Navigation Links
La Jolla Institute scientist leads team which discovers important new player in diabetes onset
Date:6/7/2010

SAN DIEGO (June 7, 2010) If you think of diabetes onset like an elaborate molecular drama, then a research team led by a La Jolla Institute scientist has unmasked a previously unknown cellular player, which is critical to proper insulin secretion. "Defective insulin secretion is a hallmark of both type 1 and type 2 diabetes," said Catherine Hedrick, Ph.D., a scientist at the La Jolla Institute for Allergy & Immunology, who led the team, which included researchers from the University of Virginia.

Working in mouse models, the team discovered that the ABCG1 protein is essential for the beta cells of the pancreas to produce sufficient amounts of insulin. Insulin is needed by the body to convert glucose from food into energy. Problems with insulin production underlie both type 1 and type 2 diabetes. "Based on our studies in mice, we think that some diabetes patients may have reduced expression of ABCG1 which impairs their insulin secretion," said Dr. Hedrick, who has previously published findings showing that type 2 diabetics have lower levels of ABCG1 than non-diabetics.

The research team also showed that proper expression of the ABCG1 protein in beta cells could be restored in the mice by treatment with some existing antidiabetic drugs. "Our study suggests that certain existing antidiabetic drugs may also provide therapeutic benefit related to restoring normal levels of ABCG1 protein in beta cells and improving insulin secretion in people with type 2 diabetes," said Dr. Hedrick. "Our research points to the need to investigate this possibility further as well as to explore the potential development of new therapies that boost ABCG1 protein levels and insulin secretion," she said.

The finding was published online today in the Journal of Clinical Investigation in a paper titled "An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells." Jeff Sturek,
'/>"/>

Contact: Bonnie Ward
contact@liai.org
619-303-3160
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Visionary concept earns La Jolla Institute scientist prestigious NIH Pioneer Award
2. La Jolla Institute discovers novel tumor suppressor
3. La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
4. Harvards Wyss Institute uses natures design principles to create specialized nanofabrics
5. Rensselaer Polytechnic Institute professor Patrick Underhill receives NSF CAREER award
6. NOAA selects University of Miami to lead major southeastern US cooperative institute
7. Oklahoma Blood Institute to Leverage BIO-key(R) Breakthrough TruDonor(TM) Fingerprint Donor Identification
8. Rensselaer Polytechnic Institute wins $2.45 million grant to support stem cell research
9. Allen Institute for Brain Science launches Allen Human Brain Atlas
10. NYU Cancer Institute experts present at American Society of Clinical Oncology annual meeting
11. UM receives 5th consecutive Howard Hughes Medical Institute grant for science education
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/3/2014)... Dec. 2, 2014 As part of our ... Technologies is pleased to announce the release of a ... to collect the workforce data that they need. ... been left by existing readers. Many such devices have ... and modern technology. Older models force users to navigate ...
(Date:11/21/2014)... 2014   Atmel® Corporation (NASDAQ: ... touch technology solutions, today launched the industry,s first family ... widest V cc range from 1.7V to 5.5V. ... I 2 C bus communication speeds, and are available ... them ideal for consumer, industrial, computer, and medical applications. ...
(Date:11/15/2014)... 13, 2014  While we may still be a few ... in "Star Trek" to gain instant access to all that ... with smartphones and tablets for monitoring and measuring our health ... This may seem a tad Orwellian to some, but a ... of these technological opportunities into their healthcare regime. ...
Breaking Biology News(10 mins):Inception Technologies to Release New Biometric Reader 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4
... Education for All) argues that the education of children ... and nutrition, which have reduced major diseases in poor ... Matthew Jukes, one of the books authors says: ... in schools, wed go a long way to enabling ...
... M2SYS Fingerprint Technology to ... Accurately Verify Check Casher Identity, ATLANTA, Sept. ... development firm, announced today its partnership,with TeraCorp Enterprises, a ... the M2SYS Bio-Plugin(TM) fingerprint,solution into TeraCash, a cutting-edge check ...
... the latest horticulture research on high tunnels, ... The American Society for Horticultural Science (ASHS) ... horticulture presentations from the 2007 ASHS Annual ... broad selection of horticulture presentations by world-class ...
Cached Biology News:Leading experts cite poor health and nutrition as major barrier to education in developing world 2M2SYS Technology Partners with TeraCorp Enterprises to Provide Added Security Within Check Cashing Solution 2HortTalks, a valuable scientific resource 2
(Date:12/19/2014)... 18, 2014 Relmada Therapeutics, Inc. (OTCQB: RLMD), ... of chronic pain, announced the results of its annual ... was a transformational year in Relmada,s history and it ... company," said Sergio Traversa , chief executive officer ... on key financial, human resource and clinical development objectives ...
(Date:12/17/2014)... Houston, TX (PRWEB) December 17, 2014 ... marketing and administration for Stoller Group. In this position, ... Stoller Group, on administrative matters, develop marketing strategy and ... and services. , “Achim has tremendous knowledge and ... president of Stoller Group. “His experience and innovative thinking ...
(Date:12/17/2014)... Xeno Diagnostics has again received an ... COLA inspection. Xeno has met all criteria for ... organization. Accreditation is earned only by laboratories that ... demonstrate continued accuracy in the performance of proficiency ... , While the Laboratory Excellence award ...
(Date:12/17/2014)... Md. , Dec. 17, 2014  United Therapeutics ... senior executive promotions as well as changes to ... Senior Executive Promotions United Therapeutics announced ... President and Co-Chief Executive Officer and David Zaccardelli ... Officer.  In connection with these promotions, Dr. Rothblatt,s title ...
Breaking Biology Technology:Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4
... Engineering Technology to Bring New Choices, More Options to Global ... ... and RESEARCH TRIANGLE PARK, N.C., Feb. 11,/PRNewswire- FirstCall/ -- DuPont (NYSE: ... to bring higher-yielding,agricultural products to the market faster. Terms of the ...
... 11 On February 8, Michael F. Brigham,President ... ) (http://www.immucell.com ),updated the investment community in ... in the interview include an overview of the,company, ... for,which investors should watch., To hear the ...
... to gently clean and help heal ... ... today,announced that it has launched the Qoustic Wound Therapy System(TM), which,advances ... a safe, cost-effective alternative to painful sharps,debridement and other surgical modalities. ...
Cached Biology Technology:DuPont and Precision BioSciences Collaborate to Accelerate Crop Product Development 2WallSt.net Updates Investment Community Through All-New Interview With ImmuCell 2Arobella Medical, LLC Launches Qoustic Wound Therapy System(TM) 2Arobella Medical, LLC Launches Qoustic Wound Therapy System(TM) 3
... tool provides the firm pressure necessary ... in tubes or plates. The multifunctional ... that firmly holds thin-wall 0.5 ml ... opening or closing. A side slot ...
... USP is a highly nutritious versatile medium ... Due to the inclusion of both Tryptone ... growth of many fastidious organisms without the ... to United States Pharmacopeia standards for use ...
...
... B-Bridge's siSolutions RNAi Services offer ... for your siRNA studies. B-Bridges advanced ... and technical expertise ensure that you ... experiments. siSolutions siRNA Design Service utilizes ...
Biology Products: