Navigation Links
Longevity mutation found in flies far and wide
Date:2/5/2014

PROVIDENCE, R.I. [Brown University] For years, researchers have been investigating how mutations of a gene called Indy (for "I'm Not Dead Yet") affect metabolism, life span, and reproductive fitness in both mammals and fruit flies. So far mutations in Indy have been studied experimentally only in the lab. No longer. A new study reports that a particularly important variation of the gene with much the same life-governing consequences has actually been widespread among fruit flies, judging by lines gathered from the wild across the entire globe for 60 years.

The naturally occurring variation is the insertion of a transposable element an invasive snippet of DNA at a specific position on Indy. Researchers, including Brown University biology professors Stephen Helfand and Robert Reenan, found that the transposable element, called Hoppel, was present to varying extents in 17 of 22 fruit fly lines gathered from all over the world as far back as the middle of last century. Hoppel was present in 100 percent of a captive fly line started in 2006 in Mumbai, India, for example, and 55 percent of flies descended from those gathered in Oahu, Hawaii, in 1955.

Helfand recalled that in 2000 when he first published a paper in Science demonstrating the effect of Indy on life span, a couple of reporters asked him why a mutation that conveyed such advantages wasn't found in the wild.

Indeed, 14 years later the prevalence of Hoppel insertion suggests that it has been beneficial to flies in the wild and therefore persisted during their evolution, said Helfand, of Brown's Department of Molecular Biology, Cellular Biology, and Biochemistry.

"It's kind of remarkable that just the Hoppel in Indy should affect fertility and life span because these flies from around the world are from such differing genetic backgrounds," said Helfand. "This suggests that we are correct that Indy does play a role in longevity. If it does it in the lab, tha
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New study finds extreme longevity in white sharks
2. Why cells stick: Phenomenon extends longevity of bonds between cells
3. Dopamine-receptor gene variant linked to human longevity
4. Gladstone scientists discover novel mechanism by which calorie restriction influences longevity
5. Personality genes may help account for longevity
6. Horse gaits controlled by genetic mutation spread by humans, new study reveals
7. New hope: Researchers discover genetic mutations that cause rare and deadly lung disease
8. Mutation discovery may improve treatment for rare brain tumor type
9. Important mutation discovered in dairy cattle
10. Scientists identified T372R mutation as potential target for diagnosis and treatment of insulinoma
11. Genetic mutation may play key role in risk of lethal prostate cancer in overweight patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Longevity mutation found in flies far and wide
(Date:6/16/2015)... /CNW Telbec/ - handyem Inc. and FlowMetric Diagnostics ... of handyem,s HPC-150 portable flow cytometer within FlowMetric ... unprecedented model of mobile laboratory platform is presented ... Pennsylvania Convention Center, ... to 18 th 2015.  By virtue of ...
(Date:6/16/2015)... GOTHENBURG, Sweden , June 16, 2015 ... including all touch fingerprint sensors in the company,s portfolio from ... . Deliveries are planned to mainly take place during the ... manufacturers in Asia . Jörgen ... another evidence of    the   growing interest from smartphone ...
(Date:6/15/2015)... , June 16, 2015 According ... Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, ... to 2020" published by MarketsandMarkets, The Natural Language Processing ... a CAGR of 18.4% for the forecast period 2015-2020. ...   46 F igures spread   through 155 ...
Breaking Biology News(10 mins):handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2Natural Language Processing Market Worth $13.4 Billion by 2020 2Natural Language Processing Market Worth $13.4 Billion by 2020 3Natural Language Processing Market Worth $13.4 Billion by 2020 4Natural Language Processing Market Worth $13.4 Billion by 2020 5
... Effects of climate change projected this century for ... threaten water supplies, buildings, transportation systems, human health, ... report produced by the University of Oregon,s Climate ... Science & Policy. The authors say that ...
... Earth are fueling the world,s highest-known microbial ecosystems, which ... Socompa volcano in the Andes by a University of ... study shows the emission of water, carbon dioxide and ... Socompa sustains complex microbial ecosystems new to science in ...
... researchers in China have discovered that chicken manure can be ... the International Journal of Environment and Pollution the ... more crude oil than soil lacking the guano. ... China, point out that contamination of soil by crude oil ...
Cached Biology News:Eugene-Springfield face Upper Willamette climate threats 2Eugene-Springfield face Upper Willamette climate threats 3Eugene-Springfield face Upper Willamette climate threats 4Earth's highest known microbial systems fueled by volcanic gases 2Earth's highest known microbial systems fueled by volcanic gases 3Fowl soil additive breaks down crude oil 2
(Date:7/7/2015)... , July 7, 2015  SME,s Advanced Manufacturing ... third-annual "30 Under 30" issue, celebrating young men and ... The July issue of Manufacturing ... professionals and students for their accomplishments. Among the standouts: ... U.S. Air Force on optimizing the topology of flapping ...
(Date:7/7/2015)... (PRWEB) , ... July 07, 2015 , ... CSM, a ... team as Vice President of Finance. Morse has an extensive background in financial management ... to the CSM team. In his new role, Morse will oversee all financial areas ...
(Date:7/6/2015)... Irvine, CA (PRWEB) , ... July 06, 2015 ... ... leader in Personalized Medicine, recently hosted their 2015 bi-annual Pain Management Medical Advisory ... Board met with Proove Biosciences’ executive Research and Development team to discuss new ...
(Date:7/6/2015)... SUNNYVALE, Calif. , July 6, 2015  Viveve Medical, ... announced that Patricia Scheller , Viveve,s Chief Executive Officer, ... present live at VirtualInvestorConferences.com on July 9, 2015. , ... 9, 2015 , , , , TIME:     ... , LINK: , , , http://tinyurl.com/viveve   , ...
Breaking Biology Technology:SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 2SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 3SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 4SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 5CSM Appoints Michael Morse as Vice President of Finance 2Proove Biosciences Gathers Key Opinion Leaders in Pain Management for Medical Advisory Board Meeting in Palm Springs, California 2Proove Biosciences Gathers Key Opinion Leaders in Pain Management for Medical Advisory Board Meeting in Palm Springs, California 3Viveve to Webcast Live at VirtualInvestorConferences.com 2Viveve to Webcast Live at VirtualInvestorConferences.com 3
... Instrumental in Dickinson Mental Health Center,s Ability ... to Track ... Oct. 18 Netsmart Technologies, Inc.,a leading provider of ... today announced that Netsmart customer,Dickinson Mental Health Center ranked ...
... Elekta, a global leader in radiation,oncology and ... at the 49th Annual Meeting of The American ... reduce,treatment times and increase efficiency. The meeting will ... Los Angeles Convention Center (Los Angeles,California, USA). Elekta ...
... Mass., Oct. 18 Alseres,Pharmaceuticals, Inc. (Nasdaq: ... Frank Bobe,Executive Vice President and Chief Business ... at Windhover Information,s 2nd,Annual Therapeutic Area Partnerships ... will be presenting an overview on Alseres ...
Cached Biology Technology:Netsmart Technologies Customer in Pennsylvania Recognized for Achieving Data Benchmarking Milestones 2Elekta Announces New Cancer Care Solutions and Highlights Personalized Efficiency at ASTRO 2007 2Elekta Announces New Cancer Care Solutions and Highlights Personalized Efficiency at ASTRO 2007 3Elekta Announces New Cancer Care Solutions and Highlights Personalized Efficiency at ASTRO 2007 4Alseres Pharmaceuticals, Inc. to Present at Windhover's Therapeutic Area Partnerships Conference 2
20X TE buffer *RNase free*...
... (serial analysis of gene expression) ... analysis. Expression profiles generated by ... detect low-abundance transcripts making it ... The I-SAGE Kit is designed ...
Incomplete Adjuvant...
2,4-Dinitrophenyl hapten is conjugated to Keyhole Limpet (KLH) protein through lysine....
Biology Products: