Navigation Links
'Methyl magnet' genes can cause family cancer risk
Date:8/16/2011

Medical researchers have discovered a new type of mechanism causing cancer susceptibility, showing that tiny changes in some anti-cancer genes can act as magnets to attract modifying "biochemical tags", effectively switching them off and predisposing families to an increased risk of the disease.

The study and its findings are reported in the leading international journal Cancer Cell.

The researchers, from the University of New South Wales (UNSW), believe a tiny spelling mistake involving a single letter in the DNA sequence near the start of the genes is what attracts the biochemical tag known as methylation.

This biochemical tag directly impacts on our DNA, by switching genes off.

"Methylation sits on top of our DNA, and provides the instructions to turn the gene off," explains study co-leader, Dr Megan Hitchins, from UNSW's Lowy Cancer Research Centre.

In one well-known cause of hereditary cancer, changes in the cancer-prevention gene MLH1 are passed from parent to child creating up to 80 percent risk of developing bowel, uterine and other cancers. However, some families with hereditary cancer have no spelling mistakes in MLH1, but instead have methylation sitting on the gene.

"When the methylation attaches to the MLH1 gene in these families, it causes it to be completely switched off and as a consequence cancer develops," says study co-leader and head of the adult cancer program at the Lowy Cancer Research Centre, Professor Robyn Ward. "But until now, we did not understand how these methylation tags were being passed from parent to child."

In the study the researchers looked at three generations of a large family, who had cancer at a young age, but in whom no spelling mistakes typical of this hereditary cancer syndrome had been found. Strikingly several members of the family from all generations had methylation tags on their gene.

"In this family, biochemical tags attached to th
'/>"/>

Contact: Dr Megan Hitchens
m.hitchins@unsw.edu.au
61-293-851-431
University of New South Wales
Source:Eurekalert

Page: 1 2

Related biology news :

1. Methylmercury warning
2. Stowers Institutes Workman Lab discovers novel histone demethylase protein complex
3. Methyl bromide alternatives indicated for North Carolina tomato production
4. Methyl bromide alternatives for California strawberry nurseries
5. Researchers develop new, more-sensitive assay for detecting DNA methylation in colon cancer
6. Epigentek Develops a New Method of Measuring Global DNA Methylation
7. UCLA stem cell researchers uncover previously unknown patterns in DNA methylation
8. Mechanism behind demethylation pinpointed in APC gene mutants
9. New test measures DNA methylation levels to predict colon cancer
10. Alternatives eyed for methyl bromide
11. Caltech geobiologists discover unique magnetic death star fossil
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/10/2014)... shelves in early 2010, and people have used them ... be tossed into a washing machine without ever having ... though, has come with risks for young children. , ... found that from 2012 through 2013, U.S. poison control ... years of age swallowing, inhaling, or otherwise being exposed ...
(Date:11/7/2014)... Nov. 7, 2014  In conjunction with the ... Departments, The Community Foundation of the Verdugos has announced the ... JUSTICE PROJECT," a $250,000 initiative to keep the Verdugo Regional ... its first six months of existence, the Lab has processed ... for local law enforcement. "Because our number one ...
(Date:11/6/2014)... -- A groundbreaking paper from a team of Florida ... of how plants could adapt to and survive environmental ... published in the latest issue of the journal ... (the complex of DNA and proteins) is organized in ... that some genes are turned on and others are ...
Breaking Biology News(10 mins):Study finds laundry detergent pods, serious poisoning risk for children 2Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Maize analysis yields whole new world of genetic science 2
... by emphysema and/or chronic bronchitis. It destroys the ... aspects of breathing, which prevents necessary gas exchange. ... of lung infections. These symptoms are associated with ... air sacs, which usually inflate with air during breathing ...
... Contrary to prevailing wisdom, a new study from plant ... family do indeed chaperone proteins across the membranes of chloroplasts, ... findings are published online in the January issue of the ... most crucial tasks in a living cell is to move ...
... available in Spanish . People with lower ... worse health care in the treatment of diabetes than the ... conclusion emerges from a research conducted at the University of ... to date on health care of this disease in the ...
Cached Biology News:New potential to treat chronic obstructive pulmonary disease 2Green plant transport mystery solved 2Poorer diabetics receive worse care than other in countries with universal health coverage 2Poorer diabetics receive worse care than other in countries with universal health coverage 3
(Date:11/18/2014)... Athena Signature Series: Turning Cancer ‘Off’ – ... a professor in the Regulatory Biology Laboratory at the Salk ... points to an “off switch” for drug resistance in cancer. ... local research is making a global impact in the fight ... join host Cheryl K. Goodman, CEO of Social Global Mobile ...
(Date:11/18/2014)... American Process Inc. (Atlanta, GA) ... partnership with researchers at Georgia Institute of Technology, ... the USDA’s Forest Products Laboratory to develop ultra-strong, ... is a rapidly emerging high performance nanomaterial extracted ... to replace heavy steel structures within cars, such ...
(Date:11/18/2014)... November 18, 2014 2014 ... Industry is professional and in-depth report on ... basic information, including its definition, characterization, application, ... outline. This exploration covers the worldwide business ... industry examination covering macroeconomic environment & financial ...
(Date:11/18/2014)... Nov. 18, 2014 PDL BioPharma, Inc. (PDL) ... connection with the acquisition of Durata Therapeutics, Inc. by ... with the termination of PDL,s credit agreement with Durata, ... of $40 million, accrued interest, and prepayment and change ... a structured financing transaction with Durata in which PDL ...
Breaking Biology Technology:American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 2American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 3PTMEG Market: 2019 Global Polytetrahydrofuran Industry Development Trends & Analysis Now at DeepResearchReports.com 2PTMEG Market: 2019 Global Polytetrahydrofuran Industry Development Trends & Analysis Now at DeepResearchReports.com 3PDL BioPharma Announces Successful Conclusion of Debt Financing Agreement with Durata Therapeutics 2
... is a little prettier in October as your grocery,s ... Guacamole. Nielsen-ranked, top-selling Wholly Guacamole, is for the second ... from October "PINK" sales to help fight for a ... Texas-Based Wholly,s support for National Breast Cancer Awareness Month. ...
... Oct. 7 Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX ) ... to market and other conditions, 27,500,000 shares of its ... of which 16,412,613 shares are being offered through the ... L.P., Lexicon,s largest stockholder. Lexicon also intends to ...
... YORK, Oct. 7 /PRNewswire-FirstCall/ - Healthnostics, Inc. (OTC ... announced today details regarding the social networking features ... the Facebook(C) model that gives individuals greater power ... interactive layer that allows users to comment and ...
Cached Biology Technology:Grocery Produce Fighting for a Cause - Wholly 'Pink' Guacamole 2Lexicon Announces Proposed Offering of 27,500,000 Shares of Common Stock 2Lexicon Announces Proposed Offering of 27,500,000 Shares of Common Stock 3Healthnostics' Medbioworld.com Portal Web Site to Include Social Networking Features 2
... Cell Lines stably express the regulatory ... line is functionally tested for induction ... expression control vector pGene/V5-His/lacZ and by ... with mifepristone (Figure 1). These cell ...
... System Modules Highly ... directional cloning into advanced ... vectors For ... Cloning Systems, the modules ...
... CHEMICON Re-Blot Western Blot Recycling Kit ... from Western blots that have been ... or other isotopes. It is not ... DAB, 4-chloronapthol, etc.), as it is ...
Applications: Western blotting ...
Biology Products: