Navigation Links
'Methyl magnet' genes can cause family cancer risk
Date:8/16/2011

Medical researchers have discovered a new type of mechanism causing cancer susceptibility, showing that tiny changes in some anti-cancer genes can act as magnets to attract modifying "biochemical tags", effectively switching them off and predisposing families to an increased risk of the disease.

The study and its findings are reported in the leading international journal Cancer Cell.

The researchers, from the University of New South Wales (UNSW), believe a tiny spelling mistake involving a single letter in the DNA sequence near the start of the genes is what attracts the biochemical tag known as methylation.

This biochemical tag directly impacts on our DNA, by switching genes off.

"Methylation sits on top of our DNA, and provides the instructions to turn the gene off," explains study co-leader, Dr Megan Hitchins, from UNSW's Lowy Cancer Research Centre.

In one well-known cause of hereditary cancer, changes in the cancer-prevention gene MLH1 are passed from parent to child creating up to 80 percent risk of developing bowel, uterine and other cancers. However, some families with hereditary cancer have no spelling mistakes in MLH1, but instead have methylation sitting on the gene.

"When the methylation attaches to the MLH1 gene in these families, it causes it to be completely switched off and as a consequence cancer develops," says study co-leader and head of the adult cancer program at the Lowy Cancer Research Centre, Professor Robyn Ward. "But until now, we did not understand how these methylation tags were being passed from parent to child."

In the study the researchers looked at three generations of a large family, who had cancer at a young age, but in whom no spelling mistakes typical of this hereditary cancer syndrome had been found. Strikingly several members of the family from all generations had methylation tags on their gene.

"In this family, biochemical tags attached to th
'/>"/>

Contact: Dr Megan Hitchens
m.hitchins@unsw.edu.au
61-293-851-431
University of New South Wales
Source:Eurekalert

Page: 1 2

Related biology news :

1. Methylmercury warning
2. Stowers Institutes Workman Lab discovers novel histone demethylase protein complex
3. Methyl bromide alternatives indicated for North Carolina tomato production
4. Methyl bromide alternatives for California strawberry nurseries
5. Researchers develop new, more-sensitive assay for detecting DNA methylation in colon cancer
6. Epigentek Develops a New Method of Measuring Global DNA Methylation
7. UCLA stem cell researchers uncover previously unknown patterns in DNA methylation
8. Mechanism behind demethylation pinpointed in APC gene mutants
9. New test measures DNA methylation levels to predict colon cancer
10. Alternatives eyed for methyl bromide
11. Caltech geobiologists discover unique magnetic death star fossil
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... , Respiratory syncytial virus (RSV) is a ... life-threating illness in very young and elderly populations. ... enters host cells through the fusion protein RSV ... interfering peptides that prevent bundle formation limit RSV ... susceptible to degradation. In this issue of the ...
(Date:4/17/2014)... NY, April 17, 2014The development of stem cell therapies ... ability to characterize stem cell populations based on cell ... discovered a new marker that is highly expressed in ... cord blood, which they describe in an article in ... Mary Ann Liebert, Inc., publishers. The article is available ...
(Date:4/17/2014)... study suggests that fish consumption advisories for expecting ... long-lived contaminants like persistent organic pollutants (POPs). ... researchers including University of Toronto Scarborough PhD student ... how different levels of environmental contamination, a mother,s ... in the body influenced exposure in her children. ...
Breaking Biology News(10 mins):JCI online ahead of print table of contents for April 17, 2014 2JCI online ahead of print table of contents for April 17, 2014 3JCI online ahead of print table of contents for April 17, 2014 4JCI online ahead of print table of contents for April 17, 2014 5JCI online ahead of print table of contents for April 17, 2014 6Fish consumption advisories fail to cover all types of contaminants 2
... an estimated 665,000 deaths, mostly among African children. Now, ... for the world,s most useful antimalarial drug, artemisinin, giving ... cost of the live-saving drug in the future. , ... been slow due to high production costs of artemisinin. ...
... a hormone released by the lining of the stomach that ... obesity -- in fact, a vaccine that lowers ghrelin levels ... treatment for obesity. However, many people eat as a ... its effectiveness as a treatment for obesity may be reduced. ...
... pose considerable health threats to humans, and the heavy metal ... are exposed to it through plant-derived foods such as grains ... can reduce the amount of Cd found in the food ... in the Cell Press journal Trends in Plant Science ...
Cached Biology News:IU chemist develops new synthesis of most useful, yet expensive, antimalarial drug 2Low ghrelin -- reducing appetite at the cost of increased stress? 2Studies shed light on how to reduce the amount of toxins in plant-derived foods 2
(Date:1/14/2014)... January 14, 2014 EquitiesIQ, a leading ... (OTCQB: ALQA). Alliqua is an emerging biomedical company acquiring, ... wound care market. , Free report download: http://equitiesiq.com/reports/alliqua/ ... a seasoned management team and Board, which launched the ...
(Date:1/14/2014)... 14, 2014 In recent years, growing ... methods in product development and promotion has led to ... mistrust, fueled by concerns about the insidious impact of ... of spectacular fines to the world’s biggest pharmas for ...
(Date:1/14/2014)... and Cardiff, UK (PRWEB) January 13, 2014 ... development leader with more than 20 years in the ... optics and photonics . Hainsey will serve as the ... to have Dr. Hainsey join SPIE as our Technology ...
(Date:1/14/2014)... Research Triangle Park, NC (PRWEB) January 14, 2014 ... diagnostic company focusing on ultra-sensitive POC diagnostic platforms and novel ... on their first round of financing netting a total of ... first outside equity capital in the company. This group of ...
Breaking Biology Technology:EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2BioMedomics, Inc. Closes $690K Round of Financing 2
... a leading laboratory services company, recently announced its formation ... as GI Pathology, D-PATH Dermatopathology and OncoMetrix. ... CEO of Poplar Healthcare, "we felt it was imperative ... individual companies could belong, while still maintaining their unique ...
... Stem Cell Assurance, Inc. (SCLZ.PK) (the "Company") ... "BioRestorative Therapies, Inc."  The Company,s new web site address ... been advised by the Financial Industry Regulatory Authority (FINRA) ... will change from "SCLZ" to "BRTX" thirty days following ...
... Aug. 17, 2011 Planet Biopharmaceuticals, Inc. and its ... pharmaceutical company focused on providing products for allergy and ... Ph.D. has been named as the company,s Executive Chairman ... Officer on August 29, 2011. Odlaug will replace William ...
Cached Biology Technology:Poplar Healthcare Forms Parent Company, Launches New Web Site 2Stem Cell Assurance, Inc. Announces Change of Name to BioRestorative Therapies, Inc. 2Planet Biopharmaceuticals, Inc. Appoints Theron (Ted) Odlaug, Ph.D. as Executive Chairman 2
... for arraying proteins of interest with ... equipment. DiscoverLight Protein Array Kits allow ... cell lysate or antibody in a ... specially designed nitrocellulose membranes with a ...
... for Alkaline Phosphatase conjugates. The product ... both the enzyme and the antibody following ... product has been chemically engineered to increase ... shelf life, resistance to various shipping conditions ...
Request Info...
NovaScreen offers cell biology, cell culture and molecular biology services for companies who lack a cell culture facility....
Biology Products: