Navigation Links
Mature T cells can switch function to better tackle infection
Date:1/20/2013

The fate of mature T lymphocytes might be a lot more flexible than previously thought. New research from the RIKEN Center for Allergy and Immunology (RCAI) in Japan and La Jolla Institute for Allergy and Immunology (LIAI) in the USA shows for the first time that mature CD4+ helper T lymphocytes can be re-programed to become killer-like CD8+ T lymphocytes and gain killing functions.

The findings are reported today in the journal Nature Immunology, by a team of researchers led by Ichiro Taniuchi from RIKEN and Hilde Cheroutre from La Jolla. The team show using transgenic mice that mature CD4+ helper T lymphocytes that have lost the transcription factor ThPOK express genes specific to CD8+ killer T lymphocytes upon exposure to a specific environmental stimulation such as the gut. This turns them into killer cells that might act to control infection.

CD4+ helper T lymphocytes and CD8+ killer T lymphocytes are important players in the body's defense mechanism against infection. CD4+ helper T lymphocytes normally only assist other cells of the immune system during an infection, whereas CD8+ killer T cells are the main actors in the elimination of infected cells.

Both types of cells are generated in the thymus, where their early precursors develop first into cells bearing both CD4 and CD8 markers. These CD4+ CD8+ cells then differentiate into cells bearing either the CD4 or CD8 marker and take on either a helper (CD4+) or killer (CD8+) fate.

The transcription factor ThPOK is known to play a crucial role in the fate determination of T lymphocytes in the thymus. It represses genes specific to CD8+ cells in precursors of helper T cells and prevents these cells from differentiating into CD8+ killer cells. The expression of ThPOK continues in mature CD4+ helper T cells and is repressed in mature CD8+ cells.

In the study, Taniuchi, Cheroutre and colleagues show that upon deactivation of ThPOK, mature CD4+ T cells revert
'/>"/>

Contact: Juliette Savin
pr@riken.jp
81-048-462-1225
RIKEN
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stopping flies before they mature
2. International team discovers likely basis of birth defect causing premature skull closure in infants
3. Ethylene of no effect -- why peppers do not mature after picking
4. Ethylene of no effect - why peppers do not mature after picking
5. Antioxidant shown to reduce blindness risk in extremely premature babies
6. New musical pacifier helps premature babies get healthy
7. Scientists uncover exciting lead into premature aging and heart disease
8. New analysis of premature infants heartbeats, breathing could be cues for leaving NICU
9. Quadruple helix DNA discovered in human cells
10. La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
11. Using snail teeth to improve solar cells and batteries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... , August 22, 2014 /PRNewswire/ ... http://www.researchandmarkets.com/research/mtm27l/biometrics_market ) has announced the addition ... America 2014-2018"  report to their offering.  ... , ,Biometrics is a technology that ... based on their physical or behavioral ...
(Date:8/22/2014)... leading source of information for businesses and professionals, has ... in its 2014 list of "some of the best ... the list, the company analyzed citation data over 11 ... had enormous impact. , The following UC Riverside researchers ... greatest number of highly cited papers in one of ...
(Date:8/22/2014)... Research presented at the 29th Annual International Papillomavirus ... Hera Therapeutics Inc. combats three types of human ... of all cervical cancer. , When tested in ... replication of HPV-16, HPV-18 and HPV-11 cells, according ... Ph.D., who presented the findings at the Seattle ...
Breaking Biology News(10 mins):Biometrics Market in North America 2014-2018: Key Vendors are 3M Cogent, Cross Match, NEC and Safran SA 2Biometrics Market in North America 2014-2018: Key Vendors are 3M Cogent, Cross Match, NEC and Safran SA 35 UC Riverside scientists among world's most influential scientific minds 2
... tap the vast, unexplored reaches of the earth,s microbial ... DOE Joint Genome Institute (DOE JGI) has announced its ... undertake in the coming year. The 44 projects, culled ... Program (CSP), represent over 60 billion nucleotides of data ...
... in Spanish . Most of the functions ... proteins, which recognise their binding partner by affinity features localized ... however, the most complicated to study from the perspective of ... interaction is brief and occurs through a large section of ...
... trials to find a successful vaccine against footrot in ... funding of $663,000 from Australian Wool Innovation (AWI) ... at Monash University,s Australian Research Council Centre of Excellence ... of Sydney. Chief investigator Professor Julian Rood said ...
Cached Biology News:US Department of Energy Joint Genome Institute announces new genome sequencing projects 2US Department of Energy Joint Genome Institute announces new genome sequencing projects 3US Department of Energy Joint Genome Institute announces new genome sequencing projects 4US Department of Energy Joint Genome Institute announces new genome sequencing projects 5US Department of Energy Joint Genome Institute announces new genome sequencing projects 6US Department of Energy Joint Genome Institute announces new genome sequencing projects 7Scientists reveal the key mechanisms for affinity between transient binding proteins 2Footrot vaccine closer than ever 2
(Date:8/22/2014)... August 22, 2014 Today the Academy of ... United States Court of Appeals for the D.C. Circuit challenging ... published in the Federal Register on June 25, 2014. ... contrary to the text and intent of the FAA Modernization ... Congress’ specific prohibition on any new rules or regulations regarding ...
(Date:8/22/2014)... BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced results for ... complete 2014 second quarter financial statements and MD&A have been filed on ... 30, , Six-months ended June 30, ( in CDN$,000 except ... , 2014 , 2013 Revenue , 2,459 ... profit , 56 , 1,485 , 385 ...
(Date:8/22/2014)... have discovered how the receptors responsible for contractions in ... new study, published today in The FASEB Journal ... regulates the cycle of all cells in the body. ... biological clock and its control are weakened in ageing ... physiology and ageing. , While currently much ...
(Date:8/22/2014)... (August 22nd), in the scientific journal PLoS ... establish the effect of serotonin on sensitivity to ... optical techniques., "Serotonin is a small molecule known ... brain functions, from the control of sleep and ... This neurotransmitter is also popularly thought to contribute ...
Breaking Biology Technology:AMA Files Petition for Review of FAA’s Interpretive Rule 2Biorem Reports 2014 Second Quarter Results 2Biorem Reports 2014 Second Quarter Results 3Treatment for overactive bladder and irritable bowel syndrome advanced through pioneering research 2From happiness to pain: Understanding serotonin's function 2
... Third Wave Technologies Inc. (Nasdaq: TWTI) today announced ... assays to RIKEN in Japan for use in various large ... Wave has been supplying its Invader SNP assays to Dr. ... Medicine at RIKEN, director of the Genome Center ...
... hit the road , ,MILWAUKEE - Ask any successful ... and you will get one answer: SALES. Despite this, sales ... in business school curricula today. What They Dont Teach You ... the Kellogg Alumni Club of Chicago titled Creating, Growing and ...
... between U.S. white collar workers and those in India is ... ,IT Manager ,U.S: $55,000 ,India: $8,500 , ,Accountant ,U.S.: $41,000 ... States were almost solely in the manufacturing sector, as more ... other Latin American countries to cut costs. Not to mention ...
Cached Biology Technology:Sales Strategies for the High-Tech Entrepreneur 2Sales Strategies for the High-Tech Entrepreneur 3Sales Strategies for the High-Tech Entrepreneur 4Sales Strategies for the High-Tech Entrepreneur 5Outsourcing Offshore - Wisconsin Companies Sending Work Abroad 2Outsourcing Offshore - Wisconsin Companies Sending Work Abroad 3
... • Small design specifically for western blots ... are specifically designed for staining western blots. ... 25 mm) of the disposable tray requires ... significant cost savings to the user. Pour ...
... pLivSelect is a direct ... recombinant identification. Recombinant selection ... survival, eliminating the need ... This quick and inexpensive ...
... Signal Enhancer does for enzyme-/substrate-based blotting what intensifying ... the signal up to 10-fold (or one order ... Western Blot Signal Enhancer membrane treatment is a ... to your current Western blotting protocol. The result ...
... through columns is a well-known separation technique ... applications are in DNA/RNA extraction in microbiology, ... purification in chemical or analytical laboratories. ... Genesis series instruments for smaller scales. The ...
Biology Products: