Navigation Links
Molecular interplay explains many immunodeficiencies
Date:11/11/2013

ee these effects in patients with X-linked severe combined immunodeficiency, whose impaired response to IL-21 causes severe antibody deficiency."

"Patients with mutations in the STAT3 gene develop Hyper IgE Syndrome, another rare immunodeficiency that manifests as compromised antibody production and greatly depleted immune defences."

Immunodeficiencies arising from mutations in single genes give scientists a unique opportunity to understand B cell signaling, and reveal potential targets for modulating B cell responses in immunodeficiency and autoimmunity.

The current study arose from analysing global gene expression in B cells from healthy people and people with STAT3 deficiency which immediately highlighted genes that were poorly expressed in disease. The Tangye lab plans to investigate other genes that impact the function of B cells.


'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-292-958-128
Garvan Institute of Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. The Association for Molecular Pathology announces highlights of Phoenix meeting
2. Penn researchers identify molecular link between gut microbes and intestinal health
3. Singapore scientists expose molecular secrets of bile duct cancers from different countries
4. Molecular Velcro may lead to cost-effective alternatives to natural antibodies
5. Grafted limb cells acquire molecular fingerprint of new location, UCI study shows
6. Molecular biology: Designer of protein factories exposed
7. The molecular clock of the common buzzard
8. Cells molecular muscles help them sense and respond to their environments
9. Trovagene Announces Abstracts to be Presented at Molecular Targets and Cancer Therapeutics Conference
10. Recent highlights in Molecular Biology and Evolution
11. Better insight into molecular interactions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/11/2015)... , Mar. 11, 2015 Research and Markets ... the "Access Control Market by Product, Application & ... report to their offering. , This ... to reach $10.4 billion by 2020, with an estimated ... report covers the products types such as contact cards ...
(Date:3/10/2015)... BOULDER, Colo. , March 10, 2015 ... Space Flight "Personalized Medicine in Human ... Ph.D. and Thomas J. Goodwin , Ph.D. was ... articles of the past two years. Specifically, ... three most downloaded scientific papers published in 2013 and ...
(Date:3/5/2015)... March 5, 2015 In Brazil ... companies already using these solutions and 42 percent planning to ... latter, approximately 25 percent of the companies will be investing ... the majority of companies in the region are currently opting ... hybrid model will command significant attention in the coming years. ...
Breaking Biology News(10 mins):Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 2Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 4
... in their genes" is a common refrain from scientists when ... and beyond. Up until now, research has focused on ... levels of HDL ("good") cholesterol. But researchers at Albert ... of Psychology of Yeshiva University have found that personality ...
... Preventice, Inc. , a developer of mobile health ... it is the latest to join medical device ... payors that are integrating with Qualcomm Life Inc., ... their 2net™ Ecosystem. (Logo: http://photos.prnewswire.com/prnh/20120417/CG89172LOGO ...
... Diego have discovered that a small dose of a commonly ... affects their ability to recruit their nestmates to otherwise good ... this week,s issue of the Journal of Experimental Biology ... bee-pollinated crops and shed light on one of the main ...
Cached Biology News:'Personality genes' may help account for longevity 2Preventice Expands Options for Wireless Patient Monitoring with Qualcomm Life 2Commonly used pesticide turns honey bees into 'picky eaters' 2
(Date:3/26/2015)... -- Roka Bioscience, Inc. (NASDAQ: ROKA ), a ... solutions for the detection of foodborne pathogens, today ... and full year ended December 31, 2014. ... quarter ended December 31, 2014 was $1.4 million ... 2013 and $1.5 million for the third quarter ...
(Date:3/26/2015)... March 26, 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" ... after dealing with certain matters, including the appointment of ... on March 26, 2015 (the "Meeting") was adjourned, as ... 2015 at 11:00 a.m. ( Toronto ... changed from that previous disclosed. The Meeting will reconvene ...
(Date:3/26/2015)... 2015  BioNano Genomics, Inc., the leader in genome ... as chief commercial officer. Salyer has more than 20 ... in life sciences. At BioNano, Salyer will oversee the ... platform to assemble a comprehensive view of complex genomes ... 32 institutions located in the United States ...
(Date:3/26/2015)... March 26, 2015 Neogen Corporation (NASDAQ: ... the third quarter of fiscal 2015, which ended Feb. ... prior year,s $6,575,000. Earnings per share in the current ... Current year-to-date net income increased 17% over prior year ... or $0.56 per share, for the same period a ...
Breaking Biology Technology:Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 2Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 3Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 4Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 5Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 6Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 7SQI Diagnostics Inc. Announces Adjournment of Meeting 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3Neogen reports 13% increase in net income 2Neogen reports 13% increase in net income 3Neogen reports 13% increase in net income 4Neogen reports 13% increase in net income 5Neogen reports 13% increase in net income 6Neogen reports 13% increase in net income 7Neogen reports 13% increase in net income 8
... Technology (NIST) has issued a new ruler, and even for ... records. Designed to be the most accurate commercially available "meter ... standard for X-ray diffractionboasts uncertainties below a femtometer. That,s 0.000 ... a neutron. The new ruler is in the form ...
... , , , ... a prospective registry showed good safety in a broad population of patients ... Genous Bio-engineered R stent for ST-elevation myocardial infarction (STEMI). , , ... of major adverse cardiac events (MACE) was 6.7 percent and the rate ...
... SAN DIEGO, Sept. 22 SoluLinK, Inc., a leader ... Catalyst, making conjugation at least 20 times faster than before ... , , Up to now, researchers, conjugation ... poor yields, poor quality and more labor and time consuming ...
Cached Biology Technology:New NIST nano-ruler sets some very small marks 2OrbusNeich's Genous(TM) Bio-Engineered R Stent(TM) is Safe in a Broad Population of Patients with Primary PCI for STEMI 2OrbusNeich's Genous(TM) Bio-Engineered R Stent(TM) is Safe in a Broad Population of Patients with Primary PCI for STEMI 3SoluLinK Introduces Product that Links All Biomolecules Greater Than 20 Times Faster with 100% Yields 2
The pCDF Expression System 1 plus Competent Cells contains 10 µg of pET-45b(+) DNA. pET-45b carries an N-terminal His•Tag ® coding sequence that is cleavable with enterokinase as well...
... to Uridine Phosphorylase 1 ( Abpromise ... Antigen: Synthetic peptide: MAATGANAEK AESHNDCPVR LLNPNIAKMK ... corresponding to amino acids 1-99 of Human ... Gene ID: 7378 ...
Request Info...
Syne-1 (N-19)...
Biology Products: