Navigation Links
Mechanisms involved in resistance to the bacteria Salmonella studied in a Ph.D. thesis
Date:2/6/2013

This press release is available in Spanish.

In their natural environment bacteria develop by forming communities of micro-organisms called biofilms that afford them greater resistance. These biofilms on farms and premises where food is processed lead to considerable economic losses besides being a potential source of contamination and transmission of the pathogen. In her PhD thesis,Violeta Zorraquino-Salvo has studied a specific protein type that activates the formation of biofilm in Salmonella and regulates bacterial motility. "Having a better idea of the mechanisms involved in these processes will help to design new, more effective strategies for preventing the formation of biofilm and its potential harm in the clinical, food and industrial ambit," points out the researcher.

Two decades ago it was discovered that a small molecule (the so-called c-di-GMP) could on its own hamper motility and activate the formation of biofilm. "This molecule is part of a signal transduction system: there are different sensory membranes on the membrane of the bacteria that pick up stimuli from the outside and transduce them into different intracellular levels of c-di-GMP, thus regulating different biological processes like biofilm formation. "In the first part of her thesis Zorraquino removed all the sensory proteins from the Salmonella's genome."We created a mutant Salmonella incapable of picking up stimuli from the medium in which it lives and therefore of producing biofilm under any circumstances. "After that, each sensory protein was inserted one by one to be able to analyse, under different ambient conditions, how each one contributed to the formation of biofilm. "We showed that under each condition tested, only some proteins are active, so each one is most likely responsible for the formation of biofilm whena given condition is present."

These results have enabled researchers to get a better idea about the mechanism by which Salmonella activates the formation of biofilm. "We have generated new knowledge that could be used to design new strategies to help to prevent the formation of biofilm in our factories and on our farms," as Violeta Zorraquino pointed out.

Bacterial motility

The second part of her research focussed on studying the effect of the same molecule (c-di-GMP) in another of Salmonella's biological processes: bacterial motility.A bacterium is capable of moving freely in a liquid medium by rotating its flagella, and when it reaches a suitable surface, it sticks to it and begins to create the biofilm."There is an intervening stepbetween being motile and sticking to a surfacein which the bacterium has to stop the rotation of its flagella completely. We have discovered what is responsible for this intervening step: cellulose, which is a component of biofilm, and the synthesis of which is activated in the presence of the c-di-GMP molecule."


'/>"/>

Contact: Oihane Lakar Iraizoz
o.lakar@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Related biology news :

1. FASEB SRC announces: Molecular Mechanisms & Physiological Consequences of Protein Aggregation
2. FASEB SRC announces conference registration open for: Neural Mechanisms in Cardiovascular Regulation
3. FASEB SRC announces conference registration open for: Mechanisms in Plant Development Conference
4. X-rays reveal the self-defence mechanisms of bacteria
5. Mechanisms for a beneficial effect of moderate alcohol consumption on osteoporosis in women
6. Researchers identify mechanisms that allow embryonic stem cells to become any cell in the human body
7. Force of nature: Defining the mechanical mechanisms in living cells
8. Symposium: Protein-Folding Diseases: Models & Mechanisms
9. Discovery of mechanisms predicting response to new treatments in colon cancer
10. UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
11. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, ... secure authentication solutions, today announced that it has ... Advanced Research Projects Activity (IARPA) to develop next-generation ... program. "Innovation has been a driving ... Thor program will allow us to innovate and ...
(Date:4/11/2017)... , April 11, 2017 NXT-ID, Inc. ... technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate governance ... Gino ... we look forward to their guidance and benefiting from their ...
(Date:4/5/2017)... 2017 Today HYPR Corp. , leading ... component of the HYPR platform is officially FIDO® ... security architecture that empowers biometric authentication across Fortune 500 ... secured over 15 million users across the financial services ... home product suites and physical access represent a growing ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and cooking events company, ... today. The bold new look is part of a transformation to increase awareness, ... significant growth period. , It will also expand its service offering from its signature ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... Dr. Bob ... at his local San Diego Rotary Club. The event entitled “Stem ... CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two ...
(Date:10/10/2017)... BARBARA, CALIFORNIA (PRWEB) , ... October 10, 2017 ... ... management, technological innovation and business process optimization firm for the life sciences and ... BoxWorks conference in San Francisco. , The presentation, “Automating GxP Validation ...
(Date:10/9/2017)... Jupiter, FL (PRWEB) , ... October 09, 2017 , ... ... episode, scheduled to broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on ... Agriculture industry is faced with the challenge of how to continue to feed a ...
Breaking Biology Technology: