Navigation Links
'Methyl magnet' genes can cause family cancer risk
Date:8/16/2011

Medical researchers have discovered a new type of mechanism causing cancer susceptibility, showing that tiny changes in some anti-cancer genes can act as magnets to attract modifying "biochemical tags", effectively switching them off and predisposing families to an increased risk of the disease.

The study and its findings are reported in the leading international journal Cancer Cell.

The researchers, from the University of New South Wales (UNSW), believe a tiny spelling mistake involving a single letter in the DNA sequence near the start of the genes is what attracts the biochemical tag known as methylation.

This biochemical tag directly impacts on our DNA, by switching genes off.

"Methylation sits on top of our DNA, and provides the instructions to turn the gene off," explains study co-leader, Dr Megan Hitchins, from UNSW's Lowy Cancer Research Centre.

In one well-known cause of hereditary cancer, changes in the cancer-prevention gene MLH1 are passed from parent to child creating up to 80 percent risk of developing bowel, uterine and other cancers. However, some families with hereditary cancer have no spelling mistakes in MLH1, but instead have methylation sitting on the gene.

"When the methylation attaches to the MLH1 gene in these families, it causes it to be completely switched off and as a consequence cancer develops," says study co-leader and head of the adult cancer program at the Lowy Cancer Research Centre, Professor Robyn Ward. "But until now, we did not understand how these methylation tags were being passed from parent to child."

In the study the researchers looked at three generations of a large family, who had cancer at a young age, but in whom no spelling mistakes typical of this hereditary cancer syndrome had been found. Strikingly several members of the family from all generations had methylation tags on their gene.

"In this family, biochemical tags attached to th
'/>"/>

Contact: Dr Megan Hitchens
m.hitchins@unsw.edu.au
61-293-851-431
University of New South Wales
Source:Eurekalert

Page: 1 2

Related biology news :

1. Methylmercury warning
2. Stowers Institutes Workman Lab discovers novel histone demethylase protein complex
3. Methyl bromide alternatives indicated for North Carolina tomato production
4. Methyl bromide alternatives for California strawberry nurseries
5. Researchers develop new, more-sensitive assay for detecting DNA methylation in colon cancer
6. Epigentek Develops a New Method of Measuring Global DNA Methylation
7. UCLA stem cell researchers uncover previously unknown patterns in DNA methylation
8. Mechanism behind demethylation pinpointed in APC gene mutants
9. New test measures DNA methylation levels to predict colon cancer
10. Alternatives eyed for methyl bromide
11. Caltech geobiologists discover unique magnetic death star fossil
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... Conn. , October 16, 2014 NXT-ID, ... or the "Company"), a biometric authentication company focused on ... its leading edge technologies including Wocket™, the Smart Wallet, ... (FiRe) Conferenece. FiRe is a leading global conference on ... Hosted by Mark Anderson , founder and ...
(Date:10/15/2014)... ability to assess the pandemic risk from strains of ... must not allow ourselves to become complacent that the ... consortium of scientists. , Influenza pandemics arise when a ... to develop widespread immunity – spreads in the human ... past 100 years, the worst of which – the ...
(Date:10/15/2014)... admitted Johannes Gutenberg University Mainz (JGU) as a ... continues to maintain a significant nationwide standing in ... acceptance of Johannes Gutenberg University Mainz as a ... in the national and international competition for the ... Rhineland-Palatinate can be proud that Mainz University has ...
Breaking Biology News(10 mins):NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
... Sunday, March 10, 2013, Cleveland: Researchers from Cleveland Clinic ... commonly used drug to treat anemia in heart failure ... nor does it reduce their risk of death from ... presented at the American College of Cardiology,s annual meeting ...
... in German . , Protein activity ... lead to uncontrolled growth and thus cancer or chronic ... Molecular Biology from the University of Zurich have identified ... proteins. Their discovery enables these proteins to be manipulated ...
... researchers have been using atomic force microscopy (AFM) to ... AFM-based measurements of chemistry and chemical properties of materials ... the University of Illinois at Urbana-Champaign report that they ... small as 15 nm, using a novel technique called ...
Cached Biology News:Cleveland Clinic research shows anemia drug does not improve health of anemic heart failure patients 2Selectively manipulating protein modifications 2University of Illinois researchers develop AFM-IR for nanometer scale chemical identification 2
(Date:10/20/2014)... Convey Computer , the leader in hybrid-core ... University won first place in the 2014 MemoCODE ... team’s solution achieved the highest overall performance in the ... finisher. , Experts from all segments of the commercial ... using a variety of design tools, hardware and software. ...
(Date:10/20/2014)... PureTech , a science and technology development ... today the closing of a $55 million growth ... a $120 Billion group of funds. The funding ... forward and to advance new healthcare related products ... really go for the big ideas that can ...
(Date:10/19/2014)... 2014 OCTOBER 20-22, 2014: ... ABIM will take place at the ... ABIM 2014 is now available at ... companies and organizations from all over the ... on the latest products and developments on ...
(Date:10/19/2014)... 2014 The report "Chocolate, Cocoa Beans, ... Prices, Geography Trend and Forecast (2011 - 2016)," ... geography and studies the major market drivers, restraints, and ... and Asia. , The global chocolate market is expected ... in 2016 at an estimated CAGR of 2.7% from ...
Breaking Biology Technology:Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4
... EAST NORRITON, Pa., Feb. 7, 2011 Tengion, Inc. (Nasdaq: ... announced that Steven Nichtberger, M.D., President and Chief Executive Officer ... CEO & Investor Conference on Monday, February 14, 2011, at ... panel discussion titled "IPO Window-Creaking Open or Wide Open?" the ...
... N.J., Feb. 7, 2011 ... today it will host a roundtable and give a ... week at the Summit for Clinical Ops Executives ( ... hotel. (Logo: http://photos.prnewswire.com/prnh/20100707/NY31446LOGO) As part ...
... of California, Berkeley, have found a way to grow nanolasers ... to a new class of faster, more efficient microprocessors, as ... They describe their work in a paper ... of the journal Nature Photonics . "Our ...
Cached Biology Technology:Tengion to Present at the 13th Annual BIO CEO & Investor Conference and the Leerink Swann 'Hot Topics in Therapeutics' Roundtable Conference 2Cmed Technology to Host Roundtable, Give Presentation About EDC Pain Points at Summit for Clinical Ops Executives (SCOPE) 2Cmed Technology to Host Roundtable, Give Presentation About EDC Pain Points at Summit for Clinical Ops Executives (SCOPE) 3Engineers grow nanolasers on silicon, pave way for on-chip photonics 2Engineers grow nanolasers on silicon, pave way for on-chip photonics 3
... Anti-Major DNA-binding protein(DBP). Protein ... NP_001343 ELISA titre using ... Suggested conditions for Western Blot: ... buffer, and HRP conjugated anti-Rabbit IgG should ...
Collected from sexually mature, mixed sex, mixed breed guinea pigs. Pricing: $120/unit for 1 - 10 units...
SEQUENASE PCR PRODUCT PRE-SEQU, 1 EA. Category: SEQUENASE....
Mouse monoclonal [IFR0104] to Salmonella enteriditis ( Abpromise for all tested applications)....
Biology Products: