Navigation Links
Molecular forces are key to proper cell division
Date:1/21/2013

AMHERST, Mass. Studies led by cell biologist Thomas Maresca at the University of Massachusetts Amherst are revealing new details about a molecular surveillance system that helps detect and correct errors in cell division that can lead to cell death or human diseases. Findings are reported in the current issue of the Journal of Cell Biology.

The purpose of cell division is to evenly distribute the genome between two daughter cells. To achieve this, every chromosome must properly interact with a football-shaped structure called the spindle. However, interaction errors between the chromosomes and spindle during division are amazingly common, occurring in 86 to 90 percent of chromosomes, says Maresca, an expert in mitosis.

"This is not quite so surprising when you realize that every single one of the 46 chromosomes has to get into perfect position every time a cell divides," he notes. The key to flawless cell division is to correct dangerous interactions before the cell splits in two.

Working with fruit fly tissue culture cells, Maresca and graduate students Stuart Cane and Anna Ye have developed a way to watch and record images of the key players in cell division including microtubule filaments that form the mitotic spindle and sites called kinetochores that mediate chromosome-microtubule interactions. They also examined the contribution of a force generated by molecular engines called the polar ejection force (PEF), which is thought to help line up the chromosomes in the middle of the spindle for division. For the first time, they directly tested and quantified how PEF, in particular, influences tension at kinetochores and affects error correction in mitosis.

"We also now have a powerful new assay to get at how this tension regulates kinetochore-microtubule interactions," Maresca adds. "We knew forces and tension regulated this process, but we didn't understand exactly how. With the new technique, we can start to d
'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
2. Molecular 2-way radio directs nerve cell branching and connectivity
3. Scientists pinpoint molecular signals that make some women prone to miscarriage
4. Webcast alert: Molecular Medicine Institute to give new hope to pediatric patients
5. Discovery of molecular pathway of Alzheimers disease reveals new drug targets
6. Ah, that new car smell: NASA technology protects spacecraft from outgassed molecular contaminants
7. New Market Forecasts Available for Critical Global Biotechnology Testing and Screening Markets: Molecular Diagnostics, Hematology, Clinical Chemistry and Nucleic Acid Testing
8. Researchers describe new molecular interactions behind the inhibition of TGF beta-signaling
9. Molecular movies may accelerate anti-cancer drug discovery
10. Molecular and protein markers discovered for liver transplant failure from hepatitis C
11. Molecular economics: New computer models calculate systems-wide costs of gene expression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecular forces are key to proper cell division
(Date:5/10/2015)... , May 11, 2015 Fingerprint Cards ... FPC1025 and FPC1155 from the distributor World Peace Industrial Group ... distributors in Asia . Deliveries are planned ... be used by smartphone manufacturers in China ... the communicated revenue guidance of + 1 000 MSEK for 2015. ...
(Date:5/5/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... commerce market, reminds investors and media that  Mr. David ... CARTES SECURE CONNEXIONS AMERICA 2015, held in Washington ... three-day conference is organized into a series of nine session ... Global Fraud: Where is the Trust in Cyberspace? and ...
(Date:4/21/2015)... 21, 2015 High crime ... are boosting access control systems market in ... a recently published report by TechSci Research " Saudi ... access control systems market in Saudi Arabia ... 2020.The access control systems market in the Kingdom is ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3
... powerful microscope, revealing its microstructure, and prepare to be ... pitted and pocked. "It is intrinsic to ... at the University of WisconsinMilwaukee (UWM). "A pit can ... steel itself." The pitting is cause for ...
... cats and humans against deadly flu pandemics, according to an ... of General Virology . The vaccine protects birds and mammals ... birds while they are still in their eggs, allowing the ... flu has posed a major challenge to scientists designing vaccines ...
... Researchers have discovered a mechanism for the rapid growth seen ... The tumors, which are made up of proliferating blood ... descent, with girls more frequently afflicted than boys. The ... blood-red lump on the head or facethen grow rapidly in ...
Cached Biology News:Nanoscale coating protect products -- and the economy 2Nanoscale coating protect products -- and the economy 3Nanoscale coating protect products -- and the economy 4Bird flu vaccine protects people and pets 2Researchers identify Achilles heel of common childhood tumor 2
(Date:5/28/2015)... , May 28, 2015  GenVec, Inc. (Nasdaq: ... CEO, Douglas J. Swirsky , will present a ... at 11 a.m. EDT on Thursday, June 4, 2015. ... Mr. Swirsky,s presentation will be available at the following ... available on GenVec,s website.  To access, visit www.genvec.com ...
(Date:5/28/2015)... 2015 The Fertility Centers of New ... Danielle Vitiello has taken on a new and expanded ... will provide guidance, leadership, oversight and quality assurance for ... Vitiello among our team of experienced reproductive endocrinologists,” said ... A. Hill, M.D. “Her expertise and compassionate, individualized care ...
(Date:5/28/2015)... Whitehouse Laboratories is excited to announce that ... with PTI Inspection Systems. Whitehouse Labs and PTI will ... method development and validation programs using the most ... includes a more formal program that facilitates cross training ... enables a more effective team approach, especially as it ...
(Date:5/28/2015)... 2015 American Process Inc. (Atlanta, ... TN) recently signed a joint agreement ... resins using nanocellulose, a rapidly emerging high performance, ... is the limited number of feedstock materials available. ... to printed parts for load bearing applications. ...
Breaking Biology Technology:GenVec To Present At The Jefferies Healthcare Conference 2Danielle Vitiello, MD of Fertility Centers of New England, Named New Medical Director 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 3American Process Inc. Announces Partnership with Oak Ridge National Laboratory to Make 3D Printing Plastic Resins Stronger and More Sustainable 2American Process Inc. Announces Partnership with Oak Ridge National Laboratory to Make 3D Printing Plastic Resins Stronger and More Sustainable 3
... Aethlon Medical, Inc. (OTC Bulletin Board: ... to address infectious disease and cancer, announced today that ... interested parties at 5:30 pm EST on January 12, ... The event will be held at the offices of ...
... ALEXANDRIA, Va., Dec. 20, 2010 Today, the Global Probiotics ... CO., LTD., announced the launch of the fourth annual Young ... awards, each in the amount of $50,000, to rising young ... probiotics and gastrointestinal microbiota in health and wellness. Applications will ...
... /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE Amex: ... previously announced public offering of 25,000,000 common shares of ... US $37,650,000. In connection with the offering, the Company ... up to 3,750,000 additional common shares to cover over-allotments, ...
Cached Biology Technology:Aethlon Medical Announces Washington, DC Shareholder Presentation 2Aethlon Medical Announces Washington, DC Shareholder Presentation 3Aethlon Medical Announces Washington, DC Shareholder Presentation 4Fourth Annual Probiotics Grant Continues to Fuel Growth In Research 2Fourth Annual Probiotics Grant Continues to Fuel Growth In Research 3Fourth Annual Probiotics Grant Continues to Fuel Growth In Research 4YM BioSciences Closes Public Offering of Common Shares 2YM BioSciences Closes Public Offering of Common Shares 3
Rabbit polyclonal to NIRF ( Abpromise for all tested applications). Antigen: Synthetic peptide derived from residues 186-235 of human NIRF. Entrez Gene ID: 115426 Swiss Protein ID: Q96PU...
...
Rabbit polyclonal to ZNF261 ( Abpromise for all tested applications). entrezGeneID: 9203 SwissProtID: Q14202...
...
Biology Products: