Navigation Links
Lipids in the brain an important factor for Alzheimer's disease?
Date:12/10/2007

Brussels & Leuven, Belgium As the most common form of dementia in the Western world, Alzheimer's disease carries enormous implications for our ageing society. It is generally accepted that the disease is caused by Alzheimer peptide (A -peptide) protofibrils. Until now, the conditions under which this type of protofibril is formed and leads to the disease remained unknown. VIB researchers have now discovered that certain lipids, present also in our brains, promote the formation of this protofibril. This discovery is of major importance because it opens up new avenues of research into finding medicines against Alzheimer's disease. It also explains earlier indications of a link between lipids and Alzheimer's disease.

Misfolded proteins: cause of various diseases

The biological functioning of cells depends on the right folding of thousands of proteins. Normally, cells automatically correct misfolded proteins. In diseases such as Alzheimers, Parkinson's and Creutzfeld-Jacob's, however, misfolded proteins are deposited in the body's tissues. In Alzheimer's disease the most common form of dementia, which in Belgium alone affects about 100,000 people misfolding of the A -amyloid peptide leads in various stages to the formation of plaques. These plaques consist of accumulations of so-called fibrils and is not in itself toxic. One of the intermediary stages in the formation of plaques is the formation of the protofibril form of the A -peptide. Protofibrils are toxic for brain cells, causing the poisoned cells to die off and leading to memory loss. This is why these protofibrils are considered to be the main cause of the symptoms of Alzheimer's disease.

Surrounding brain lipids destabilize plaques

VIB researchers were able, using certain lipids, to convert the fibrils into protofibrils. This came as a surprise, for it had long been assumed that the fibrils and the plaque they cause are stable and that once they have
'/>"/>

Contact: Sooike Stoops
info@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Chemists get grip on slippery lipids
2. Invasion of the brain tumors
3. HIV is a double hit to the brain
4. AIDS interferes with stem cells in the brain
5. 60 second test could help early diagnosis of common brain diseases
6. U of MN researchers discover noninvasive diagnostic tool for brain diseases
7. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
8. Influence of sex and handedness on brain is similar in capuchin monkeys and humans
9. Inside the brain of a crayfish
10. Specific brain protein required for nerve cell connections to form and function
11. Brains timing linked with timescales of the natural visual world
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2015)... Conn. , May 20, 2015 NXT-ID, ... announces that its wholly owned subsidiary, 3D-ID LLC, a ... under Team Battelle for the biometrics technology portion of ... Suite Contract from the Department of the Army. ... recognition products developed for government, law enforcement and security ...
(Date:5/14/2015)... Research and Markets ( http://www.researchandmarkets.com/research/5whpxg/fingerprint ) ... Market in Smart Mobile Devices " report to ... was a watershed year for fingerprint sensors in smartphones ... Apple gave fingerprint sensors a raison d,etre in the ... are a must-have feature in flagship smartphones. ...
(Date:5/10/2015)... GOTHENBURG, Sweden , May 11, 2015 ... touch fingerprint sensors FPC1025 and FPC1155 from the distributor World ... one of FPC,s distributors in Asia . ... the sensors will be used by smartphone manufacturers in ... is included in the communicated revenue guidance of + 1 000 ...
Breaking Biology News(10 mins):NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2
... Assessment Tool (FRAX) is now easily accessible via iPhone, making ... use in any clinical setting. The FRAX tool generates ... major osteoporotic event, The 10 year probability of a hip ... accessible. This provides a guide for assessors, interpreting the results ...
... June 10, from 2-3:30 p.m. EDT, Stanford University Professor Jon ... public briefing on Capitol Hill. Krosnick is a professor ... the Woods Institute for the Environment at Stanford. He is ... the National Science Foundation. The poll covers a broad range ...
... your heart even though they do not actually touch your ... engineering PhD student Yu Mike Chi,s dissertation. This technology ... his Cognionics team the top spot in the UC San ... the startup and $15K in legal services. Engineers and ...
Cached Biology News:Wireless sensor startup wins UC San Diego $80K Entrepreneur Challenge 2Wireless sensor startup wins UC San Diego $80K Entrepreneur Challenge 3
(Date:5/28/2015)... 28, 2015 Biscayne Pharmaceuticals, Inc ., ... its growth hormone-releasing hormone (GHRH) technology will be discussed in ... Annual Meeting. The data show that the family of ... blockers, is present on many primary breast cancer cells ... GHRH antagonists could have broad anti-cancer potential in breast ...
(Date:5/28/2015)... Fertility Centers of New England is proud to announce ... a new and expanded role as Medical Director. In ... and quality assurance for the practice. , “We are ... experienced reproductive endocrinologists,” said Fertility Centers of New England ... and compassionate, individualized care have helped set FCNE apart ...
(Date:5/28/2015)... Minneapolis, MN (PRWEB) May 28, 2015 ... makes it a point to ask his audiences ... of future trends including robotics, solar cells, fuel ... sequencing, 3D printers, advanced battery storage technology, driverless ... assistants, and high-quality but inexpensive online education. ...
(Date:5/28/2015)... (PRWEB) May 28, 2015 In two ... James L. Sherley, M.D., Ph.D., will present the company’s ... In a conference talk, he will describe ... culture designs with computer simulation to produce the first-ever ... number and quality over time in culture. When ...
Breaking Biology Technology:Data Presented At 2015 ASCO Annual Meeting Shows Biscayne Pharmaceuticals' GHRH Antagonist Target Is Expressed Across All Breast Cancer Subtypes 2Data Presented At 2015 ASCO Annual Meeting Shows Biscayne Pharmaceuticals' GHRH Antagonist Target Is Expressed Across All Breast Cancer Subtypes 3Danielle Vitiello, MD of Fertility Centers of New England, Named New Medical Director 2Futurist Jack Uldrich to Deliver 4 Keynote Addresses in June 2Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 2Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 3
... Medical Technologies, Inc. (Nasdaq: PMTI ), ... for cosmetic treatments, today announced the termination of ... Q-MED AB (OMX Nordic Exchange, Stockholm Mid Cap:QMED), ... Sweden. The international distribution agreement was originally ...
... Volcano Corporation,(Nasdaq: VOLC ), a leader ... diagnosis and treatment of coronary and peripheral artery,disease, said ... of,Axsun Technologies, Inc. , Axsun ... optical,engines used in medical Optical Coherence Tomography (OCT) imaging ...
... Turbulent EconomyOAKBROOK TERRACE, Ill., Jan. 7 AeA, the ... the high-tech industry, announced today that the NASDAQ OMX ... outperformed the Dow Jones Industrial Average (.INDU), S&P 500, ... 2008.On May 19, 2008, AeA and The NASDAQ Stock ...
Cached Biology Technology:Palomar and Q-MED AB Terminate International Distribution Agreement 2Palomar and Q-MED AB Terminate International Distribution Agreement 3Palomar and Q-MED AB Terminate International Distribution Agreement 4Palomar and Q-MED AB Terminate International Distribution Agreement 5Volcano Announces Closing of Axsun Technologies Acquisition 2NASDAQ OMX AeA Illinois Tech Index Outperforms Market 2NASDAQ OMX AeA Illinois Tech Index Outperforms Market 3
... of vacuum concentrators/centrifugal evaporators offers a wide ... rapid and safe concentration of heat-labile samples. ... oil-free or high vacuum pumps, a choice ... of rotors (eliminating sample loss by transfer), ...
For relative and/or absolute quantification with standard accuracy requirements using MS or NMR instruments...
Control primers and template for 5kb and 15 kb products....
0.2ml Gradient Block MBSR. Robot compatible block ejection mechanism. Stackable. (96 well block - holds 1 plate 0.2ml x 96 well plate)...
Biology Products: