Navigation Links
MGH researcher Gary Ruvkun named a co-recipient of the Lasker Award
Date:9/13/2008

discovery that plant genes could be silenced by the action of tiny RNAs similar to the worm sequences studied by Ruvkun and Ambros implied that the same mechanism operated in plants and animals.

In 2000 Ruvkun's team discovered let-7, another tiny regulatory RNA that shuts down its target gene the same way that lin-4 silences lin-14. They also found that the let-7 RNA sequence had been snipped out of a larger RNA molecule that folds back on itself in a hairpin shape. Later that year Ruvkun published evidence that animals from fish to flies to humans have their own versions of let-7, implying that the mechanism is universal to all but the most primitive animal species.

In 2001 Ruvkun collaborated with Craig Mello, PhD, of UMass and Andrew Fire, PhD, then at the Carnegie Institution, to show that the microRNAs of both lin-4 and let-7 are released from their precursor hairpin RNA molecules by the enzyme Dicer, which is also critical to the RNA interference process that Mello and Fire had discovered and for which they received the 2006 Nobel Prize.

It now appears that the human genome contains between 500 and 1,000 microRNAs involved in a broad range of normal and disease-related activities. Researchers have just begun exploring their potential for the diagnosis, prognosis and treatment of disorders. In addition to continuing investigation of RNA's role in controlling gene expression, Ruvkun's team studies other mechanisms involved in the development, metabolism and longevity of C. elegans, including genes involved in the regulation and storage of fat.

Ruvkun is a professor of Genetics at Harvard Medical School and an investigator at the MGH Center for Computational and Integrative Biology. He holds a bachelor's degree in Biophysics from the University of California at Berkeley and a PhD in Biophysics from Harvard University. Among the many other awards he has received some shared with Ambros and Baulcombe are the Fra
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Curbing coal emissions alone might avert climate danger, say researchers
2. Researchers develop nano-sized cargo ships to target and destroy tumors
3. Gap junction protein vital to successful pregnancy, researchers find
4. Cortisol and fatty liver: Researchers find cause of severe metabolic disorders
5. Researchers seeking to identify Alzheimers risk focus on specific blood biomarker
6. Childrens National researcher receives ACCP Distinguished Investigator Award
7. New once-a-week treatment for type 2 diabetes developed by Mount Sinai researcher
8. ISU researchers help map first plant-parasitic nematode genome sequence
9. Collaboration between researchers yields more comprehensive portrait of brain cancer
10. Tel Aviv University researchers create new stem cell screening tool
11. NYU Cancer Institute researcher among first NIH EUREKA award recipients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... referred for evaluation of suspected genetic conditions, whole-exome ... percent, including detection of a number of rare ... according to a study appearing in JAMA ... with the American Society of Human Genetics annual ... coding regions of thousands of genes simultaneously using ...
(Date:10/17/2014)... is available in German . ... very few drugs. When treating overdoses, doctors are often limited ... difficult if there is a combination of drugs involved. So ... accidentally swallows his grandmother,s pills? ETH professor Jean-Christophe Leroux from ... find an answer to this question. "The task was to ...
(Date:10/16/2014)... cultivated efficiently, they are anything but sustainable: environmental ... cultivation is becoming increasingly evident. Despite their disadvantages, ... are regarded as the sole possibility of achieving ... finds Bernhard Schmid, an ecology professor at the ... of agriculture and forestry. After all, a new ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Emergency aid for overdoses 2Emergency aid for overdoses 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
... Researchers have discovered an isolated, self-sustaining, bacterial community living ... surface in a South African gold mine. It is ... on geologically produced sulfur and hydrogen and one of ... depend on energy from the Sun in any way. ...
... risks of a manned flight to Mars ranks the possibility ... the brains of astronauts, leaving them in a vegetative state, ... NASA's Mars scientists, the cosmic radiation risk remains a show-stopper ... too heavy to reach Mars, which, at its closest, is ...
... iguanas on the Galápagos Islands live without predators - at ... Since then they have been confronted with cats and dogs ... therefore a suitable model of study in order to discover ... behaviour and endocrine stress response to novel predation threats. Scientists ...
Cached Biology News:Otherworldly bacteria discovered two miles down 2Mars mission Risk 29: Scientists research ways to reduce radiation-induced brain damage 2Mars mission Risk 29: Scientists research ways to reduce radiation-induced brain damage 3Mars mission Risk 29: Scientists research ways to reduce radiation-induced brain damage 4Too mellow for our predatory world 2Too mellow for our predatory world 3Too mellow for our predatory world 4
(Date:10/20/2014)... 2014 OncLive® is ... Center at Thomas Jefferson University has joined its ... Strategic Alliance Partnership program, the Sidney Kimmel Cancer ... raise awareness of the Center’s cutting-edge research programs, ... Clinicians and other health care professionals from the ...
(Date:10/19/2014)... 2014 OCTOBER 20-22, 2014: ... ABIM will take place at the ... ABIM 2014 is now available at ... companies and organizations from all over the ... on the latest products and developments on ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The Asia-Pacific ... Analytics market in Asia-Pacific with analysis and forecast of ... million in 2014 to $208 million by 2019, at ... 2014 to 2019. , Browse through the TOC of ... idea of the in-depth analysis provided. It also provides ...
(Date:10/19/2014)... 2014 According to market research ... WLAN Controllers; Wireless gateways)]- Global Advancements, Forecasts and ... global Outdoor Wi-Fi market with analysis and forecasting ... also identifies the drivers and the restrains for ... opportunities and challenges. , Browse 65 market data ...
Breaking Biology Technology:Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 4
... Germany , June 16, 2010 ,The medical devices company joimax(R) GmbH is ... had already been the motto of,the last company move back in 2005. , ... The US market has an enormous ... to Irvine, California , one,of high-tech industry centers in the United States ...
... This release is avaiable in French . ... of high-tech products such as computer displays or solar ... chemical composition as inorganic materials, preventing scientists from using ... of researchers led by McGill,s Dr. Dmitrii Perepichka and ...
... June 15 BioMed Realty Trust, Inc. (NYSE: BMR ) ... of $0.15 per share of common stock, representing a 7.1% increase over ... is equivalent to an annualized dividend of $0.60 per common share. ... BioMed also announced that its board of directors ...
Cached Biology Technology:joimax(R) Moves Into Larger Premises 2Organic nanoelectronics a step closer 2BioMed Realty Trust Declares Second Quarter 2010 Common Stock and Preferred Stock Dividends 2BioMed Realty Trust Declares Second Quarter 2010 Common Stock and Preferred Stock Dividends 3
Goat polyclonal to MLH3 Immunogen: Synthetic peptide: RQSLQQSMPPCEPP (Human) from C Terminus of the protein sequence according to NP_055196....
Rabbit polyclonal to NMDAR1 e/f/g/h ( Abpromise for all tested applications)....
Polyclonal Antibody to Coronin / CORO1C This antibody was developed against synthetic peptides corresponding to amino acids 407-420 of human CORO1C....
Peptide-affinity Purified Polyclonal Antibody to Retinoic Acid-Induced 3 (RAI3/RAIG1)...
Biology Products: