Navigation Links
Molecular basis identified for tissue specific immune regulation in the eye and kidney
Date:2/20/2013

diagnosed with AMD every year."

The research team looked at the two parts of CFH affected by the mutations. Both regions are capable of recognising host tissues, through interacting with sugars called glycosaminoglycans (GAGs). Successfully recognising these GAGs lets CFH build up a protective layer on the surface of our tissues that prevents our own immune system from attacking them.

It had always been believed that the region with mutations associated with aHUS was the most important for host recognition and for years people have been researching how to readdress immune dysregulation based on this belief. However, the recent discovery of a single common genetic alteration in the other part of CFH that is associated with eye disease raised the possibility that this previous opinion was not fully accurate.

The Manchester researchers compared the way the different regions of the protein interacted with eye tissue and kidney tissue. They discovered that the region of CFH that helps protect the kidney had no effect in the eye. Instead the other part of CFH, which is subject to the AMD-associated genetic alteration, was fundamentally important in protecting the eye, but this region did not contribute to the binding of CFH to kidney tissue.

Their findings show, for the first time, that the level of importance of the two regions of CFH changes depending on which tissue the protein finds itself. This specificity appears to be mediated by the presence of different populations of GAGs.

Dr Simon Clark says: "Our findings suggest that the particular structure within the eye and kidney tissue determines precisely how and where CFH will bind. It's as if the tissues have their own molecular postcodes."

He continues: "We're very pleased to be able to show why mutations in CFH are so tissue specific. This is important because if we're going to improve treatments for devastating diseases, such as AMD, we need to be able to dev
'/>"/>

Contact: Morwenna Grills
Morwenna.Grills@manchester.ac.uk
44-161-275-2111
University of Manchester
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Explosive breakthrough in research on molecular recognition
2. Mainz scientists confirm original tetrahedral model of the molecular structure of water
3. FASEB SRC announces: Molecular Mechanisms & Physiological Consequences of Protein Aggregation
4. FASEB SRC announces conference registration open for: Ciliate Molecular Biology
5. Elsevier launches new open access journal: Molecular Metabolism
6. Virginia Tech computer scientists develop new way to study molecular networks
7. Molecular forces are key to proper cell division
8. La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
9. Molecular 2-way radio directs nerve cell branching and connectivity
10. Scientists pinpoint molecular signals that make some women prone to miscarriage
11. Webcast alert: Molecular Medicine Institute to give new hope to pediatric patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... 4, 2014   Neurotechnology , a provider ... the latest version of its fingerprint matching algorithm ... MINEX evaluation organized by NIST. The MINEX ... the INCITS 378 fingerprint standard template format. MINEX ... tenders in the United States ...
(Date:11/3/2014)... ANGELES , Nov. 3, 2014  NeuroSigma ... -based life sciences company focused on commercialization ... system for the treatment of neurological and ... of Industrial Property has issued a Notice of ... patent application is co-owned by NeuroSigma and the ...
(Date:11/2/2014)... support of a bold quest to rid the world ... today announced an award of US$156 million to PATH ... building new vaccines that will interrupt the cycle of ... zero" agenda. Such vaccines would ensure that parasite reintroduction ... "immunological bed net." , This approach to developing ...
Breaking Biology News(10 mins):Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 2NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 3New malaria vaccines to prevent infection and block transmission get a shot in the arm 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 3New malaria vaccines to prevent infection and block transmission get a shot in the arm 4
... provide a look at the ash and gas clouds being ... NOAA,s GOES-13 satellite to provide a week long look at ... westerly winds carry the debris (ash and smoke) far to ... down the ash before it can go far in the ...
... 2012 Scientists at The Scripps Research Institute have ... the market to treat neuropathic pain and epilepsy, helps ... treatments, gabapentin targets stress systems in the brain that ... 12-week trial of 50 treatment-seeking cannabis users, those who ...
... /PRNewswire-iReach/  -- Global Information Inc. is announces limited time ... important Boston healthcare conferences: Next-Gen Kinase ... rapidly maturing kinase inhibitors field will gather to explore ... Next-Gen Kinase Inhibitors Conference in Cambridge, MA. ...
Cached Biology News:NASA's new satellite movie of 1 week's ash activity from Mexico's Popocatepetl Volcano 2Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit 2Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit 3Attendees Save Up To $800 on Boston-area Pharmaceutical and Healthcare Conferences, Early Bird Discounts Expiring April 27 2Attendees Save Up To $800 on Boston-area Pharmaceutical and Healthcare Conferences, Early Bird Discounts Expiring April 27 3
(Date:11/18/2014)... New Brunswick, NJ (PRWEB) November 18, 2014 ... of Data Quality and Transparency Reporting solutions, announced ... has gone live using its Consummate Providerâ„¢ solution ... Consummate Providerâ„¢ is a Global, SaaS based, Data ... Science organizations and their third party Providers improve ...
(Date:11/18/2014)... Ft. Lauderdale, FL (PRWEB) November 18, 2014 ... 12) have announced the launch of PAWSitively Curing ... Awareness Month. This new 501(c) (3) non-profit organization is ... Every dollar donated goes directly to the University ... proud to partner with PAWSitively Curing Cancer as the ...
(Date:11/18/2014)... Philadelphia, PA (PRWEB) November 18, 2014 ... healthcare planning and design expertise to the nation's hospitals ... is best served by those dedicating their careers to ... As a respected contributor in her respective field, Laura ... engineering expertise at the 2014 Winter Simulation Conference. ...
(Date:11/18/2014)... , Nov. 18, 2014  Asterias Biotherapeutics, ... in the emerging field of regenerative medicine, today ... (oligodendrocyte progenitor cells) for complete cervical spinal cord ... ten "Top Advanced Therapies Projects to Watch" by ... to receive this significant industry honor, which represents ...
Breaking Biology Technology:Alanda Software Completes Successful Implementation of Global Data Quality & Vendor Management Solution for Top Tier Global Biopharmaceutical Company 2PAWSitively Curing Cancer, Inc. Launched By Two Children for National Pet Cancer Awareness Month 2PAWSitively Curing Cancer, Inc. Launched By Two Children for National Pet Cancer Awareness Month 3Array Healthcare Simulation Expert Slated to Speak at Winter Simulation Conference 2Asterias Biotherapeutics Named as a "Top Advanced Therapies Projects to Watch" and Will Present at the Therapeutic Area Partnerships Conference 2Asterias Biotherapeutics Named as a "Top Advanced Therapies Projects to Watch" and Will Present at the Therapeutic Area Partnerships Conference 3
... NEW YORK, Jan. 27, 2011 The Alzheimer,s ... has awarded a grant of $195,000 to ALS ... toxic proteins implicated in Alzheimer,s disease. ... will identify and develop small-molecule brain-penetrant inducers of ...
... SAN CARLOS, Calif. and HOPKINTON, Mass., Jan. 27, ... Sciences, Inc. (Nasdaq: CALP ) today ... automated methods for next generation sequencing sample preparation ... to enable researchers to leverage NuGEN,s Ovation® and ...
... technique for rapidly prototyping nanoscale devices and structures that ... away when done. Hard-tip, soft-spring lithography (HSL) rolls ... high resolution -- and the best of polymer pen ... HSL could be used in the areas of electronics ...
Cached Biology Technology:Alzheimer's Drug Discovery Foundation Funds ALS Biopharma to Develop Small Molecules for Alzheimer's Disease 2NuGEN and Caliper Partner to Eliminate Next-Gen Sequencing Sample Preparation Bottlenecks 2NuGEN and Caliper Partner to Eliminate Next-Gen Sequencing Sample Preparation Bottlenecks 3Making a point 2Making a point 3