Navigation Links
Molecular basis identified for tissue specific immune regulation in the eye and kidney
Date:2/20/2013

diagnosed with AMD every year."

The research team looked at the two parts of CFH affected by the mutations. Both regions are capable of recognising host tissues, through interacting with sugars called glycosaminoglycans (GAGs). Successfully recognising these GAGs lets CFH build up a protective layer on the surface of our tissues that prevents our own immune system from attacking them.

It had always been believed that the region with mutations associated with aHUS was the most important for host recognition and for years people have been researching how to readdress immune dysregulation based on this belief. However, the recent discovery of a single common genetic alteration in the other part of CFH that is associated with eye disease raised the possibility that this previous opinion was not fully accurate.

The Manchester researchers compared the way the different regions of the protein interacted with eye tissue and kidney tissue. They discovered that the region of CFH that helps protect the kidney had no effect in the eye. Instead the other part of CFH, which is subject to the AMD-associated genetic alteration, was fundamentally important in protecting the eye, but this region did not contribute to the binding of CFH to kidney tissue.

Their findings show, for the first time, that the level of importance of the two regions of CFH changes depending on which tissue the protein finds itself. This specificity appears to be mediated by the presence of different populations of GAGs.

Dr Simon Clark says: "Our findings suggest that the particular structure within the eye and kidney tissue determines precisely how and where CFH will bind. It's as if the tissues have their own molecular postcodes."

He continues: "We're very pleased to be able to show why mutations in CFH are so tissue specific. This is important because if we're going to improve treatments for devastating diseases, such as AMD, we need to be able to dev
'/>"/>

Contact: Morwenna Grills
Morwenna.Grills@manchester.ac.uk
44-161-275-2111
University of Manchester
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Explosive breakthrough in research on molecular recognition
2. Mainz scientists confirm original tetrahedral model of the molecular structure of water
3. FASEB SRC announces: Molecular Mechanisms & Physiological Consequences of Protein Aggregation
4. FASEB SRC announces conference registration open for: Ciliate Molecular Biology
5. Elsevier launches new open access journal: Molecular Metabolism
6. Virginia Tech computer scientists develop new way to study molecular networks
7. Molecular forces are key to proper cell division
8. La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
9. Molecular 2-way radio directs nerve cell branching and connectivity
10. Scientists pinpoint molecular signals that make some women prone to miscarriage
11. Webcast alert: Molecular Medicine Institute to give new hope to pediatric patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Va. , Dec. 15, 2014 The Defense ... easier to detect and prevent counterfeit microcircuits from entering ... started performing an in-house microcircuit anti-counterfeit initiative dubbed DNA ... microcircuits while increasing their reliability throughout the supply chain. ...
(Date:12/17/2014)... , Dec. 16, 2014 Research and Markets ... the "Global Chemical Sensor Market 2015-2019" report ... One major trend upcoming in this ... biomedical applications. Chemical sensors help in recording of patient ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of ...  report to their offering. One major ... With continuous advances in technology, it is important to ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... researchers have scored a direct hit. They have made ... and more potent antibiotics., The rapid development of bacterial ... has become a major public health concern. Because resistant ... can create antibiotics, understanding how these molecules function could ...
... the 100-year anniversaries of Annals of the Entomological Society ... two oldest oldest journals. The occasion will be celebrated ... December, where over 2,000 entomologists will gather for four ... Both journals were launched the same year (1908), but ...
... by biologists at Tufts University has discovered a ... put on by fireflies each summer. Using both ... costs of firefly courtship displays, the biologists have ... to be published in the November 2007 issue ...
Cached Biology News:Scientists decipher mechanism behind antimicrobial 'hole punchers' 2ESA celebrates 100 years of insect science journals 2Biologists expose hidden costs of firefly flashes 2Biologists expose hidden costs of firefly flashes 3
(Date:12/25/2014)... (PRWEB) December 25, 2014 The report ... by Product Type & Provider Type - Global Advancements, ... market with an in-depth analysis and forecasting of revenues. ... spread through 221 pages and in-depth TOC on “Service ...
(Date:12/24/2014)... , Dec. 24, 2014  Vermillion, Inc. (Nasdaq: ... gynecologic disease, announced today that the Company closed ... Oracle Investment Management, Jack W. Schuler , ... proceeds were $10.5 million, before offering expenses.  The ...
(Date:12/24/2014)... GMO corn cases filed across the United States, and ... being consolidated in a Kansas federal court for pretrial proceedings. ... Corn Litigation, MDL No. 2591 in the U.S. District Court ... GMO corn multidistrict litigation (MDL) has been handed over to ...
(Date:12/24/2014)... On Friday, December 19, 2014, President ... Continuing Resolution Appropriations Act of 2015, which for the ... funding through the Congressionally Directed Medical Research Programs (CDMRP) ... Association (HA), working in conjunction with its allies on ...
Breaking Biology Technology:Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2
... Portfolio of Transfusion Solutions Offers Choice, ... Opportunity for Blood Bank Industry, ROCKAWAY, ... subsidiary of German-based Biotest AG, a worldwide,supplier of traditional and ... clearance from the U.S. Food and Drug,Administration (FDA) to begin ...
... Historic First Loss on Custom Medical Devices, SOUTH ... by Endotec, Inc. -- Vincent J. Capricci, 56, is ... district, and an avid,hunter, golfer and fisherman. After minor ... infection which destroyed his ankle joint.,He was out of ...
... its revolutionary Trusted LASIK Eye Surgeons directory service ... . What sets the Trusted LASIK Surgeons directory ... only the best LASIK Surgeons in the United ... LASIK Surgeon Dr. R. Wayne Bowman, are screened ...
Cached Biology Technology:Biotest Diagnostics Receives FDA Clearance for Full Line of Traditional Blood Bank Reagents 2Biotest Diagnostics Receives FDA Clearance for Full Line of Traditional Blood Bank Reagents 3FDA Gets Knocked Out in Endotec, Inc. Ruling 2FDA Gets Knocked Out in Endotec, Inc. Ruling 3Trusted LASIK Surgeons Welcomes Dallas LASIK Eye Surgery Specialist Dr. R. Wayne Bowman to its LASIK Directory 2Trusted LASIK Surgeons Welcomes Dallas LASIK Eye Surgery Specialist Dr. R. Wayne Bowman to its LASIK Directory 3Trusted LASIK Surgeons Welcomes Dallas LASIK Eye Surgery Specialist Dr. R. Wayne Bowman to its LASIK Directory 4Trusted LASIK Surgeons Welcomes Dallas LASIK Eye Surgery Specialist Dr. R. Wayne Bowman to its LASIK Directory 5Trusted LASIK Surgeons Welcomes Dallas LASIK Eye Surgery Specialist Dr. R. Wayne Bowman to its LASIK Directory 6
... provides valuable walk-away time and relief from ... technology for parallel processing of stacking and ... automation for any laboratory in need of ... can be set-up within minutes to most ...
... polyclonal to MLF1 Interacting Protein/PBIP1 (phospho ... tested applications). Antigen: ... amino acids 73-83 of Human MLF1 ... Gene ID: 359815 ...
... space and organize gloves, safety glasses, ... are the perfect benchtop storage bins ... processing and manufacturing. Clear static-dissipative PVC ... they attract. Many other sizes and ...
... for genome-wide microRNA expression profiling and ... Paraflo microfluidic on-chip synthesis platform. These ... our comprehensive microRNA Expression Profiling Service. ... Rice microRNA Microarray contains all known ...
Biology Products: