Navigation Links
Mount Sinai scientists and international team shed new light on schizophrenia
Date:7/22/2014

NEW YORK, NY -- As part of a multinational, collaborative effort, researchers from the Icahn School of Medicine at Mount Sinai have helped identify over 100 locations in the human genome associated with the risk of developing schizophrenia, in the largest genomic study published on any psychiatric disorder to date, conducted with 80,000 people. The findings, published online in Nature, point to biological mechanisms and pathways that may underlie schizophrenia, and could lead to new approaches to treating the disorder, which has seen little innovation in drug development in more than 60 years.

Schizophrenia, a debilitating psychiatric disorder that affects approximately 1 out of every 100 people worldwide, is characterized by hallucinations, paranoia, and a breakdown of thought processes, and often emerges in the teens and early 20s. Its lifetime impact on individuals and society is high, both in terms of years of healthy life lost to disability and in terms of financial cost, with studies estimating the cost of schizophrenia at over $60 billion annually in the U.S. alone.

"By studying the genome, we are getting a better handle on the genetic variations that are making people vulnerable to psychiatric disease," said Tom Insel, director of the National Institute of Mental Health, which helped fund the study. "Through the wonders of genomic technology, we are in a period in which, for the first time, we are beginning to understand many of the players at the molecular and cellular level."

In the genome-wide association study (GWAS) published in Nature, the authors looked at over 80,000 genetic samples from schizophrenia patients and healthy volunteers and found 108 specific locations in the human genome associated with risk for schizophrenia. Eighty-three of those loci had not previously been linked to the disorder.

"Through its open and extensive worldwide data sharing policies, The Psychiatric Genomics Consortium (PGC), whi
'/>"/>

Contact: Glenn Farrell
glenn.farrell@mssm.edu
650-690-1598
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Mining mountains of data for medical insights
2. Mountain ecosystems scientists to convene at University of Nevada, Reno
3. How does snow affect the amount of water in rivers?
4. Earth Week: Bark beetles change Rocky Mountain stream flows, affect water quality
5. Researchers find arid areas absorb unexpected amounts of atmospheric carbon
6. Scientists say new computer model amounts to a lot more than a hill of beans
7. Rocky Mountain wildflower season lengthens by more than a month
8. Genetics linked to children viewing high amounts of violent media
9. Arctic inland waters emit large amounts of carbon
10. Large amounts of folic acid shown to promote growth of breast cancer in rats
11. Study of Nepalese pilgrims challenges diagnosis of acute mountain sickness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... --  Neurotechnology , a provider of high-precision biometric, robotics ... Development Kit (SDK). The SentiGaze algorithm enables designers ... to track eye movements and generate heatmaps based on ... be used for applications such as analysis of websites ... can also be used to develop interfaces for a ...
(Date:2/23/2015)... 23, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce ... 62114357 for DISTRIBUTED VOICE DIRECTED PAYMENT METHOD ... a new groundbreaking payment method. Payment accounts may be ... only be accessed if both the speech (the word ...
(Date:2/12/2015)... , Feb. 12, 2015 NXT-ID, Inc. ... the "Company"), a biometric authentication company focused on the ... filed provisional patent 62/113114 for DISTRIBUTED METHOD ... The patent further establishes NXT-ID,s position in ... intellectual property portfolio the ability for multiple devices to ...
Breaking Biology News(10 mins):Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 3NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 3
... SALT ... Jeffrey R. Botkin will chair a federal panel that will review scientists, ... couples who used "test-tube fertilization" to have babies. ... the capability of developing into any tissue type in the human body," ...
... 2009 Bacteria commonly used to indicate health risks ... all. Pathogenic E. coli were pervasive in stream-water samples ... This is one of the unexpected findings from recent ... rely on indicator bacteria to determine if water is ...
... -- If you don,t know how a human cell is ... when the cell goes haywire -- as it does in ... researcher has been awarded a $1.2 million grant to explore ... development and their connections to human disease. Tim Megraw, ...
Cached Biology News:Utah ethicist heads stem cell panel 2Utah ethicist heads stem cell panel 3How good are tests for E. coli in streams? 2Researcher awarded $1.2 million grant to study centrosomes and cilia 2
(Date:3/4/2015)... March 4, 2015 ... Paris en décembre 2011, l,étude ...   », qui compare   l es ...   sorafénib dans le carcinome hépatocellulaire avancé, a ... du foie avancé   ; les résultats sont ...
(Date:3/3/2015)... astronaut Scott Kelly , who is making final preparations ... and working on the International Space Station, will be available ... Monday, March 9. Kelly will participate from ... of his training. The interviews will be preceded at 5 ... training and previous spaceflights. To schedule an interview, ...
(Date:3/3/2015)... SAN DIEGO , March 3, 2015  Neurocrine ... that Kevin Gorman , President and Chief Executive ... Barclays Global Healthcare Conference in Miami.   ... at 10:15am ET (7:15am PT).  The presentation will be ... at http://www.neurocrine.com .   Listeners are ...
(Date:3/3/2015)... California (PRWEB) March 03, 2015 Crown ... service company, has launched a new Life Science division ... for preclinical research. , The first products released ... isotype controls, and soon to be released in vivo ... will continue to expand their life science portfolio with ...
Breaking Biology Technology:Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 2Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 3Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 4Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 5Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 6NASA Astronaut Scott Kelly Available for Interviews before One-Year Space Station Mission 2Crown Bioscience Launches Life Science Product Catalog 2
... SANTA MONICA, Calif., May 27 Cord Blood America, Inc. ... preservation company ( http://www.cordblood-america.com ) ... to families nationwide and internationally, said today that it has ... in the first five months of 2009. "On April ...
... Microbia, Inc. (formerly Microbia Precision Engineering), an ... specialty ingredients and biomaterials from fermentation technology, ... company as vice president of process development. ... of manufacturing and process development for Bristol-Myers ...
... in German . , The enzyme ... able to rapidly ,and efficiently detoxify chemical warfare agents ... subway attacks in 1995. A detailed understanding ,of the ... for efforts aiming to improve their properties. A group ...
Cached Biology Technology:Cord Blood America Says Debt Reduced $4.194 Million in 2009 2Microbia, Inc. Names Alex Chu as Vice President of Process Development 2Structure of enzyme against chemical warfare agents determined 2
V beta 5 Purified Anti-Human clone MH3-2, Isotype Mouse IgG 2a , kappa, 0.1 mg Consult technical datasheet for details....
...
... II xi 2-D system runs both gel dimensions in ... gels can be separated in a single run using ... core in much the same manner as the slab ... second-dimension slab gels may be cast in the casting ...
Vitronectin Immunogen: Purified, full length, native human protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: