Navigation Links
Mapping of cancer cell fuel pumps paves the way for new drugs
Date:4/28/2013

For the first time, researchers at Karolinska Institutet in Sweden have managed to obtain detailed images of the way in which the transport protein GLUT transports sugars into cells. Since tumours are highly dependent on the transportation of nutrients in order to be able to grow rapidly, the researchers are hoping that the study published in the scientific magazine Nature Structural & Molecular Biology will form the basis for new strategies to fight cancer cells.

In order to be able to fuel their rapid growth, cancer tumours depend on transporter proteins to work at high speed to introduce sugars and other nutrients that are required for the cell's metabolism. One possible treatment strategy would therefore be to block some of the transporters in the cell membrane which operate as fuel pumps, thus starving out and killing the cancer cells.

One important group of membrane transporters is the GLUT family, which introduces glucose and other sugars into the cell. Glucose is one of the most important energy sources for cancer cells and GLUT transporters have been shown to play a key role in tumour growth in many different types of cancer. In the current study, researchers from Karolinska Institutet have performed a detailed study of the way in which suger transport is executed by the protein XylE, from the Escherichia coli bacterium, whose function and structure is very similar to GLUT transporters in humans. For the first time, the researchers have described the way in which the protein's structure changes between two different conformations when it binds and transports a sugar molecule.

"In showing details of the molecular structure of the region that bind the sugar, our study opens up the opportunities to more efficiently develop new substances that may inhibit GLUT transporters", says Pr Nordlund at the Department of Medical Biochemistry and Biophysics, one of the researchers behind the study. "Information on the structure of t
'/>"/>

Contact: Karolinska Institutet Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related biology news :

1. Brain Activity Mapping Project aims to understand the brain
2. Mapping effort charts restoration tack for Great Lakes
3. Carnegie debuts revolutionary biosphere mapping capability at AGU
4. USDA scientists collaborate with global researchers to advance the mapping of the barley genome
5. Influenza research: Can dynamic mapping reveal clues about seasonality?
6. Physics and math shed new light on biology by mapping the landscape of evolution
7. Geosphere: How geology, technology, modeling, and mapping see into Earths past and present
8. Road-mapping the Asian brain
9. Beyond base pairs: Mapping the functional genome
10. Speeding up drug discovery with rapid 3-D mapping of proteins
11. Novel screening tests for liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... gap in stillbirth rates between indigenous and non-indigenous women ... still at risk of stillbirth due to preventable causes, ... September) in BJOG: An International Journal of Obstetrics ... study used data from the Queensland Perinatal Data Collection ... 2011. It aimed to assess the differences in stillbirth ...
(Date:9/2/2014)... Earthquake rupture through a U.S. suburb , Observations ... Davis in the hours and days after the August ... why the earthquake caused so much damage in the ... blog, hosted by the American Geophysical Union. , ... The Next Places to Direct Our Curiosity , ...
(Date:9/2/2014)... will present the prestigious Parker/Gentry Award to Mr. Rhett ... conservation awareness. The Parker/Gentry Award is given annually by ... organization whose efforts have had a significant impact on ... can serve as a model to others. , Rhett ... and conservation news website that draws more than 2 ...
Breaking Biology News(10 mins):Stillbirth gap closing between indigenous and non-indigenous women, shows Australian study 2Stillbirth gap closing between indigenous and non-indigenous women, shows Australian study 3This week From AGU: California earthquake, future Mars rovers, models underestimate ozone 2
... ,URBANA A University of Illinois study reports a promising ... who have developed resistance to chemotherapy. U of I ... lunasin binds to a specific receptor in highly metastatic colon ... "When lunasin was used in combination with the chemotherapy drug ...
... Cystic fibrosis (CF), a chronic disease that clogs the ... by a genetic defect in a chloride channel called ... not fully understand how or why this defect occurs, ... Children (SickKids) in Toronto, Ontario, Canada has found a ...
... at Nanjing university present a rather striking finding that plant ... the route of food-intake. Moreover, once inside the host, they ... regulate host physiology. MicroRNAs are a class of ... MicroRNAs bind to target messenger RNAs to inhibit protein ...
Cached Biology News:Soy peptide + chemo drug block colon cancer's spread to liver 2Unraveling a new regulator of cystic fibrosis 2We are not only eating 'materials', we are also eating 'information' 2
(Date:9/3/2014)... Korea (PRWEB) September 03, 2014 ... Seoul Viosys (C.E.O. Jaejo Kim, http://www.seoulviosys.com ... launched the Viophoton technology for the first ... utilizes functional photons of specific energy which ... produce life-extending efficacy for food preservation applications. ...
(Date:9/2/2014)... LONDON , Sept. 2, 2014 ... Human Reproductive Technologies: Products and Global ... STUDY GOALS AND OBJECTIVES The objective of ... look at the market for reproductive technologies and ... and indication. The products in some markets are ...
(Date:9/2/2014)... DALLAS , Sept. 2, 2014 /PRNewswire-iReach/ -- ... Sodium Bicarbonate Industry" and "2014 Market Research Report ... research database. Photo - http://photos.prnewswire.com/prnh/20140902/141873 ... on Global Sodium Bicarbonate Industry" is a professional ... and Global Sodium Bicarbonate market. The ...
(Date:9/2/2014)... The Little Company of Mary Hospital in ... 290,000 square-foot West Pavilion patient tower, which included the ... Products for the nurse’s lounge near the maternity ward. ... Mary Hospital’s $180 million, four-year Campus Transformation project ... of the West Pavilion tower to the North Pavilion, ...
Breaking Biology Technology:Human Reproductive Technologies: Products and Global Markets 2Human Reproductive Technologies: Products and Global Markets 3Human Reproductive Technologies: Products and Global Markets 4Human Reproductive Technologies: Products and Global Markets 5Human Reproductive Technologies: Products and Global Markets 6Human Reproductive Technologies: Products and Global Markets 7Human Reproductive Technologies: Products and Global Markets 8Human Reproductive Technologies: Products and Global Markets 9Human Reproductive Technologies: Products and Global Markets 10Human Reproductive Technologies: Products and Global Markets 11Human Reproductive Technologies: Products and Global Markets 12Human Reproductive Technologies: Products and Global Markets 13Human Reproductive Technologies: Products and Global Markets 14Human Reproductive Technologies: Products and Global Markets 15Human Reproductive Technologies: Products and Global Markets 16Human Reproductive Technologies: Products and Global Markets 17Sodium Bicarbonate Market & Ammonium Acetate Industry: China & Global Analysis 2Sodium Bicarbonate Market & Ammonium Acetate Industry: China & Global Analysis 3Sodium Bicarbonate Market & Ammonium Acetate Industry: China & Global Analysis 4Sodium Bicarbonate Market & Ammonium Acetate Industry: China & Global Analysis 5Tufftec® Lockers from Scranton Products Selected by Little Company of Mary Hospital Near Chicago to Create an Uplifting Environment 2Tufftec® Lockers from Scranton Products Selected by Little Company of Mary Hospital Near Chicago to Create an Uplifting Environment 3
... , , KENILWORTH, N.J., July ... results for the 2009 second quarter. , , ... have given us the strength to again power through tough challenges - ... said Fred Hassan, chairman and CEO. , , ...
... ... Accreditation and Compliance Excellence Solution , ... San Francisco, CA (PRWEB) July 21, 2009 -- Quantros, a leading ... industry , announced today the highly positive results East Jefferson General Hospital (EJGH) has ...
... ... Europe, Canada, and Russia requiring confidential, direct buyer representation for a ... Board Certified real estate attorney and Lic. Real Estate Broker, Christian ... broker and real estate attorney exclusively for premium property buyers, greatly ...
Cached Biology Technology:Schering-Plough Reports Financial Results for 2009 Second Quarter 2Schering-Plough Reports Financial Results for 2009 Second Quarter 3Schering-Plough Reports Financial Results for 2009 Second Quarter 4Schering-Plough Reports Financial Results for 2009 Second Quarter 5Schering-Plough Reports Financial Results for 2009 Second Quarter 6Schering-Plough Reports Financial Results for 2009 Second Quarter 7Schering-Plough Reports Financial Results for 2009 Second Quarter 8Schering-Plough Reports Financial Results for 2009 Second Quarter 9Schering-Plough Reports Financial Results for 2009 Second Quarter 10Schering-Plough Reports Financial Results for 2009 Second Quarter 11Schering-Plough Reports Financial Results for 2009 Second Quarter 12Schering-Plough Reports Financial Results for 2009 Second Quarter 13Schering-Plough Reports Financial Results for 2009 Second Quarter 14Schering-Plough Reports Financial Results for 2009 Second Quarter 15Schering-Plough Reports Financial Results for 2009 Second Quarter 16Schering-Plough Reports Financial Results for 2009 Second Quarter 17Schering-Plough Reports Financial Results for 2009 Second Quarter 18Schering-Plough Reports Financial Results for 2009 Second Quarter 19Schering-Plough Reports Financial Results for 2009 Second Quarter 20Schering-Plough Reports Financial Results for 2009 Second Quarter 21Schering-Plough Reports Financial Results for 2009 Second Quarter 22Schering-Plough Reports Financial Results for 2009 Second Quarter 23Schering-Plough Reports Financial Results for 2009 Second Quarter 24Schering-Plough Reports Financial Results for 2009 Second Quarter 25Schering-Plough Reports Financial Results for 2009 Second Quarter 26Schering-Plough Reports Financial Results for 2009 Second Quarter 27Quantros ACE Helps East Jefferson General Hospital Achieve Best-in-Class Performance 2Quantros ACE Helps East Jefferson General Hospital Achieve Best-in-Class Performance 3Miami Beach Real Estate Attorney Opens Miami Real Estate Brokerage for International Luxury Miami Beach Condo Buyers From Distressed Sellers 2Miami Beach Real Estate Attorney Opens Miami Real Estate Brokerage for International Luxury Miami Beach Condo Buyers From Distressed Sellers 3
... unique human proteins on a 1x3 ... a cross section of all cellular ... high-quality results. Additional control proteins and ... validity and reproducibility., ,UNIchip protein microarrays ...
... UNIchip AV-400 contains 400 unique ... nitrocellulose-coated glass slide. The proteins, all ... Ontology classification, are arrayed in quadruplicate ... and a specific chip layout guarantee ...
... The Sub-Plates are E.Coli glycerol stocks ... well contains 50 cDNA clones with approximately ... of the a master plate well, the ... 96-well PCR to identify the positive well(s). ...
... The TNT Coupled Reticulocyte Lysate ... eukaryotic in vitro translations: a single-tube, ... Systems greatly simplify the process and ... in vitro translation results. Standard rabbit ...
Biology Products: