Navigation Links
Longevity mutation found in flies far and wide

t's great, but now we can show that it does it in the wild."

In the study, published online Jan. 31 in the journal Aging, the researchers, led by postdoctoral scholar Chen-Tseh Zhu, describe experiments that confirm that the Hoppel transposon's presence positively affected life span and fertility in the flies. What they found is that the optimal case for those two traits was heterozygosity: one allele, or copy, of the Indy gene in a fly having the insertion and the other not having it.

Life span and fertility

The researchers measured the physiological effects of Hoppel by looking at flies from three different lines: one from Oahu gathered in 1950s, another from Captain Cook, Hawaii, gathered in 2007, and one with its origin in Hidalgo, Mexico, in 2005. Each line had some flies with at least one copy of Indy with Hoppel and some with no Hoppel in Indy.

The heterozygous females in these lines ended up laying about 10 percent more eggs than flies that had no Indy alleles with Hoppel. Flies for whom both Indy alleles had Hoppel laid the fewest eggs. This demonstrates that one Indy allele with Hoppel had a strong selective advantage in reproductive fitness, Helfand said.

For life span, flies that had Hoppel on at least one Indy allele lived considerably longer than flies with no Hoppel on either chromosome. For example, among one group of females, by day 60, more than 80 percent of heterozygotes, and about 80 percent with Hoppel on both alleles were still alive. For those without any Hoppel insertion, less than 60 percent were still buzzing about by day 60.

Indy and Hoppel

For all the prior lab work, researchers are still not completely sure how Indy works, with our without mutations such as the Hoppel insertion. The protein the gene encodes appears to help gate metabolically important small nutrients such as citrate in the cell cytoplasm. Mutations in the gene appea

Contact: David Orenstein
Brown University

Page: 1 2 3

Related biology news :

1. New study finds extreme longevity in white sharks
2. Why cells stick: Phenomenon extends longevity of bonds between cells
3. Dopamine-receptor gene variant linked to human longevity
4. Gladstone scientists discover novel mechanism by which calorie restriction influences longevity
5. Personality genes may help account for longevity
6. Horse gaits controlled by genetic mutation spread by humans, new study reveals
7. New hope: Researchers discover genetic mutations that cause rare and deadly lung disease
8. Mutation discovery may improve treatment for rare brain tumor type
9. Important mutation discovered in dairy cattle
10. Scientists identified T372R mutation as potential target for diagnosis and treatment of insulinoma
11. Genetic mutation may play key role in risk of lethal prostate cancer in overweight patients
Post Your Comments:
Related Image:
Longevity mutation found in flies far and wide
(Date:7/31/2015)... Kina, 31. juli 2015 Den 10. internationale ... af BGI fra den 22. - 25. oktober i ... fejrer sin 10-års fødselsdag i år. Siden starten i ... årlige møder på ,omik,-feltet, og er en af de ... ICG-10 fokuserer på nylige gennembrud og fremskridt inden ...
(Date:7/31/2015)... 2015 BGI llevará a cabo la 10ª Conferencia ... 25 de octubre de 2015, en Shenzhen, ... décimo aniversario este año. Desde su inauguración en 2006, ... anuales más influyentes del mundo en los campos de ... más dinámicas, entusiastas y amenas. ICG-10 se ...
(Date:7/31/2015)... , 31 de julho de 2015 ... ) será realizada pela BGI de 22-25 de ... . A conferência está celebrando seu 10 ... 2006, a ICG se tornou uma das reuniões mais ... dos encontros científicos mais dinâmicos, entusiastas e prazerosos. ...
Breaking Biology News(10 mins):Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
... April 14, 2011 A natural hormone known to inhibit ... Medical Center researchers have demonstrated. Scientists led by Dr. ... the anti-aging hormone Klotho suppressed both renal fibrosis a ... of cancer. The findings are available online in the ...
... following highlights summarize research papers that have been recently published ... Little Ice Age resulted from more than just solar calm ... the amount of light the Sun puts out, varies with ... TSI is notably higher or lower than its average values. ...
... and toad skins already are renowned as cornucopias of ... ACS,s Journal of Proteome Research reveals that ... antibacterial and antiviral substances that could inspire a new ... out that scientists know little about the germ-fighting proteins ...
Cached Biology News:Anti-aging hormone Klotho inhibits renal fibrosis, cancer growth 2AGU journal highlights -- April 13, 2011 2AGU journal highlights -- April 13, 2011 3AGU journal highlights -- April 13, 2011 4AGU journal highlights -- April 13, 2011 5AGU journal highlights -- April 13, 2011 6AGU journal highlights -- April 13, 2011 7
(Date:7/31/2015)... 2015 In today,s fast changing healthcare ... drive positive health outcomes, improve profitability and enhance ... care in their communities. At ThoughtSpot 2015, ... AmerisourceBergen announced a new set of innovative capabilities ... and help independent pharmacies endure the industry,s most ...
(Date:7/31/2015)... ... July 31, 2015 , ... Global Resorcinol Market 2015-2019 is ... on the global resorcinol industry. The report highlights the various growth prospects and ... and analysis of primary and secondary inputs from the existing players of the ...
(Date:7/31/2015)... , July 31, 2015 China Cord ... China,s leading provider of cord blood ... cell storage services, today announced that the Company has ... U.S. Securities and Exchange Commission. The filed Form 20-F ... March 31, 2015. The Form 20-F can be accessed ...
(Date:7/31/2015)... ... July 31, 2015 , ... R-Biopharm is proud to ... hydrolyzed gluten in foods, has been accepted by AOAC International as Official First ... in Fermented Cereal-Based Products by R5 Competitive ELISA,” based on a specific monoclonal ...
Breaking Biology Technology:AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 2AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 3Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at 2Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at 3Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at 4China Cord Blood Corporation Files Its Annual Report on Form 20-F 2RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2
... In a column I wrote last year, I alluded to ... global. In fact, there are now 4,284 biotech companies in 25 ... , ,Moreover: , , The biotech industry has 622 publicly ... $16 billion in R&D in 2001. , , The industry ...
... of industry, government, and more than 200 universities ... University), Internet2 is leading the way toward revolutionary ... effective access to Internet2s main infrastructure is still ... and Director of the Division of Information ...
... The University of Wisconsin-Madisons Education Building, which originally ... been unfinished for 104 years, but thanks to ... modernize and complete the building, one of Bascom ... Tashia F. Morgridge, both UW-Madison alumni, hope the ...
Cached Biology Technology:In Globalizing Biotech, Midwest Must Differentiate From Pack 2In Globalizing Biotech, Midwest Must Differentiate From Pack 3In Globalizing Biotech, Midwest Must Differentiate From Pack 4From the back roads to the superhighway: Making the connection to Internet2 2Cisco Chairman donates $31 million for UW building renovation 2
Amino-acids and Derivatives Rabbit Anti-conjugated L-isoleucine Polyclonal Antibody...
Phosphatidylinositol transfer protein beta isoform (PtdIns transfer protein beta) (PtdInsTP) (PI-TP-beta). [Source:Uniprot/SWISSPROT;Acc:P48739] Antigen: Recombinant Protein Epitope Signature Tag...
Anti-MMP-25 (Membrane-type MMP-6, Mt6MMP), hinge region; rabbit host...
Mouse monoclonal [88B] to nicotinic Acetylcholine Receptor ( Abpromise for all tested applications)....
Biology Products: