Navigation Links
MicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer
Date:12/13/2012

Between the blueprint of the genome and the products of its expression lie microRNAs, which can boost or lower the rate at which genes become stuff. In fact, many cancers use microRNA to magnify the expression of faulty genes or shrink the expression of helpful genes that would otherwise suppress tumors. A University of Colorado Cancer Center study published in the December issue of the Journal of Biological Chemistry shows that in medulloblastoma, a malignant brain tumor of children, microRNA-218 is especially low. The article also shows that adding microRNA-218 to neural stem cells engineered to develop medulloblastoma decreases the development of the cancer.

"For the past five years, we've been looking at microRNAs in medulloblastoma, asking how they are normally expressed and how this expression differs in the disease. One of the microRNA's most different in the medulloblastoma is microRNA-218," says Rajeev Vibhakar, MD, PhD, MPH, investigator at the CU Cancer Center, assistant professor of pediatrics at the CU School of Medicine, and the paper's senior author.

When Vibhakar and colleagues inquired into the effects of lower microRNA-218 levels, they found its involvement in pathways that signal the metabolism, growth, migration and invasion of tumor tissues. MicroRNA-218 is a tumor suppressor low miRNA-218 equals low function in a range of tumor suppressor genes, equals high tumor growth.

In fact, the group found 618 genes whose expression was manipulated by microRNA-218.

"One of these genes was CDK6," Vibhakar says. Finding a gene target is especially important because whereas it's difficult to drug microRNA it's fairly simple to drug genes. As it turned out, Pfizer already had a drug that targets CDK6 and in a follow-up study published in the Journal of NeuroOncology, when Vibhakar and colleagues tested the drug in medulloblastoma cells, they found reduced cancer cell survival.

"Especially important is
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Discovery of pathway leading to depression reveals new drug targets
2. Discovery of molecular pathway of Alzheimers disease reveals new drug targets
3. Naïve fish: Easy targets for spear fishers
4. New potential targets discovered for treating squamous cell lung cancers
5. Scientists use worms to unearth cancer drug targets
6. Wayne State University researchers program targets safer river fishing, anglers health
7. Blocking DNA: HDAC inhibitor targets triple negative breast cancer
8. Its a trap! New laboratory technique captures microRNA targets
9. Unique adaptations to a symbiotic lifestyle reveal novel targets for aphid insecticides
10. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
11. Crestor Delivers Latest LDL-C Targets in High-Risk Patients at Lower Doses than Other Statins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... that legume plants regulate their symbiotic relationship with ... transmitted through the plant structure from leaves into ... nodules in the roots. This collaborative study was ... Basic Biology, the Graduate University for Advanced Studies ... Science in Japan. , Legumes, an important ...
(Date:9/18/2014)... in the primitive brainstem has revealed how we fall ... of Medicine and the University at Buffalo School of ... "sleep node" identified in the mammalian brain whose activity ... deep sleep. , Published online in August in ... of all of the brain,s sleep-promoting activity originates from ...
(Date:9/18/2014)... can operate inside the bore of an MRI scanner ... research partnership program at Brigham and Women,s Hospital in ... in conjunction with real-time MRI images, can make prostate ... discomforting for the patient. The novel system also has ... precision. , Developed by a team of robotics engineers ...
Breaking Biology News(10 mins):For legume plants, a new route from shoot to root 2No sedative necessary: Scientists discover new 'sleep node' in the brain 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5
... A new report published by an independent global ... system needs an immediate transformation to meet current and ... The Commission on Sustainable Agriculture and Climate Change today ... policy responses to the global challenge of feeding the ...
... 2011 For the first time, researchers have ... of the enzymes involved in degrading persistent pollutants ... Professor Michel Sylvestre of Centre INRSInstitut Armand-Frappier in ... not only to help develop effective biocatalysts for ...
... (University of Turku and VTT Technical Research Centre of Finland) ... Institute for Health and Welfare) have discovered that the SHARPIN ... leading journal, the study concludes that SHARPIN regulates the movement ... cancer cells. It is likely that the discovery will also ...
Cached Biology News:Global commission delivers food security policy recommendations 2Global commission delivers food security policy recommendations 3
(Date:9/19/2014)... NC (PRWEB) September 19, 2014 ... Biobased Product Label for its Organic Cotton . ... product’s amount of renewable biobased ingredients meets or exceeds ... intermediate materials composed in whole or in significant part ... logo/label will allow our Organic cotton to be immediately ...
(Date:9/19/2014)... The new , Healthcare and Life Sciences Review ... PharmaBoardroom.com for free download , looks beyond ... economy in 2009, and the austerity measures that followed, to ... times of trouble. "Despite the crisis, ... and the general conditions to invest are favorable to the ...
(Date:9/18/2014)... DALLAS , Sept. 18, 2014 /PRNewswire-iReach/ -- ... and China Acetic Acid Industry" and "2014 Deep ... Industry" reports to its research database. ... 2014 Deep Research Report on Global and China ... research report on China ...
(Date:9/18/2014)... Texas (PRWEB) September 18, 2014 ... Chancellor John Sharp, Texas A&M Health Science Center ... U.S. Department of Health and Human Services (HHS), ... dedicated a national pandemic influenza vaccine manufacturing facility ... as an anchor for the Texas A&M Biocorridor ...
Breaking Biology Technology:Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 4Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4
... Advanced Biofuels, LLC, a joint venture between BP ... into collaboration with Fagen, Inc. for the introduction ... is the world,s most experienced biofuels engineering, procurement ... than any other company.  They are the largest, ...
... Exciting new data presented today at the ... role in the development of diabetes and non-alcoholic fatty ... . Though an early stage animal model, the French ... with gut microbiota transplantation - the engrafting of new ...
... , Luis Montaner from the Wistar Institute, Philadelphia, USA ... model to a cohort of HIV-infected patients on antiretroviral ... be used to optimize laboratory capacity in settings where ... is not intended to replace CD4 count testing or ...
Cached Biology Technology:Butamax™ and Fagen Announce Collaboration to Retrofit Ethanol Plants for Biobutanol Production 2Gut Microbiota Transplantation may Prevent Development of Diabetes and Fatty Liver Disease 2Gut Microbiota Transplantation may Prevent Development of Diabetes and Fatty Liver Disease 3
... siSolutions siRNA Custom Synthesis ... effective duplex RNA to knockdown ... 21-mers (19 RNA base pairs ... recently-published 27-mers, or other lengths ...
EDG-1 Western blot control Source: Cell Lysate Application: Western Blotting Control...
Hybridization cassette for one slide...
Request Info...
Biology Products: