Navigation Links
Mapping of cancer cell fuel pumps paves the way for new drugs
Date:4/28/2013

For the first time, researchers at Karolinska Institutet in Sweden have managed to obtain detailed images of the way in which the transport protein GLUT transports sugars into cells. Since tumours are highly dependent on the transportation of nutrients in order to be able to grow rapidly, the researchers are hoping that the study published in the scientific magazine Nature Structural & Molecular Biology will form the basis for new strategies to fight cancer cells.

In order to be able to fuel their rapid growth, cancer tumours depend on transporter proteins to work at high speed to introduce sugars and other nutrients that are required for the cell's metabolism. One possible treatment strategy would therefore be to block some of the transporters in the cell membrane which operate as fuel pumps, thus starving out and killing the cancer cells.

One important group of membrane transporters is the GLUT family, which introduces glucose and other sugars into the cell. Glucose is one of the most important energy sources for cancer cells and GLUT transporters have been shown to play a key role in tumour growth in many different types of cancer. In the current study, researchers from Karolinska Institutet have performed a detailed study of the way in which suger transport is executed by the protein XylE, from the Escherichia coli bacterium, whose function and structure is very similar to GLUT transporters in humans. For the first time, the researchers have described the way in which the protein's structure changes between two different conformations when it binds and transports a sugar molecule.

"In showing details of the molecular structure of the region that bind the sugar, our study opens up the opportunities to more efficiently develop new substances that may inhibit GLUT transporters", says Pr Nordlund at the Department of Medical Biochemistry and Biophysics, one of the researchers behind the study. "Information on the structure of t
'/>"/>

Contact: Karolinska Institutet Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related biology news :

1. Brain Activity Mapping Project aims to understand the brain
2. Mapping effort charts restoration tack for Great Lakes
3. Carnegie debuts revolutionary biosphere mapping capability at AGU
4. USDA scientists collaborate with global researchers to advance the mapping of the barley genome
5. Influenza research: Can dynamic mapping reveal clues about seasonality?
6. Physics and math shed new light on biology by mapping the landscape of evolution
7. Geosphere: How geology, technology, modeling, and mapping see into Earths past and present
8. Road-mapping the Asian brain
9. Beyond base pairs: Mapping the functional genome
10. Speeding up drug discovery with rapid 3-D mapping of proteins
11. Novel screening tests for liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)...  BellBrook Labs, a leader in high throughput screening ... a TR-FRET (time resolved Forster resonance energy transfer) ... high throughput screening assay for glycosyltransferases and other ... sensitive detection of hundreds of human and microbial ...
(Date:1/22/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) a ... the recent success of the Wocket™ smart wallet at CES 2015 in ... was named as one of the "11 Hot Products at CES" in ... At CES So Far" by Newseveryday.com and "The top 10 gadgets from ...
(Date:1/22/2015)... YORK , Jan. 21, 2015  Analyst Report Issued by ... Card Brands report showed that planet-wide, transactions at merchants on ... while the total number of credit, debit, and prepaid cards ... U.S. were victims of fraudulent card usage in 2012, and ...
Breaking Biology News(10 mins):BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2
... Australia, the United Kingdom and United States, including University of ... tactics, such as assisted migration, in the face of the ... policy ideas in a paper published July 18 in the ... that both the rapid rate of climate change and the ...
... as they evolve, biologists have unearthed several interesting patterns. ... members of a taxonomic group -- such as the ... elephant are often thousands or millions of times ... time two SFI researchers explain these patterns within an ...
... a close relative of the toadfish, doesn,t need good looks to ... nest for his potential partner, he calls to nearby females by ... buoyancy. The sound he makes is not a song or a ... a ballad. Female midshipman find it very alluring, and they only ...
Cached Biology News:Global warming experts recommend drastic measures to save species 2Predicting the distribution of creatures great and small 2When fish talk, scientists listen 2
(Date:1/22/2015)... Diego, California (PRWEB) January 22, 2015 ... Promotional Offer to their comprehensive portfolio of Eppendorf ... allows customers to purchase a Centrifuge 5424/5424 R and ... Bundle of either Eppendorf Research plus or Eppendorf Reference ...
(Date:1/22/2015)... Madison, WI (PRWEB) January 22, 2015 Dr. ... at the 12th annual Scripps Natural Supplements Pre-Conference seminar on ... Supplements Conference is an annual continuing education conference for health ... 15th and included the topic of probiotics in health. Dr. ...
(Date:1/22/2015)... January 22, 2015 Selexis SA, a ... Research Cell Banks (RCBs) used for drug discovery to ... Banks will include Next-Generation Sequencing (NGS) data ... de-risks biologic manufacturing by ensuring the integrity of the ...
(Date:1/22/2015)... , Nueva Jersey , 22 de enero ... for Biomedical Research abre hoy su llamada a nominaciones ... cuya investigación científica ha hecho, o tiene el potencial ... salud humana. Las nominaciones se aceptarán hasta el 15 ...
Breaking Biology Technology:Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4
... AcelRx Pharmaceuticals, Inc.,today announced positive results from ... efficacy of its lead product candidate, ARX-01, for ... replacement surgery.,The primary endpoint evaluated pain intensity (Sum ... 12-hour study period compared to baseline.,Results demonstrated that ...
... PAREXEL International Corporation,(Nasdaq: PRXL ), ... it has established an alliance with Safe Implementation,of ... network of,clinical sites with specialized capabilities in the ... from SITS, access to more than 800,investigator sites ...
... report that the small fraction of people who know ... finding has led many to assume that the public ... popular awareness grows, education expands and commercialization increases. , ... Cultural Cognition Project at Yale Law School in collaboration ...
Cached Biology Technology:AcelRx Pharmaceuticals Reports Positive Results From a Phase 2 Clinical Trial of Sublingual Sufentanil NanoTabs(TM) in Treating Post-Operative Pain 2AcelRx Pharmaceuticals Reports Positive Results From a Phase 2 Clinical Trial of Sublingual Sufentanil NanoTabs(TM) in Treating Post-Operative Pain 3PAREXEL Establishes Alliance with SITS Network of Clinical Sites Specializing in Stroke Studies 2PAREXEL Establishes Alliance with SITS Network of Clinical Sites Specializing in Stroke Studies 3PAREXEL Establishes Alliance with SITS Network of Clinical Sites Specializing in Stroke Studies 4Nanotech: To know it is not necessarily to love it 2
... phase extraction through columns is a well-known ... applications. Typical applications are in DNA/RNA extraction ... or compound purification in chemical or analytical ... on the Genesis series instruments for smaller ...
... pipetting software for life science applications on ... GENESIS WORKSTATION instruments including the Te-MO multichannel ... user the simple graphical configuration of the ... the powerful scripting language the most flexible ...
... consultation. Peptide synthesis and purification (>80% ... Conjugation to KLH. 5mg unconjugated peptide ... New Zealand white female rabbits. 70 ... production bleeds. Elisa testing Total ...
... is a comprehensive suite of advanced ... designed to reliably extract biological signals ... studies containing thousands of samples, Partek ... and will analyze large data sets ...
Biology Products: