Navigation Links
Mount Sinai study identifies new gene variations associated with heart rate
Date:4/14/2013

(New York, NY April 14, 2013) Through a collaborative genome-wide study on individuals, researchers have discovered 14 new genetic variations that are associated with heart rate. Since heart rate is a marker of cardiovascular health, these findings could provide a better understanding of genetic regulation of heart beat and is a first step towards identifying targets for new drugs to treat cardiovascular disease.

The study, titled, "Identification of Heart Rate-Associated Loci and Their Effects on Cardiac Conduction and Rhythm Disorders," was published online this week in the April issue of Nature Genetics. Led by researchers at the Icahn School of Medicine at Mount Sinai and the Medical Research Council Epidemiology Unit in Cambridge, UK, the collaboration involved 268 researchers from 211 institutions, as well as six large research consortia joined forces.

In order to gain new insights into the genetic regulation of heart rate, Dr. Ruth Loos, Director of the Genetics of Obesity and Related Metabolic Traits Program at the Charles Bronfman Institute for Personalized Medicine at Mount Sinai and honorary investigator at the Medical Research Council Epidemiology Unit and her team, spent three years working on a genome-wide association study using data from 181,171 participants from 65 studies during 2009-2012. "Without any prior hypothesis, we studied the entire human genome hoping to identify new genetic variations that no one before had even imagined would play a role in the regulation of heart rate," said Dr. Loos, senior author of the study. "This discovery is just the beginning of something new and exciting and can hopefully be used to identify new drugs that can be used for the treatment of heart rhythm disorders."

In a follow-up study, experimental down-regulation of gene expression was then conducted on fruit flies and zebra fish, to better understand how genetic variations might affect heart rate. These experiments
'/>"/>

Contact: Renatt Brodsky
Renatt.Brodsky@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. UNH research adds to mounting evidence against popular pavement sealcoat
2. Expedition to undersea mountain yields new information about sub-seafloor structure
3. CU research shows warming climate threatens ecology at mountain research site west of Boulder
4. Accelerating climate change exerts strong pressure on Europes mountain flora
5. Global warming has driven Europes mountain plants to migrate 2.7 meters upwards in 7 years
6. European mountain plant population shows delayed response to climate change
7. Medbox Developing a Patent Pending Wall-Mounted Biometric Kiosk for Storage of Sensitive Medicine Samples and Supplies for Doctors Offices.
8. Nitrogen pollution changing Rocky Mountain National Park vegetation, says CU-Boulder-led study
9. NCEAS DataONE streamlines search and analysis of massive amounts of ecological data
10. Mount Sinai researchers solve mystery surrounding the death of two sisters nearly 50 years ago
11. IdentiSys acquires the Identification, Security and Presentation Divisions of Mountainland Business Systems, a Utah based reseller
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... and TELTOW, Germany , ... 2015 Siggraph Conference, SensoMotoric Instruments (SMI) shows ... reality , based on Epson,s Moverio BT-200 ... tracking platform. With this new solution, unprecedented quality and ... hands-free interaction with context-sensitive displays. For the first time, ...
(Date:8/5/2015)... York , August 5, 2015 ... report titled "Facial Recognition Market - Global Industry Analysis, ... the global market for facial recognition is forecast to ... driven by increased demand for surveillance systems by civil ... rising number of crimes and terrorist activities across the ...
(Date:8/4/2015)... Aug. 4, 2015  AMRI (NASDAQ: AMRI ) today reported ... 2015. Highlights: , Second quarter contract revenue ... 2014 , Adjusted contract margins of ... $0.22, including a $0.05 decrease in EPS from royalties in the ... million "We are very pleased to present another ...
Breaking Biology News(10 mins):SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24
... NEW YORK, NY (July 6, 2011) - A new study ... intestine do not have the recommended number of samples to ... 2011 issue of Gastrointestinal Endoscopy , analyzed a national ... TX). More than 100,000 patients had a biopsy of ...
... colorectal cancer mortality rates are concentrated in the northern ... to fall behind, according to a report in ... the American Association for Cancer Research. Ahmedin Jemal, ... American Cancer Society, said the decrease in death rates ...
... of Americathere,s a new group in town. Four middle-school ... California, entered The Christopher Columbus Awards Competition, a science, ... students to identify a community problem and solve it ... popular group the Backstreet Boys, the students call themselves ...
Cached Biology News:Low adherence to biopsy guidelines affects celiac disease diagnosis in the United States 2Southern US states lag in reducing death rates from colorectal cancer 2Middle-school students educate community on proper computer posture 2
(Date:8/27/2015)... CA (PRWEB) , ... August 27, 2015 , ... ... in Personalized Medicine, recently presented new data on the relationship of genetics and ... 20th World Congress on Heart Disease in Vancouver, British Columbia, Canada. The event, ...
(Date:8/26/2015)... , ... August 26, 2015 , ... ... increasing its investment in the development and manufacture of highly valued cardiac markers ... company’s scientific team's extensive expertise with protein chemistry has led to the development ...
(Date:8/26/2015)... BEIJING , August 26, 2015 ... Acheivements  DiaCardio wins 1 st place  ... competition, led in Israel by venture capital ... from countries including the US, China , ... Latin America .  Impressive achievement for the ...
(Date:8/26/2015)... ... August 26, 2015 , ... PRC Clinical, a Clinical Trial ... with local sponsors in southern California. The Clinical Trial Management Expert CRO seeks to ... regulatory pathways., , Stem Cell Meeting on the Mesa ...
Breaking Biology Technology:Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 2Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 3Lee Biosolutions Announces Increased Investment in the Development and Manufacturing of Biomarkers Used in Early Detection Of Heart Disease 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 3Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 4Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 5Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 6PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 2PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 3
... (NYSE Amex: PIP ), a biodefense company developing ... financial and operational results for the third quarter and ... third quarter of 2009, PharmAthene recognized revenues of $6.8 ... of 2008. For the nine months ended September 30, ...
... ... government business development services to its technology incubator companies, bringing a potential for millions of ... ... signed a Memorandum of Understanding with the University of Florida to provide its ...
... DNDN ) today reported results for the quarter ended ... was $25,000 compared to $26,000 for the quarter ended September ... 2009 was $80,000 compared to $83,000 for the nine months ... for the third quarter of 2009 were $25.8 million compared ...
Cached Biology Technology:PharmAthene Reports Third Quarter 2009 Financial and Operational Results 2PharmAthene Reports Third Quarter 2009 Financial and Operational Results 3PharmAthene Reports Third Quarter 2009 Financial and Operational Results 4PharmAthene Reports Third Quarter 2009 Financial and Operational Results 5PharmAthene Reports Third Quarter 2009 Financial and Operational Results 6PharmAthene Reports Third Quarter 2009 Financial and Operational Results 7PharmAthene Reports Third Quarter 2009 Financial and Operational Results 8New Program to Bring University of Florida Incubator Companies Millions in New Contracts 2New Program to Bring University of Florida Incubator Companies Millions in New Contracts 3New Program to Bring University of Florida Incubator Companies Millions in New Contracts 4Dendreon Reports Third Quarter 2009 Financial Results and Continuing Progress Toward PROVENGE Commercialization 2Dendreon Reports Third Quarter 2009 Financial Results and Continuing Progress Toward PROVENGE Commercialization 3Dendreon Reports Third Quarter 2009 Financial Results and Continuing Progress Toward PROVENGE Commercialization 4Dendreon Reports Third Quarter 2009 Financial Results and Continuing Progress Toward PROVENGE Commercialization 5Dendreon Reports Third Quarter 2009 Financial Results and Continuing Progress Toward PROVENGE Commercialization 6
... Highly nutritious peptone, used ... production of bacterial toxins, ... of bacteria with high ... Haemophilus, Neisseria, Pasteurella, Salmonella ...
... Human Raji cells were cultured in RPMI ... at the log phase of growth. In ... forms, cells were fixed in acetone-methanol. The ... adhesive coated slide, with each wells surface specifically ...
... in Minimum Essential Medium (Eagle) with 2 mM ... growth. In order to keep the antigens ... acetone-methanol. The cells are arrayed on a ... wells surface specifically treated to enhance cellular attachment ...
CELLine System cultivation flask (for secreted products)...
Biology Products: