Navigation Links
Mayo Clinic: Brain disorder suggests common mechanism may underlie many neurodegenerative diseases
Date:1/11/2009

, which include early-onset parkinsonism (stiffness, slowness and rigidity), depression, severe weight loss, and increasing difficulty in breathing. Once symptoms occur, typically in the patient's mid-40s, the disease is rapidly progressive and fatal.

In a subsequent study published in August 2008, the consortium reported that eight patients who died from the disease had substantial loss of neurons in the midbrain area known as the substantia nigra. They also found a molecular signature of Perry syndrome "inclusions," or clumps, of a protein known as TDP-43 which is found in patients with frontotemporal dementia or with motor neuron disease. What these clumps represent is not known, says co-author and neuropathologist Dennis Dickson, M.D. "But they are clearly a marker of the disease process in all of these disorders, suggesting a common process is perturbed," he says.

Mayo geneticists hypothesized that Perry syndrome may be caused by mutations within the same gene, even though families afflicted with this disorder are unrelated, and come from different continents. The disease is autosomal dominant, meaning that the chance of inheriting the disease is 50 percent if one parent carries a copy of a mutant gene. With the help and participation of eight families with Perry syndrome, the Mayo-led team set out to find the defective gene.

They determined that each family had one of five novel mutations in the DCTN1 gene, whose protein produces a large subunit of the dynactin complex known as p150glued. This protein is essential to the movement of cargo along the microtubule rails. "Curiously, the mutations all cluster in the p150glued cytoskeleton-associated protein glycine-rich domain and its 'GKNDG' binding motif," Dr. Farrer says. "This region acts like a parking brake, so Perry mutations in p150glued mean that this brake is affected. It would be analogous to driving that train with faulty brakes."

What amazed the researchers ar
'/>"/>

Contact: Kevin Punskky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Invasion of the brain tumors
2. HIV is a double hit to the brain
3. AIDS interferes with stem cells in the brain
4. 60 second test could help early diagnosis of common brain diseases
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Influence of sex and handedness on brain is similar in capuchin monkeys and humans
8. Inside the brain of a crayfish
9. Specific brain protein required for nerve cell connections to form and function
10. Brains timing linked with timescales of the natural visual world
11. Adult brain can change, study confirms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... Lithuania , March 2, 2015   Neurotechnology ... technologies, today introduced the SentiGaze Software Development Kit ... to create applications that use off-the-shelf webcams to track ... user gazes at a monitor. Heatmaps can be used ... the effectiveness of online advertising. The SDK can also ...
(Date:2/24/2015)... YORK , Feb. 24, 2015 This report analyzes ... by the following Segments: Face Biometrics, and Voice Biometrics. The report ... , Japan , Europe , ... & Africa , and Latin America ... 2013 through 2020. Also, a seven-year historic analysis is provided for ...
(Date:2/19/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kx9zp8/military ) ... Electro-Optical / Infrared Systems Market by Type, by ... to 2020" report to their offering. ... expected to reach $16.35 billion by 2020, to ... report segments the military electro-optical/infrared systems market on ...
Breaking Biology News(10 mins):Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 3World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3
... policymakers to encourage the transition from coal-based electricity production to ... Such a mechanism would help limit carbon dioxide (CO ... in Copenhagen last December, the United States pledged to reduce ... percent by 2020. Dagobert Brito, the George A. ...
... DURHAM, N.C. -- Faced with threats such as habitat ... worldwide may become extinct before scientists can even discover them, ... American and British researchers in the journal Proceedings of ... overall, there could be between 5 million and 50 million ...
... NC In its early stages, prostate cancer requires ... male sex characteristics) for growth, and current first-line therapies ... development and spread. However, advanced prostate ... ineffective. Scientists aren,t sure how this shift occurs ...
Cached Biology News:Researchers calculate the cost of CO2 emissions, call for carbon tax 2Thousands of undiscovered plant species face extinction 2UNC team finds new target for treatment of advanced prostate cancer 2
(Date:3/3/2015)... , March 3, 2015  RegeneRx Biopharmaceuticals, Inc. ... in the scientific journal, Expert Opinion on Biological ... colleague, Dr. Zhenggang Zhang , at the Henry ... reported that Thymosin beta 4 (TB4) has the capacity ... 24 hours or more post-injury, leading to neurological recovery ...
(Date:3/3/2015)... 03, 2015 Becht Engineering Co., ... it has acquired The CECON Group, Inc., located ... were not announced. , Becht Engineering (http://www.becht.com ... sector including oil and gas production, refining, petrochemical, ... nuclear power sectors. The company has twelve offices ...
(Date:3/3/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/gxqhg9/gene_therapy ) ... report "Gene Therapy - Technologies, Markets and ... Gene therapy technologies are described in detail ... with genetically modified vectors. Gene therapy is an ... of administration as well as targeted gene therapy ...
(Date:3/3/2015)... 2015 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ... announced it has initiated commissioning activities for its 30,000 ... Sarnia, Ontario , Canada.  Commissioning ... with the facility being in commercial operation in Q3 ... two months and it is carrying out commissioning and ...
Breaking Biology Technology:Researchers at Henry Ford Hospital Propose Thymosin Beta 4 as Novel Way to Treat Neural Injury and Neurodegenerative Diseases 2Researchers at Henry Ford Hospital Propose Thymosin Beta 4 as Novel Way to Treat Neural Injury and Neurodegenerative Diseases 3Gene Therapy Market Report 2014-2024 - Technologies, Markets and Companies 2Gene Therapy Market Report 2014-2024 - Technologies, Markets and Companies 3BioAmber Begins Commissioning of Sarnia Commercial Plant 2BioAmber Begins Commissioning of Sarnia Commercial Plant 3
... api Software, Inc . has entered into agreements to provide ... systems, for whom it may become a key retention tool. ... that parts of the bundle play a role in staff ... severe nursing shortages. , ,Shift bidding, for example, has ...
... around the Midwest looking for new ways to increase ... of bringing in developers to develop open lands and ... with tax incentives and reduced fees to relocate a ... common practice with even large municipalities in Chicago giving ...
... Court in eBay Inc. v. Mercexchange LLC, held that ... granted an injunction must be determined under the standard ... inadequacy of remedies at law; (3) balancing of hardships; ... Federal Circuit's approach that an injunction should be granted ...
Cached Biology Technology:Medical software may be a retention tool 2Electronic signs for municipalities: Las Vegas or lost revenues? 2Electronic signs for municipalities: Las Vegas or lost revenues? 3Electronic signs for municipalities: Las Vegas or lost revenues? 4Supreme Court decision in eBay case could affect value of patents 2
Form: Concentrated Applications: ELISA...
Request Info...
Form: Ready to use Applications: ELISA...
... have hydrophobic plastic supports that retain stiffness ... toxic/hazardous solutions. Paper segments on each strip ... solution. Complementary indicator charts provide clear comparison. ... 1pH units; In packs of 100; each ...
Biology Products: