Navigation Links
Leading cause of death in 'preemies' might be controlled by resetting a molecular switch
Date:12/2/2007

Washington, D.C. -- Blocking signals from a key molecular receptor that normally switches on the intestines immune response but instead becomes too intense in the presence of stress and toxins may help reverse necrotizing enterocolitis (NEC), a leading cause of death in premature newborns, according to scientists at the American Society for Cell Biology 47th annual meeting.

David J. Hackam and his laboratory team at the Childrens Hospital of Pittsburgh report that neonatal mice with inactivating mutations in the Toll-like receptor 4 (TLR4) are protected from NEC. Its a case of defenders becoming unwitting attackers, says Hackam.

Toll-like receptors are key players in the innate immune system. Protruding from enterocytes that form the innermost barrier-like layer of the small and large intestines, TLR4 receptors are primed to recognize pathogenic bacteria and sound the alarm.

But Hackams group found that the stresses of oxygen deprivation and bombardment by bacterial toxins, conditions that can occur in premature infants with underdeveloped lungs, stimulate too much production of TLR4. Like an unstoppable alarm, the increased numbers of TLR4 blare out signals that eventually tip the cells into cellular suicide. They also stop enterocytes from migrating to close wounds in the intestines.

These events, which do not occur in the TLR4-deficient mice, allow NEC to spread as the fragile lining of the gut gives way, releasing a flood of pathogens into the bloodstream. Even with modern advances in neonatal care, NEC affects 20 percent of premature babies and is fatal in nearly half of all cases, according to Hackam.

Hackams group discovered another way to switch off the molecular alarm in mice with NEC by interfering with production of a focal adhesion kinase (FAK) that the researchers found associated with TLR4. By shutting down FAK with small interfering RNA, the TLR4 siren was silenced. Under these conditions, the res
'/>"/>

Contact: John Fleischman
jfleischman@ascb.org
513-929-4635
American Society for Cell Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. M2SYS Partners with SecuGen Corporation to Support Market Leading Hamster Plus Fingerprint Reader with Auto-On Technology
2. Leading experts cite poor health and nutrition as major barrier to education in developing world
3. Ossur -- leading orthopedic pioneer - expands network to Asia
4. Leading researchers to reveal comprehensive dos and donts for prostate cancer
5. BIO-key(R) PocketCop(R) Project Leading the Nation According to Televised Report
6. Are current projections of climate change-impacts on biodiversity misleading?
7. Cleveland Clinic leading clinical program to improve early-stage lung cancer detection
8. deCODE discovers cause of major subtype of glaucoma
9. Study begins to reveal clues to the cause and progression of sepsis
10. Bleeding, not inflammation, is major cause of early lung infection death
11. Gamma globulin effective in treating eye infections caused by adenoviruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2015)... , June 25, 2015  TAKE Solutions Ltd., a ... by the United States Patent and Trademark Office (USPTO) ... process leverages TAKE Solutions, Clinical Accelerators to reduce the ... (when compared to standardization without the accelerators), thus reducing ... At the heart of the patented ...
(Date:6/24/2015)... Calif. , June 24, 2015  Synaptics ... of human interface solutions, today announced that Sharp ... to provide secure authentication for its latest flagship ... reached more than 200 million shipments of its ... Sharp reinforces Synaptics, strength, scalability and leadership in ...
(Date:6/23/2015)... MINNETONKA, Minn. , June 23, 2015 /PRNewswire/ ... technology company that supports the entire spectrum of ... iMedNet ™ , the company,s ... has been awarded a Silver 2015 Stevie® Award ... the Health Products & Services Website category.  The ...
Breaking Biology News(10 mins):TAKE Solutions Awarded Patent By USPTO 2Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2MedNet Solutions' iMedNet eClinical Wins Silver Stevie Award 2
... when one master gene actually suppresses the action of ... report that appears online in the journal Proceedings of ... of bone and cartilage cells that are differentiated from ... associate professor of molecular and human genetics at BCM, ...
... stroke in the U.S. over the past 50 years has ... a study in the December 27 issue of JAMA. , ... more than 750,000 new strokes occurring each year in the ... behind heart disease and cancer and the leading neurologic cause ...
... multiplied and differentiated into brain cells on a new ... more like a living body than any other cell ... will report the invention-which may one day replace the ... issue of the PLoS ONE. Shuguang Zhang, associate director ...
Cached Biology News:Signaling for cartilage 2Incidence of stroke decreases over last 50 years 2MIT creates 3-D scaffold for growing stem cells 2MIT creates 3-D scaffold for growing stem cells 3
(Date:7/7/2015)... , July 7, 2015   Moleculera ... two-year, $300,000 matching grant from the Oklahoma Center ... This grant supports the development and clinical validation ... directed against neuronal antigens in patients experiencing neuropsychiatric ... Such panels are intended to assist physicians in ...
(Date:7/7/2015)... ... ... The global aptamers market is expected to reach $244.93 ... 17.89% between 2015 and 2020. The aptamer type segments included in this report ... is segmented into diagnostics, therapeutics development, R&D, and other applications. Diagnostics applications will ...
(Date:7/7/2015)... ND (PRWEB) , ... July 07, 2015 , ... CSM, ... executive team as Vice President of Finance. Morse has an extensive background in financial ... industries to the CSM team. In his new role, Morse will oversee all financial ...
(Date:7/7/2015)... ... July 07, 2015 , ... The Pistoia Alliance, a global, ... life science R&D, has attracted a number of new members from across the ... company joining as a Core member, and DNAnexus and Tessella as Participating members. ...
Breaking Biology Technology:Moleculera Labs Receives Grant from OCAST to Develop Assays to Identify Individuals with Neuropsychiatric Disorders of Autoimmune Origin 2Moleculera Labs Receives Grant from OCAST to Develop Assays to Identify Individuals with Neuropsychiatric Disorders of Autoimmune Origin 3Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 2Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 3Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 4Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 5CSM Appoints Michael Morse as Vice President of Finance 2Pistoia Alliance Continues to Attract New Members 2
... 2012 PAC more accurately tracks true ... provider, Elsevier/Gold Standard , announced today an agreement with ... of a new price type, Predictive Acquisition Cost (PAC). ... need for a pricing standard that more closely tracks true ...
... Sales Performance, a global sales support organization providing consulting, ... $4 million to purchase and relocate to an expanded ... corridor. The company expects to create over 200 new ... next five years. In addition, through an innovative incentive ...
... The American Botanical Council (ABC) has announced the ... Literature Award in the reference and technical book category. ... of Botanical Medicines (CRC Press, 2011), has been ... http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The ABC James ...
Cached Biology Technology:Elsevier/Gold Standard Exclusive Publisher of New Predictive Drug Price Type 2Elsevier/Gold Standard Exclusive Publisher of New Predictive Drug Price Type 3City of Mason and Top Gun Sales Performance Announce $4 Million Investment In New Corporate Headquarters 2Herbal Microscopy Book Receives American Botanical Council's James A. Duke Book Award 2Herbal Microscopy Book Receives American Botanical Council's James A. Duke Book Award 3Herbal Microscopy Book Receives American Botanical Council's James A. Duke Book Award 4Herbal Microscopy Book Receives American Botanical Council's James A. Duke Book Award 5
Human Aminopeptidase P2/XPNPEP2 Affinity Purified PAb ENTREZ GeneID: 7512...
Collected from 8-12 week old sexually mature rats. Pricing: $100/unit for 1 - 10 units...
PlusOne Acrylamide PAGE, 1 kg. Category: Electrophoresis Systems & Standards & Reagents, Electrophoresis Standards and Reagents, Gel Casting Chemicals....
... RNA Quantitation Kit is one of ... the quantitation of RNA in solution. ... more sensitive than absorbance measurements. As ... detected with fluorescence microplate readers and ...
Biology Products: