughs in technology expand options for diagnosing and treating disease 10Latest breakthroughs in technology expand options for diagnosing and treating disease 11
... For use as a carrier ... precipitation. Physical form: Solution in ... 7.4, 1 mM EDTA Preparation ... Concentration: 10 ...
... White solid.. PACKAGED UNDER INERT GAS. ... reaction is "driven" to completion. A protective agent ... found in many other preparations. Blocks the lethal ... by titration. Contaminants: Heavy metals: ≤1 ...
... of Japan, also named Sendai virus) Envelope ... of molecules by means of membrane fusion. ... Protein, Oligo, cDNA, Antibodies, Vector, and Biomolecule ... EX has a high fusing capability in ...
... Genome ChIP-on-chip Microarray is specifically designed ... cerevisiae) DNA binding proteins by pairing ... microarrays. This set delivers robust hybridization ... true binding events and fewer false ...
Biology Products: