Navigation Links
Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
Date:12/3/2007

WASHINGTON, Dec. 3 A team of researchers from the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) have developed an optical device that allows them to peer through the eyes of a mouse and monitor the cells passing through its bloodstream.

In the Dec. 1 issue of the journal Optics Letters, published by the Optical Society of America, the team describes how they used the device, called a retinal flow cytometer, to non-invasively sample the blood passing through the vessels in the retinal tissue in the back of the eye. There they were able to detect circulating fluorescently labeled cells as they wound their way through the mouse.

"We could detect and count circulating cells continuously without drawing blood samples," says MGH/HMS investigator Charles Lin.

The ability to count circulating cells is important in diseases like multiple myeloma because the number of cancer cells in the bloodstream at the onset of the disease may represent only a tiny fraction of circulating cells in the bloodstream.

Though few in number, these rare cells nevertheless can be relentless. Multiple myeloma starts when cancerous immune system cells residing in the bone marrow quickly multiply out of control. Rather than forming a solid tumor, though, they spread throughout the body and crowd out other cells in the bloodstream. Multiple myeloma cells can invade bones throughout the body, eroding and weakening them and leading to fractures and sometimes paralysis because of compression of the spinal cord. Eroding the bones can also drastically increase the calcium levels in the blood, sometimes causing kidney failure. Moreover, multiple myeloma cells can crowd out the oxygen-ferrying red blood cells in the bloodstream and cause anemia.

Multiple myeloma is treatable, but the disease has a high rate of recurrence. Scientists like Lin and his collaborator Irene Ghobrial of the Dana-Farber
'/>"/>

Contact: Colleen Morrison
cmorri@osa.org
202-416-1437
Optical Society of America
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. M2SYS Partners With Gnosis Medical Services to Provide Accurate Patient Identification in Developing Countries Through Innovative Biometrics Solution
2. Rhythmic breathing adapts to external beat through brain calculus
3. New technique can be breakthrough for early cancer diagnosis
4. Breakthrough research identifies how cells from pigs may cure diabetes
5. Male contraception breakthroughs to be presented, Seattle Sept. 27-28
6. West Nile virus spread through nerve cells linked to serious complication
7. Major genetic breakthrough for ankylosing spondylitis brings treatment hope
8. ACT Ensures Integrity of Testing Process Through Deployment of BIO-keys(R) Biometric ID Technology
9. Oosight microscope enables embryonic stem cell breakthrough
10. UK scientists working to help cut ID theft
11. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... by the Red Queen in Lewis Carroll,s Through ... Illinois and National University of Singapore improved a ... evolve over decades to millions of years. , ... for competition, incorporates the "Red Queen Effect," an ... the 1970s, which suggests that organisms must constantly ...
(Date:7/30/2014)... between two points is a straight line, and now ... the familiar axiom to heart. , Though competition ... with each racing for the chance to fertilize the ... cooperative groups that allow them to take a straighter ... conducted by Heidi Fisher, a post-doctoral student working in ...
(Date:7/30/2014)... Press (OUP) is pleased to announce its new relationship ... 2015, OUP and CINP will partner to publish ... a fully open-access journal. , Alan Frazer, Editor-in-Chief of ... size and expertise of OUP will further facilitate the ... of the very leading journals within neuropsychopharmacology. The conversion ...
Breaking Biology News(10 mins):Classic Lewis Carroll character inspires new ecological model 2Classic Lewis Carroll character inspires new ecological model 3When cooperation counts 2When cooperation counts 3OUP to partner with the International College of Neuropsychopharmacology 2
... June 21, 2011 Cervical ripening that instigates ... onset of normal term labor, researchers at UT Southwestern ... conventional premise that premature cervical ripening and remodeling is ... process, and that normal term ripening is caused primarily ...
... (June 20, 2011) Researchers at Virginia Commonwealth University ... that have implications for cancer as well as many ... and hypertension. This discovery has pioneered the formation of ... possibilities of developing future gene therapies to treat cancer ...
... LANSING, Mich. As human populations increase and available arable ... food more efficiently. Michigan State University researchers believe that ... help meet this goal. "We already know how to ... a day we have the science to be able ...
Cached Biology News:Researchers find process of cervical ripening differs between term and preterm birth 2Discoveries in mitochondria open new field of cancer research 2MSU nets $5 million grant to increase dairy production efficiency 2
(Date:7/31/2014)... Rancho BioSciences , the scientific ... Array Suite with tranSMART . Scientists that ... send data in tranSMART to Array Suite for further ... tranSMART including the new 1.2 release. Array Suite ... for the analysis of high dimensional quantification data, including ...
(Date:7/31/2014)... SoundConnect , an award winning ... to announce the addition of Adobe Connects Learning ... tools to quickly deploy and manage online courses ... for desktop and mobile learning solutions. , Adobe ... online training solution, enabling organizations to deploy, measure, ...
(Date:7/30/2014)... and PARIS , July ... Sanofi (EURONEXT: SAN and NYSE: SNY) today announced that ... Drug Administration (FDA) rare pediatric disease priority review voucher ... for alirocumab.  The priority review voucher entitles the holder ... for an expedited 6-month review from the filing date ...
(Date:7/30/2014)... 2014  Replikins Ltd. today released new data on ... Before the current outbreaks, the mean Ebola Reston gene ... between 1995 and 2002 was 1.1; the mean Replikin ... sixteen-fold in 2013, thus predicting the current outbreaks in ... been shown to be able to predict outbreaks (1). ...
Breaking Biology Technology:Rancho BioSciences, in Partnership with Omicsoft, have Integrated Array Suite with tranSMART 2Rancho BioSciences, in Partnership with Omicsoft, have Integrated Array Suite with tranSMART 3SoundConnect Enhances Portfolio with Adobe Connect Learning Management System (LMS) 2Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 2Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 3Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 4Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 5Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 6
... Madison, Wis . - Did the state of Wisconsin improperly ... installed by Menasha Corp. ? , ,The Wisconsin ... week to hear the case, and there is an estimated ... for Menasha Corp. , ,At issue is the definition of ...
... Madison, Wis. - Whether you pronounce it nitch or ... same way, and thanks in large measure to the Internet, ... Brandworks University 2007 , is centered on what some ... Internet and its low-cost distribution channel have emerged as the ...
... Madison, Wis. - Just as the Milwaukee ... contending Major League team, Wisconsin is attempting to join the ... infrastructure. , ,That building process reached another milestone with the ... annual angel capital investments, according to a new report compiled ...
Cached Biology Technology:Internet-enabled niche markets take center stage 2Internet-enabled niche markets take center stage 3Wisconsin building toward the major leagues of venture capital 2Wisconsin building toward the major leagues of venture capital 3
A trigger solution for Flashlight labeled materials....
... Lab Quantas unique combination of Coulter ... resolution capabilities and accurate cell counting. ... wavelengths, including UV, allowing flexible fluorochrome ... applications typically only achievable with larger, ...
... Reader is Cellomics‘ latest product ... Cell-based Screening". The KineticScan Reader ... do both temporal and high-resolution ... dynamic distribution and activity of ...
... cytometry system is the superior cell-sorting instrument ... years, BD cell sorters have been the ... university, pharmaceutical, and biotechnology research facilities throughout ... demands of today, we have improved the ...
Biology Products: