Navigation Links
Molecular forces are key to proper cell division
Date:1/21/2013

AMHERST, Mass. Studies led by cell biologist Thomas Maresca at the University of Massachusetts Amherst are revealing new details about a molecular surveillance system that helps detect and correct errors in cell division that can lead to cell death or human diseases. Findings are reported in the current issue of the Journal of Cell Biology.

The purpose of cell division is to evenly distribute the genome between two daughter cells. To achieve this, every chromosome must properly interact with a football-shaped structure called the spindle. However, interaction errors between the chromosomes and spindle during division are amazingly common, occurring in 86 to 90 percent of chromosomes, says Maresca, an expert in mitosis.

"This is not quite so surprising when you realize that every single one of the 46 chromosomes has to get into perfect position every time a cell divides," he notes. The key to flawless cell division is to correct dangerous interactions before the cell splits in two.

Working with fruit fly tissue culture cells, Maresca and graduate students Stuart Cane and Anna Ye have developed a way to watch and record images of the key players in cell division including microtubule filaments that form the mitotic spindle and sites called kinetochores that mediate chromosome-microtubule interactions. They also examined the contribution of a force generated by molecular engines called the polar ejection force (PEF), which is thought to help line up the chromosomes in the middle of the spindle for division. For the first time, they directly tested and quantified how PEF, in particular, influences tension at kinetochores and affects error correction in mitosis.

"We also now have a powerful new assay to get at how this tension regulates kinetochore-microtubule interactions," Maresca adds. "We knew forces and tension regulated this process, but we didn't understand exactly how. With the new technique, we can start to d
'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
2. Molecular 2-way radio directs nerve cell branching and connectivity
3. Scientists pinpoint molecular signals that make some women prone to miscarriage
4. Webcast alert: Molecular Medicine Institute to give new hope to pediatric patients
5. Discovery of molecular pathway of Alzheimers disease reveals new drug targets
6. Ah, that new car smell: NASA technology protects spacecraft from outgassed molecular contaminants
7. New Market Forecasts Available for Critical Global Biotechnology Testing and Screening Markets: Molecular Diagnostics, Hematology, Clinical Chemistry and Nucleic Acid Testing
8. Researchers describe new molecular interactions behind the inhibition of TGF beta-signaling
9. Molecular movies may accelerate anti-cancer drug discovery
10. Molecular and protein markers discovered for liver transplant failure from hepatitis C
11. Molecular economics: New computer models calculate systems-wide costs of gene expression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecular forces are key to proper cell division
(Date:8/29/2014)... available in German . ... organisms is considered the oldest form of communication. Acting ... for example, the sexual attraction between males and females. ... to coordinate reproductive behavior in males and females. Scientists ... the Algarve in Faro, Portugal, and at the Max ...
(Date:8/29/2014)... Boulder, Colo., USA - The rise of the Tibetan ... on Earth -- is important for both its profound ... In this study published in GSA Bulletin , ... -- "clumped" isotope thermometry -- using modern and fossil ... Zhada basin in southwestern Tibet. , Views range ...
(Date:8/28/2014)... study reports that an expansion of marine protected areas ... ecological functions. According to investigators from the Wildlife ... fish have focused on saving the largest numbers of ... provide key and difficult-to-replace ecological functions. , ... by fish species that also are food for millions ...
Breaking Biology News(10 mins):Ready for mating at the right time 2Ready for mating at the right time 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7Study finds marine protected areas inadequate for protecting fish and ocean ecology 2
... to a collection of test tubes in her Iowa State ... they were holding very weak coffee. That meant microorganisms ... converting sugars into hydrocarbons, said Jarboe, an Iowa State assistant ... the sugars in those test tubes were produced by the ...
... Heavy and prolonged snowfall can bring about unexpected conditions ... in the Arctic, according to experts. A new international ... helps plants to grow bigger, heavy and prolonged snow can, ... of killer fungal strains. The research results, published in ...
... studies in this special issue document the substantial and growing ... the burden of a chikungunya outbreak in India. Luiz ... country,s worsening trend; from 1999-2009, where cases rose at 6.2% ... Carmen Perez and co-workers, reporting on dengue vector control ...
Cached Biology News:Iowa State hybrid lab combines technologies to make biorenewable fuels and products 2Iowa State hybrid lab combines technologies to make biorenewable fuels and products 3Arctic snow harbors deadly assassin 2World Health Organization releases latest Dengue Bulletin 2World Health Organization releases latest Dengue Bulletin 3World Health Organization releases latest Dengue Bulletin 4World Health Organization releases latest Dengue Bulletin 5World Health Organization releases latest Dengue Bulletin 6World Health Organization releases latest Dengue Bulletin 7World Health Organization releases latest Dengue Bulletin 8
(Date:8/28/2014)... Spin-charge converters are important devices in spintronics, an ... charge of electrons but also on their spin ... transformation of electric into magnetic signals and vice ... Sinova from the Institute of Physics at Johannes ... the UK, Prague, and Japan, has for the ...
(Date:8/28/2014)... 28, 2014 The ability for organizations ... that will allow individuals to perform at the highest ... for employers looking to compete in this post–recession era. ... this trend, as the sector increasingly focuses on the ... which will have real results on the organization's development ...
(Date:8/28/2014)... Aug. 28, 2014   SunTrust Robinson Humphrey ... veterans to its equity research team in biotechnology ... expansion in equity research demonstrates our commitment to ... to enhance their investment decision making," said ... "We continue to make significant investments in differentiated ...
(Date:8/28/2014)... 28, 2014  Armetheon, Inc. ( www.armetheon.com ), ... to late-stage cardiovascular drug candidates, today announced that ... round of financing. The Series A round was ... with participation from investors that included Atheneos Capital ... Larry Hsu , the founder of Impax ...
Breaking Biology Technology:A new, tunable device for spintronics 2A new, tunable device for spintronics 3Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3
... 2012 Codexis, Inc. (Nasdaq: CDXS ), ... of biofuels, bio-based chemicals, and pharmaceutical intermediates, today announced ... presenting at the Jefferies Global Clean Technology Conference, to ... 23, 2012 at 1:45 p.m. ET. A live webcast ...
... Pharmaceuticals, Inc. (Nasdaq: AVNR ) today announced that ... Conference. , Citi 2012 Global Health Care Conference ... February 29, 2012 , 9:00 a.m. ET ... presentation will be available at http://ir.avanir.com . ...
... Feb. 21, 2012 /PRNewswire-Asia/ -- Simcere Pharmaceutical Group (NYSE: ... in the development, manufacturing, and marketing of branded generic ... will report its unaudited financial results for the fourth ... Wednesday, March 7, 2012, before the market opens in ...
Cached Biology Technology:Simcere Pharmaceutical Group to Announce Fourth Quarter and Fiscal Year 2011 Financial Results on Wednesday, March 7, 2012 2
Liquid. 50 μg/ml in PBS, pH 7.4. PROTECT FROM LIGHT. A convenient form of propidium iodide useful for flow cytometry studies. RTECS SF7949600, CAS 25535-16-4, M.W. 668.4. ...
... Kit contains a green fluorescent-labeled inhibitor, FAM-VAD-FMK, ... valylalanylaspartic acid (VAD) fluoromethyl ketone (FMK), a ... added to a population of cells, the ... covalently binds to a reactive cysteine residue ...
Lyophilized solid. Suitable for evaluating functional activity of human complement components and for other research requiring a high level of hemolytic activity. ...
... VersArray ChipWriter Pro system, 220-240 V, uses ... proteins, oligonucleotides, carbohydrates, lipids, and other biomolecules ... applications. This system can generate high-density arrays ... slide or greater than 57,000 spots per ...
Biology Products: