Navigation Links
Mitochondrial mutations: When the cell's 2 genomes collide
Date:2/5/2013

PROVIDENCE, R.I. [Brown University] Diseases from a mutation in one genome are complicated enough, but some illnesses arise from errant interactions between two genomes: the DNA in the nucleus and in the mitochondria. Scientists want to know more about how such genomic disconnects cause disease. In a step in that direction, scientists at Brown University and Indiana University have traced one such incompatibility in fruit flies down to the level of individual nucleotide mutations and describe how the genetic double whammy makes the flies sick.

"This has relevance to human disease but it's also relevant to all organisms because these two genomes are in all animals and all plants," said David Rand professor of biology at Brown and senior author of the study published online Jan. 31 in PLOS Genetics. "There are a lot of metabolic diseases that are mitochondrial in origin and they have peculiar genetic tracking a two-part system needs to be considered."

Five years ago at Brown, Rand and two postdoctoral researchers Colin Meiklejohn, of Brown and Indiana University, and Kristi Montooth, now an assistant professor at Indiana University began searching for an example in the convenient testbed of fruit flies. They started mixing and matching mitochondrial and nuclear genomes from different strains and species of flies that carried natural mutations produced during evolution to observe what conflicts might arise. They found that when they placed the "simw 501" mitochondrial DNA from Drosophila simulans flies into Drosophila melanogaster flies with "Oregon R" nuclear DNA, bad things happened.

The flies with this combination lived but had an array of problems. Their most noticeable flaw was that whisker-like bristles on their backs were only half the length of those in normal flies. The flies also had developmental delays, reproduced less effectively, and tired more quickly, which makes sense because the mitochondria is the cell's
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Discovery of a new family of key mitochondrial proteins for the function and viability of the brain
2. FASEB SRC announces conference: Mitochondrial Assembly & Dynamics in Health, Disease & Aging
3. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
4. Stem cells can repair a damaged cornea
5. Scientists produce eye structures from human blood-derived stem cells
6. Study demonstrates cells can acquire new functions through transcriptional regulatory network
7. Epigenetic signatures direct the repair potential of reprogrammed cells
8. Researchers print live cells with a standard inkjet printer
9. Nanopills release drugs directly from the inside of cells
10. Protein jailbreak helps breast cancer cells live
11. Newly found protein helps cells build tissues
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mitochondrial mutations: When the cell's 2 genomes collide
(Date:10/15/2014)... Gauß-Allianz has admitted Johannes Gutenberg University Mainz (JGU) ... science hub continues to maintain a significant nationwide ... , "The acceptance of Johannes Gutenberg University Mainz ... a milestone in the national and international competition ... state of Rhineland-Palatinate can be proud that Mainz ...
(Date:10/15/2014)... , Oct. 15, 2014   Neurotechnology ... today announced the availability of the VeriLook ... Surveillance 3.0 provides real-time biometric face identification using ... digital surveillance cameras. The new version not only ... differentiates people from objects while they are moving ...
(Date:10/14/2014)... is how to produce enough food to feed the ... Agriculture Organization of the United Nations predicts that food ... to feed a growing global population, and plants are ... production. Plants—grains, cereals, fruits, vegetables, and more—feed humans ... must tap into our knowledge of how plants work ...
Breaking Biology News(10 mins):Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
... warts was on target at the halfway mark, according to ... manager, sexual health specialist Dr David Jardine , More ... in the trial so far run from the Princess Alexandra ... proven safe, and we want to know if it improves ...
... Institute researchers have discovered that when a crucial portion ... viruses, bacteria and other foreign invaders is reversed, the ... published in the April issue of AIDS Research and ... of such peptides in gene therapy using HIV-based vectors ...
... primarily carried by cats. It is transmitted to humans by ... is particularly dangerous for pregnant women, whose foetuses can be ... system, such as people infected with HIV. In severe cases, ... even death , Now researchers from London and Geneva ...
Cached Biology News:UCLA AIDS Institute researchers find a peptide that encourages HIV infection 2Toxoplasmosis infection trick revealed by scientists 2
(Date:10/20/2014)... Oct. 20, 2014 Mapp Biopharmaceutical,s valiant ... antibody therapeutic to fight the Ebola outbreak will ... time-consuming the production of pharmaceuticals can be, according ... said that while some may be taken aback ... those with industry knowledge are well aware of ...
(Date:10/20/2014)... VIENNA , October 20, 2014 ... of gastrointestinal (GI) disorders and the delivery of care ... liver diseases and worrying inequalities in the provision of ... survey, which was commissioned by United European Gastroenterology (UEG), ... greater political and public awareness of the burden of ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 ... Partners LLC, announced today that Ellen Teplitzky, an ... support for the pharmaceutical industry, has joined the ... of its legal services practice. NDA Partners ... expert witness and testimony, to top law firms ...
(Date:10/19/2014)... , Oct. 19, 2014 NextCODE Health, which enables ... genome in real time, today announced the launch of its ... Exchange , at the American Society of Human Genetics (ASHG) ... learn more, sign up and apply for free beta access, ... features and benefits can be viewed here . ...
Breaking Biology Technology:Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3
... Governor Jim Doyle today announced his "Grow Wisconsin" ... the recommendations is to increase broadband and communications ... ,Mike Tye, AT&T regional vice present of Law ... by the "Grow Wisconsin" initiative unveiled today by ...
... of Patients Compensation Fund could be illegal , ... expressed support yesterday for Gov. Jim Doyles Grow Wisconsin ... expressed support, but takes issue with the provisions for ... strongest criticism for Doyles proposed use of funds from ...
... getting to see what the rest of the world is ... for spring break, content to play a few rounds of golf ... of hype over Arizonas biotech efforts. While I managed to accomplish ... efforts to invest in technology. , ,First, there was the ...
Cached Biology Technology:Republicans criticize Doyles growth package 2Republicans criticize Doyles growth package 3Republicans criticize Doyles growth package 4Commentary: Is our Biosphere too cheesy? 2
... CLS number is a new product number, ... If showing no availability yet, please order ... contact customer service for assistance. ... Dim: D H 100 20 ...
BD BioCoat Laminin 100 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse laminin....
... 5-OxoETE-d7 is used as an internal standard ... isotope dilution mass spectrometry. 5-OxoETE is a ... of 5-HETE in human neutrophils. It stimulates ... EC50 of 2 nM. 5-OxoETE selectively stimulates ...
... a 10.0 kb Autographa californica (AcNPV) polyhedrin ... AcNPV polyhedrin promoter and two AcNPV p10 ... a Sma I cloning site, followed by ... inverted polyhedrin promoter has been inserted containing ...
Biology Products: