Navigation Links
Lipids in the brain an important factor for Alzheimer's disease?
Date:12/10/2007

Brussels & Leuven, Belgium As the most common form of dementia in the Western world, Alzheimer's disease carries enormous implications for our ageing society. It is generally accepted that the disease is caused by Alzheimer peptide (A -peptide) protofibrils. Until now, the conditions under which this type of protofibril is formed and leads to the disease remained unknown. VIB researchers have now discovered that certain lipids, present also in our brains, promote the formation of this protofibril. This discovery is of major importance because it opens up new avenues of research into finding medicines against Alzheimer's disease. It also explains earlier indications of a link between lipids and Alzheimer's disease.

Misfolded proteins: cause of various diseases

The biological functioning of cells depends on the right folding of thousands of proteins. Normally, cells automatically correct misfolded proteins. In diseases such as Alzheimers, Parkinson's and Creutzfeld-Jacob's, however, misfolded proteins are deposited in the body's tissues. In Alzheimer's disease the most common form of dementia, which in Belgium alone affects about 100,000 people misfolding of the A -amyloid peptide leads in various stages to the formation of plaques. These plaques consist of accumulations of so-called fibrils and is not in itself toxic. One of the intermediary stages in the formation of plaques is the formation of the protofibril form of the A -peptide. Protofibrils are toxic for brain cells, causing the poisoned cells to die off and leading to memory loss. This is why these protofibrils are considered to be the main cause of the symptoms of Alzheimer's disease.

Surrounding brain lipids destabilize plaques

VIB researchers were able, using certain lipids, to convert the fibrils into protofibrils. This came as a surprise, for it had long been assumed that the fibrils and the plaque they cause are stable and that once they have
'/>"/>

Contact: Sooike Stoops
info@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Chemists get grip on slippery lipids
2. Invasion of the brain tumors
3. HIV is a double hit to the brain
4. AIDS interferes with stem cells in the brain
5. 60 second test could help early diagnosis of common brain diseases
6. U of MN researchers discover noninvasive diagnostic tool for brain diseases
7. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
8. Influence of sex and handedness on brain is similar in capuchin monkeys and humans
9. Inside the brain of a crayfish
10. Specific brain protein required for nerve cell connections to form and function
11. Brains timing linked with timescales of the natural visual world
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , January 22, 2015 , ... year  The European Patent Office to present a video ... British nominations to be featured: Christofer Toumazou and ... former finalists and winners of the Award   Starting ...
(Date:1/22/2015)... EyeLock, Inc. , a market leader of iris-based identity authentication ... to the new role of Senior Vice President of Mobile ... mobile platforms and wearable solutions for EyeLock,s technologies. Gerber brings ... semiconductor industry to his role at EyeLock, with expertise in ...
(Date:12/24/2014)...  Since its launch in December 2014, the 1U™ ... of trying to remember their usernames and passwords through replacing ... smartphones. To assist people who have struggled to remember usernames ... 1U and focuses on redefining identity, announced today that it ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3
... of scientists from the U.S. Department of Energy,s (DOE) ... of Science has made a major step in understanding ... is necessary to carry out important biological processes. The ... Nature Structural & Molecular Biology , confirms that ...
... PHILADELPHIA New study results strengthen the evidence that people ... an increased risk for developing colorectal cancer, even after adjusting ... reason not to smoke, or to quit as soon as ... president emeritus, epidemiology and surveillance research at the American Cancer ...
... secondhand smoke for a prolonged period of time and ... cancer, even in women who never smoked cigarettes themselves. ... smoke could increase risk of breast cancer is one ... scientist at the Northern California Cancer Center,s Berkeley office. ...
Cached Biology News:Grooving down the helix 2Grooving down the helix 3Cigarette smoking increases colorectal cancer risk 2Exposure to secondhand cigarette smoke over a lifetime increased breast cancer risk later in life 2
(Date:2/26/2015)... 2015 The Pittcon 2015 Exposition, ... Ernest N. Morial Convention Center in New Orleans, ... February 19, 2015) displaying products and services used ... government labs. The Exposition will offer the latest ... to, analytical chemistry; drug discovery; nanotechnology; life sciences ...
(Date:2/26/2015)... Innovation is more urgent than ever. Radical business ... world and transforming global markets in industry after ... care, disruption is constantly underway. , As technology ... the foundations of established business models, large-scale innovation ... the next wave of mega-change. , This wave ...
(Date:2/26/2015)... February 26, 2015 According to a ... Biotechnology Market For Transgenic Crops (Corn, Soybean, Cotton and ... Analysis, Size, Share, Growth, Trends and Forecast, 2013 – ... 15,300 million in 2012 and is expected to reach ... of 9.5% from 2013 to 2019. , Demand ...
(Date:2/26/2015)... 2015 Regis Technologies announced new ... oncology drug substances. , Regis Technologies is proud to ... Potent Compound Suite (PCS) for 2015. , Regis is ... cGMP facility in Morton Grove, Illinois. The PCS addition ... compounds up to about one kilogram per batch. ...
Breaking Biology Technology:Pittcon 2015 Announces Exposition Highlights 2One Million Acts of Innovation Canada Creates Partnership with The Economist Events’ Innovation Forum 2Global Agricultural Biotechnology Market is Expected to Reach USD 28,694.1 Million in 2019 : Transparency Market Research 2Global Agricultural Biotechnology Market is Expected to Reach USD 28,694.1 Million in 2019 : Transparency Market Research 3Regis Extends cGMP Services to Oncology Market 2
... years, carbon nanotubes (CNTs) have been the flagship ... nanotubes ranging from microelectronic devices to cancer therapy. ... mechanical and electrical properties far superior to most ... have failed to converge on the true mechanical ...
... /PRNewswire/ - LPBP Inc. (LPBP) - At the ... the Certificates of,the President and Chief Executive Officer ... in respect of its interim filings for the ... which certificates were,previously filed. The re-filing of these ...
... Company Maintains Quarterly Revenues in Challenging Marketplace, ... (OTC:,SPOM - News), a leading developer of biosensor ... announced its second,quarter results for the period ended ... period were US$1,089,000, a 1% increase over,first quarter ...
Cached Biology Technology:True properties of carbon nanotubes measured 2True properties of carbon nanotubes measured 3SPO Medical Reports Second Quarter 2008 Results 2SPO Medical Reports Second Quarter 2008 Results 3
... immunological studies, vaccine development, and biosensor ... powerful Paraflo microfluidic on-chip synthesis platform. ... of our comprehensive Epitope Peptide Microarray ... Probe content is completely customer ...
... designed for quantitative assays using recombinant ... on the flexible and powerful Paraflo ... specified sequences can be synthesized on-chip ... with custom sequence design. These microarrays ...
... for the first time, you can identify ... more efficiently without interferences. The Agilent Multiple ... unwanted, multiple high-abundant proteins from human serum, ... just one device. With this revolutionary system, ...
... Microarrays designed for pathway studies, protein-protein ... (PTB) Studies built on the flexible ... platform. These microarrays are available as ... Microarray Service. Custom Probe ...
Biology Products: