Navigation Links
Little too late: Researchers identify disease that may have plagued 700-year-old skeleton
Date:7/14/2014

European researchers have recovered a genome of the bacterium Brucella melitensis from a 700-year-old skeleton found in the ruins of a Medieval Italian village.

Reporting this week in mBio, the online open-access journal of the American Society for Microbiology, the authors describe using a technique called shotgun metagenomics to sequence DNA from a calcified nodule in the pelvic region of a middle-aged male skeleton excavated from the settlement of Geridu in Sardinia, an island off the coast of Italy. Geridu is thought to have been abandoned in the late 14th century. Shotgun metagenomics allows scientists to sequence DNA without looking for a specific target.

From this sample, the researchers recovered the genome of Brucella melitensis, which causes an infection called brucellosis in livestock and humans. In humans, brucellosis is usually acquired by ingesting unpasteurized dairy products or from direct contact with infected animals. Symptoms include fevers, arthritis and swelling of the heart and liver. The disease is still found in the Mediterranean region.

"Normally when you think of calcified material in human or animal remains you think about tuberculosis, because that's the most common infection that leads to calcification," says senior study author Mark Pallen, PhD, professor of microbial genomics at Warwick Medical School in Coventry, England. "We were a bit surprised to get Brucella instead."

The skeleton contained 32 hardened nodules the size of a penny in the pelvic area, though Pallen says it's unclear if they originated in the pelvis, or higher up in the chest or other body part.

In additional experiments, the research team showed that the DNA fragments extracted had the appearance of aged DNA they were shorter than contemporary strands, and had characteristic mutations at the ends. They also found that the medieval Brucella strain, which they called Geridu-1, was c
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Variations of a single gene can lead to too much or too little growth, study shows
2. Chemical fingerprinting tracks the travels of little brown bats
3. NTU researchers study little mighty creature for scientific breakthrough
4. Little did we know about beetle diversity: Astonishing 138 new species in a single genus
5. Cell therapy a little more concrete thanks to VIB research
6. AACR news: Little molecule makes big difference in bladder cancer metastasis
7. Climate change may have little impact on tropical lizards
8. Solitary lemurs avoid danger with a little help from the neighbors
9. Genetic secrets of the worlds toughest little bird
10. Little changes -- large effects
11. Beyond the little blue pill: scientists develop compound that may treat priapism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Wis. No matter how many times it,s ... social, communicating creatures. , But by using ... organisms radically alter their behavior to suit their ... of them are present, and act accordingly. , ... millions, it may change from innocuous to pathogenic, ...
(Date:9/18/2014)... turned its newborn screening program into a model other states ... the first-ever Newborn Screening Quality Award from the March of ... M.P.H., Arizona,s Department of Health Services director, with the award ... policy of full transparency for the length of time it ... lab for analysis, and set a target of having 95 ...
(Date:9/18/2014)... global cycles of carbon and nitrogen comprise all ... and environmental systems have caused imbalances and perturbations ... gases (GHGs). Increased GHGs result in climate changes ... ecosystems, oceans and the atmosphere. Understanding these feedback ... branch of environmental science during the past three ...
Breaking Biology News(10 mins):Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3March of Dimes honors Arizona with first-ever newborn screening award 2March of Dimes honors Arizona with first-ever newborn screening award 3Greenhouse gas research enters a new era 2
... from the University of Southern Denmark have identified how a ... in a cell,s membrane. Such holes cause high blood pressure, ... medication for high blood pressure. High blood pressure can ... a specific mutated protein. Now the researchers at University of ...
... suffer from the consequences of maternal drug exposure during pregnancy, ... used substances. This motivated the study, published in the ... to decipher the molecular basis of how the major psychoactive ... brain development of the unborn foetus. The study ...
... have engineered an efficient and environmentally friendly catalyst for ... extensively in modern industry to manufacture fertilizer and refine ... element, it is generally not found as the pure ... (H2O) or to carbon in methane (CH4), the primary ...
Cached Biology News:Punctured cell membranes lead to high blood pressure 2Cannabis during pregnancy endangers fetal brain development 2Engineers teach old chemical new tricks to make cleaner fuels, fertilizers 2Engineers teach old chemical new tricks to make cleaner fuels, fertilizers 3Engineers teach old chemical new tricks to make cleaner fuels, fertilizers 4
(Date:9/18/2014)... About POCT POCT, ... clinical laboratory. It helps in making fast clinical ... medication. POCT is gaining popularity due to the ... as diabetes, heart disease, and obesity. It is ... to minimize errors during the diagnosis of patients. ...
(Date:9/18/2014)... Ireland , September 18, 2014 ... and Markets ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has ... "Biocompatible Materials - Global Strategic Business ... ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes ... in US$ Million by the following ...
(Date:9/18/2014)... 18, 2014 Research and Markets ... "Global N-acetylcysteine Industry Report 2014" report to ... Industry Report 2014 is a professional and in-depth ... N-acetylcysteine industry. The report provides a ... applications and industry chain structure. The N-acetylcysteine market ...
(Date:9/18/2014)...  U.S. biotech company Kultevat has strengthened ... technology developed by the Donald Danforth Plant Science ... for applications in production of natural rubber in ... developed under the direction of Roger Beachy , ... of the Danforth Plant Science Center, and is used ...
Breaking Biology Technology:POCT Market in China 2014-2018 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global N-acetylcysteine Industry Report 2014 2Kultevat obtains license of gene switch technology 2
... a provider of single-molecule DNA analysis technology, announced Thursday it ... of brain tumor, known as oligodendroglioma. OpGen, based in Madison, ... and professor of genetics and chemistry at the University of ... , ,Optical mapping, invented by Schwartz, will enable researchers to ...
... investors, and media is a leading indicator, the technology market is ... when he said DEMO 2004 felt "like a bit of the ... were repeated by dozens of attendees who talked to or emailed ... this industry unlike any we've felt in the past 36 months. ...
... to offshore outsourcing as an issue du jour. I ... (an election year at that for America) due to ... future of the U.S. Prominent voices along every point ... Democratic presidential nomination to the Bush Administration and a ...
Cached Biology Technology:OpGen joins UW, Henry Ford Heath in Improving Brain Tumor Treatment 2The Tech Market is Looking Up 2The Tech Market is Looking Up 3The Tech Market is Looking Up 4The Great Offshore Outsourcing Debate 2
... AP Conjugate Stabilizer is an aqueous ... protein and other non-toxic stabilizing chemicals ... pH 5.5 6.5. This ... methylisothiazolone and 0.02% bromonitrodioxane as a ...
... binding is a problem in your ... immobilized NeutrAvidin products as superior alternatives ... a modified avidin derivative that combines ... biotin-binding protein with exceptionally low nonspecific ...
Cells are grown to a specified density and induced, when necessary. Protein expression samples are collected at 3 growth points and analyzed by SDS-PAGE/Coomassie....
... generated hybridomas against a large variety ... you are provided with personalized project ... lines developed by Covance remain exclusive ... hybridoma development project has four phases: ...
Biology Products: