Navigation Links
Molecular basis identified for tissue specific immune regulation in the eye and kidney
Date:2/20/2013

Both AMD, which affects around 50 million people worldwide, and aHUS, a rare kidney disease that affects children, are associated with incorrectly controlled immune systems. A protein called complement factor H (CFH) is responsible for regulating part of our immune system called the complement cascade. Genetic alterations in CFH have been shown to increase a person's risk of developing either AMD or aHUS, but rarely both. Why this is the case has never been explained until now.

Researchers from the Wellcome Trust Centre for Cell Matrix Research and the Ophthalmology and Vision Research Group in The University of Manchester's Institute of Human Development have been expanding on their previous work that demonstrated a single common genetic alteration in CFH prevents it from fully protecting the back of the human eye. The research teams of Professor Tony Day and Professor Paul Bishop found that a common genetically altered form of CFH associated with AMD couldn't bind properly to a layer under the retina called Bruch's membrane. Having a reduced amount of CFH in this part of the eye leads to low-level inflammation and tissue damage, eventually resulting in AMD.

However, this mutation that changes CFH function in the eye has no affect on the protein's ability to regulate the immune system in the kidney. A cluster of genetic mutations in a completely different part of CFH are associated with the kidney disease aHUS, but these have no affect on the eyes.

In their most recent study, which was funded by the Medical Research Council and published in the Journal of Immunology, the Manchester researchers have identified why these mutations in CFH result in diseases in very specific tissues. Professor Day explains: "For the first time we've been able to identify why these protein mutations are so tissue specific. We're hoping our discovery will open the door to the development of tissue specific treatments to help the millions of people
'/>"/>

Contact: Morwenna Grills
Morwenna.Grills@manchester.ac.uk
44-161-275-2111
University of Manchester
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Explosive breakthrough in research on molecular recognition
2. Mainz scientists confirm original tetrahedral model of the molecular structure of water
3. FASEB SRC announces: Molecular Mechanisms & Physiological Consequences of Protein Aggregation
4. FASEB SRC announces conference registration open for: Ciliate Molecular Biology
5. Elsevier launches new open access journal: Molecular Metabolism
6. Virginia Tech computer scientists develop new way to study molecular networks
7. Molecular forces are key to proper cell division
8. La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
9. Molecular 2-way radio directs nerve cell branching and connectivity
10. Scientists pinpoint molecular signals that make some women prone to miscarriage
11. Webcast alert: Molecular Medicine Institute to give new hope to pediatric patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... kind of stem cell, those referred to as ,facultative, ... is apparently nothing that differentiates these cells from the ... they retain the capacity to become stem cells again. ... an organ that hosts cells that stimulate tissue growth, ... case of a transplant. Knowledge of the underlying ...
(Date:10/29/2014)... — Cambridge, MA and Hebei, China — BGI Tech ... quality sequencing of the Jujube genome. Jujube is the ... the Jujube genome is particularly difficult to sequence due ... It is the first time that a genome in ... has been recently published in Nature Communications ...
(Date:10/29/2014)... 2014 – Ghrelin is a hormone released by the ... is commonly viewed as a psychoactive substance that primarily ... caloric food. , This knowledge, combined with findings ... ghrelin has the potential to stimulate alcohol craving. , ... humans and found that, as they had anticipated, alcohol ...
Breaking Biology News(10 mins):A mechanism that allows a differentiated cell to reactivate as a stem cell revealed 2BGI Tech and Hebei Agricultural University complete the genome sequencing of the jujube tree 2Ghrelin stimulates an appetite for drinking alcohol 2
... that increases your risk for Alzheimer,s disease? And what if you ... you,re old but when you,re young? Brace yourself. ... to the development of late-onset Alzheimer,s. In 1993, researchers discovered a ... us that triples the risk for getting Alzheimer,s. In 2009, ...
... 3, 2011) Cancer studies from Mercer University (Ga.) ... American Association of Pharmaceutical Scientists, (AAPS) National Biotechnology Conference ... May 18 at the Hilton San Francisco Union Square. ... Cervical Cancer Cervical cancer is the second ...
... evolutionary legacies to become much better at using ... that can power vehicles in the near future, an ... has found. A U.S. Department of Energy (DOE) ... to compare the efficiency of plants and photovoltaic solar ...
Cached Biology News:Alzheimer's risk gene disrupts brain's wiring 50 years before disease hits 2Alzheimer's risk gene disrupts brain's wiring 50 years before disease hits 3AAPS national biotechnology conference to highlight breakthrough cancer treatments 2NREL's multi-junction solar cells teach scientists how to turn plants into powerhouses 2NREL's multi-junction solar cells teach scientists how to turn plants into powerhouses 3
(Date:10/31/2014)... (PRWEB) October 30, 2014 The ... Product Development’s decades-long heritage in successful medical device ... context for what it takes to successfully innovate ... As part of a two-hour on-site class, Insight ... school of business, McCormick School of Engineering, medical ...
(Date:10/31/2014)... The report "Dairy Alternative (Beverage) Market by ... Unsweetened), Channel (Supermarket, Health Store, Pharmacy, Convenience Store) ... 2018," defines and segments the dairy alternative beverage ... and volume for plant-based dairy alternative beverages. , ... Billion by 2018 with the Asia-Pacific region as ...
(Date:10/31/2014)... ATLANTA , Oct. 31, 2014  Atlanta-based ... research efforts accompanying the onset of Ebola by ... options. Scientists at Georgia Tech,s Center for Computational ... and algorithms to find alternative uses for existing ... be able to aid the bout against Ebola. ...
(Date:10/30/2014)... Dallas, Texas (PRWEB) October 30, 2014 ... China Naltrexone HCL Industry” is a professional and ... The report provides basic Naltrexone HCL information, including ... as well as industry overview. This research covers ... as well as global industry analysis covering macroeconomic ...
Breaking Biology Technology:Insight Product Development Gives Northwestern University Students Foundation for Innovation Success 2Insight Product Development Gives Northwestern University Students Foundation for Innovation Success 3Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 2Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 3Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 4Atlanta-Based Intellimedix May Help Solve Ebola With Computer Algorithms 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3
... 3.0 ,First the Boom, Then the Bust, Now ... York Times Award-winning Journalist to Address Madison Business, ... Times to Discuss Dotcom and Technology Future. , ... in the Monday Business section of The New ...
... Its Saturday night. Your 4 year old has stomach pains, ... provide all sorts of personal medical information including her medical history ... pain, and you try to remember if you told the person ... or two as the triage nurse does not see bleeding or ...
... promoted Wendel Barr to the position of president, early ... position of president, early development, in Harrogate, UK. ... decision-making employed by its clients in the preclinical segment. ... senior vice presidents and also wil serve on the ...
Cached Biology Technology:Childrens Medical Hospital of Wisconsin Goes Digital 2Childrens Medical Hospital of Wisconsin Goes Digital 3Childrens Medical Hospital of Wisconsin Goes Digital 4Covance Appoints Co-Presidents for Early Development Services 2
... PS10 ProteinChip Arrays are preactivated with ... free primary amine groups. The PS10 array ... former PS1 array, but with an updated ... spot chips with 2 mm diameter spots ...
... Activator of Caspase/DIABLO Liquid. In 100 ... FREEZE/THAW CYCLES. Amino acid residues 56 - 239 ... ® sequence was expressed in and purified ... along with cytochrome c during apoptosis ...
...
... Fixed clamp trays and universal trays ... Magnetic drive Shaking speed: ... 25 mm amplitude Clamps ... 2000 ml, including Fernbach flasks ...
Biology Products: