Navigation Links
Methylation signaling controls angiogenesis and cancer growth
Date:11/28/2013

(Boston) A study led by researchers at Boston University School of Medicine (BUSM) demonstrates a new mechanism involving a signaling protein and its receptor that may block the formation of new blood vessels and cancer growth. The findings are published in the December issue of Science Signaling.

Angiogenesis creates new blood vessels in a process that can lead to the onset and progression of several diseases such as cancer and age-related macular degeneration.

Vascular endothelial growth factor (VEGF) is a signaling protein produced by damaged cells, which binds to one of its receptors VEGFR-2, located on the surface of blood vessel cells. Once VEGF is bound to its receptor, it is activated and sends a biochemical signal to the inside of the blood vessel cell to initiate angiogenesis. There are currently multiple Federal Drug Administration-approved medications that target this process. However these medications are limited by insufficient efficacy and the development of resistance.

The researchers demonstrated that a biochemical process called methylation, which can regulate gene expression, also affects VEGFR-2, and this can lead to angiogenesis. Using multiple methods, the researchers were able to interfere with the methylation process of VEGFR-2 and subsequently block angiogenesis and tumor growth.

"The study points to the methylation of VEGFR-2 as an exciting, yet unexplored drug target for cancer and ocular angiogenesis, ushering in a new paradigm in anti-angiogenesis therapy," said Nader Rahimi, PhD, associate professor of pathology, BUSM, who served as the study's senior investigator.


'/>"/>

Contact: Jenny Eriksen
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Page: 1

Related biology news :

1. The secret of DNA methylation
2. The first ant methylomes uncover the relationship between DNA methylation and caste differentiation
3. mTOR: A key brain signaling mechanism for rapidly acting antidepressants
4. New book on Signaling by Receptor Tyrosine Kinases by Cold Spring Harbor Laboratory Press
5. Scientists construct visual of intracellular zip code signaling linked to learning, memory
6. Memorial Sloan-Kettering researchers develop new method for tracking cell signaling
7. Structure of cell signaling molecule suggests general on-off switch
8. Signaling pathway linked to fetal alcohol risk
9. FASEB SRC announces conference: TGF-β Superfamily: Signaling in Development & Disease
10. FASEB SRC announces conference registration open for: NAD Metabolism & Signaling
11. FASEB SRC announces conference registration open for: Histone Deacetylases, Sirtuins, and Reversible Acetylation in Signaling and Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... an unprecedented evolution experiment scientists from GEOMAR Helmholtz ... Institute of Sea Fisheries have demonstrated for the ... algae of the world,s oceans, Emiliania huxleyi ... rising water temperatures. In their study, the researchers ... evolutionary adaptations to these two aspects of climate ...
(Date:9/15/2014)... Ebola virus outbreak in West Africa, which has claimed ... a deeper understanding of the molecular biology of the ... vaccines or antiviral drugs to treat or prevent Ebola ... Virginia (UVA), USA under the leadership of Dr ... structural biologist has obtained the crystal structure of ...
(Date:9/15/2014)... September 15, 2014 Schizophrenia is generally considered to ... many risk factors, both genetic and environmental, with other ... The normal path for brain development is determined by ... and a wide range of environmental factors. , However, ... populations are required in order to map the disturbances ...
Breaking Biology News(10 mins):Small algae with great potential 2Small algae with great potential 3Protein secrets of Ebola virus 2Brain Development in Schizophrenia Strays from the Normal Path 2
... AUSTIN, Texas , April 17, 2013 Vermillion, ... company focused on gynecologic cancers and women,s health, announced the ... with the U.S. Army Medical Research and Materiel Command ... titled, "Cost Reduction Using OVA1 in a Treatment Algorithm ...
... Recent developments in postharvest disease control will be highlighted at ... sponsored by the University of California, Riverside Extension ... run from 8 a.m. to 5 p.m. Tuesday, April 23, and ... Santa Barbara . This year,s conference will include a large ...
... Committee for the Asian hornet, the Vespa velutina ... Community (region), the Charter Provincial Councils, the Beekeeping sector ... aimed at controlling the Vespa velutina populations ... an invasive species from France that preys on bees ...
Cached Biology News:U.S. Army and Vermillion to Assess Health and Economic Benefits of OVA1 as a Standard of Care 2U.S. Army and Vermillion to Assess Health and Economic Benefits of OVA1 as a Standard of Care 3U.S. Army and Vermillion to Assess Health and Economic Benefits of OVA1 as a Standard of Care 4Conference to highlight latest in postharvest pest control 2
(Date:9/15/2014)... Sept. 15, 2014 The chemistry, taste, and health ... a new article published by the nonprofit American Botanical Council ... climate change and its effects on the phytochemical compounds in ... study conducted by Dr. Ahmed in the Yunnan ... and has implications for the future of medicinal botanicals. Dr. ...
(Date:9/15/2014)...  The second annual International Plasma Awareness Week ... initiative of the Plasma Protein Therapeutics Association ... designed to: , Raise global awareness about ... plasma donors in saving and improving lives , ... diseases Member companies are planning a ...
(Date:9/13/2014)... 2014 Boehringer Laboratories Inc., with a ... to announce the successful broadcast of a live surgery ... Claros, MD, FACS, FAMBS, and Maher El Chaar, MD, ... System. , This sleeve gastrectomy surgery was performed ... than four hundred surgeons from around the world during ...
(Date:9/12/2014)... Mountain View, CA (PRWEB) September 12, 2014 ... its fundraising campaign on Indiegogo. , The film, ... Stephen Hawking, Buzz Aldrin, Shimon Peres, Ashton Kutcher, Will.i.Am, ... changing the world and there’s only one university in ... it to help change the lives of a billion ...
Breaking Biology Technology:Tea Taste and Quality Affected by Climate Change 2Tea Taste and Quality Affected by Climate Change 3Tea Taste and Quality Affected by Climate Change 4International Plasma Awareness Week To Celebrate Donors And Spotlight Rare Diseases 2International Plasma Awareness Week To Celebrate Donors And Spotlight Rare Diseases 3Boehringer Laboratories, Inc. Announces Live Surgery Using Innovative System to Calibrate Sleeve Gastrectomy 2Documentary Film that Follows Singularity University Students as They Change the World Launches its IndieGoGo Fundraising Campaign 2
... Dec. 20 Northwest,Biotherapeutics, Inc. (OTC Bulletin ... ("NWBT") announced today that Lonza Group AG ... NWBT,s DCVax(R)-Brain,product and other NWBT DCVax(R) products ... DCVax(R) cancer vaccine products infringed,certain gene expression ...
... teens and adults, HIGHLANDS RANCH, Colo., Dec. 19 ... its treatment services to,include a detox program. The new ... adults, and the hospital has added several new physicians ... abuse and,mental illness)., Teen suicide rates nationally are ...
... PALO ALTO, Calif., Dec. 19 Alexza,Pharmaceuticals, Inc. (Nasdaq: ... V. Barron, MD, FACC to its Board of Directors. ... Medical Officer at Genentech,where he leads the Development organization, ... Dr. Barron joined Genentech in 1996 as a clinical ...
Cached Biology Technology:Lonza Withdraws Majority of Claims in Patent Lawsuit Against Northwest Biotherapeutics 2Lonza Withdraws Majority of Claims in Patent Lawsuit Against Northwest Biotherapeutics 3Lonza Withdraws Majority of Claims in Patent Lawsuit Against Northwest Biotherapeutics 4Highlands Behavioral Health Hospital Unveils New Substance Abuse Detox Program 2Alexza Elects Dr. Hal V. Barron to Its Board of Directors 2Alexza Elects Dr. Hal V. Barron to Its Board of Directors 3
Goat anti-VAV2 Class: Antibody Product Group: Miscellaneous Antibody...
... Mouse monoclonal [F30 P7 D7 ... for all tested applications). ... conjugated to Ovalbumin, corresponding to amino ... Entrez Gene ID: ...
DAP12 Market Segment: Protein Kinases...
G-protein coupled purinergic receptor P2Y8...
Biology Products: