Navigation Links
Men and women are different in terms of genetic predispositions
Date:9/20/2012

We are not all the same when it comes to illness. In fact, the risk of developing a disease such as diabetes or heart disease varies from one individual to another. A study led by Emmanouil Dermitzakis, Louis-Jeantet Professor at the Faculty of Medicine of the University of Geneva (UNIGE) reveals that the genetic predisposition to develop certain diseases may differ from one individual to another depending on their sex. Together with his collaborators, the professor has shown that genetic variants have a different impact on the level of gene expression between men and women. The results of this research have been published in the scientific journal Genome Research.

For decades geneticists have been interested in genetic variants that affect the level of gene expression. These variants spark the interest of researchers because they play a role in the predisposition to certain diseases. Professor Dermitzakis' team from UNIGE, in collaboration with Oxford University, focused on the fundamental differences in the genetics of gene expression between men and women. After analyzing the impact of genetic variants on the level of gene expression in women, and then in men, the scientists have found that the effect of certain variants affecting gene expression and the genetic risk of developing a disease resulting from these genetic variants is different depending on the sex of the individual.

Everyone will agree that men and women are different but, beyond the obvious, genetics brings to light more subtle differences. The researchers found that even with the same DNA mutation in men and in women, the impact on the level of gene expression will be different. Of all the genetic variants that have an impact on the level of gene expression, about 15% work differently depending on whether they are acting upon a man or a woman.

We already knew that certain environmental factors like diet had a variable impact depending on the sex of an individual. Today, we are able to confirm that genetic variants have a different impact on the level of gene expression in men and women; that is to say that although two individuals of opposite sex both have a same variant predisposing them to a disease, they will not have the same propensity to develop it, states Professor Dermitzakis.


'/>"/>

Contact: Emmanouil Dermitzakis
emmanouil.dermitzakis@unige.ch
41-223-795-483
Universit de Genve
Source:Eurekalert

Related biology news :

1. 2 servings of salmon a week is healthy for pregnant women and their babies
2. American Society of Plant Biologists honors early career women scientists
3. Supplement use predicts folate status in Canadian women
4. Knee injuries in women linked to motion, nervous system differences
5. Women & Infants participating in study of treatment of common viral infection in pregnancy
6. Vitamin D for pregnant women and babies -- how much is enough?
7. Breast cancer in young women: A distinct disease
8. Womens scientific achievements often overlooked and undervalued
9. Brain circuitry is different for women with anorexia and obesity
10. Considerable prevalence of both malaria, STIs exist among pregnant women in sub-Saharan Africa
11. UCSB anthropologists finds high levels of omega-3 fatty acids in breast milk of Amerindian women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)...  Veratad Technologies, LLC ( www.veratad.com ), an innovative ... verification solutions, announced today they will participate as a ... thru May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions ... evolving digital world, defining identity is critical to nearly ...
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert ... a media edge server, the M820, which features the company,s hybrid ... software provided by Tera Probe, Inc., will be showcased during the ... the NAB show at the Las Vegas ... ...
(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... grow at a CAGR of 30.37% during the period 2017-2021. ... prepared based on an in-depth market analysis with inputs from industry ... over the coming years. The report also includes a discussion of ...
Breaking Biology News(10 mins):
(Date:6/19/2017)... ... June 19, 2017 , ... As Vice President, Product ... including training, implementation, support, and client process and SOP development. , Mr. Guinter ... held leadership roles for service providers and top-tier pharmaceuticals, and as an independent ...
(Date:6/19/2017)... (PRWEB) , ... June 19, 2017 , ... A colony ... among its cells and tissues by delivering pollen and nectar containing nutrients necessary for ... means to stay healthy. , Many recent indicators point to a decline in honey ...
(Date:6/16/2017)... ... June 16, 2017 , ... CTNext , Connecticut’s go-to resource for ... at The LOFT at Chelsea Piers in Stamford. , Nine finalists, all of whom ... judges for an opportunity to secure $10,000 awards to help support business growth. The ...
(Date:6/15/2017)... ... June 15, 2017 , ... The ... an artist’s journey through creative experimentation and interdisciplinary collaboration. Feature Creep, a solo ... 22nd. An opening reception will be held at EKG, located at 3600 Market ...
Breaking Biology Technology: