Navigation Links
Looking at neurons from all sides
Date:4/27/2008

HOUSTON (April 28, 2008) A new technique that marries a fast-moving laser beam with a special microscope that look at tissues in different optical planes will enable scientists to get a three-dimensional view of neurons or nerve cells as they interact, said Baylor College of Medicine scientists in a report that appears today in the journal Nature Neuroscience.

Most microscopes can only study cell function in two dimensions, said Dr. Gaddum Duemani Reddy, an M.D./Ph.D. student at BCM at Houston and Rice University and also first author of the study. To look at different planes, you have move your preparation (of cells) or the objective lens. That takes time, and we are looking at processes that happen in milliseconds.

To solve that problem, he said, they developed a trick to quickly move a laser beam in three dimensions and then adapted that laser beam to the multi-photon microscope they were using. That allowed them to see the neurons function in three dimensions, giving them a much better view of its activity.

A multiphoton microscope looks much like a conventional, upright microscope but it has an adaption that allows it to look at tissues in sections. A conventional multiphoton microscope does that very slowly, he said.

With ours, you can do it very quickly. We are starting to see how a single neuron behaves in our laboratory, he said. The next step, he said, will be to use to it to look a clusters or colonies of neurons. This will enable them to actually see the neuronal interactions.

At present, the technology is applied in my lab to study information processing of single neurons in brain slice preparations by 3D multi-site optical recording, said Dr. Peter Saggau, professor of neuroscience at BCM and the papers senior author.

He is collaborating with two other labs on using the technology in other ways. In one, he said, researchers plan to use the technology to monitor nerve activity in the bra
'/>"/>

Contact: Graciela Gutierrez
ggutierr@bcm.edu
713-798-4712
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
2. Inflammation triggers cell fusions that could protect neurons, Stanford research shows
3. Neurons hard wired to tell left from right
4. Weill Cornell team discovers how brains own tPA helps regulate blood flow to neurons
5. Overexcited neurons not good for cell health
6. The birth and death of dopamine neurons: A new model for neurodegeneration
7. The accumulation of sugar in neurons may explain the origin of several neurodegenerative diseases
8. Mice use specialized neurons to detect carbon dioxide in the air
9. Sidestepping cancers chaperone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... shown for the first time how bacteria can grow ... them the opportunity to get tremendous insights into bacteria ... also discovered the bacterial growth in chronic lung infections ... down by the immune cells. The researchers discovered the ... the bacteria, forcing the bacteria to switch to a ...
(Date:10/16/2014)... have a new synthesis of recent research findings to ... in the two states. , The Ecology and ... Washington: A Synthesis of the Relevant Biophysical Science and ... published by the U.S. Forest Service,s Pacific Northwest Research ... managers for a synthesis of the large body of ...
(Date:10/16/2014)... Post-menopausal women experienced improvements in vaginal atrophy, with ... bleeding, after 12 weeks of daily 10 milligram ... nutritional supplement previously shown to help relieve certain ... study reported in a poster at the North ... , "These data documented improved vaginal epithelium, without ...
Breaking Biology News(10 mins):Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2New report synthesizes best available science on management of moist mixed-conifer forests 2S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2
... balance of biodiversity within North American small-mammal communities is so ... about 12,000 years ago that the current climate change could ... down the food chain, say Stanford biologists. The evidence lies ... excavated from a cave in Northern California. What they ...
... WALL, N.J. , May 5 BIO-key International, Inc. (OTC ... BIO-key will be presenting at the Annual SafeTrace User Group Meeting being held ... Lake City, Utah . , , ... http://www.newscom.com/cgi-bin/prnh/20050509/BIOKEYLOGO ) , , , ...
... Italy , May 10, 2010 Health Robotics,today ... guidelines for controlled substances, including,tamper-evident syringe caps, biometric identification, restricting ... , , ... "In addition to being the only company ...
Cached Biology News:Small mammals -- and rest of food chain -- at greater risk from global warming than thought 2Small mammals -- and rest of food chain -- at greater risk from global warming than thought 3BIO-key(R) International Invited to Speak at Annual SafeTrace(R) User Group Meeting 2Health Robotics' i.v.STATION Certified as the Only Robot to Comply with Security Guidelines for Controlled Substances 2Health Robotics' i.v.STATION Certified as the Only Robot to Comply with Security Guidelines for Controlled Substances 3Health Robotics' i.v.STATION Certified as the Only Robot to Comply with Security Guidelines for Controlled Substances 4
(Date:10/22/2014)... and HONG KONG , Oct. ... disease therapeutics enterprise, announced today that rare disease expert ... as vice president, research. Dr. McKew brings more than ... leadership positions at the National Institutes of Health, Wyeth ... by Wyeth). Dr. McKew will lead aTyr,s efforts to expand ...
(Date:10/20/2014)... Mapp Biopharmaceutical,s valiant effort to produce ... fight the Ebola outbreak will make the public ... of pharmaceuticals can be, according to Kalorama Information.  ... some may be taken aback by the three-month ... knowledge are well aware of the complex issues ...
(Date:10/20/2014)... PARK, Calif. , Oct. 20, 2014 /PRNewswire/ ... today that the Company has signed a Notice ... of Regenerative Medicine (CIRM), effective October 1, 2014.  ... Clinical Development payments and the release of additional ... million CIRM grant award for clinical development of ...
(Date:10/20/2014)... , A major pan-European survey into the ... care has revealed changing trends in many important GI ... of healthcare services across the continent. The results of ... (UEG), have been announced today and led to calls ... of GI disorders across Europe ...
Breaking Biology Technology:aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5
... and the University of Puerto Rico have granted an ... that can be designed to emit light in any ... Performance Indicator, LLC, of Lowell, Mass., acquired the ... energy absorbed by a substance is released relatively slowly ...
... , STOCKHOLM, Aug. 17 ... Representative Diana DeGette (D. Colo) will be a keynote speaker at ... 2009. Ms. DeGette, co-sponsor of the pioneering Stem Cell Research ... healthcare reform, will help open SALSS, a vital showcase for the ...
... , , ... a biotechnology company developing antiviral therapies with a focus on ... appointment of Paul Truex to its Board of Directors. , ... CEO of Anthera Pharmaceuticals - a private pharmaceutical company focused ...
Cached Biology Technology:UGA, UPR grant license for long-persistence glow materials, in any color 2UGA, UPR grant license for long-persistence glow materials, in any color 3UGA, UPR grant license for long-persistence glow materials, in any color 4Swedish-American Life Science Summit (SALSS) to Address Major Issues Including Healthcare Reform, Synthetic Biology and Innovative Financing for Biotechs 2Swedish-American Life Science Summit (SALSS) to Address Major Issues Including Healthcare Reform, Synthetic Biology and Innovative Financing for Biotechs 3Swedish-American Life Science Summit (SALSS) to Address Major Issues Including Healthcare Reform, Synthetic Biology and Innovative Financing for Biotechs 4Eiger BioPharmaceuticals Appoints Paul Truex to Board of Directors 2
Mouse monoclonal antibody to CDC2L5 - cell division cycle 2-like 5 (cholinesterase-related cell division controller)...
...
... Baculovirus Transfer Vector is a derivative of the ... for blue fluorescent protein (BFP), followed by a ... genes are expressed as BFP-6xHis fusion proteins when ... (EcoR I, Stu I, Sac I, Not I, ...
Our Histology, Immunohistochemistry and tissue arrays services include samples processing, different type of staning, histollogical stains, image analysis, tissue arrays, immunohistochemistry, etc....
Biology Products: