Navigation Links
Mitochondrial mutations: When the cell's 2 genomes collide
Date:2/5/2013

PROVIDENCE, R.I. [Brown University] Diseases from a mutation in one genome are complicated enough, but some illnesses arise from errant interactions between two genomes: the DNA in the nucleus and in the mitochondria. Scientists want to know more about how such genomic disconnects cause disease. In a step in that direction, scientists at Brown University and Indiana University have traced one such incompatibility in fruit flies down to the level of individual nucleotide mutations and describe how the genetic double whammy makes the flies sick.

"This has relevance to human disease but it's also relevant to all organisms because these two genomes are in all animals and all plants," said David Rand professor of biology at Brown and senior author of the study published online Jan. 31 in PLOS Genetics. "There are a lot of metabolic diseases that are mitochondrial in origin and they have peculiar genetic tracking a two-part system needs to be considered."

Five years ago at Brown, Rand and two postdoctoral researchers Colin Meiklejohn, of Brown and Indiana University, and Kristi Montooth, now an assistant professor at Indiana University began searching for an example in the convenient testbed of fruit flies. They started mixing and matching mitochondrial and nuclear genomes from different strains and species of flies that carried natural mutations produced during evolution to observe what conflicts might arise. They found that when they placed the "simw 501" mitochondrial DNA from Drosophila simulans flies into Drosophila melanogaster flies with "Oregon R" nuclear DNA, bad things happened.

The flies with this combination lived but had an array of problems. Their most noticeable flaw was that whisker-like bristles on their backs were only half the length of those in normal flies. The flies also had developmental delays, reproduced less effectively, and tired more quickly, which makes sense because the mitochondria is the cell's
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Discovery of a new family of key mitochondrial proteins for the function and viability of the brain
2. FASEB SRC announces conference: Mitochondrial Assembly & Dynamics in Health, Disease & Aging
3. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
4. Stem cells can repair a damaged cornea
5. Scientists produce eye structures from human blood-derived stem cells
6. Study demonstrates cells can acquire new functions through transcriptional regulatory network
7. Epigenetic signatures direct the repair potential of reprogrammed cells
8. Researchers print live cells with a standard inkjet printer
9. Nanopills release drugs directly from the inside of cells
10. Protein jailbreak helps breast cancer cells live
11. Newly found protein helps cells build tissues
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mitochondrial mutations: When the cell's 2 genomes collide
(Date:5/6/2015)... May 6, 2015 LifeBEAM, a developer of ... producer, announced today that they will expand their partnership ... first bio-sensing cycling helmet and the first joint project ... new colors in order to give cyclists more style ... addition, LifeBEAM and Lazer announced their plan to release ...
(Date:4/21/2015)... April 21, 2015 High ... policies are boosting access control systems market in ... to a recently published report by TechSci Research " ... the access control systems market in Saudi ... by 2020.The access control systems market in the Kingdom ...
(Date:4/14/2015)... Conn. , April 14, 2015 NXT-ID, ... a biometric authentication company focused on the growing mobile ... been nominated for the 2015 New York Design Awards ... The Design100, New York City Design Awards are part ... based on over 2,500 ratings from the marketplace, industry ...
Breaking Biology News(10 mins):LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... N.Y. Some cellular proteins have multiple, and occasionally ... colleagues at Cold Spring Harbor Laboratory demonstrate in a ... [link: to paper via doi #] that the oncogenic ... growth and prevent cancerous proliferation by stabilizing p53, the ...
... The official Kickoff meeting of the Building ... by the Museum fr Naturkunde , Berlin, took place ... the project and to set goals and objectives for the ... of EU BON,s framework with the Global Earth Biodiversity ...
... new article published in the Journal of Paleontology ... describe the most diverse group of fossilized green lacewing ... who value them in organic pest control, for their ... relatives to these insects are most diverse in southeastern ...
Cached Biology News:A cancer-promoting protein is found to also suppress cell growth 2The large-scale EU project EU BON: Towards integration with its global counterpart GEO BON 2
(Date:5/29/2015)... 29, 2015 When a leading ... a request to design an industrial oven ... prescription medications being produced using a 3D-printing process, ... a robotic gantry, heat-saving windows, and internal actuators ... of 3D-printed pills to exact specifications. , To ...
(Date:5/29/2015)... , May 29, 2015  Caris Life ... two studies in which researchers utilized Caris Molecular ... to identify potential therapeutic targets in patients with ... of the programmed cell death protein 1 (PD-1) ... June 1 at the 2015 American Society of ...
(Date:5/29/2015)... IRVING, Texas , May 29, 2015 /PRNewswire/ ... company focused on fulfilling the promise of precision ... five studies that demonstrate the clinical utility of ... comprehensive tumor profiling service, in helping to identify ... aggressive tumors. In each of the studies, results ...
(Date:5/29/2015)... May 28, 2015 Research and Markets ... Jain PharmaBiotech,s new report "Cytogenetics - Technologies, ... This report deals with cytogenetics in a ... to describe the chromosome structure and identify abnormalities ... biology, it is also referred to as molecular ...
Breaking Biology Technology:New industrial oven with “pill pushing” robotic gantry precisely removes excess moisture from 3D-printed pharmaceuticals 2Multi-Platform Molecular Profiling from Caris Life Sciences Identifies Clinically Actionable Targets for Novel Immunotherapy Drugs 2Multi-Platform Molecular Profiling from Caris Life Sciences Identifies Clinically Actionable Targets for Novel Immunotherapy Drugs 3Multi-Platform Molecular Profiling from Caris Life Sciences Identifies Clinically Actionable Targets for Novel Immunotherapy Drugs 4Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 2Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 3Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 4Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 5Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 6Global Cytogenetics Market Report 2015-2024 - Technologies, Markets and Companies 2Global Cytogenetics Market Report 2015-2024 - Technologies, Markets and Companies 3
... May 14, 2012   USHIFU, LLC (US HIFU), a ... ultrasound (HIFU) technologies, announced today that Mark Carol, ... chief development officer. With more than 25 years ... Dr. Carol will focus on continued development of ...
...  /PRNewswire-Asia/ -- 3SBio Inc. (NASDAQ: SSRX ) ("3SBio" ... on researching, developing, manufacturing and marketing biopharmaceutical products, today ... ended March 31, 2012. First ... net revenues increased by 24.5% over the first quarter ...
... at Nanyang Technological University (NTU), it comes in the form of ... kills them without the need for antibiotics. The killer coating, ... and fungi that it comes in contact with, is now being ... specialising in animal care products. The next step is ...
Cached Biology Technology:US HIFU Adds Mark Carol, MD, As Chief Development Officer 2US HIFU Adds Mark Carol, MD, As Chief Development Officer 3US HIFU Adds Mark Carol, MD, As Chief Development Officer 43SBio Inc. Announces Unaudited First Quarter 2012 Results 23SBio Inc. Announces Unaudited First Quarter 2012 Results 33SBio Inc. Announces Unaudited First Quarter 2012 Results 43SBio Inc. Announces Unaudited First Quarter 2012 Results 53SBio Inc. Announces Unaudited First Quarter 2012 Results 63SBio Inc. Announces Unaudited First Quarter 2012 Results 73SBio Inc. Announces Unaudited First Quarter 2012 Results 83SBio Inc. Announces Unaudited First Quarter 2012 Results 93SBio Inc. Announces Unaudited First Quarter 2012 Results 103SBio Inc. Announces Unaudited First Quarter 2012 Results 11NTU scientists invent superbug killers 2NTU scientists invent superbug killers 3