Navigation Links
Medical imaging breakthrough uses light and sound to see microscopic details inside our bodies

See it for yourself: a new breakthrough in imaging technology using a combination of light and sound will allow health care providers to see microscopic details inside the body. Access to this level of detail potentially eliminates the need for some invasive biopsies, but it also has the potential to help health care providers make diagnoses earlier than ever beforeeven before symptoms arise. Details describing this advance are published online in the FASEB Journal (

In the online research report, researchers from St. Louis describe how they combined photoacoustic tomography (PAT) with gold nanobeacons (GNB) to achieve an unprecedented level of imaging detail. Specifically, the researchers were able to identify the first signs of new blood vessel growth, which is necessary for new tumors to form. Specifically, not only were the newest blood vessels with initial blood flow imaged, but pre-vessel formation of inter-vessel bridges and vessel off-shoot sprouts in which blood flow had yet to begin also were captured. This is the first time that the angiogenic process was imaged in such clear detail without a microscope. The scientists anticipate that the combined use of PAT and GNB will be able to further pinpoint precise molecular disease markers.

According to one of the researchers involved in the work, Dipanjan Pan, Ph.D. from the Consortium for Translational Research in Advanced Imaging and Nanomedicine at the Washington University School of Medicine, "This study further establishes the opportunity provided by molecular imaging and photoacoustic tomography to identify, characterize, and guide the rational management of high-risk patients with life-threatening disease earlier when treatment is the most likely to help and quality of life is best preserved."

To make this advance, the researchers implanted mice with a gel (Matrigel) that stimulates natural capillary formation, mimicking the same process occurring in an aggressive cancer or unstable atherosclerotic plaque. Then they used GNB to target a prominent molecular indicator of proliferating new vessels. Unlike common ultrasound techniques that send in a sound wave and "listen" for the echo, PAT sends in a light beam that excites and warms certain proteins, such as the hemoglobin in red blood cells. The minutely heated proteins emit a sound wave that is then detected by the ultrasound transducer.

"This type of imaging verges on Star Trek territory," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "We're now exploring inner space with tools developed for outer space.

Early tumors and latent infections give rise to microscopic changes in blood vessels that no one could pick up until this technique came along. It's the new age of nanomedicine."


Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Related biology news :

1. American College of Medical Genetics receives $13.5M NIH contract
2. Researchers design artificial cells that could power medical implants
3. Salk scientist Fred H. Gage to receive the Keio Medical Science Prize
4. New book dissects statistics for doctors and medical students
5. Supercomputer provides massive computational boost to biomedical research at TGen
6. A card-swipe for medical tests
7. Rhode Island Hospital simulation center examines benefits and applications of medical simulation
8. Case Western Reserve receives Ellison Medical Foundation New Scholar in Aging award
9. NC State finds new nanomaterial could be breakthrough for implantable medical devices
10. TECNALIA investigates advanced biomaterials to make more reliable and hardwearing medical implants
11. New book helps medical students master clinical skills
Post Your Comments:
(Date:5/20/2016)... -- VoiceIt is excited to announce its new marketing ... working together, VoiceIt and VoicePass will offer an ... slightly different approaches to voice biometrics, collaboration between ... Both companies ... "This marketing and technology partnership allows VoiceIt ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... of Infosys (NYSE: INFY ), and Samsung SDS, ... partnership that will provide end customers with a more ... payment services.      (Logo: ) ... financial services, but it also plays a fundamental part in ...
(Date:4/15/2016)...  A new partnership announced today will help ... in a fraction of the time it takes ... life insurance policies to consumers without requiring inconvenient ... Diagnostics, rapid testing (A1C, Cotinine and HIV) and ... weight, pulse, BMI, and activity data) available at ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, former senior ... the University of North Carolina Kenan-Flagler Business School effective June 27. ... Kenan-Flagler, with a focus on the school’s international efforts, leading classes and participating ...
(Date:6/27/2016)... BOSTON , June 27, 2016   Ginkgo ... biology to industrial engineering, was today awarded as ... a selection of the world,s most innovative companies. ... at scale for the real world in the ... organism engineers work directly with customers including Fortune ...
(Date:6/24/2016)... SAN DIEGO , June 24, 2016 /PRNewswire/ ... that more sensitively detects cancers susceptible to PARP ... individual circulating tumor cells (CTCs). The new test ... of HRD-targeted therapeutics in multiple cancer types. ... therapies targeting DNA damage response pathways, including PARP, ...
(Date:6/24/2016)... ... ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical journal articles ... findings are the subject of a new article on the Surviving Mesothelioma website. ... blood, lung fluid or tissue of mesothelioma patients that can help point doctors to ...
Breaking Biology Technology: