Navigation Links
'Methyl magnet' genes can cause family cancer risk

Medical researchers have discovered a new type of mechanism causing cancer susceptibility, showing that tiny changes in some anti-cancer genes can act as magnets to attract modifying "biochemical tags", effectively switching them off and predisposing families to an increased risk of the disease.

The study and its findings are reported in the leading international journal Cancer Cell.

The researchers, from the University of New South Wales (UNSW), believe a tiny spelling mistake involving a single letter in the DNA sequence near the start of the genes is what attracts the biochemical tag known as methylation.

This biochemical tag directly impacts on our DNA, by switching genes off.

"Methylation sits on top of our DNA, and provides the instructions to turn the gene off," explains study co-leader, Dr Megan Hitchins, from UNSW's Lowy Cancer Research Centre.

In one well-known cause of hereditary cancer, changes in the cancer-prevention gene MLH1 are passed from parent to child creating up to 80 percent risk of developing bowel, uterine and other cancers. However, some families with hereditary cancer have no spelling mistakes in MLH1, but instead have methylation sitting on the gene.

"When the methylation attaches to the MLH1 gene in these families, it causes it to be completely switched off and as a consequence cancer develops," says study co-leader and head of the adult cancer program at the Lowy Cancer Research Centre, Professor Robyn Ward. "But until now, we did not understand how these methylation tags were being passed from parent to child."

In the study the researchers looked at three generations of a large family, who had cancer at a young age, but in whom no spelling mistakes typical of this hereditary cancer syndrome had been found. Strikingly several members of the family from all generations had methylation tags on their gene.

"In this family, biochemical tags attached to the MLH1 gene were present in all three generations. This was intriguing since these markers are usually removed during the production of eggs and sperm," Dr Hitchins said.

"What we found was that a subtle change near the gene was acting like a magnet to attract methylation. So it was not the methylation itself that was being passed from parent to child, but rather the DNA change, and this acted as a methyl magnet," she said.

The methylation was cleared away in the sperm and eggs and then recreated in each new generation, the researchers said.

Professor Ward said the discovery pinpointed the cause of cancer in this family and it offered new options for genetic diagnosis, counselling and early interventions in other families at risk of hereditary cancers.

The team is also exploring the use of certain drugs to clear away the methylation in cancer to switch the anti-cancer genes back on again. In the future these drugs may be used to create a more targeted approach to cancer treatment and possibly prevention.


Contact: Dr Megan Hitchens
University of New South Wales

Related biology news :

1. Methylmercury warning
2. Stowers Institutes Workman Lab discovers novel histone demethylase protein complex
3. Methyl bromide alternatives indicated for North Carolina tomato production
4. Methyl bromide alternatives for California strawberry nurseries
5. Researchers develop new, more-sensitive assay for detecting DNA methylation in colon cancer
6. Epigentek Develops a New Method of Measuring Global DNA Methylation
7. UCLA stem cell researchers uncover previously unknown patterns in DNA methylation
8. Mechanism behind demethylation pinpointed in APC gene mutants
9. New test measures DNA methylation levels to predict colon cancer
10. Alternatives eyed for methyl bromide
11. Caltech geobiologists discover unique magnetic death star fossil
Post Your Comments:
(Date:10/29/2015)... , October 29, 2015 ... authentication company focused on the growing mobile commerce ... announces that StackCommerce, a leading marketplace to discover ... the Wocket® smart wallet on StackSocial for this ... ("NXT-ID" or the "Company"), a biometric authentication company ...
(Date:10/27/2015)... Synaptics Inc. (NASDAQ: SYNA ), the leader ... adopted the Synaptics ® ClearPad ® Series ... newest flagship smartphones, the Nexus 5X by LG and ... --> --> Synaptics works closely with ... in the joint development of next generation technologies. Together, ...
(Date:10/23/2015)... , Oct. 23, 2015 Research and Markets ... "Global Voice Recognition Biometrics Market 2015-2019" report ... --> The global voice recognition biometrics market ... --> --> ... been prepared based on an in-depth market analysis with ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... The United States Golf ... the 2016 USGA Green Section Award. Presented annually since 1961, the USGA Green Section ... her work with turfgrass. , Clarke, of Iselin, N.J., is an extension ...
(Date:11/24/2015)... ... 2015 , ... Copper is an essential micronutrient that all ... copper is also toxic to cells. With a $1.3 million award from the ... a systematic study of copper in the bacteria Pseudomonas aeruginosa (P. aeruginosa), a ...
(Date:11/24/2015)... 24, 2015 --> ... report "Oligonucleotide Synthesis Market by Product & Services (Primer, ... Diagnostic, DNA, RNAi), End-User (Research, Pharmaceutical & Biotech, Diagnostic ... the market is expected to reach USD 1,918.6 Million ... a CAGR of 10.1% during the forecast period. ...
(Date:11/24/2015)... New York , November 24, 2015 ... to a recent market research report released by Transparency ... projected to expand at a CAGR of 17.5% during ... "Non-invasive Prenatal Testing Market - Global Industry Analysis, Size, ... estimates the global non-invasive prenatal testing market to reach ...
Breaking Biology Technology: