Navigation Links
Lab-engineered kidney project reaches early milestone
Date:6/21/2012

WINSTON-SALEM, N.C. June 21, 2012 Regenerative medicine researchers at Wake Forest Baptist Medical Center have reached an early milestone in a long-term project that aims to build replacement kidneys in the lab to help solve the shortage of donor organs.

In proof-of-concept research published online ahead of print in Annals of Surgery, the team successfully used pig kidneys to make "scaffolds" or support structures that could potentially one day be used to build new kidneys for human patients. The idea is to remove all animal cells leaving only the organ structure or "skeleton." A patient's own cells would then be placed on the scaffold, making an organ that the patient theoretically would not reject.

While this is one of the first studies to assess the possibility of using whole pig kidneys to engineer replacement organs, the idea of using organ structures from pigs to help human patients is not new. Pig heart valves removed of cells have been used for more than three decades to provide heart valve replacements in human patients.

"It is important to identify new sources of transplantable organs because of the critical shortage of donor organs," said lead author Giuseppe Orlando, M.D., an instructor in surgery and regenerative medicine at Wake Forest Baptist. "These kidneys maintain their innate three-dimensional architecture, as well as their vascular system, and may represent the ideal platform for kidney engineering."

For the research, pig kidneys were soaked in a detergent to remove all cells, leaving behind the organ's "skeleton," including its system of blood vessels. In addition, the structure of the nephron the kidney's functional unit was maintained. The scaffolds were implanted in animals, where they were re-filled with blood and were able to maintain normal blood pressure, proving that the process of removing cells doesn't affect the mechanical strength of the vessels.

"There are many chall
'/>"/>

Contact: Karen Richardson
krchrdsn@wakehealth.edu
336-716-4453
Wake Forest Baptist Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. NIH supporting Arizona State University research to help in fight against kidney disease
2. Intensive kidney dialysis indicates better survival rates than conventional dialysis
3. Kidney stone mystery solved
4. UCSF artificial kidney project tapped for accelerated FDA program
5. BGI and the Childrens Hospital of Philadelphia launch the 1,000 Rare Diseases Project
6. IU role in Human Microbiome Project exposes battle history between bacteria, viruses in human body
7. Reed Elsevier Environmental Challenge shortlists 2012 projects
8. BGI, GE Healthcare team up on pioneering stem cell science projects
9. Southampton researchers lead 2 international projects to help people out of poverty
10. University leads £6 million EU project to tackle obesity
11. EU project: Searching for exotics in the shrimp nets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... alert the world to Global Warming, has called for ... underground. He says that Carbon Capture, combined with limits ... avoid global warming getting out of control over the ... made the call during his presentation to the International ... meeting to discuss Carbon Capture and Storage. , ...
(Date:8/28/2014)... world,s most important crop-producing countries will be fully saturated ... current trends continue, according to a new study led ... pest types can already be found in around half ... spread advances at its current rate, scientists fear that ... overwhelmed by pests within the next 30 years. , ...
(Date:8/27/2014)... the mysteries of the human genome was unveiled today ... most detailed comparison yet of how the genomes of ... The research, appearing August 28 in in the journal ... the three species, genomes is "read out," and how ... The results add billions of entries to a publicly ...
Breaking Biology News(10 mins):Global warming pioneer calls for CO2 to be taken from atmosphere and stored underground 2New study charts the global invasion of crop pests 2Encyclopedia of how genomes function gets much bigger 2Encyclopedia of how genomes function gets much bigger 3Encyclopedia of how genomes function gets much bigger 4
... Energy,s Savannah River National Laboratory and the Chernobyl Center,s ... issue of the Health Physics Journal entitled, ... Zone 25 Years After the Accident," (Vol. 101, ... Office of Environmental Management,s (EM) International Program, SRNL and ...
... Energy Department,s laboratories are making headway on two projects ... charges faster, lasts longer, runs more safely, and might ... Lithium batteries are used in a variety of everyday ... battery could also significantly increase the charge capacity of ...
... named 13 U.S. Department of Energy (DOE) researchers as ... and Engineers (PECASE). This is the highest honor bestowed ... who are early in their independent research careers. The ... a variety of fields - from research to help ...
Cached Biology News:Journal focuses on Savannah River National Labratory, Chernobyl Laboratory collaboration 2Journal focuses on Savannah River National Labratory, Chernobyl Laboratory collaboration 3National labs leading charge on building better batteries 2US Department of Energy PECASE recipients 2US Department of Energy PECASE recipients 3US Department of Energy PECASE recipients 4
(Date:8/28/2014)... Aug. 28, 2014   SunTrust Robinson Humphrey ... veterans to its equity research team in biotechnology ... expansion in equity research demonstrates our commitment to ... to enhance their investment decision making," said ... "We continue to make significant investments in differentiated ...
(Date:8/28/2014)... (PRWEB) August 27, 2014 Scientists, researchers, ... for SPIE Laser Damage 2014 symposium. Marking ... for high-power lasers will run 14-17 September. The event ... optics and photonics . , The premier conference for ... laser damage to optical materials will engage researchers and ...
(Date:8/28/2014)... August 28, 2014 Supplementing their ... a promotion for Eppendorf Safe Lock Centrifuge ... purchase the highest quality tubes at an affordable ... for customers doing chemical, medical, pharmaceutical, and life ... are not regularly able to afford Eppendorf products. ...
(Date:8/27/2014)... Aug. 27, 2014 Rhythm, a biopharmaceutical company ... deficiencies that result in metabolic disorders, announced today that ... with the U.S. Securities and Exchange Commission (SEC) relating ... its common stock. The number of shares to be ... not yet been determined. Citigroup and Cowen ...
Breaking Biology Technology:SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3Rhythm Files Registration Statement for Proposed Initial Public Offering 2
... CA Because they are riddled with defects, bulk ... the other hand, are so small there,s no room ... of a meter.) Yet while nanocrystalline materials may approach ... have shown only a limited ability to withstand large ...
... The board of directors,of Eli Lilly and Company (NYSE: ... 2008 of $0.47 a share on outstanding common stock. This,is ... quarters of 2008 and,brings the total annual dividend for 2008 ... 10, 2008, to shareholders of record at,the close of business ...
... DIEGO, Oct. 20 Cardium Therapeutics,(Amex: CXM ... announced,today that it has received 510(k) clearance from ... the RapidBlue(TM) System, an endovascular,temperature modulation device. InnerCool,s ... manage and control patient body temperature.,This new system ...
Cached Biology Technology:Engineering nanoparticles for maximum strength 2Engineering nanoparticles for maximum strength 3Engineering nanoparticles for maximum strength 4Cardium Announces FDA 510(K) Clearance of InnerCool's RapidBlue(TM) Endovascular System 2Cardium Announces FDA 510(K) Clearance of InnerCool's RapidBlue(TM) Endovascular System 3Cardium Announces FDA 510(K) Clearance of InnerCool's RapidBlue(TM) Endovascular System 4Cardium Announces FDA 510(K) Clearance of InnerCool's RapidBlue(TM) Endovascular System 5Cardium Announces FDA 510(K) Clearance of InnerCool's RapidBlue(TM) Endovascular System 6Cardium Announces FDA 510(K) Clearance of InnerCool's RapidBlue(TM) Endovascular System 7Cardium Announces FDA 510(K) Clearance of InnerCool's RapidBlue(TM) Endovascular System 8Cardium Announces FDA 510(K) Clearance of InnerCool's RapidBlue(TM) Endovascular System 9Cardium Announces FDA 510(K) Clearance of InnerCool's RapidBlue(TM) Endovascular System 10
alpha/beta-Tubulin Antibody Ship: Hot Store: -20 C...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
...
Biology Products: