Navigation Links
Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
Date:12/3/2007

WASHINGTON, Dec. 3 A team of researchers from the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) have developed an optical device that allows them to peer through the eyes of a mouse and monitor the cells passing through its bloodstream.

In the Dec. 1 issue of the journal Optics Letters, published by the Optical Society of America, the team describes how they used the device, called a retinal flow cytometer, to non-invasively sample the blood passing through the vessels in the retinal tissue in the back of the eye. There they were able to detect circulating fluorescently labeled cells as they wound their way through the mouse.

"We could detect and count circulating cells continuously without drawing blood samples," says MGH/HMS investigator Charles Lin.

The ability to count circulating cells is important in diseases like multiple myeloma because the number of cancer cells in the bloodstream at the onset of the disease may represent only a tiny fraction of circulating cells in the bloodstream.

Though few in number, these rare cells nevertheless can be relentless. Multiple myeloma starts when cancerous immune system cells residing in the bone marrow quickly multiply out of control. Rather than forming a solid tumor, though, they spread throughout the body and crowd out other cells in the bloodstream. Multiple myeloma cells can invade bones throughout the body, eroding and weakening them and leading to fractures and sometimes paralysis because of compression of the spinal cord. Eroding the bones can also drastically increase the calcium levels in the blood, sometimes causing kidney failure. Moreover, multiple myeloma cells can crowd out the oxygen-ferrying red blood cells in the bloodstream and cause anemia.

Multiple myeloma is treatable, but the disease has a high rate of recurrence. Scientists like Lin and his collaborator Irene Ghobrial of the Dana-Farber
'/>"/>

Contact: Colleen Morrison
cmorri@osa.org
202-416-1437
Optical Society of America
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. M2SYS Partners With Gnosis Medical Services to Provide Accurate Patient Identification in Developing Countries Through Innovative Biometrics Solution
2. Rhythmic breathing adapts to external beat through brain calculus
3. New technique can be breakthrough for early cancer diagnosis
4. Breakthrough research identifies how cells from pigs may cure diabetes
5. Male contraception breakthroughs to be presented, Seattle Sept. 27-28
6. West Nile virus spread through nerve cells linked to serious complication
7. Major genetic breakthrough for ankylosing spondylitis brings treatment hope
8. ACT Ensures Integrity of Testing Process Through Deployment of BIO-keys(R) Biometric ID Technology
9. Oosight microscope enables embryonic stem cell breakthrough
10. UK scientists working to help cut ID theft
11. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... YORK , Nov. 18, 2014   ... identity authentication solutions, and MorphoTrust USA ... and services, today announced a strategic partnership to ... enterprise, motor vehicle administration (MVA), airport screening and ... in identity-related solutions, MorphoTrust serves consumers through a ...
(Date:11/10/2014)... on U.S. store shelves in early 2010, and people ... small packets can be tossed into a washing machine ... powder. The convenience, though, has come with risks for ... Nationwide Children,s Hospital found that from 2012 through 2013, ... younger than 6 years of age swallowing, inhaling, or ...
(Date:11/6/2014)... TALLAHASSEE, Fla. -- A groundbreaking paper from a team ... better understanding of how plants could adapt to and ... The research, published in the latest issue of the ... how chromatin (the complex of DNA and proteins) is ... material, so that some genes are turned on and ...
Breaking Biology News(10 mins):EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Study finds laundry detergent pods, serious poisoning risk for children 2Maize analysis yields whole new world of genetic science 2
... Nearly 50% of couples who were interviewed at least 3 ... their surplus, stored embryos for stem cell research, according to ... April 26, 2007, advanced online publication of Cell Stem Cell, ... International Society for Stem Cell Research. , The key ...
... MIT Media Lab have invented a way to reversibly ... the prospect of controlling the haywire neuron activity that ... , Such diseases often must be treated by removing ... lead to the development of optical brain prosthetics to ...
... Dick at Ontario Cancer Institute (OCI) have developed a method ... stem cells. The converted cells, when transplanted into special mice ... entire disease process from the very moment it begins. The ... Dick, Senior Scientist at OCI, the research arm of Princess ...
Cached Biology News:Many couples choose to donate surplus embryos for stem cell research 2MIT: Pulsing light silences overactive neurons 2Cancer scientists create 'human' leukemia process to map how disease begins, progresses 2
(Date:11/17/2014)... 17, 2014 Soligenix, Inc. (OTCQB: SNGX) ... developing products that address unmet medical needs in ... today the formation of a Medical Advisory Board ... Company as it advances the Phase 3 clinical ... of cutaneous T-cell lymphoma (CTCL), a rare class ...
(Date:11/16/2014)... James Hill and Ken Crooks will co-present ... Later” scheduled for Thursday, November 20, 1-2 EST. ... many in the lab design domain by installing 27 ... chemistry teaching laboratories at Gallahue Hall. The renovation project ... growth within the chemistry program. Now, three years later, ...
(Date:11/15/2014)... New York, NY (PRWEB) November 14, 2014 ... expansion plan, QuickSTAT is making significant investments in ... evolving world of modern cold chain and the ... will support QuickSTAT’s ongoing focus on customized logistics ... Towers and enhancement of existing facilities. There will ...
(Date:11/15/2014)... (PRWEB) November 14, 2014 ... ‘ISCTR’ announced today that the society’s Governing Board ... Rowe, Edwards Lifesciences chief scientific officer and Dr. ... medical officer, Abbott Vascular. Mr. Rowe and ... medical device development experts. , Dr. Nabil ...
Breaking Biology Technology:Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 2Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 3Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 4Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 5Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 6Don't miss the I2SL High-Tech Talks Webinar Series Presenting: Butler University's Renovation With Filtered Fume Hoods, 3 Years Later 2Don't miss the I2SL High-Tech Talks Webinar Series Presenting: Butler University's Renovation With Filtered Fume Hoods, 3 Years Later 3QuickSTAT Announces Global Expansion Plan to Enhance Its Global Network and Cold Chain Logistics Capabilities for Life Sciences 2International Society for Cardiovascular Translational Research Governing Board Adds Medical Industry Leaders 2
... said this week that she would like Wisconsin to double ... the Act 255 program. , ,In an interview, Burke said ... but she would like to double the tax credits from ... Act 255, which had bipartisan support, the state made available ...
... Wis. Small Tree Communications said it ... Chippewa Valley Angel Investing Network , which invested $445,000 in ... drivers and other products for Apple's Mac OS X. It ... million in funding has been allocated for the company to ...
... Wis. Fiserv, Inc. , the Brookfield-based provider ... Wisconsin companies to make the annual Fortune 500 ... , ,Fiserv, which reported $4.1 billion in annual revenue ... 488 after ranking 510th last year. The annual ranking will ...
Cached Biology Technology:Burke would like to double Act 255 angel tax credits 2
MagSi uniform silica particles coated with a carboxyl group containing polymer, covalently attached to the bead surface....
Goat polyclonal to DRAK2...
MMP-2 / MMP-9 Inhibitor IV is a potent, selective, slow binding and mechanism based inhibitor of human gelatinases. • Molecular weight: 306.4 • Molecular Formula: C(15)H(14)O(3)S(2). &bul...
... CDX2, a member of the caudal-related ... that regulates both proliferation and differentiation in ... role in triggering cells towards the phenotype ... in the maintenance of the phenotype. Clone ...
Biology Products: