Navigation Links
Manufacturing process developed for HIV microbicide
Date:7/3/2014

Lincoln, Neb., July 3, 2014 Scientists at the University of Nebraska-Lincoln College of Engineering's Biological Process Development Facility have successfully produced a drug compound with potential to block HIV transmission in women.

The compound features the 5P12-Rantes molecule, discovered by scientists at the Mintaka Foundation in Switzerland to block HIV transmission by preventing the virus from attaching to human cells. Mintaka has contracted with the UNL facility to develop the manufacturing method for the compound.

The UNL facility has delivered its first batch of the compound to the non-profit research organization for formulation as a vaginal cream for use in clinical trials in South America. The facility landed the $3.8 million contract in 2010 from Mintaka to develop this biological production process for the microbicide.

The successful production run also confirms that the manufacturing process developed at the BPDF is ready to be transferred to a large-scale manufacturing facility, said Scott Johnson, Good Manufacturing Practices coordinator for the UNL facility.

Robin Offord, Mintaka's executive director, said his organization is "happy with the robust nature of the process developed at BPDF."

"Properly validated GMP production is key to Mintaka's plans to empower women and girls in developing countries with a means of protection from HIV/AIDS," he said. "Already, we have successfully transferred the technology to our collaborating institution in South Africa with excellent pilot scale results."

The BPDF's role in this phase of development illustrates the complexity of bringing drugs to clinical trial, officials said.

Good Manufacturing Practices are the strict guidelines imposed by the Food and Drug Administration for the development and manufacture of all pharmaceuticals, with rigorous procedures to test and validate every aspect of the development and production process.
'/>"/>

Contact: Kimberly Tedrow, BPDF media contact
ktedrow2@unl.edu
402-472-1962
University of Nebraska-Lincoln
Source:Eurekalert

Page: 1 2

Related biology news :

1. Solar panel manufacturing is greener in Europe than China, study says
2. Major breakthrough in stem cell manufacturing technology
3. 3-D Printing and Additive Manufacturing: Preview issue of groundbreaking peer-reviewed journal now available
4. 3D Printing and Additive Manufacturing
5. Manufacturing a new gut to treat GI diseases
6. New technique controls dimensions of gold nanorods while manufacturing on a large scale
7. Training the future biomanufacturing workforce
8. Nanosensors could aid drug manufacturing
9. 3-D Printing and Additive Manufacturing preview issue publishing Fall 2013
10. Althea Technologies & Profectus BioSciences Sign Manufacturing Agreement For Plasmid DNA Production
11. Manufacturing crack-resistant lightweight components
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/12/2014)... dendritic cells in human skin have assorted functions in ... researchers in the journal EMBO Molecular Medicine . ... composition of dendritic cells in psoriatic skin lesions might ... disease. , "We urgently need new ways to ... patients and reduce the incidence of known side effects ...
(Date:9/11/2014)... The classical treatise "Flora of Northumberland and Durham" ... Advanced Books platform as an example of ... create a new sort of resource and data re-use. ... botany of the region, which can be seen as ... on-line semantically enriched re-publication marries the meticulous detail ...
(Date:9/11/2014)... of DDT, American peregrine falcons ( Falco peregrines anatum ... to stop rearing young birds in captivity and placing ... published models that year in ESA,s journal ... falcon in California, with and without direct human intervention ... birds would continue to recover without captive rearing, though ...
Breaking Biology News(10 mins):Dendritic cells affect onset and progress of psoriasis 2Re-publication of 'Flora of Northumberland and Durham' (1831): A dramatic account of change 2Re-publication of 'Flora of Northumberland and Durham' (1831): A dramatic account of change 3Volunteer 'eyes on the skies' track peregrine falcon recovery in California 2Volunteer 'eyes on the skies' track peregrine falcon recovery in California 3Volunteer 'eyes on the skies' track peregrine falcon recovery in California 4Volunteer 'eyes on the skies' track peregrine falcon recovery in California 5
... Tom Corbett was honored today by the ... the Year Award in recognition of his leadership and commitment ... Pennsylvania . Corbett received the award ... Chicago, Ill. "This recognition from the ...
... R. Lewandowski, who opened with the line, "What if I ... with just refrigerator magnets and a laser pointer?", got raves ... team,s product, based on those common items, is a hand-held ... when digesting red blood cells. The Rapid Assessment of ...
... by Cornell University,s Creative Machines Lab has created a computer ... their squishy, muscle-like features in order to teach themselves to ... how nature builds complex animals from jellyfish to jaguars. ... evolve a diverse series of gaits and gallops. The ...
Cached Biology News:Governor Corbett Presented 2013 Biotechnology Industry Organization Governor of the Year Award 2Governor Corbett Presented 2013 Biotechnology Industry Organization Governor of the Year Award 3Hand-held device cheaply, quickly diagnosis malaria 2Hand-held device cheaply, quickly diagnosis malaria 3
(Date:9/12/2014)... Nasa Ames Research Base, Mountain View, CA (PRWEB) September ... announces the launch of its fundraising campaign on Indiegogo. ... producer Matt Rutherford, features Stephen Hawking, Buzz Aldrin, Shimon ... , Exponential technology is changing the world and there’s ... students how to harness it to help change the ...
(Date:9/11/2014)... it has uncovered the secret behind the unusual ... metal dichalcogenide (TMDC) materials, the two-dimensional semiconductors that ... , Using two-photon excitation spectroscopy, the researchers ... most promising of 2D materials, and found evidence ... energy states in which single photons can be ...
(Date:9/11/2014)... SARASOTA, Fla. , Sept. 11, 2014 ... novel anti-infective pharmaceuticals, announced today that the ... issued a ,Notice of Allowance, for patent ... Their Uses,.  The ,486 patent application relates ... act through gene-silencing and can be designed ...
(Date:9/11/2014)... TORONTO , Sept. 11, 2014 /PRNewswire/ - Portage ... Canadian Securities Exchange: PBT.U), announces that it intends ... to US$ 2 million for funding its preclinical ... Holding Company Limited, ("Biohaven"). The Company ... up to 20 million common shares at a ...
Breaking Biology Technology:Documentary Film that Follows Singularity University Students as They Change the World Launches its IndieGoGo Fundraising Campaign 2Excitonic dark states shed light on TMDC atomic layers 2Excitonic dark states shed light on TMDC atomic layers 3Lakewood-Amedex Receives Notice Of Allowance From The United States Patent and Trademark Office (USPTO) For A New Patent Covering Its nanoRNA Gene-Silencing Technology 2Lakewood-Amedex Receives Notice Of Allowance From The United States Patent and Trademark Office (USPTO) For A New Patent Covering Its nanoRNA Gene-Silencing Technology 3Portage Announces Proposed Private Placement 2Portage Announces Proposed Private Placement 3Portage Announces Proposed Private Placement 4
... Halozyme Therapeutics,Inc. (Nasdaq: HALO ), a biopharmaceutical ... that it will present at two investor conferences in ... Summit to be held at the,Mark Hopkins InterContinental Hotel ... a.m. Pacific Time (12:30 p.m. Eastern Time); and, ...
... Masimo (Nasdaq:,MASI), the inventor of Pulse CO-Oximetry ... purchasing the Masimo Radical-7, the company,s flagship,product, ... as a standard feature., Conventional pulse ... drops in oxygen saturation values, known as ...
... Washington, DC Widespread use of nanoscale silver ... benefits against the possibility of significant environmental risk, ... this emerging technology, according to a new report ... (PEN). , But existing information about the ...
Cached Biology Technology:Halozyme Therapeutics to Present at Upcoming Investor Conferences 2Masimo Announces Desaturation Index 3D Alarm as Standard Feature in All Radical-7 Pulse CO-Oximetry Devices 2Masimo Announces Desaturation Index 3D Alarm as Standard Feature in All Radical-7 Pulse CO-Oximetry Devices 3Nanoscale silver: No silver lining? 2Nanoscale silver: No silver lining? 3
... the MSn performance of the LTQ linear ... generate extensive structural information for the most ... Multiple dissociation techniques (PQD, ETD, CID) , ... , Fast polarity switching for high-sensitivity analysis ...
Request Info...
The Synergy HT utilizes a unique dual-optics design combined with monochromator wavelength selection to provide uncompromised performance in absorbance, fluorescence and luminescence reading modes. ...
... SYBR Green I nucleic acid gel stain ... that has bright fluorescence when bound to dsDNA ... for detecting dsDNA in gels using laser scanners ... acid stain has also found uses in capillary ...
Biology Products: