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Michigan Tech researchers link 11 genetic variations to type 2 diabetes
Date:4/1/2008

ELA is used to compare the genetic makeup of unrelated individuals to sort out disease-related genes. The team has also developed another approach, which uses a two-stage association test that incorporates founders phenotypes, called TTFP, that can examine the genomes of family members going back generations.

In the past, researchers have dealt with the nuclear family, parents and children, but this could go back to grandparents, great-grandparents . . . as far back as you want.

The team has published their findings in the European Journal of Human Genetics. An abstract is available at www.nature.com/ejhg/journal/v15/n11/abs/5201902a.html.

Now that theyve developed the software, the analysis is relatively simple, says Sha. But getting the genetic data to work on is not. We dont have the data sets yet to work with, she says, clearly frustrated. Thats the problem with having no medical school.

Those who do have data sets, however, can use the teams software to help find the causeand hopefully, the curesfor a panoply of illnesses. ELA is available in Windows and Linux versions at www.math.mtu.edu/~shuzhang/software.html, and TTFP is available by request.


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Contact: Marcia Goodrich
mtunews@mtu.edu
906-487-2343
Michigan Technological University
Source:Eurekalert

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