Navigation Links
Men and women are different in terms of genetic predispositions
Date:9/20/2012

We are not all the same when it comes to illness. In fact, the risk of developing a disease such as diabetes or heart disease varies from one individual to another. A study led by Emmanouil Dermitzakis, Louis-Jeantet Professor at the Faculty of Medicine of the University of Geneva (UNIGE) reveals that the genetic predisposition to develop certain diseases may differ from one individual to another depending on their sex. Together with his collaborators, the professor has shown that genetic variants have a different impact on the level of gene expression between men and women. The results of this research have been published in the scientific journal Genome Research.

For decades geneticists have been interested in genetic variants that affect the level of gene expression. These variants spark the interest of researchers because they play a role in the predisposition to certain diseases. Professor Dermitzakis' team from UNIGE, in collaboration with Oxford University, focused on the fundamental differences in the genetics of gene expression between men and women. After analyzing the impact of genetic variants on the level of gene expression in women, and then in men, the scientists have found that the effect of certain variants affecting gene expression and the genetic risk of developing a disease resulting from these genetic variants is different depending on the sex of the individual.

Everyone will agree that men and women are different but, beyond the obvious, genetics brings to light more subtle differences. The researchers found that even with the same DNA mutation in men and in women, the impact on the level of gene expression will be different. Of all the genetic variants that have an impact on the level of gene expression, about 15% work differently depending on whether they are acting upon a man or a woman.

We already knew that certain environmental factors like diet had a variable impact depending on the sex of an individual
'/>"/>

Contact: Emmanouil Dermitzakis
emmanouil.dermitzakis@unige.ch
41-223-795-483
Universit de Genve
Source:Eurekalert

Page: 1 2

Related biology news :

1. 2 servings of salmon a week is healthy for pregnant women and their babies
2. American Society of Plant Biologists honors early career women scientists
3. Supplement use predicts folate status in Canadian women
4. Knee injuries in women linked to motion, nervous system differences
5. Women & Infants participating in study of treatment of common viral infection in pregnancy
6. Vitamin D for pregnant women and babies -- how much is enough?
7. Breast cancer in young women: A distinct disease
8. Womens scientific achievements often overlooked and undervalued
9. Brain circuitry is different for women with anorexia and obesity
10. Considerable prevalence of both malaria, STIs exist among pregnant women in sub-Saharan Africa
11. UCSB anthropologists finds high levels of omega-3 fatty acids in breast milk of Amerindian women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... Deutschland und GERMANTOWN, Maryland , June ... ®   Produktlinie mit DNA-Tests verbessert den ... (NASDAQ: QGEN ; Frankfurt Prime Standard: QIA) hat ... STR-Testkits der Produktlinie Investigator ® ... Markt eingeführt. Die neuen Kits zur Erstellung genetischer Fingerabdrücke ...
(Date:6/17/2015)... , June 17, 2015  Crossmatch™, a leading ... that its U.are.U ® 4500 fingerprint readers ... Eateries, Inc., a San Jose, ... to increase security, improve accountability and reduce fraud ... instant, non-repudiable identity confirmation for employee sign in ...
(Date:6/16/2015)... 16, 2015 Fingerprint Cards has received ... in the company,s portfolio from one of its module partners ... mainly take place during the third quarter 2015. The sensors ... . Jörgen Lantto, CEO of FPC, comments: ...   growing interest from smartphone OEMs in integrating touch fingerprint ...
Breaking Biology News(10 mins):QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2
... in Colombia,s Cerrejn coal mine by researchers from the Smithsonian ... Natural History helps to explain the origin of one of ... Cerrejonemys wayuunaiki takes its genus name from Cerrejn, ... spoken by the Wayuu people who live on the Guajira ...
... if you are making cellulosic ethanol, you want less lignin ... are using pyrolytic methods, you want more lignin because lignin ... or minimize lignin content, an understanding of lignin synthesis is ... adaptation to life on land, as it strengthens plant cell ...
... through which it can protect itself against newly-developing cancer ... in our organs every day. Once tumours have developed, ... from the immune system. Scientists from the research group ... (HZI) in Braunschweig have now succeeded to reveal a ...
Cached Biology News:Convergent evolution in lignin biosynthesis: Tools for re-engineering biomass composition 2The immune system's guard against cancer 2The immune system's guard against cancer 3
(Date:7/1/2015)... 1, 2015   Decision Resources Group ... of Otezla are its oral administration, alternative mechanism ... by surveyed rheumatologists. Otezla was the first oral ... of active psoriatic arthritis in the ... care includes conventional oral treatments including disease-modifying antirheumatic ...
(Date:7/1/2015)... and BANGALORE, India , ... genomic profiling company that uses next generation sequencing technology ... Scott A. Storrer as chief executive officer. ... he will be responsible for all strategy, business expansion ... , who has served as Strand,s chairman and CEO ...
(Date:7/1/2015)... , July 1, 2015  Axovant Sciences ... focused on the treatment of dementia, today announced ... on July 22 at 5:45 p.m. EDT following ... Alzheimer,s Association International Conference 2015 (AAIC). ... , Dr. Lawrence Friedhoff , ...
(Date:7/1/2015)... ... 2015 , ... A newly launched business plan contest will ask startup companies ... in life sciences R&D. The Pistoia Alliance President’s Startup Challenge 2015 will see small ... period of expert mentorship from a senior industry figure drawn from the Pistoia Alliance ...
Breaking Biology Technology:Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 2Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 3Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 2Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 3Pistoia Alliance Launches Startup Challenge 2Pistoia Alliance Launches Startup Challenge 3
... Feb. 1 Fears that the economy is not,only ... had,investors in a skittish mood during January. However, biotech ... well ahead of the,NASDAQ, which posted a January loss ... "Healthcare is usually able to ride out extremely volatile ...
... 1 Taligen Therapeutics, Inc. today,announced it anticipates ... Series B,financing. The financing was led by Alta ... including Sanderling Ventures, Tango,and High Country Venture., ... infusion of capital but the,addition of two world ...
... DIEGO, Feb. 1 Cardium Therapeutics (Amex:,CXM) ... million registered direct,offering with institutional and other ... on January 31, 2008. Empire Asset Management,Company ... the transaction., (Logo: http://www.newscom.com/cgi-bin/prnh/20051018/CARDIUMLOGO ), ...
Cached Biology Technology:January Market Jitters Fails to Derail Biotech 2January Market Jitters Fails to Derail Biotech 3January Market Jitters Fails to Derail Biotech 4Taligen Therapeutics Secures Series B Financing 2Cardium Completes $5.3 Million Registered Direct Offering 2Cardium Completes $5.3 Million Registered Direct Offering 3Cardium Completes $5.3 Million Registered Direct Offering 4