Navigation Links
Mount Sinai researchers develop first successful laboratory model for studying hepatitis C
Date:8/2/2013

By differentiating monkey stem cells into liver cells and inducing successful infection, researchers from the Icahn School of Medicine at Mount Sinai have shown for the first time that the hepatitis C virus (HCV) can replicate in monkeys, according to research published in the journal Gastroenterology. The new findings may lead to the first new animal model and provide new avenues for developing treatments and vaccines for this disease, which impacts more than three million people in the United States.

Scientists have tried for decades to develop animal models to study HCV, but the virus was incapable of infecting any species except for humans and chimpanzees. With a recent National Institutes of Health-imposed moratorium restricting chimpanzee research, the Mount Sinai research team turned to a close relative of chimpanzees and humansmacaques. Led by Matthew Evans, PhD, and Valerie Gouon-Evans, PhD, of Mount Sinai, the research team sought to find out why previous attempts to infect macaques with HCV failed.

Dr. Gouon-Evans, who is Assistant Professor of in the Department of Developmental and Regenerative Biology at Mount Sinai, worked with a team at the Fred Hutchison Cancer Research Center in Seattle to differentiate macaque stem cells into liver cells. Dr. Evans, who is an Assistant Professor in the Department of Microbiology, and his team then attempted to infect these cells with HCV in a petri dish. They found that these differentiated cells were able to support HCV infection and replication, although not as effectively as in human liver cells.

"Now that we know that HCV infection in macaque cells is possible, we wanted to find out why it only worked in liver cells that were derived from stem cells," said Dr. Gouon-Evans. "By identifying where in the viral life cycle the infection is dysfunctional, we can develop an effective animal model of HCV."

Dr. Evans and his team found that HCV was less efficient at enter
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. AMP concerned about the structure and application of gap fill payment amounts
2. Total amount of exercise important, not frequency, research shows
3. Earthquake swarms; marine Ediacaran fossil traces; Alca obsidian; Mammoth Mountain
4. Mount Sinai celebrates team science at second-annual SINAInnovations Conference Nov. 18-19, 2013
5. Mount Sinai discovers new liver cell for cellular therapy to aid in liver regeneration
6. Going green: Nation equipped to grow serious amounts of pond scum for fuel
7. Intermountain Medical Center reseachers develop new 3-D technology to treat atrial fibrillation
8. Mount Sinai Selects Exemplar LIMS for Genomics Core Facility
9. The right amount of vitamin D for babies
10. Mount Sinai study identifies new gene variations associated with heart rate
11. Mount Sinai leads global program using stem cells to accelerate cures for Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/10/2015)... 10, 2015  Continuing its 167-year history of offering ... introduces The Eye Scanning Password Authenticator , a ... to secure websites or sensitive data. Employing ... international borders, the device has a small camera that ... the iris, converting them into an encrypted ID that ...
(Date:3/4/2015)... Research and Markets ( http://www.researchandmarkets.com/research/48tj8z/global_biometrics ... "Global Biometrics Market Forecast and Opportunities, 2020" ... for biometric authentication systems is projected to grow ... The driving forces for this highly ... projects and constant development in technology. In 2014, ...
(Date:2/25/2015)... , Feb. 25, 2015  ABC Financial ... billing in the Health and Fitness Industry, today ... as to MYiCLUBonline.  The latest upgrade includes advances ... inclusion of cardless check-in via Identity One fingerprint ... first time through interactive displays at the International ...
Breaking Biology News(10 mins):Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2Global Biometrics Market Forecast and Opportunities, 2020 2Global Biometrics Market Forecast and Opportunities, 2020 3ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3
... The Sixth Annual Sue Kim Hanson Lecture in Immunology on ... in honor of Sue Kim Hanson, MA, PhD 02, a ... with her husband and daughter, were passengers on United Airline ... Center on September 11, 2001. The lecture titled, Mechanisms ...
... Fisheries Service, has reported in an online scientific journal ... River dolphin, or baiji, during a six-week survey in ... extinct due to fishing and commercial development, which would ... of human activity. The research paper, published ...
... 2007)While the wily coyote reigns as top dog in much ... coexists with its larger relative, the wolf, according to a ... densities are more than 30 percent lower in areas that ... most recent edition of the Journal of Animal Ecology, details ...
Cached Biology News:Lecture to honor victim of Sept. 11 tragedy 2Scientists fear rare dolphin driven to extinction by human activities 2Who's afraid of the big, bad wolf? Coyotes 2
(Date:3/27/2015)... York (PRWEB) March 27, 2015 Governor ... 2015 application period for 43North - the world’s largest ... including a grand prize of $1 million, six $500,000 ... from around the world to compete for prizes that ... enterprises in the Western New York region. , ...
(Date:3/26/2015)... San Bruno, CA (PRWEB) March 26, 2015 ... organization (CRO), announced today several management and executive ... role of Chief Financial Officer (CFO) and member of ... Vice President of Business Operations, and Sue Dowden will ... Tony Taricco, co-founder and current Chief Operations Officer (COO), ...
(Date:3/26/2015)... The Market Element LLC, a leading ... with Designing Gig LLC to provide website design, development, ... “Forging this alliance with Designing Gig represents a pivotal ... a comprehensive, end-to-end, digital solution for our clients, which ... Chuck Miller, president of The Market Element. “For small ...
(Date:3/26/2015)... and CINCINNATI , March 26, ... SHP, NASDAQ: SHPG ) and Cincinnati Children,s ... research collaboration for rare diseases. The goal of the ... to treat rare diseases with high unmet medical ... Cincinnati Children,s research expertise. As a nationally ranked ...
Breaking Biology Technology:Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 2Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 3Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 4Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 5PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 2PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 3The Market Element LLC and Designing Gig LLC Form Strategic Alliance 2Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 2Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 3Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 4Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 5
... Positive results from Pyratine XR(TM) rosacea-specific study also slated ... March 8, 2009 - NAPA, Calif., March 5 ... sciences company engaged in the development of technologies that ... Pyratine XR(TM) is officially launching at the American Academy ...
... the launch of a suite of miRNA functional ... vector based precursor miRNA expression clones; 2) miTarget(TM) ... 3) All-in-One(TM) miRNA RT-qPCR system.Constructed in a lentiviral ... collections cover all known miRNAs for human ...
... 5 Poniard Pharmaceuticals, Inc. (Nasdaq: ... oncology therapies, today announced that it will hold ... quarter and year-end financial results and provide a ... the Company,s lead product candidate.Jerry McMahon, Ph.D., chairman ...
Cached Biology Technology:Pyratine XR(TM) Launches at 67th AAD Meeting, Offering Hope to 14 Million Rosacea Sufferers 2Pyratine XR(TM) Launches at 67th AAD Meeting, Offering Hope to 14 Million Rosacea Sufferers 3GeneCopoeia Introduces Genome-Wide MicroRNA (miRNA) Functional Analysis Tools 2Poniard Pharmaceuticals to Host Fourth Quarter and Year-End 2008 Financial Results Conference Call on March 12 2
E2F-5...
DAP12 Market Segment: Protein Kinases...
Rabbit polyclonal to Flagellin ( Abpromise for all tested applications). Antigen: Synthetic peptide from the flagellin C terminal domain of Burkholderia pseudomallei....
Naphthol Blue Black, CI 20470...
Biology Products: