Navigation Links
Molecular forces are key to proper cell division
Date:1/21/2013

AMHERST, Mass. Studies led by cell biologist Thomas Maresca at the University of Massachusetts Amherst are revealing new details about a molecular surveillance system that helps detect and correct errors in cell division that can lead to cell death or human diseases. Findings are reported in the current issue of the Journal of Cell Biology.

The purpose of cell division is to evenly distribute the genome between two daughter cells. To achieve this, every chromosome must properly interact with a football-shaped structure called the spindle. However, interaction errors between the chromosomes and spindle during division are amazingly common, occurring in 86 to 90 percent of chromosomes, says Maresca, an expert in mitosis.

"This is not quite so surprising when you realize that every single one of the 46 chromosomes has to get into perfect position every time a cell divides," he notes. The key to flawless cell division is to correct dangerous interactions before the cell splits in two.

Working with fruit fly tissue culture cells, Maresca and graduate students Stuart Cane and Anna Ye have developed a way to watch and record images of the key players in cell division including microtubule filaments that form the mitotic spindle and sites called kinetochores that mediate chromosome-microtubule interactions. They also examined the contribution of a force generated by molecular engines called the polar ejection force (PEF), which is thought to help line up the chromosomes in the middle of the spindle for division. For the first time, they directly tested and quantified how PEF, in particular, influences tension at kinetochores and affects error correction in mitosis.

"We also now have a powerful new assay to get at how this tension regulates kinetochore-microtubule interactions," Maresca adds. "We knew forces and tension regulated this process, but we didn't understand exactly how. With the new technique, we can start to d
'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
2. Molecular 2-way radio directs nerve cell branching and connectivity
3. Scientists pinpoint molecular signals that make some women prone to miscarriage
4. Webcast alert: Molecular Medicine Institute to give new hope to pediatric patients
5. Discovery of molecular pathway of Alzheimers disease reveals new drug targets
6. Ah, that new car smell: NASA technology protects spacecraft from outgassed molecular contaminants
7. New Market Forecasts Available for Critical Global Biotechnology Testing and Screening Markets: Molecular Diagnostics, Hematology, Clinical Chemistry and Nucleic Acid Testing
8. Researchers describe new molecular interactions behind the inhibition of TGF beta-signaling
9. Molecular movies may accelerate anti-cancer drug discovery
10. Molecular and protein markers discovered for liver transplant failure from hepatitis C
11. Molecular economics: New computer models calculate systems-wide costs of gene expression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecular forces are key to proper cell division
(Date:12/19/2014)... , Dec. 18, 2014  23andMe, Inc., the ... a study that pinpoints fine-scale differences in genetic ancestry ... . Since immigrants first arrived more ... States has served as a meeting place ... American history and the ongoing mixing of peoples with ...
(Date:12/17/2014)... YORK , Dec. 15, 2014  HITLAB ... Good Clinical Practices (GCP) audit to confirm its ... (FDA) regulations. This accomplishment enables HITLAB to conduct ... utilizing the highest principles for patient safety and ... improve global healthcare access, quality, and delivery with ...
(Date:12/15/2014)... 12, 2014 Research and Markets ... the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition is ... Facial recognition system measures the overall facial feature ... mouth, and the distance between eyes. Facial recognition ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... University of Southampton, which examines how dolphins might process their ... to detect targets, such as sea mines, in bubbly water. ... ,bubble nets, around schools of fish, which force the fish ... pick off. However, such bubble nets would confound the best ...
... Hamburg, Hannover and Graz, as well as further partners, ... focus will be set on degradable magnesium implants. One ... to develop first prototypes of orthopedic implants. Since ... a new Helmholtz Virtual Institute that will evolve in ...
... National data indicate that milk consumption has declined among ... quality has more than doubled. Although this suggests that ... children,s diets, a new study suggests that in fact ... to changes in their consumption of sodas and flavored ...
Cached Biology News:Do dolphins think nonlinearly? 2Do dolphins think nonlinearly? 3New research association started: Magnesium implants shall facilitate bone fracture healing 2Sugar-sweetened drinks are not replacing milk in kid's diets 2Sugar-sweetened drinks are not replacing milk in kid's diets 3
(Date:12/17/2014)... 16, 2014 “Never say, ‘I ... Universität Marburg’s Department of Physics, advises young women ... newly released SPIE Women in Optics 18-month ... shy to ask questions.” , In the annual ... mathematics) occupations ranging from university professor and laboratory ...
(Date:12/17/2014)... RIDGE, N.J. (PRWEB) December 17, 2014 ... (Euronext: IPN; ADR: IPSEY), today ... mg (referred to as Somatuline®) was approved by ... the treatment of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in ... locally advanced or metastatic disease to improve progression-free ...
(Date:12/17/2014)... This report is a professional ... For an overview analysis, the report introduces quartz ... structure, industry overview, policy analysis, and news analysis, ... has witnessed rapid development with key manufacturers increasing ... report mentions quartz tubing upstream raw materials and ...
(Date:12/17/2014)... Park, CA (PRWEB) December 17, 2014 ... announces today that it has entered into a ... Midland Company (ADM) to apply DNA2.0’s proprietary protein ... enzyme engineering process. , “We are extremely excited ... ProteinGPS engineering platform. This proprietary bioengineering technology ...
Breaking Biology Technology:Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 2Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 3Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 5Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 6Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 7Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 82020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2
... -- Company provides revenue guidance and strategic plan ... /PRNewswire-FirstCall/ - Neptune Technologies &,Bioressources Inc. ("Neptune") (NASDAQ.NEPT ... fourth quarter and year ended May 31, 2008. ... of fiscal year 2008,and has achieved its sixth ...
... 28 deCODE genetics,(Nasdaq: DCGN ) today announced ... Jeffrey Gulcher,s presentation at Thomas Weisel Partners Healthcare,Conference 2008., ... ET / 5:30 PM GMT / 6:30,PM British Summer ... Hotel,Boston, MA. The webcast can be accessed through the ...
... again included,Baxa Corporation on its annual ranking of the ... 4,611 and was among the top,five industries ranked on ... founding in 1975 and currently employs more than 450 ... "The Inc 5000 list promotes the very best in ...
Cached Biology Technology:Neptune Technologies Reports Record Fiscal 2008 Fourth Quarter and Year End Results 2Neptune Technologies Reports Record Fiscal 2008 Fourth Quarter and Year End Results 3Neptune Technologies Reports Record Fiscal 2008 Fourth Quarter and Year End Results 4Neptune Technologies Reports Record Fiscal 2008 Fourth Quarter and Year End Results 5Neptune Technologies Reports Record Fiscal 2008 Fourth Quarter and Year End Results 6deCODE genetics to Webcast Presentation at Thomas Weisel Partners Healthcare Conference 2008 2Baxa Corporation Named to Inc. 5000 for Second Consecutive Year as One of the Fastest-Growing Private Companies in the US 2
... camera controller is the successor to the original ... any of the cameras in the Nikon DS ... USB2.0 interface. The DS-U2 transmits information at high ... equipping both hub and mass storage USB 2.0 ...
... The Helios gene gun low-pressure system, 100-120 ... of biomaterials into cells. The system includes ... helium regulator, tubing prep station, syringe kit, ... low-pressure regulator, and instructions. The dimensions of ...
... gene gun optimization kit provides a variety ... affecting particle delivery with the Helios gene ... of 0.6 micrometer, 1.0 micrometer, and 1.6 ... cartridge kit, that provides 0.5 g polyvinylpyrrolidone ...
... HEXALIGHT robot is based on PI's experience ... more than a decade. PI Hexapods were ... and antenna adjustments over wide ranges in ... degrees of freedom with 3 m minimum ...
Biology Products: