Navigation Links
Leading cause of death in 'preemies' might be controlled by resetting a molecular switch
Date:12/2/2007

Washington, D.C. -- Blocking signals from a key molecular receptor that normally switches on the intestines immune response but instead becomes too intense in the presence of stress and toxins may help reverse necrotizing enterocolitis (NEC), a leading cause of death in premature newborns, according to scientists at the American Society for Cell Biology 47th annual meeting.

David J. Hackam and his laboratory team at the Childrens Hospital of Pittsburgh report that neonatal mice with inactivating mutations in the Toll-like receptor 4 (TLR4) are protected from NEC. Its a case of defenders becoming unwitting attackers, says Hackam.

Toll-like receptors are key players in the innate immune system. Protruding from enterocytes that form the innermost barrier-like layer of the small and large intestines, TLR4 receptors are primed to recognize pathogenic bacteria and sound the alarm.

But Hackams group found that the stresses of oxygen deprivation and bombardment by bacterial toxins, conditions that can occur in premature infants with underdeveloped lungs, stimulate too much production of TLR4. Like an unstoppable alarm, the increased numbers of TLR4 blare out signals that eventually tip the cells into cellular suicide. They also stop enterocytes from migrating to close wounds in the intestines.

These events, which do not occur in the TLR4-deficient mice, allow NEC to spread as the fragile lining of the gut gives way, releasing a flood of pathogens into the bloodstream. Even with modern advances in neonatal care, NEC affects 20 percent of premature babies and is fatal in nearly half of all cases, according to Hackam.

Hackams group discovered another way to switch off the molecular alarm in mice with NEC by interfering with production of a focal adhesion kinase (FAK) that the researchers found associated with TLR4. By shutting down FAK with small interfering RNA, the TLR4 siren was silenced. Under these conditions, the res
'/>"/>

Contact: John Fleischman
jfleischman@ascb.org
513-929-4635
American Society for Cell Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. M2SYS Partners with SecuGen Corporation to Support Market Leading Hamster Plus Fingerprint Reader with Auto-On Technology
2. Leading experts cite poor health and nutrition as major barrier to education in developing world
3. Ossur -- leading orthopedic pioneer - expands network to Asia
4. Leading researchers to reveal comprehensive dos and donts for prostate cancer
5. BIO-key(R) PocketCop(R) Project Leading the Nation According to Televised Report
6. Are current projections of climate change-impacts on biodiversity misleading?
7. Cleveland Clinic leading clinical program to improve early-stage lung cancer detection
8. deCODE discovers cause of major subtype of glaucoma
9. Study begins to reveal clues to the cause and progression of sepsis
10. Bleeding, not inflammation, is major cause of early lung infection death
11. Gamma globulin effective in treating eye infections caused by adenoviruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/19/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kx9zp8/military ) ... Electro-Optical / Infrared Systems Market by Type, by ... to 2020" report to their offering. ... expected to reach $16.35 billion by 2020, to ... report segments the military electro-optical/infrared systems market on ...
(Date:2/12/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce market, ... for DISTRIBUTED METHOD AND SYSTEM TO IMPROVE ... further establishes NXT-ID,s position in the emerging "Internet of ... ability for multiple devices to collaborate with one another ...
(Date:2/5/2015)... , 5. Februar 2015 ... spezialisiertes Logistikunternehmen und hat eine neue Marketingkampagne ... Logistikfirma (Clinical Logistics Organization – CLO) der ... Kampagne lautet First , mit Schwerpunkt ... Foto: http://photos.prnewswire.com/prnh/20150205/173753 Logo ...
Breaking Biology News(10 mins):Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 3Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3
... may do more than keep the body cool. It also ... respiratory condition among trained athletes. New research appearing in the ... the American College of Chest Physicians (ACCP), shows that athletes ... who do not have breathing problems. Warren Lockette, ...
... a living sensor that can spot contamination. They have ... spills even in previously untreatable cold areas, microbiologists heard ... General Microbiology,s Autumn meeting being held this week at ... is in the sub-arctic. It contains over 230,000 tonnes ...
... Switzerland have developed a new method to ... systems, these "Pyrex"-like nanoparticles are more stable ... chemical environments than currently used nanoparticles made ... could extend the range of potential nanoparticle ...
Cached Biology News:Athletes' 'sweat and tears' linked to asthma 2Athletes' 'sweat and tears' linked to asthma 3Living sensor can warn of arsenic pollution 2
(Date:2/26/2015)... , Feb. 26, 2015  23andMe, the leading personal ... Black as Privacy Officer and Corporate Counsel. Black ... privacy laws as well as health care regulations. As ... will be responsible for reviewing, updating and enhancing the ... U.S. and abroad. She joined the company January 5, ...
(Date:2/26/2015)... Synageva BioPharma Corp. (NASDAQ: GEVA ... rare disorders, today reported 2014 full year financial ... and financial guidance.  Synageva,s management team will host ... to review the financial results and provide a ... by telephone, please dial (877) 445-4603 for U.S. ...
(Date:2/26/2015)... , Feb. 26, 2015 Protiviti ( ... latest version of the Governance Portal , designed ... risk and compliance (GRC) tasks across multiple business units ... updated to help customers better align their controls with ... Treadway Commission ) requirements. In response to client feedback, ...
(Date:2/26/2015)... 26, 2015 The Movement for Indefinite ... support life extension technologies and awareness. The event is ... Time, on March 21st 2015, in a live Google ... Eric Schulke, Founder of MILE, says, “Our lives are ... The Movement for Indefinite Life Extension is raising awareness ...
Breaking Biology Technology:23andMe Appoints Kate Black as Privacy Officer and Corporate Counsel 2Synageva BioPharma Reports 2014 Full Year Financial Results 2Synageva BioPharma Reports 2014 Full Year Financial Results 3Synageva BioPharma Reports 2014 Full Year Financial Results 4Synageva BioPharma Reports 2014 Full Year Financial Results 5Synageva BioPharma Reports 2014 Full Year Financial Results 6Synageva BioPharma Reports 2014 Full Year Financial Results 7Synageva BioPharma Reports 2014 Full Year Financial Results 8Synageva BioPharma Reports 2014 Full Year Financial Results 9Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 2Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 3Indefinite Life Extension Activists Organize Online Demonstration 2Indefinite Life Extension Activists Organize Online Demonstration 3
... (OSL:DIAG),today announced that it has signed a ... provider of gene expression-based,diagnostic testing and services ... scheduled in early2009, DiaGenic will be able ... its innovative blood-based,gene-expression diagnostic test for early ...
... Northern Antibiotics Ltd., the,developer of novel ... by multidrug-resistant Gram-negative bacteria, revealed today animal,efficacy ... at the 48th,Annual ICAAC/IDSA 46th Annual Meeting ... developed two series of novel polymyxin (NAB),compounds ...
... 28 Volcano Corporation,(Nasdaq: VOLC ), a leader ... diagnosis and treatment of coronary and peripheral artery,disease, today ... the,third quarter and first nine months of fiscal 2008 ... conference call to discuss its financial,results and operating activities ...
Cached Biology Technology:Diagenic Partners With DNAVision to Offer First Breast Cancer and Alzheimers Gene-Expression Blood Tests 2Northern Antibiotics Presents New Data on Novel Polymyxin Compounds at the Joint ICAAC/IDSA 2008 2Northern Antibiotics Presents New Data on Novel Polymyxin Compounds at the Joint ICAAC/IDSA 2008 3Volcano Corporation Schedules Third Quarter Conference Call, Webcast 2
MOUSE ANTI SIMIAN VIRUS 5 Immunogen: Simian virus 5...
MOUSE ANTI SIMIAN VIRUS 5:FITC Immunogen: Simian virus 5...
MOUSE ANTI HUMAN MBP (67-74) Immunogen: Human myelin basic protein...
... DNAclear cDNA Purification Kit is designed to purify ... as cDNA synthesis and PCR. The process is ... ng to 3 g can be efficiently purified ... steps: 1) DNA is bound to the Microfilter ...
Biology Products: