Navigation Links
Mitochondrial mutations: When the cell's 2 genomes collide
Date:2/5/2013

power plant.

Once the team, including lead author Meiklejohn, had a bona fide mitochondrial-nuclear incompatibility to study, they could then begin looking for exactly where the problem lay and how it was causing disease. In the paper, they describe the genetic and biochemical experiments they conducted to find out.

Brown graduate student Marissa Holmbeck, the paper's second author, measured the productivity of several enzymes in the mitochondria's power generation process. Two enzymes that are derived entirely from nuclear genes ran just as well in the sick flies as in healthy ones, but three enzymes that are jointly managed by mitochondrial and nuclear genes lagged behind in activity.

"The different complexes that are jointly encoded by the mitochondrial and nuclear subunits, those are the ones where we are seeing the defect in activity," Holmbeck said.

Each mutation alone, in fact, does little or no harm to flies. It is only when both are present that the flies fall ill.

Meanwhile, Meiklejohn and Montooth tracked those mutations to just two altered nucleotide letters one in each genome. In the mitochondrial genome, a G to U mutation in an RNA suggested a problem with protein production inside the mitochondria. This was confirmed when they discovered an A to V mutation in the nuclear protein that adds an amino acid to this same mitochondrial RNA.

The biochemical and genetic evidence pointed to flaws in how fast the mitochondria of the sick flies could produce proteins needed to promote growth.

"The specifics of this paper are tracking that down to the individual nucleotide," Rand said, "But the more general lesson is that this coevolution of mitochondrial and nuclear genes has been going on for millions of years in millions of organisms and is going on in human populations today."

In human beings, a well-known mitochondrial disease, for example, is an aversion to exercise that is due to a mu
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Discovery of a new family of key mitochondrial proteins for the function and viability of the brain
2. FASEB SRC announces conference: Mitochondrial Assembly & Dynamics in Health, Disease & Aging
3. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
4. Stem cells can repair a damaged cornea
5. Scientists produce eye structures from human blood-derived stem cells
6. Study demonstrates cells can acquire new functions through transcriptional regulatory network
7. Epigenetic signatures direct the repair potential of reprogrammed cells
8. Researchers print live cells with a standard inkjet printer
9. Nanopills release drugs directly from the inside of cells
10. Protein jailbreak helps breast cancer cells live
11. Newly found protein helps cells build tissues
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mitochondrial mutations: When the cell's 2 genomes collide
(Date:4/22/2014)... London PETA International Science Consortium Ltd.,s nanotechnology expert ... strategy for nanomaterial hazard assessment" at the 7th ... 2014, in Antalya, Turkey. , Dr. Monita Sharma ... from the US National Academy of Sciences, " Toxicity ... Strategy ," which recommends use of non-animal methods involving ...
(Date:4/22/2014)... nanotechnology researchers at the University of Kentucky has discovered ... using RNA. , The research, led by Peixuan ... Nanobiotechnology at the UK College of Pharmacy and Markey ... as a Boiling-Resistant Anionic Polymer Material To Build Robust ... F. Khisamutdinov and Daniel L. Jasinski. , The article, ...
(Date:4/22/2014)... and precipitation on the global distribution of plant and ... the UV-B radiation, is often neglected. The landscape ecologists ... Universities in Olomouc (Czechia), Halle and Lneburg have processed ... such a way that they can be used to ... The basic input data were provided by a NASA ...
Breaking Biology News(10 mins):RNA shows potential as boiling-resistant anionic polymer material for nanoarchitectures 2UV-radiation data to help ecological research 2
... in Uganda who self-paid for their antiretroviral medications experienced ... or supply logistical disruptions. These treatment interruptions led ... patients. , These findings by a team led by ... Kampala, and UCSF are reported in the April 22, ...
... pediatric specialists at Baylor College of Medicine have discovered a ... that allows drugs to enter cancer cells. , The research ... and Biomolecular Chemistry. , All living cells defend themselves ... form a protective cocoon around the cell's inner machinery and ...
... cells to turnover their contents, something that they do ... and radiation, but it is not known if this ... survive the anti-cancer therapy. However, in a study using ... the University of Pennsylvania have now shown that autophagy ...
Cached Biology News:Resistance to anti-HIV drugs in Uganda developed due to drug supply problems 2Buckyballs used as 'passkey' into cancer cells 2
(Date:1/14/2014)... DC (PRWEB) January 14, 2014 Carahsoft ... for Thursday, January 23, 2014 at 2pm EST (11am ... Knowledge.” The topic focuses on how technology can turn ... critical decisions for government agencies. The online webinar will ...
(Date:1/14/2014)... pet owners drew up their lists of New Year,s resolutions for ... of my furry companion." Nowadays there are pet salons, dog and ... take the little canine or feline darlings along wherever mommy or ... pricey toys at the pet store. But anyone who has ever ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo ... institutes from the National Institutes of Health (NIH) to ... more effective treatments to patients on a faster timeline. ... Translational Sciences (NCATS) and the National Eye Institute (NEI) ...
(Date:1/14/2014)... 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), a ... innovative therapies addressing major unmet medical needs using ... Notice of Allowance from the United States Patent ... compounds (sd-rxRNA®), for the treatment of fibrosis. The ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
... subsidiary in Philadelphia Area -, PHILADELPHIA, Feb. ... cellular imaging, announced today the appointment of Chris ... subsidiary of Paris-based Mauna,Kea Technologies and develops and ... improves patient care by eliminating the,need for unnecessary ...
... Prescription Rates, According ... to a New Report from Decision Resources, WALTHAM, ... leading research and advisory firms focusing on pharmaceutical and,healthcare ... ustekinumab will become the clinical gold standard,for psoriasis by ...
... the world,s leading,online bioscience job board and life ... pharmaceutical job candidates at its Biotech,Bay Career Fair ... The BioSpace Career Fair drew a steady ... career candidates from,around the Northern California region. For ...
Cached Biology Technology:Chris Tihansky Appointed President of In Vivo Cellular Imaging Leader Cellvizio Inc. 2Centocor/Janssen-Cilag's Ustekinumab Will Become the Gold Standard for Psoriasis By 2011 2BioSpace Career Fair in San Francisco Welcomes Over 1,000 Bioscience Professionals 2
Recombinant Viral CCI/Fc Chimera, CF...
... DeStreak Reagent, 1 ml. ... 2-D gels by preventing streaking.Eliminates ... oxidation of proteins.Stabilizes proteins throughout ... simplified, well-resolved protein patterns.Ideal for ...
LIVE/DEAD® Cell-Mediated Cytotoxicity Kit *for animal cells* *2000 assays*...
SlowFade Antifade Kit with DAPI...
Biology Products: