Navigation Links
Lack of key enzyme in the metabolism of folic acid leads to birth defects
Date:1/17/2013

AUSTIN, Texas Researchers at The University of Texas at Austin have discovered that the lack of a critical enzyme in the folic acid metabolic pathway leads to neural tube birth defects in developing embryos.

It has been known for several decades that folic acid supplementation dramatically reduces the incidence of neural tube defects, such as spina bifida and anencephaly, which are among the most common birth defects. In some populations, folic acid supplementation has decreased neural tube defects by as much as 70 percent.

However, scientists still do not fully understand how folic acid decreases neural tube defects, or why folic acid supplementation does not eliminate birth defects in all pregnancies.

"Now, we've found that mutation of a key folic acid enzyme causes neural tube defects in mice," said Dean Appling, professor of biochemistry in the College of Natural Sciences. "This is the clearest mechanistic link yet between folic acid and birth defects."

Appling and his colleagues published their research in the Jan. 8 issue of Proceedings of the National Academy of Sciences (PNAS).

The scientists made the discovery using mice that lack a gene for a folic acid enzyme called Mthfd1l, which is required for cells to produce a metabolite called formate. Embryos need formate to develop normally.

"This work reveals that one of the ways that folic acid prevents birth defects is by ensuring the production of formate in the developing embryo," said Appling, "and it may explain those 30 percent of neural tube defects that cannot be prevented by folic acid supplementation."

Appling said that the mice provide researchers with a strong model system that they can use to further understand folic acid and its role in birth defects in humans. In fact, humans share the same gene for the folic acid enzyme with the mouse and all other mammals. Indeed, it has recently been discovered that point mut
'/>"/>

Contact: Dean Appling, professor
dappling@austin.utexas.edu
512-471-4796
University of Texas at Austin
Source:Eurekalert

Page: 1 2

Related biology news :

1. RUB researchers find over active enzyme in failing hearts
2. Powerful enzymes create ethanol from agricultural harvest waste
3. Nutrient-sensing enzymes key to starvation response and survival in newborn mammals
4. Can compressed fluids increase enzyme activity in industrial bioprocesses?
5. Inhibition of enzyme NOX4 prevents liver fibrosis
6. Researchers use blood testing to predict level of enzymes that facilitate disease progression
7. New inhibitors of elusive enzymes promise to be valuable scientific tools
8. Remarkable enzyme points the way to reducing nitric acid use in industry
9. Ancient enzymes function like nanopistons to unwind RNA
10. Brain enzyme is double whammy for Alzheimers disease
11. Is it a rock, or is it Jell-O? Defining the architecture of rhomboid enzymes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Miranda, a small, icy moon of Uranus, is one ... the solar system. Despite its relatively small size, Miranda ... that resulted in the formation of at least three ... coronae. , These coronae are visible in Miranda,s ... km across. Arden corona, the largest, has ridges and ...
(Date:9/18/2014)... McGill University and the Quebec government have discovered ... Canadian Journal of Fisheries and Aquatic Sciences . ... cleansers, or industrial cleansers, to which they are ... size and buoyancy, they may readily pass through ... contaminant in the world,s oceans, but have only ...
(Date:9/18/2014)... that prompts millions of Americans to undertake jaunts into the ... a little longer within a century, according to new research. ... areas of the United States as summer temperatures linger later ... Global Ecology and Biogeography . For instance, the paper ... tree of New Hampshire could change color one to ...
Breaking Biology News(10 mins):Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7Microplastic pollution discovered in St. Lawrence River sediments 2Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4
... transmitted between two individuals in a population is crucial ... New research has laid the foundation for a ... allow for more targeted prevention strategies. By using ... Physical Review Letters , outlines a predictive model of ...
... British Columbia , Feb. 5, 2013 Xenon, ... rare diseases, today announced that it has received a ... marketing approval of Glybera®, a novel gene therapy treatment ... the first gene therapy approved in the Western world. ...
... of Alberta polar bear researcher along with eleven international ... Arctic ecosystem change to deal with a climate change ... Andrew Derocher co-authored a policy perspective in the journal ... populations to accept that just one unexpected jump in ...
Cached Biology News:Can you predict how a disease will spread in a population? 2Xenon Receives a Milestone Payment for Marketing Approval of Glybera in Europe 2Polar bear researchers urge governments to act now and save the species 2
(Date:9/19/2014)... Charlotte, NC (PRWEB) September 19, 2014 ... Certified Biobased Product Label for its Organic Cotton ... the product’s amount of renewable biobased ingredients meets or ... or intermediate materials composed in whole or in significant ... “This logo/label will allow our Organic cotton to be ...
(Date:9/18/2014)... Bipartisan passage this week by the U.S. ... development and commercialization of new technologies and promote growth ... SPIE, the international society for optics and photonics ... (RAMI) Act, now moves to the full Senate for ... optimistic that it will win passage there as well ...
(Date:9/18/2014)... KEEGO HARBOR, Mich. , Sept. 18, 2014  Health ... -based biotech firm investigating early-stage algae bioactive compounds and metabolic ... member to the company,s board of directors. Ms. Nola ... executive and investment advisor joined the board effective September 17, ... have Ms. Masterson agree to join our board," states ...
(Date:9/18/2014)... 2014 Research and Markets ... N-acetylcysteine Industry Report 2014" report to their ... Report 2014 is a professional and in-depth study ... industry. The report provides a basic ... and industry chain structure. The N-acetylcysteine market analysis ...
Breaking Biology Technology:Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2Global N-acetylcysteine Industry Report 2014 2
... Communications MILWAUKEE When the topic of economic crisis comes ... Wisconsin. With institutions such as the University of Wisconsin-Milwaukee ... out talented graduates every year and a long history as ... stable environment that would attract big business. , ,However, ...
... to have a good grasp on their tangible property. ... value of their products. On the other hand, they ... Companies may understand that inventions could generally have some ... is possible to obtain patents on those inventions. However, ...
... NameProtect Inc. has announced the availability of its ... data to trademark professionals from a wide range of ... is meant to achieve efficient and competitive trademark clearance ... , ,Users will be able to integrate references ...
Cached Biology Technology:A cry for unity for the economy of southeast Wisconsin 2A cry for unity for the economy of southeast Wisconsin 3A cry for unity for the economy of southeast Wisconsin 4Save money through smart patenting 2Save money through smart patenting 3Save money through smart patenting 4NameProtect announces Web-enhanced trademark software 2
...
Agarose for baculovirus plaque assays which allow optimal growth of plated insect cells....
BD BaculoGold Max-XP Insect Cell Medium 1 Liter...
Mycoplasma and virus tested...
Biology Products: