Navigation Links
MBL scientists find genes linked to human neurological disorders in sea lamprey genome
Date:2/24/2013

MBL, WOODS HOLE, Mass. Scientists at the Marine Biological Laboratory (MBL) have identified several genes linked to human neurological disorders, including Alzheimer's disease, Parkinson's disease and spinal cord injury, in the sea lamprey, a vertebrate fish whose whole-genome sequence is reported this week in the journal Nature Genetics.

"This means that we can use the sea lamprey as a powerful model to drive forward our molecular understanding of human neurodegenerative disease and neurological disorders," says Jennifer Morgan of the MBL's Eugene Bell Center for Regenerative Biology and Tissue Engineering. The ultimate goals are to determine what goes wrong with neurons after injury and during disease, and to determine how to correct these deficits in order to restore normal nervous system functions.

Unlike humans, the lamprey has an extraordinary capacity to regenerate its nervous system. If a lamprey's spinal cord is severed, it can regenerate the damaged nerve cells and be swimming again in 10-12 weeks.

Morgan and her collaborators at MBL, Ona Bloom and Joseph Buxbaum, have been studying the lamprey's recovery from spinal cord injury since 2009. The lamprey has large, identified neurons in its brain and spinal cord, making it an excellent model to study regeneration at the single cell-level. Now, the lamprey's genomic information gives them a whole new "toolkit" for understanding its regenerative mechanisms, and for comparing aspects of its physiology, such as inflammation response, to that of humans.

The lamprey genome project was accomplished by a consortium of 59 researchers led by Weiming Li of Michigan State University and Jeramiah Smith of the University of Kentucky. The MBL scientists' contribution focused on neural aspects of the genome, including one of the project's most intriguing findings.

Lampreys, in contrast to humans, don't have myelin, an insulating sheath around neurons that allows f
'/>"/>

Contact: Diana Kenney
dkenney@mbl.edu
508-289-7139
Marine Biological Laboratory
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MBL scientists find genes linked to human neurological disorders in sea lamprey genome
(Date:8/10/2015)... BOSTON and TELTOW, Germany ... SensoMotoric Instruments (SMI), a world leader in Eye ... the completion of its OEM Eye Tracking Platform for ... Eye Tracking Platform contains reference designs for seamless integration ... kiosk systems, virtual reality HMDs and augmented reality smart ...
(Date:8/6/2015)... , Aug. 6, 2015 Synaptics ... of human interface solutions, today announced collaboration with ... on Windows 10. Microsoft leveraged Synaptics, deep expertise ... operating system. Through stringent testing, ... fully certified with Microsoft,s Precision TouchPad (PTP) specification ...
(Date:8/4/2015)... Research and ... addition of the "Digital Forensics Market ... (Computer Forensics, Network Forensics, Mobile Device Forensics, ... and Region - Global Forecast to 2020" ... By Component (Hardware, Software, and Service), Sub-Segment ...
Breaking Biology News(10 mins):SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3Synaptics Chosen for Human Interface Co-Development on Windows 10 2Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2
... animals don,t pick their mates by pure chance it,s ... decades of examining his work, experts agree that he pretty ... is, "What have we learned since then?" asks a Texas ... an evolutional biologist who has studied Darwin,s work for years, ...
... RICHLAND, Wash. -- DNA might be the blueprint for ... to understand how and which proteins work together have ... unobtrusive enough to use in live cells. Using the ... a well-studied complex of proteins known as RNA polymerase. ...
... T-cells react to foreign protein fragments and therefore are ... attack the body,s own material are in most cases ... however, undergo a kind of reeducation to become "regulatory ... group led by immunologist Professor Ludger Klein of LMU ...
Cached Biology News:Why do we choose our mates? Ask Charles Darwin, prof says 2TRAPping proteins that work together inside living cells 2TRAPping proteins that work together inside living cells 3They are young and need the job: A second chance for dangerous T-cells 2They are young and need the job: A second chance for dangerous T-cells 3
(Date:8/28/2015)... - RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSXV: ... the development of autologous cell therapies, today reported ... 2015, corporate highlights, and near-term milestones.  The company,s ... www.sedar.com ,  www.edgar.com and at ... to launch its RCS-01 treatment for aging and ...
(Date:8/28/2015)... ... ... launch of FireflySci Inc. (FFS) in early 2015, the company continues to shake up the ... Fonz in a lab coat and Large Marge have been posted on the company’s Facebook ... FireflySci is proud to be the only cuvette manufacturer is the world that has an ...
(Date:8/27/2015)... VA (PRWEB) , ... August 27, 2015 , ... ... contractors solve complex business problems, is pleased to announce their ranking as one of ... annual ranking of the fastest-growing private companies across the nation. , “It is truly ...
(Date:8/27/2015)... 2015 /PRNewswire/ - Portage Biotech Inc. ("Portage") (OTC ... Pharmaceutical Holding Company Limited (Biohaven), announced today that ... of BHV-0223, a glutamate modulating agent. Biohaven filed ... recently obtained clearance from the U.S. Food and ... Portage holds 54% equity interest in Biohaven, a ...
Breaking Biology Technology:RepliCel Reports Second Quarter 2015 Financial Results 2RepliCel Reports Second Quarter 2015 Financial Results 3RepliCel Reports Second Quarter 2015 Financial Results 4RepliCel Reports Second Quarter 2015 Financial Results 5Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4
... Sequella, Inc., a clinical-stage biopharmaceutical company focused ... receipt of a Small Business Innovation Research (SBIR) ... Allergy and Infectious Diseases (NIAID), National Institutes of ... the company,s novel tuberculosis (TB) lead dipiperidine drug ...
... the unexpected happens, www.WhatWillYourPlanBe.com offers post college-aged women ... healthMONTVALE, N.J., Feb. 17 Many young women ... go according to plan, particularly when it comes ... the reality is that the unexpected often happens ...
... to EUR1.06bn, - Adjusted Earnings per Share Improves by 36.6% From ... EBITDA Margin Rises From 19.0 to 19.5%, - CEO Dr. Axel ... considers itself well equipped to meet the global challenges in, ... in, the core business.", , ...
Cached Biology Technology:Sequella Receives SBIR Funding Grant from the NIH for Further Development of Tuberculosis Drug SQ609 2Sequella Receives SBIR Funding Grant from the NIH for Further Development of Tuberculosis Drug SQ609 3Helping Young Women Succeed in Today's Unpredictable World 2Helping Young Women Succeed in Today's Unpredictable World 3Helping Young Women Succeed in Today's Unpredictable World 4Following a Record Year in 2008 Gerresheimer Again Sets its Sights on Substantial Growth in 2009 2Following a Record Year in 2008 Gerresheimer Again Sets its Sights on Substantial Growth in 2009 3Following a Record Year in 2008 Gerresheimer Again Sets its Sights on Substantial Growth in 2009 4
Sf21 Insect Cells (Frozen) in Max-XP Medium...
Lyophilized solid. Suitable for evaluating functional activity of human complement components and for other research requiring a high level of hemolytic activity. ...
... Ciphergen's ProteinChip arrays have been developed ... biological samples. A variety of ProteinChip ... proteins according to their unique biochemical ... spots, allowing side-by-side sample comparison, and ...
... ProteinChip arrays have been developed for ... samples. A variety of ProteinChip chemical ... according to their unique biochemical properties. ... allowing side-by-side sample comparison, and the ...
Biology Products: