Navigation Links
MIT: Mending broken hearts with tissue engineering
Date:11/2/2008

CAMBRIDGE, Mass.--Broken hearts could one day be mended using a novel scaffold developed by MIT researchers and colleagues.

The idea is that living heart cells or stem cells seeded onto such a scaffold would develop into a patch of cardiac tissue that could be used to treat congenital heart defects, or aid the recovery of tissue damaged by a heart attack. The biodegradable scaffold would be gradually absorbed into the body, leaving behind new tissue.

The accordion-like honeycomb scaffold, to be reported in the Nov. 2 online edition of Nature Materials, is the first to be explicitly designed to match the structural and mechanical properties of native heart tissue. As a result, it has several advantages over previous cardiac tissue engineering scaffolds.

Further, the MIT team's general approach has applications to other types of engineered tissues. "In the long term we'd like to have a whole library of scaffolds for different tissues in need of repair," said Lisa E. Freed, corresponding author of the paper and a principal research scientist in the Harvard-MIT Division of Health Sciences and Technology (HST). Each scaffold could be tailor-made with specific structural and mechanical properties. "We're already on the way to a few other examples," Freed said.

With respect to the current work, "previous scaffolds did not necessarily possess structural or mechanical properties consistent with the native myocardial [heart muscle] structure," said George C. Engelmayr Jr., lead author of the paper and an HST postdoctoral fellow. Heart muscle, he explained, is "directionally dependent" meaning its cells are aligned in specific directions.

The researchers reasoned that "borrowing more closely from nature's lessons," as they write in Nature Materials, might lead to a tissue with properties closer to the real thing. So, using a laser similar to that used for eye surgery, they created a scaffold with directionally dependen
'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Substance in red wine found to keep hearts young
2. Eat less or exercise more? Either way leads to more youthful hearts
3. Cigarette smoke, alcohol damage hearts worse as combo
4. Runners high may also strengthen hearts
5. Human derived stem cells can repair rat hearts damaged by heart attack
6. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
7. NIH awards Clemson bioengineer $1.5 million to improve durability of tissue heart valves
8. Generation innovation: Young UC San Diego bioengineer to use NIH grant to fuel tissue engineering
9. Buckyballs have high potential to accumulate in living tissue
10. New technique sees into tissue at greater depth, resolution
11. Fly studies reveal immune cell responses to tumor and tissue damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... YORK , Nov. 19, 2014  Earlier this ... at New York College, and one of the most ... biosensor signals that are transmitted from Smartphones to third ... were Smartphones and has one of the earliest known ... discussing its usage in the military, child care, elder ...
(Date:11/18/2014)... 2014   News Highlights: ... develop The Partners Data Lake, an agile data ... Lake will allow researcher and clinicians to explore ... the lives of patients , The Partners ... across the Partners system, breaking down physical barriers ...
(Date:11/11/2014)... -- Forensicon, Inc., a Chicago -based digital ... promotion of Yaniv Schiff from Senior Computer ... new role as Director, he will lead company efforts ... and provide leadership within the company,s digital forensics practice ... Schiff joined Forensicon in 2006 and ...
Breaking Biology News(10 mins):Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2
... The genome of Medicago , a close relative of alfalfa ... been sequenced by an international team of scientists, capturing around 94 ... insights into the evolution of the Papilionoid subfamily of ... Plants in this family can house and work with ...
... SALT LAKE CITY While previous studies have linked ... disease, new research at the Intermountain Medical Center Heart ... to the onset of a dangerous heart condition known ... the flagship facility for the Intermountain Healthcare system, studied ...
... Ditching the diet for Thanksgiving? Turkey with all ... to miss their goals, according to a new Cornell ... subconsciously bending willpower every day. "We,re slaves to ... and of psychology at Cornell, who co-authored the article ...
Cached Biology News:Genome sequence sheds new light on how plants evolved nitrogen-fixing symbioses 2New study links excessive amounts of vitamin D to onset of atrial fibrillation 2New study links excessive amounts of vitamin D to onset of atrial fibrillation 3
(Date:11/21/2014)... The science of light and how it ... than 200 primary students in a traveling program organized ... Otago Physics Department and funded by an SPIE ... the university’s OSA/SPIE Student Chapter visited six primary schools ... from small, rural schools hands-on lessons in optics and ...
(Date:11/21/2014)... The report, "Synthetic Biology ... Cloning kits), Technology (Bioinformatics, Nanotechnology, Gene Synthesis, ... Bioremediation) - Global Forecast to 2018", analyses ... opportunities, and challenges. , Browse 99 market ... 185 pages and in-depth TOC of the ...
(Date:11/21/2014)... 2014 Deep Research Report on Global ... and in-depth research report on the Sodium ferrocyanide ... its definition, classification, application, and industry chain structure ... the international market analysis, including China’s domestic market ... Europe, Asia, China, Japan etc. regions) industry analysis ...
(Date:11/21/2014)... and SAN DIEGO , Nov. 20, ... announced that President and CEO Marc Hedrick , M.D. will ... DATE:   Thursday, December 4, 2014 TIME:    11:15 ... here or paste this URL into your browser,s address ... investors pre-register to save time and receive event updates. ...
Breaking Biology Technology:Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 4Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 4
... /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY ... Eastland as Chief Financial Officer and Vice President, ... responsibilities will include financial management, investor relations and ... than 25 years of financial management experience to ...
... -- Chemists at Indiana University Bloomington have designed a molecule ... to release the ions in the presence of ultraviolet light. ... Society today (online), IU Bloomington chemist Amar Flood and ... how it works and, just as importantly, how they know ...
... Innovations (MBI) will be showcasing Zequanox ,™ ... at the International Conference on Aquatic Invasive Species ... September 2, 2010.  The conference is attended by participants ... and other stakeholders involved in the issues of aquatic ...
Cached Biology Technology:ONCOTHYREON APPOINTS JULIE M. EASTLAND AS CHIEF FINANCIAL OFFICER 2IU chemists develop new 'light switch' chloride binder 2IU chemists develop new 'light switch' chloride binder 3Marrone Bio Innovations to Present Invasive Mussel Control Solution 2
... comprehensive microarray service for systematic discovery ... non-coding RNAs (ncRNAs) using a novel ... which enables highly sensitive and specific ... This comprehensive service includes custom probe ...
... comprehensive kinase analysis service utilizing high ... microarrays synthesized on Paraflo microfluidic chips ... measurement of kinase kinetic activities, and ... includes preparation of your kinase sample, ...
... a unique new tool, OligoMix for low ... needs in genomics, proteomics, synthetic biology, drug ... MIXTURE of a large number of DESIGNED ... single microtube. OligoMix is made from an ...
... PF 2D is an automated, two-dimensional fractionation ... mixtures. Part of Beckman Coulters ProteomeLab ... results in just hours. The system ... in cell lysates, addressing a key challenge ...
Biology Products: