Navigation Links
Lipids in the brain an important factor for Alzheimer's disease?
Date:12/10/2007

formed they cannot disappear or be transformed into another structure. Ivo Martins, Joost Schymkowitz and Frederic Rousseau (VIB, Vrije Universiteit Brussel), and Inna Kupperstein and Bart De Strooper (VIB, K.U.Leuven) have shown that certain lipids normally occurring in the brain can destabilize the fibrils, and therefore also the plaque that is so typical of Alzheimer's disease. The liberated protofibrils are toxic for brain cells, causing them to die off at least in vitro. The researchers were able to show that this also happens in vivo by injecting laboratory animals (mice) with the protofibrils. This caused memory loss in the mice. The researchers explain that these symptoms are comparable with those of early stage dementia in humans.

Producing protofibrils for new applications in medicine

The discovery opens up a new avenue of research into possible medicines against Alzheimer's disease. It indicates that substances that neutralize the toxicity or the formation of protofibrils might be able to be used as medicines against Alzheimer's disease. With the discovery of a method for producing toxic protofibrils, the researchers at the VIB have provided a good model for finding medicines that could counteract the formation of protofibrils. Their research also indicates that the concentration of lipids in the brain greatly influences the biological equilibrium between non-toxic plaques and toxic oligomeres. These results open up new avenues of research into the effects of fat metabolism for diseases such as Alzheimer's.


'/>"/>

Contact: Sooike Stoops
info@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Chemists get grip on slippery lipids
2. Invasion of the brain tumors
3. HIV is a double hit to the brain
4. AIDS interferes with stem cells in the brain
5. 60 second test could help early diagnosis of common brain diseases
6. U of MN researchers discover noninvasive diagnostic tool for brain diseases
7. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
8. Influence of sex and handedness on brain is similar in capuchin monkeys and humans
9. Inside the brain of a crayfish
10. Specific brain protein required for nerve cell connections to form and function
11. Brains timing linked with timescales of the natural visual world
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2015)... Feb. 10, 2015  Alere Inc. (NYSE: ALR), ... financial results for the quarter ended December 31, ... and President of Alere said, "We made substantial ... as the global leader in rapid diagnostics and ... Alere Health divestiture in early January enabled us ...
(Date:2/5/2015)... Jan. 26, 2015   Epic Sciences , a precision ... announced that Murali Prahalad , Ph.D., president and CEO, ... Conference (PMWC) 2015: Silicon Valley, which is taking place ... Calif. on January 26-28, 2015. ... Age as Biomarkers." Last year, Epic Sciences was a finalist ...
(Date:2/5/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce market, ... Online CEO Conference on January 29 th at ... , CEO of NXT-ID will present and host a ... smart wallet and its full suite of biometric technologies. ...
Breaking Biology News(10 mins):Alere Inc. Announces Fourth Quarter 2014 Results 2Alere Inc. Announces Fourth Quarter 2014 Results 3Alere Inc. Announces Fourth Quarter 2014 Results 4Alere Inc. Announces Fourth Quarter 2014 Results 5Alere Inc. Announces Fourth Quarter 2014 Results 6Alere Inc. Announces Fourth Quarter 2014 Results 7Alere Inc. Announces Fourth Quarter 2014 Results 8Alere Inc. Announces Fourth Quarter 2014 Results 9Alere Inc. Announces Fourth Quarter 2014 Results 10Alere Inc. Announces Fourth Quarter 2014 Results 11Alere Inc. Announces Fourth Quarter 2014 Results 12Alere Inc. Announces Fourth Quarter 2014 Results 13Alere Inc. Announces Fourth Quarter 2014 Results 14Alere Inc. Announces Fourth Quarter 2014 Results 15Alere Inc. Announces Fourth Quarter 2014 Results 16Alere Inc. Announces Fourth Quarter 2014 Results 17Alere Inc. Announces Fourth Quarter 2014 Results 18Alere Inc. Announces Fourth Quarter 2014 Results 19Alere Inc. Announces Fourth Quarter 2014 Results 20Alere Inc. Announces Fourth Quarter 2014 Results 21Alere Inc. Announces Fourth Quarter 2014 Results 22Alere Inc. Announces Fourth Quarter 2014 Results 23Alere Inc. Announces Fourth Quarter 2014 Results 24Alere Inc. Announces Fourth Quarter 2014 Results 25Alere Inc. Announces Fourth Quarter 2014 Results 26Alere Inc. Announces Fourth Quarter 2014 Results 27Alere Inc. Announces Fourth Quarter 2014 Results 28Alere Inc. Announces Fourth Quarter 2014 Results 29Alere Inc. Announces Fourth Quarter 2014 Results 30Alere Inc. Announces Fourth Quarter 2014 Results 31Alere Inc. Announces Fourth Quarter 2014 Results 32Alere Inc. Announces Fourth Quarter 2014 Results 33Alere Inc. Announces Fourth Quarter 2014 Results 34Alere Inc. Announces Fourth Quarter 2014 Results 35Alere Inc. Announces Fourth Quarter 2014 Results 36
... Post-It Notes Three things that started out as obscure inventions ... the next idea to stick with modern society look like" ... humble lizard, according to a University of Calgary biologist who ... virtually any surface, including glass., Unlike most creatures, geckos dont ...
... Forest Complex a 6,900 square mile (18,000 square ... potentially support some 2,000 tigers, making it one of ... to a new study by Thailands Department of National ... Wildlife Conservation Society. The study, which appears in ...
... and other human-caused ecological changes are outpacing the ... threats of disease, reduced diversity in plant and ... heritage, according to research presented at a University ... in the peer-reviewed journal Molecular Ecology. The ...
Cached Biology News:Sticky questions tackled in gecko research 2Study says 2000 tigers possible in Thailand 2Global warming and other research from UCLA summit featured in journal 2
(Date:3/3/2015)... FAYETTEVILLE, Ark. (PRWEB) March 03, 2015 ... Resource Systems Inc. to their international sales network. ... efficient gas dissolution technology to Canada’s Atlantic Provinces, ... Systems has served as one of Canada’s premiere ... clients in both the municipal water and wastewater ...
(Date:3/3/2015)... , March 3, 2015  Regenicin, Inc. (OTC Bulletin ... in the development of and commercialization of regenerative cell ... organs, announced today that it has received the final ... Bioscience Holdings, Inc. (OTC Bulletin Board: AMBS ... Amarantus made the final payments due to Regenicin in ...
(Date:3/3/2015)... Calif. (PRWEB) March 03, 2015 The ... management excellence were honored by the Global Supply ... event which took place on Wednesday, February 25th, 2015, ... The GSCRC was formed to bring together supply chain ... leaders to advance the professional discipline through opportunities to ...
(Date:3/3/2015)... , March 3, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: ... the scientific journal, Expert Opinion on Biological Therapy ... Dr. Zhenggang Zhang , at the Henry Ford ... that Thymosin beta 4 (TB4) has the capacity to ... hours or more post-injury, leading to neurological recovery in ...
Breaking Biology Technology:BlueInGreen® Continues Canadian Expansion, Partners with Resource Systems Inc. 2Regenicin (RGIN) Receives $2.3 Million in Final Payment from Amarantus 2Regenicin (RGIN) Receives $2.3 Million in Final Payment from Amarantus 3Global Supply Chain Resiliency Council Names Award Winners 2Global Supply Chain Resiliency Council Names Award Winners 3Global Supply Chain Resiliency Council Names Award Winners 4Researchers at Henry Ford Hospital Propose Thymosin Beta 4 as Novel Way to Treat Neural Injury and Neurodegenerative Diseases 2Researchers at Henry Ford Hospital Propose Thymosin Beta 4 as Novel Way to Treat Neural Injury and Neurodegenerative Diseases 3
... pretty ignorant about the whole topic of biofuels until I ... , ,While assembling the speakers helped illuminate me, it was ... listened to some of the excellent Q&A that I really ... case for biofuels, or renewable energy, is compelling given the ...
... Communications , a provider of high-end networking solutions for ... Apples Xserve G5. , ,Using its optimized drivers and ... the company claims a 60% performance improvement for its ... Small Trees solution utilizes CX-4, a copper interconnect standard ...
... are pitfalls and competitors to reckon with if the state ... cell researcher Prof. Gabriela Cezar . , ,Cezar, who ... this week at a luncheon sponsored by the Wisconsin Innovation ... current state of stem-cell technology and where the field can ...
Cached Biology Technology:Midwest is key player for Biofuels industry 2Midwest is key player for Biofuels industry 3Midwest is key player for Biofuels industry 4Midwest is key player for Biofuels industry 5Midwest is key player for Biofuels industry 6Competition for stem cell research is fierce 2Competition for stem cell research is fierce 3
Acetate Plate Sealers 100/Box...
... is a concentrated formulation of a rinsing ... action technology, as well as for manual ... David Brigati M.D., Department of Pathology, University ... is recommended for all the rinsing steps ...
... The standard of the Axima ... of high mass accuracy, resolution, sensitivity ... versatility with both linear and reflectron ... field reflectron enables the generation of ...
Rat Aortic Smooth Muscle Cells (RAOSMC) (>500,000 cells)...
Biology Products: