Navigation Links
Lipids in the brain an important factor for Alzheimer's disease?
Date:12/10/2007

Brussels & Leuven, Belgium As the most common form of dementia in the Western world, Alzheimer's disease carries enormous implications for our ageing society. It is generally accepted that the disease is caused by Alzheimer peptide (A -peptide) protofibrils. Until now, the conditions under which this type of protofibril is formed and leads to the disease remained unknown. VIB researchers have now discovered that certain lipids, present also in our brains, promote the formation of this protofibril. This discovery is of major importance because it opens up new avenues of research into finding medicines against Alzheimer's disease. It also explains earlier indications of a link between lipids and Alzheimer's disease.

Misfolded proteins: cause of various diseases

The biological functioning of cells depends on the right folding of thousands of proteins. Normally, cells automatically correct misfolded proteins. In diseases such as Alzheimers, Parkinson's and Creutzfeld-Jacob's, however, misfolded proteins are deposited in the body's tissues. In Alzheimer's disease the most common form of dementia, which in Belgium alone affects about 100,000 people misfolding of the A -amyloid peptide leads in various stages to the formation of plaques. These plaques consist of accumulations of so-called fibrils and is not in itself toxic. One of the intermediary stages in the formation of plaques is the formation of the protofibril form of the A -peptide. Protofibrils are toxic for brain cells, causing the poisoned cells to die off and leading to memory loss. This is why these protofibrils are considered to be the main cause of the symptoms of Alzheimer's disease.

Surrounding brain lipids destabilize plaques

VIB researchers were able, using certain lipids, to convert the fibrils into protofibrils. This came as a surprise, for it had long been assumed that the fibrils and the plaque they cause are stable and that once they have
'/>"/>

Contact: Sooike Stoops
info@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Chemists get grip on slippery lipids
2. Invasion of the brain tumors
3. HIV is a double hit to the brain
4. AIDS interferes with stem cells in the brain
5. 60 second test could help early diagnosis of common brain diseases
6. U of MN researchers discover noninvasive diagnostic tool for brain diseases
7. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
8. Influence of sex and handedness on brain is similar in capuchin monkeys and humans
9. Inside the brain of a crayfish
10. Specific brain protein required for nerve cell connections to form and function
11. Brains timing linked with timescales of the natural visual world
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... Calif. , April 20, 2015 Huntington ... Gabriel Valley to implant a new miniaturized, wireless monitoring ... System is the first and only FDA-approved heart failure ... hospital admissions when used by physicians to manage heart ... sensor that is implanted in the pulmonary artery (PA) ...
(Date:4/14/2015)... 2015  HYPR Corp. today announced it has ... Alliance tm , an industry consortium transforming online ... share technology and collaborate to deliver open specifications ... secure and private, and easier to use. ... protects sensitive user information and eliminates the dependency ...
(Date:4/13/2015)... 13, 2015  higi, a leading cloud-based consumer engagement ... fully engage with their communities around health and wellness, ... and secure API.  ... accessible, affordable, and convenient vehicle to receive validated health ... The API will allow higi,s trusted partners, ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... The Scripps Research Institute (TSRI) have found an easier way to ... new method allows scientists to add a marker to certain cells, ... from a larger cell population. The technique, which is ... Chemie International Edition , makes use of the tight binding of ...
... (RQR), Palais des congrs de Montral, Montral, Qubec, Canada, 22-26 ... 2013 -- The Society for the Study of Reproduction ... the 46th SSR Annual Meeting to be held in Montral, ... Meetings page ( http://www.ssr.org/Meetings.shtml ) for details; information will be ...
... New Rochelle, NY, January 8, 2013The world,s leading zebrafish ... promote science education. Scientific papers, many authored by students ... curricula and educational tools, a collection of abstracts (including ... from the recent Zebrafish in Education Workshops ...
Cached Biology News:Chemists devise inexpensive, benchtop method for marking and selecting cells 2Chemists devise inexpensive, benchtop method for marking and selecting cells 3Surprising teaching tool in K-12 science education -- Zebrafish research 2
(Date:4/27/2015)... 27, 2015   Aratana Therapeutics, Inc . ... focused on the licensing, development and commercialization of ... commentary on clinical study data involving ADXS31-164 (AT-014) ... at the American Association for Cancer Research (AACR) ... novel Lm -LLO immunotherapy developed by Advaxis, ...
(Date:4/27/2015)... HEIDELBERG , Germany , April ... need in treatment of millions of cancer patients   ... a patent in Europe entitled ... Health,s discovery that EPHB4 is a novel receptor for Erythropoietin ... stimulates the production of red blood cells and is ...
(Date:4/27/2015)... 27, 2015 tru Shrimp™ Systems announced ... Texas A&M University for the exclusive worldwide rights to ... raceway systems. The license agreement for the patented technology, ... to countries such as China, Taiwan, France, Germany, Italy, ... “We have had inquires from all over the world ...
(Date:4/27/2015)... , April 27, 2015 Elsevier ... products and services, and Qatar University Research Office   have ... Awards. The awards ceremony, held last week at ... , was attended by more than 40 guests representing ... were presented by Professor Sheikha Abdulla Al-Misnad , President ...
Breaking Biology Technology:Aratana Therapeutics Comments on ADXS31-164 (AT-014) Study Data Presented During Poster Session at the American Association for Cancer Research (AACR) Annual Meeting 2015 2Molecular Health Gains Patent for Novel Receptor Utilizing Computational Biomarker Discovery Technology 2tru Shrimp™ Systems Acquires Global Patent for Tidal Basin™ Shrimp Production 2Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 2Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 3Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 4Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 5
... Nov. 24 Boston Scientific,Corporation (NYSE: BSX ) ... which is being held December 2 - 3 in New ... will make a 30-minute presentation on,Tuesday, December 2, beginning at ... A live webcast of Mr. Tobin,s remarks will be ...
... CLAREMONT, Calif., Nov. 24 Keck Graduate Institute,s (KGI) Biotechnology ... educational event on Monday, Dec. 8, 2008. , ... (TCA), a network of individual investors who fund early-stage, technology ... of the public interested in becoming angel investors. The ...
... Omrix,s Biopharmaceutical Expertise Complements ETHICON,s Industry-Leading Surgery Portfolio ... N.J. and NEW YORK, Nov. 24 Johnson & ... Inc. (Nasdaq: OMRI ), a fully integrated ... products, today announced a definitive agreement whereby Omrix will ...
Cached Biology Technology:KGI Entrepreneur Program Hosts Angel Investing Educational Meeting 2Johnson & Johnson Announces Definitive Agreement to Acquire Omrix 2Johnson & Johnson Announces Definitive Agreement to Acquire Omrix 3Johnson & Johnson Announces Definitive Agreement to Acquire Omrix 4Johnson & Johnson Announces Definitive Agreement to Acquire Omrix 5
HiTrap NHS-activated HP, 1 x 5 ml. Category: Chromatography Systems & Accessories, Systems....
Human Serpin A8/AGT Affinity Purified Polyclonal Ab Keywords: Ang II, AngII, Hypertension, Salt Homeostasis, Pre-eclampsia...
Human CXCL14/BRAK Affinity Purified Polyclonal Ab...
Human/Mouse G9a/EHMT2 MAb (Clone A8620A) Keywords: Eu-HMTase2...
Biology Products: