Navigation Links
MIT creates tiny backpacks for cells
Date:11/6/2008

CAMBRIDGE, Mass. -- MIT engineers have outfitted cells with tiny "backpacks" that could allow them to deliver chemotherapy agents, diagnose tumors or become building blocks for tissue engineering.

Michael Rubner, director of MIT's Center for Materials Science and Engineering and senior author of a paper on the work that appeared online in Nano Letters on Nov. 5, said he believes this is the first time anyone has attached such a synthetic patch to a cell.

The polymer backpacks allow researchers to use cells to ferry tiny cargoes and manipulate their movements using magnetic fields. Since each patch covers only a small portion of the cell surface, it does not interfere with the cell's normal functions or prevent it from interacting with the external environment.

"The goal is to perturb the cell as little as possible," said Robert Cohen, the St. Laurent Professor of Chemical Engineering at MIT and an author of the paper.

The researchers worked with B and T cells, two types of immune cells that can home to various tissues in the body, including tumors, infection sites, and lymphoid tissues a trait that could be exploited to achieve targeted drug or vaccine delivery.

"The idea is that we use cells as vectors to carry materials to tumors, infection sites or other tissue sites," said Darrell Irvine, an author of the paper and associate professor of materials science and engineering and biological engineering.

Cellular backpacks carrying chemotherapy agents could target tumor cells, while cells equipped with patches carrying imaging agents could help identify tumors by binding to protein markers expressed by cancer cells.

Another possible application is in tissue engineering. Patches could be designed that allow researchers to align cells in a certain pattern, eliminating the need for a tissue scaffold.

The polymer patch system consists of three layers, each with a different function, stack
'/>"/>

Contact: Teresa Herbert
therbert@mit.edu
617-258-5403
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Early-stage gene transcription creates access to DNA
2. MIT creates new material for fuel cells
3. Novel living system recreates predator-prey interaction
4. Using evolution, UW team creates a template for many new therapeutic agents
5. Auto immune response creates barrier to fertility; could be a step in speciation
6. MIT creates 3-D images of living cell
7. Accelerometer backpacks aid study of gliding behavior in the flying lemur
8. Scripps research scientists identify compounds for stem-cell production from adult cells
9. Lung airway cells activate vitamin D and increase immune response
10. New method provides panoramic view of protein-RNA interactions in living cells
11. Simple chemical procedure augments therapeutic potential of stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/18/2015)... CORAL SPRINGS, Florida , March 18, 2015 ... as well as businesses, new revolutionary smart wallets and apps ... rapid pace.  Companies currently entrenched in the mobile payment industry ... ), Alibaba Group Holding Ltd. (NYSE: BABA ), ... GOOG ) and Facebook Inc. (NASDAQ: ...
(Date:3/17/2015)... March 17, 2015  MecklerMedia Corporation (OTCQX: MECK) ... for service robots ever held in ... on May 11-13, 2015 at the Javits Convention ... the event include: Acorn Product Development; Axis NJ; ... Kinova Robotics; Littler; NewBotic Corporation; Neya Systems LLC; ...
(Date:3/12/2015)... , March 12, 2015 The mascots ... Brenner Children,s Hospital, part of Wake Forest Baptist Medical ... initiative for the 2015 ACC Men,s Basketball Tournament. Young ... with them and getting their autographs. Brenner ... Baptist. It is the only children,s hospital in northwest ...
Breaking Biology News(10 mins):Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2
... release is available in German . , In ... immune system must be able to recognize myriad different foreign ... Institute of Immunobiology and the Centre for Biological Signalling Studies ... immune system,s B-cells can be activated by numerous substances from ...
... know about smoking, diet, exercise and available methods ... approximately half of all cancers nationwide. ... will host its Ninth Annual International Conference on ... Convention Center, located in Philadelphia. Thousands of scientists ...
... new study from North Carolina State University finds that fish ... than fish that live much further away. The surprising finding ... selenium, found near such facilities, which unfortunately poses problems of ... at least 30 kilometers (km) from a coal-fired power plant ...
Cached Biology News:One lock, many keys 2Study: Fish near coal-fired power plants have lower levels of mercury 2
(Date:3/26/2015)... Louisville, CO (PRWEB) March 26, 2015 ... agency has formed a strategic alliance with Designing Gig ... to their clients. , “Forging this alliance ... company. Now we can extend a comprehensive, end-to-end, ... design, development, strategy, and execution,” said Chuck Miller, president ...
(Date:3/26/2015)... (PRWEB) March 26, 2015 ReliantHeart, Inc., ... and Transonic, a supplier of precision transit-time flow measurement ... will greatly improve the efficiency of the HeartAssist5® ... LVAD patients to experience greater mobility and peace of ... the miniature flow board, will draw 1/6th of the ...
(Date:3/25/2015)... 26, 2015 Agnition announced today that ... American Farmer, airing for the first time at 7:30 ... American Farmer will explore the extremely important role soil ... with a patented Microbial Catalyst™ technology that enhances soil ... The segment will air again on April 28. , ...
(Date:3/25/2015)... IL (PRWEB) March 25, 2015 ... Symmetry® Top-Loading Balances and Analytical Balances to get ... expanded line of weighing balances from the trusted ... Toploading Balances increase your efficiency by providing ... variety of samples. Weighing modes include parts counting, ...
Breaking Biology Technology:The Market Element LLC and Designing Gig LLC Form Strategic Alliance 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2New Economical Top-Loading and Analytical Symmetry Balances from Cole-Parmer 2
... Genesis,Pharmaceuticals Enterprises, Inc. (OTC Bulletin Board: GNPH) ... with its principal operations,in the People,s Republic ... its new,corporate website with the domain address, ... an overview of the Company, its corporate ...
... Wash., Nov. 3 SCOLR Pharma, Inc.,(Amex: DDD ... the Rodman &,Renshaw 10th Annual Healthcare Conference to be ... in New York City., Daniel O. Wilds, SCOLR ... of the Company,s operations on Tuesday, November 11,2008 at ...
... MATEO, Calif., Nov. 3 Top-line preliminary data,from ... drug,relaxin for the treatment of acute heart failure ... at the American Heart Association,s (AHA),Scientific Sessions 2008 ... Professor of Medicine, University of California,San Francisco, will ...
Cached Biology Technology:Genesis Pharmaceuticals Launches New Corporate Website 2Top-Line Preliminary Data From Phase II/III Study of Corthera's Relaxin in Acute Heart Failure to be Presented in Satellite Symposium at AHA Scientific Sessions 2008 2
... PP2A1, purified Formulation: 50mM Tris-HCl, ... Brij-35, 0.2mM PMSF, 1mM benzamidine, ... Properites: PP2A1 (Protein Phosphatase 2A1) ... ammonium sulfate precipitation, QSepharose,amino-hexyl agarose, ...
Borosilicate Glass. Certified for use with the Beacon 2000 Systems, 1,000 tubes/case...
...
... Immunogen : Recombinant human HMGN2/HMG-17 ... BSA, 0.15M NaCl, 0.05% sodium ... glycerol to 30% Quality Assurance: ... acid extracts of murine 10T ...
Biology Products: