Navigation Links
Lipids in the brain an important factor for Alzheimer's disease?
Date:12/10/2007

Brussels & Leuven, Belgium As the most common form of dementia in the Western world, Alzheimer's disease carries enormous implications for our ageing society. It is generally accepted that the disease is caused by Alzheimer peptide (A -peptide) protofibrils. Until now, the conditions under which this type of protofibril is formed and leads to the disease remained unknown. VIB researchers have now discovered that certain lipids, present also in our brains, promote the formation of this protofibril. This discovery is of major importance because it opens up new avenues of research into finding medicines against Alzheimer's disease. It also explains earlier indications of a link between lipids and Alzheimer's disease.

Misfolded proteins: cause of various diseases

The biological functioning of cells depends on the right folding of thousands of proteins. Normally, cells automatically correct misfolded proteins. In diseases such as Alzheimers, Parkinson's and Creutzfeld-Jacob's, however, misfolded proteins are deposited in the body's tissues. In Alzheimer's disease the most common form of dementia, which in Belgium alone affects about 100,000 people misfolding of the A -amyloid peptide leads in various stages to the formation of plaques. These plaques consist of accumulations of so-called fibrils and is not in itself toxic. One of the intermediary stages in the formation of plaques is the formation of the protofibril form of the A -peptide. Protofibrils are toxic for brain cells, causing the poisoned cells to die off and leading to memory loss. This is why these protofibrils are considered to be the main cause of the symptoms of Alzheimer's disease.

Surrounding brain lipids destabilize plaques

VIB researchers were able, using certain lipids, to convert the fibrils into protofibrils. This came as a surprise, for it had long been assumed that the fibrils and the plaque they cause are stable and that once they have
'/>"/>

Contact: Sooike Stoops
info@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Chemists get grip on slippery lipids
2. Invasion of the brain tumors
3. HIV is a double hit to the brain
4. AIDS interferes with stem cells in the brain
5. 60 second test could help early diagnosis of common brain diseases
6. U of MN researchers discover noninvasive diagnostic tool for brain diseases
7. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
8. Influence of sex and handedness on brain is similar in capuchin monkeys and humans
9. Inside the brain of a crayfish
10. Specific brain protein required for nerve cell connections to form and function
11. Brains timing linked with timescales of the natural visual world
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... Calif. , Nov. 20, 2014   Atmel® ... leader in microcontroller (MCU) and touch technology solutions, today ... temperature sensors with the widest V cc ... higher temperature accuracy and faster I 2 C bus ... and serial EEPROM memory making them ideal for consumer, ...
(Date:11/18/2014)... -- The Parenteral Drug Association (PDA) today confirmed that seven ... at least seven more will participate in the upcoming 2014 ... in Washington D.C. , Dec. 2-4. ... from the regulatory agencies in the United States ... effort to help advance the use of metrics in the ...
(Date:11/12/2014)... , Nov. 12, 2014 Crossmatch™, a ... that its U.are.U ® fingerprint readers have been ... in Central Mexico . The bakery ... to eliminate payroll issues caused by employees clocking in ... the U.are.U fingerprint readers, Montparnasse relied on paper timecards ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2
... animal compares males to choose a mate, she can't order ... to rely on external cues that may indicate genetic quality. ... the peacock's tail, as cues that females might use. , ... between male genetic quality and ornament quality can be maintained. ...
... progenitor cells differentiate into cartilage cells when one master ... College of Medicine researchers in a report that appears ... of Sciences. , Skeletons are made of bone and ... stem cell, said Dr. Brendan Lee, associate professor of ...
... into brain cells on a new three-dimensional scaffold of ... living body than any other cell culture system. , ... invention-which may one day replace the ubiquitous Petri dish ... PLoS ONE. Shuguang Zhang, associate director of MIT's Center ...
Cached Biology News:Female pronghorns choose mate based on substance as well as show 2Signaling for cartilage 2MIT creates 3-D scaffold for growing stem cells 2MIT creates 3-D scaffold for growing stem cells 3
(Date:12/19/2014)... 2014 BioPlus Specialty Pharmacy ... the promotion of Nick Maroulis, Pharm.D. to the newly ... , In this position, Dr. Maroulis will continue ... the directors of our multi-site pharmacies as the company ... and during that time he has served in many ...
(Date:12/19/2014)... , Dec. 19, 2014 Decision Resources ... will grow at a 12 percent compound annual growth ... of the aging population and the increasing adoption of ... America will also spur demand for dental ... dental implant and periodontal treatments. Other key ...
(Date:12/19/2014)... December 18, 2014 LayerBio is an ... and wound care. The National Eye Institute (NEI) at ... a Phase I SBIR grant to develop a drug-eluting ... the most common cause of vision loss in people ... worldwide. According to Dr. Ken Mandell, LayerBio’s Founder and ...
(Date:12/19/2014)... In contrast to traditional LED lights where the spectrum ... proprietary LED technology to incorporate their spectra in a ... critical in low proximity installations. The Valoya L-series offers ... which is up to four times longer than commonly ... was clearly higher when compared to traditional fluorescent or ...
Breaking Biology Technology:BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2
... who run St. Josephs Regional Medical Center here have a ... a walk-in clinic, an expensive practice that ties up valuable ... runny noses. To discourage people from using the ER for ... a $150 minimum fee. , ,The story is a symptom ...
... Wisconsin businesses have had to find new ways to compete. ... and most CEOs have taken a hard look at their ... attempting to be more effective, productive and competitive; all of ... shrinking market opportunity due to global competition and outsourcing! ...
... good one: pulling the states world-class health care technology ... well into the future. , ,The 20th Annual ... and Wednesday at Madisons Monona Terrace Convention Center, will ... the states burgeoning life sciences industry. The Wisconsin Technology ...
Cached Biology Technology:Health Care Reform is Working Its Way Back on to the Political Agenda 2Health Care Reform is Working Its Way Back on to the Political Agenda 3Technology Helps Our Economy to Survive and Grow 2Technology Helps Our Economy to Survive and Grow 3Conference Zeroes in on Homegrown Innovation - 20th Life Science & Venture Conference Full of High-Tech Insights 2
... functionally defined by their capacity to self ... multiple specialized progenitor cells, which can commit ... stem cells (NSCs) are capable of differentiating ... and oligodendrocytes. During the isolation and expansion ...
Anti Human JAM-1, Monoclonal Antibody, Clone M.Ab.F11...
Contained in EZ-Tn5™ Kits and are available separately for sequencing of an insertion site....
Request Info...
Biology Products: