Navigation Links
Molecular interplay explains many immunodeficiencies
Date:11/11/2013

ee these effects in patients with X-linked severe combined immunodeficiency, whose impaired response to IL-21 causes severe antibody deficiency."

"Patients with mutations in the STAT3 gene develop Hyper IgE Syndrome, another rare immunodeficiency that manifests as compromised antibody production and greatly depleted immune defences."

Immunodeficiencies arising from mutations in single genes give scientists a unique opportunity to understand B cell signaling, and reveal potential targets for modulating B cell responses in immunodeficiency and autoimmunity.

The current study arose from analysing global gene expression in B cells from healthy people and people with STAT3 deficiency which immediately highlighted genes that were poorly expressed in disease. The Tangye lab plans to investigate other genes that impact the function of B cells.


'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-292-958-128
Garvan Institute of Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. The Association for Molecular Pathology announces highlights of Phoenix meeting
2. Penn researchers identify molecular link between gut microbes and intestinal health
3. Singapore scientists expose molecular secrets of bile duct cancers from different countries
4. Molecular Velcro may lead to cost-effective alternatives to natural antibodies
5. Grafted limb cells acquire molecular fingerprint of new location, UCI study shows
6. Molecular biology: Designer of protein factories exposed
7. The molecular clock of the common buzzard
8. Cells molecular muscles help them sense and respond to their environments
9. Trovagene Announces Abstracts to be Presented at Molecular Targets and Cancer Therapeutics Conference
10. Recent highlights in Molecular Biology and Evolution
11. Better insight into molecular interactions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... CITY (July 28, 2014)The Brain & Behavior Research ... Klerman and Freedman Prizes, recognizing exceptional clinical and ... supported by NARSAD Young Investigator Grants. The grants ... in neurobiological and psychosocial research for the prevention, ... that affect one in four people. , Six ...
(Date:7/28/2014)... and treat HIV infection has been problematic until now ... arouse as they get rid of the invaders. Now, ... and the National Institutes of Health (NIH) have demonstrated ... around the time of infection could have long-term ... appeared in Nature . , Interferons, named ...
(Date:7/28/2014)... statistical tools to map social connections in prairie ... techniques, shedding light on prairie dog communities that ... and guide future conservation efforts. The work was ... and the National Evolutionary Synthesis Center (NESCent). , ... to bubonic plague," says Dr. Jennifer Verdolin, lead ...
Breaking Biology News(10 mins):The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 2The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 3The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 4Interfering with interferon 2Social network research may boost prairie dog conservation efforts 2
... Ill. --- Driving down a country road at night your ... creature doesnt move. Depending on your speed and other conditions, ... you do, its because you are in what is fittingly ... study, published online Nov. 13 by the journal PLoS Biology. ...
... CAMBRIDGE, MA MIT researchers have identified a family of ... critical for normal brain function. Their research could lead ... The team, led by MIT biology professor Frank Gertler, ... to direct the formation of axons and dendrites, the ...
... professor of biology in Arts & Sciences, has been awarded ... study pathways in bioenergy conversion. One is a long-term NIH ... $1,203,250. It started on August 1. The renewal award means ... The U.S. Department of Agriculture, U.S. Department of Energy, ...
Cached Biology News:Northwestern study looks at sensing, movement and behavior 2Northwestern study looks at sensing, movement and behavior 3MIT IDs proteins key to brain function 2NIH grants enable energy studies 2NIH grants enable energy studies 3
(Date:7/28/2014)... 2014 The National Model Aviation Museum, ... is pleased to announce that it has been granted ... the United States Air Force. , The certification is ... concluded this spring with an on-site inspection by Sarah ... , The National Museum of the United States ...
(Date:7/25/2014)... MA -- Trillions of bacteria live in each person,s ... help digest food and stave off harmful infections, but ... , To help shed light on the role of ... associate professor Eric Alm recently tracked fluctuations in the ... year. The findings, described in the July 25 issue ...
(Date:7/25/2014)... CA (PRWEB) July 25, 2014 WABC Radio ... Your Pet with Lorry Young will be hosting California-based ... talk about stem cell therapy in pets. Dr. Harman ... benefits of stem cell therapy for pets suffering from osteoarthritis ... the Regenerative Veterinary Medicine industry forward. , Young has invited ...
(Date:7/25/2014)... , July 25, 2014 /PRNewswire-iReach/ -- Xybion Corporation, ... for global corporations operating in highly regulated industries, ... first annual Global User Group Conference, Xybion International ... Philadelphia, Pennsylvania at the Sheraton ... http://photos.prnewswire.com/prnh/20140724/130263 This year,s conference ...
Breaking Biology Technology:AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 3Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3
... new kind of biosensor can tell., A new and ... Vanderbilt University that can measure the interactions between free-floating, ... RNA., That is precisely the kind of capability needed ... have been opened up by the 15-year-plus effort to ...
... have developed tools to help solve two of the main ... to quickly test stem cell response to different drugs or ... viable stem cells to study from only a few available ... of stems cells on devices the size of a standard ...
... approach to discover life on Mars were successfully launched ... orbit experiment to assess their survivability in the space ... new approach is based on technology similar to that ... embodied in the Life Marker Chip (LMC) experiment, which ...
Cached Biology Technology:When proteins, antibodies and other biological molecules kiss, a new kind of biosensor can tell 2When proteins, antibodies and other biological molecules kiss, a new kind of biosensor can tell 3Putting stem cell research on the fast track 2Putting stem cell research on the fast track 3Putting stem cell research on the fast track 4Life on Mars 'pregnancy test' successfully launched 2
Total Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and Lupus diseased tissues are available....
... technology, the Lone Wolf valve has the ... proportional valve available on the market. This ... high-speed performance, and ensures maximum accuracy., ... system control and patient comfort. , Maintains ...
... The Precision Slide Table is designed for ... bore design provides maximum force output while ... four sets of stainless steel ball bearings ... Bumpers or self-compensating shock absorbers provide energy ...
Hamster serum...
Biology Products: