Navigation Links
Misplaced molecules: New insights into the causes of dementia
Date:3/1/2013

This press release is available in German.

A shortage of a protein called TDP-43 caused muscle wasting and stunted nerve cells. This finding supports the idea that malfunction of this protein plays a decisive role in ALS and FTD. The study is published in the "Proceedings of the National Academy of Sciences of the USA" (PNAS).

ALS is an incurable neurological disease which manifests as rapidly progressing muscle wasting. Both limbs and respiratory muscles are affected. This leads to impaired mobility and breathing problems. Patients commonly die within a few years after the symptoms emerged. In rare cases, of which the British physicist Stephen Hawking is the most notable, patients can live with the disease for a long time. In Germany estimates show over 150,000 patients suffering from ALS an average of 1 in 500 people.

Proteins gone astray

Over the last few years, there has been increasing evidence that ALS and FTD a form of dementia associated with changes in personality and social behaviour may have similar or even the same origins. The symptoms overlap and common factors have also been found at the microscopic level. In many cases, particles accumulate and form clumps in the patient's nerve cells: this applies particularly to the TDP-43 protein.

"Normally, this protein is located in the cell nucleus and is involved in processing genetic information," explains molecular biologist Dr. Bettina Schmid, who works at the DZNE Munich site and at LMU. "However, in cases of disease, TDP-43 accumulates outside the nucleus forming aggregates." Schmid explains that it is not yet clear whether these clumps are harmful. "However, the protein's normal function is clearly disrupted. It no longer reaches the nucleus to perform its actual task. There seems to be a relationship between this malfunction and the di
'/>"/>

Contact: Dirk Frger
presse@dzne.de
0049-228-433-02260
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study provides insights into plant evolution
2. Life experiences put their stamp on the next generation: New insights from epigenetics
3. Discovery of sexual mating in Candida albicans could provide insights into infections
4. New insights into the borderline personality brain
5. Study offers new insights into the mechanics of muscle fatigue
6. New insights into how immune system fights atherosclerosis
7. Study offers insights into role of muscle weakness in Down syndrome
8. Basketball teams offer insights into building strategic networks
9. Research provides new insights into dogs natural feeding behavior and finds they target a daily dietary intake that is high in fat
10. Insights into a new therapy for a rare form of cystic fibrosis
11. Notre Dame research could provide new insights into tuberculosis and other diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... Aug. 19, 2014 To improve students, chances ... grades, the University of Houston (UH) implemented a ... students at risk for failure. , Through ... Board (THECB), the Department of Biology and Biochemistry ... students taking "General Biology" for non-majors and "Introductory ...
(Date:8/19/2014)... It,s not a monkey. It,s not a lemur. It,s not ... the Philippine tarsier: a tiny, adorable and downright "cool" primate ... that Americans are familiar with," said Rafe Brown, curator-in-charge at ... eyes and ears; an extremely cute, furry body; a long ... expanded fingers and toe tips that look a bit like ...
(Date:8/19/2014)... biomarker strongly associated with basal-like breast cancer, a ... types of chemotherapy. The biomarker, a protein called ... designed to treat this often deadly cancer. , ... Cancer Genome Atlas, molecular biologists Curt M. Horvath ... bioinformatics techniques to detect patterns of gene expression ...
Breaking Biology News(10 mins):University of Houson program earns kudos for improving grades, retaining students 2University of Houson program earns kudos for improving grades, retaining students 3Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 2Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 3Biomarker in an aggressive breast cancer is identified 2Biomarker in an aggressive breast cancer is identified 3
... Some soil microorganisms are capable of forging associations with ... these relationships play a highly important ecological and agronomic ... a fungus) thus gives plants a mechanism for improving ... has been in existence for 400 million years and ...
... Oregon State University graduate student working on a ... station on the Tahoe National Forest has photographed ... been confirmed in California since the 1920s. Katie ... on another carnivore called the American marten when ...
... defined biochemical pathway in plants may provide the scientific ... of alternative transportation fuels than currently can be produced, ... materials that determine cell shape and size through a ... geneticist and cellular biologist. By learning more about the ...
Cached Biology News:A common genetic mechanism discovered in nitrogen-fixing plants 2A common genetic mechanism discovered in nitrogen-fixing plants 3Scientists believe photograph depicts wolverine in California 2Newly defined signaling pathway could mean better biofuel sources 2Newly defined signaling pathway could mean better biofuel sources 3Newly defined signaling pathway could mean better biofuel sources 4
(Date:8/21/2014)... Boston, MA (PRWEB) August 21, 2014 ... collaboration company, has been recognized as one of ... 500 | 5000 magazine for the 2nd consecutive ... on its 33rd annual Inc. 500|5000, an exclusive ... list represents the most comprehensive look at the ...
(Date:8/20/2014)... An analysis of patented university inventions licensed to ... path to commercialization. To open these roadblocks, the ... results during the discovery stage could lead to ... are frequently derived from discoveries made in university ... well known during clinical trials, which have a ...
(Date:8/20/2014)... Fla. , Aug. 20, 2014 ... will host a conference call to provide an ... 2014Time:4:30 p.m. Eastern daylight timeDial-in numbers:(888) 505-4369 (U.S. ... 9126599 Live web cast: www.neurotropebioscience.com , under "Investor ... hours after completion through September 2, 2014 at ...
(Date:8/20/2014)... , Aug. 20, 2014  PAREXEL International Corporation (NASDAQ: ... be presenting at the Baird Healthcare Conference in New ... Chief Financial Officer, will be making a presentation on ... on Wednesday, Sept. 3, 2014. A live ... "Investors" section of PAREXEL,s website at www.PAREXEL.com ...
Breaking Biology Technology:SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 3Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3Neurotrope To Host Conference Call 2PAREXEL International To Present At Baird Healthcare Conference 2
... reflection, and this one is no different. These last 12 months ... doubt look back on 2005 and pronounce it the year the ... of things, the previous four years were a standing eight count, ... like hell and a lot was lost on bad bets, but ...
... newsletter contains the most-read stories from our Web site in 2005. ... month to over 70,000 last month, many of them sticking around ... to what drew your interest. , ,Let me take a moment ... isnt until March 2 and were more than a third full ...
... care in the United States are enough to make anyone ... seven Americans (15.7 percent) lack health insurance. Thats just short ... federal figures, health spending accounts for 15.3 percent of the ... works out to $5,670 for each American. By 2013, the ...
Cached Biology Technology:2005: the year of the comeback 22005: the year of the comeback 3Health care economics make definition of 'cost' problems difficult 2Health care economics make definition of 'cost' problems difficult 3
The Zymo-Spin PI Fast-Spin column features durable polypropylene construction and is the same column featured in the His-Spin Protein Miniprep. Capacity is 800 l....
LAL Chromogenic Endpoint assay...
...
Catch and Release® v2.0 Reversible Immunoprecipitation System...
Biology Products: