Navigation Links
Low-cost sterilization method for cats and dogs is focus of new research project
Date:7/17/2013

WINSTON-SALEM, N.C. July 18, 2013 As an expert in molecular genetics, Colin E. Bishop, Ph.D.'s, usual role at the Wake Forest Baptist Medical Center's Institute for Regenerative Medicine is to apply the techniques of genetics and developmental biology to the regeneration of human organs.

But, with a background specifically in reproductive genetics, Bishop is also on a mission to help solve the over-population of homeless dogs and cats. Bishop has been awarded a two-year pilot grant from Michelson Prize and Grants (MPG), a division of the Found Animals Foundation, to develop a one-shot, non-surgical method for sterilizing companion animals.

According to MPG, an estimated six million to eight million cats and dogs enter U.S. shelters and three to four million of these animals are euthanized. Bishop is one of about 20 grant recipients worldwide working on developing non-surgical, single dose sterilization technology. The foundation will award a $25 million prize to the first research entity to develop a successful product.

Bishop's approach is to develop an injection to destroy particular cells in the hypothalamus, an area in the brain about the size of a pearl that controls reproduction in mammals. Because brain cells do not regenerate, it is believed that the treatment will lead to permanent sterility in the animals. Just like neutering or spaying, this method has the potential to eliminate the unwanted mating behaviors of companion animals without affecting their general health.

Specifically, the treatment aims to destroy GnRH cells in the hypothalamus that stimulate hormones that control male and female fertility. Bishop is designing a novel system for delivering a toxin to the GnRH cells. He will engineer nano-sized packages called exosomes that are generated from adult stem cells. These packages will be tagged to carry the molecular "address" of the GnRH cells, so that other cell types will not be affected. Inside the package will be a deadly "message" a toxin derived from influenza-A that is designed to bind with and kill the GnRH cells.

The milestones of the two-year project include generating engineered exosomes from mouse stem cells and evaluating their potential to fuse with the GnRH cells. The team will then load the exosomes with the toxin and test their ability to kill GnRH cells in a laboratory setting and in mice.

The ultimate goal of MPG and the Found Animals Foundation is "to end shelter euthanasia of healthy, adoptable animals." According to the Found Animals website, a one-shot sterilization method could also be used internationally to reduce the population of homeless dogs and cats.


'/>"/>

Contact: Karen Richardson
krchrdsn@wakehealth.edu
336-716-4453
Wake Forest Baptist Medical Center
Source:Eurekalert

Related biology news :

1. Low-cost in-vitro fertilization method developed at CU may help couples in developing countries
2. Low-cost nano-biosensor to detect foodborne pathogen that causes listeriosis
3. Can algae-derived oils support large-scale, low-cost biofuels production?
4. Plants provide accurate low-cost alternative for diagnosis of West Nile Virus
5. Students create low-cost biosensor to detect contaminated water in developing nations
6. Low-cost carbon capture gets X-rayed
7. Low-cost nanosheet catalyst discovered to split hydrogen from water
8. Memorial Sloan-Kettering researchers develop new method for tracking cell signaling
9. Researchers create method to rapidly identify specific strains of illness
10. Gasification method turns forest residues to biofuel with less than a euro per liter
11. Gasification method turns forest residues to biofuel with less than a euro per litre
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... LONDON , April 26, 2016 ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... a partnership to integrate the Onegini mobile security ... (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The ... enhanced security to access and transact across channels. ...
(Date:4/14/2016)... Israel , April 14, 2016 ... Authentication and Malware Detection, today announced the appointment of ... assumed the new role. Goldwerger,s leadership appointment ... on the heels of the deployment of its platform ... BioCatch,s behavioral biometric technology, which discerns unique cognitive and ...
(Date:3/23/2016)... March 23, 2016 ... Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender Anbieter ... Unternehmen mit SpeechPro zusammenarbeitet, um erstmals dessen ... wird die Möglichkeit angeboten, im Rahmen mobiler ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... 29, 2016 , ... Summit for Stem Cell has received a $250,000 grant ... stem cell therapy for the treatment of Parkinson’s disease. The Summit research project is ... Scripps Research Institute in San Diego, CA. , The aim of of ...
(Date:4/28/2016)... Hill, Conn. (PRWEB) , ... April 28, 2016 ... ... of financing and ongoing support for Connecticut's innovative, growing companies, today announced the ... digital health and financial technology (fintech) companies. , “VentureClash looks to ...
(Date:4/27/2016)... ... 2016 , ... Shimadzu Scientific Instruments (SSI) will be showcasing ... Conference and Expo. Shimadzu’s high-performance instruments enable laboratories to test cannabis products for ... stop by booth 1021 to learn how Shimadzu’s instruments can help improve QA/QC ...
(Date:4/27/2016)... ... 27, 2016 , ... The Board of Directors of Biohaven ... Tilton as Chief Commercial Officer.  Mr. Tilton joined Biohaven from Alexion Pharmaceuticals, Inc. ... responsible for the commercialization of multiple orphan drug indications. Mr. Tilton has ...
Breaking Biology Technology: