Navigation Links
Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests
Date:7/11/2013

CINCINNATIA recently discovered form of the protein that triggers blood clotting plays a critical role in promoting the growth of metastatic pancreatic cancer and primary breast cancer, according to the cumulative findings from two new scientific manuscripts published online ahead of print in the International Journal of Cancer and PNAS (Proceedings of the National Academy of Sciences).

The protein, called "Tissue Factor," is present in various tissuesfor example, walls of blood vessels. Earlier studies suggested that alternatively spliced Tissue Factor (asTF) may contribute to cancer growth, but the molecular events leading to this were previously unknown.

New research conducted through an international collaboration between the labs of Vladimir Bogdanov, PhD, of the University of Cincinnati Cancer Institute, and Henri Versteeg, PhD, of the Einthoven Laboratory for Experimental Vascular Medicine at the Leiden University Medical Center in Leiden, the Netherlands, articulates how asTF fuels growth and metastasis of solid cancers.

Using preclinical animal models, Bogdanov and Versteeg's teams obtained the first scientifically validated evidence that asTF promotes the spread of pancreatic cancer and promotes primary growth of breast cancer tumors.

"We have demonstrated that targeting asTF with a novel monoclonal antibodydeveloped based on our 10 years of studying asTFalso stops the growth of breast cancer in an animal model, giving us a promising new target to fight certain forms of breast cancer," says Bogdanov, who originally described asTF in 2003. UC filed a patent for this technology in January 2013.

Bogdanov and Versteeg presented their findings at the XXIV Congress of the International Society on Thrombosis and Haemostasis in Amsterdam, the Netherlands (held June 29-July 4, 2013).

"Many molecules on the surface of cellsincluding integrinsare important for the function of both no
'/>"/>

Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Mechanism found connecting metastatic breast cancer and arthritis
2. Cancerous tumors deliver pro-metastatic information in secreted vesicles
3. Should high-dose interleukin-2 continue to be the treatment of choice for metastatic melanoma?
4. TGen-US Oncology data guides treatment of metastatic triple-negative breast cancer patients
5. Thomas Jefferson University researchers discover new pathways that drive metastatic prostate cancer
6. LSUHSC research discovers new drug target for metastatic breast cancer
7. Modulating the immune system to combat metastatic cancer
8. How cancer spreads: Metastatic tumor a hybrid of cancer cell and white blood cell
9. PARP inhibitor shows activity in pancreatic, prostate cancers among patients carrying BRCA mutations
10. Commonly used diabetes drug may help to prevent primary liver cancer
11. Biology professor secures grant to save West Virginias primary natural history collection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2015)... ., Aug. 20, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market ... has joined The Smart Card Alliance and the EMV ... Alliance and the Smart Card Alliance Latin America (SCALA) ... industry peers and thought leaders promoting adoption of smart ...
(Date:8/18/2015)... DUBLIN , Aug. 17, 2015 ... the addition of the "Global Biometric Authentication ... Application - Estimation & Forecast, 2015-2020" report ... biometric authentication and identification systems market is expected ... from 2015 to 2020 and generate over $25 ...
(Date:8/12/2015)... Florida , August 12, 2015 ... pace of mobile payment innovation and advanced biometrics technology ... replace the way consumers rely on using their credit ... with reinventing the future for payment services led by ... NXTD ), :  Google, Inc. (NASDAQ: GOOG ...
Breaking Biology News(10 mins):NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 2NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 4Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6
... (DOE) has announced plans to fund research at the ... on technologies that would help reduce greenhouse gas emissions ... of carbon dioxide (CO2). The project is in collaboration ... Funded by the DOE through the 2009 American ...
... butterfly wings has inspired a 3.2m, three-year research project ... security, energy and the environment. The University of Exeter ... collaborative contract to develop new technologies based on groundbreaking ... years a team of physicists from the University of ...
... and industry leaders from around the world will gather ... Targets and Cancer Therapeutics International Conference, which will feature ... "Cancer is a complex disease and to treat ... activity that takes place at the molecular level," said ...
Cached Biology News:UAB, partners seek safe carbon dioxide storage for 'greener' power generation 2UAB, partners seek safe carbon dioxide storage for 'greener' power generation 3£3.2m ($5.4 million) research project to capture brilliance of butterfly wings 2
(Date:8/27/2015)... TRIANGLE PARK, N.C. , Aug. 27, 2015 ... on the decision by FedEx, UPS and The ... of certain biological specimens classified as ,select agents, ... and long history of handling these sensitive shipments. ... knowledge of global transportation regulations, trained and certified ...
(Date:8/26/2015)... N.J. , Aug. 26, 2015  Roka Bioscience, ... focused on providing advanced testing solutions for the detection ... CEO will present at the Sidoti & Company Emerging ... conference will be held at the New York Marriott ... presentation will be available through the investor relations section ...
(Date:8/26/2015)... Intrexon Corporation (NYSE: XON ), a ... its previously announced public offering of common stock, including ... option to purchase an additional 731,707 shares of common ... share.  The exercise of the underwriters, option brought the ... Intrexon to 5,609,756 shares and increased the total gross ...
(Date:8/26/2015)... SPRINGS, Florida , August 26, 2015 /PRNewswire/ ... of the biggest factors fueling the optimism in ... approvals, M&A,s, collaborations and life sciences advancements.  Active ... developments are Pressure BioSciences, Inc. (OTCQB: PBIO), Sequenom, ... (NASDAQ: SRPT ), Raptor Pharmaceutical Corp. (NASDAQ: ...
Breaking Biology Technology:Marken Ensures Safe Transportation Of Select Agents And Toxins 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 4New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 2New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 3New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 4New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 5New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 6New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 7
... Today the Purchase Agreement Entered Into Between Genmab, ... PDL,s Manufacturing ... Received Antitrust Clearance, COPENHAGEN, February 26 Genmab ... into between Genmab and,PDL BioPharma, Inc. under which Genmab ...
... growth ... 2007 Highlights: * Product revenues increased ... oximeter units increase 20% to 116,300 units, IRVINE, Calif., Feb. 26 ... Low Perfusion pulse oximetry, today announced its financial,results for both the quarter and ...
... in Q4 2006 - a 45% ... increase Q4 2007 ... Q4 2007 New Bookings ... ), a leading provider of centralized ECG,eClinical technology, ePRO and other services to the ...
Cached Biology Technology:Purchase Agreement for Antibody Manufacturing Facility Receives Antitrust Clearance 2Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 2Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 3Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 4Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 5Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 6Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 7Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 8Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 9Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 10Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 11Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 12eResearchTechnology Reports Fourth Quarter and Full Year 2007 Results 2eResearchTechnology Reports Fourth Quarter and Full Year 2007 Results 3eResearchTechnology Reports Fourth Quarter and Full Year 2007 Results 4eResearchTechnology Reports Fourth Quarter and Full Year 2007 Results 5eResearchTechnology Reports Fourth Quarter and Full Year 2007 Results 6eResearchTechnology Reports Fourth Quarter and Full Year 2007 Results 7eResearchTechnology Reports Fourth Quarter and Full Year 2007 Results 8eResearchTechnology Reports Fourth Quarter and Full Year 2007 Results 9
Thermo Forma provides an array of accessory Racks for the Cryo/CryoPlus 16" Diameter storage system. To maximise inventory capacity a Jumbo Arrowhead configuration is recommended. You may choose betw...
Immulon 1 B 1x12 Strip, flat bottom; consistent medium binding affinity for hydrophobic complexes and proteins....
The Holten Horizontal series of laminar airflow work benches offers comfort and ease of use....
The 891 45° Fixed Angle Rotor is designed to provide aerosol containment and can be removed from a centrifuge (seal entact) and opened under an environmental hood....
Biology Products: