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La Jolla Institute scientist Klaus Ley receives Malpighi award
Date:10/25/2010

ents in the blood vessels that are key to triggering inflammation. Inflammation, as shown by Dr. Ley and other researchers, is a major contributor to plaque buildup in heart disease and other conditions. Thanks to the discovery of the adhesion cascade, a therapy for peripheral artery disease is now in clinical trials. The therapy seeks to significantly reduce inflammation, and the resulting arterial plaque buildup, by blocking one or more steps in the adhesion cascade.

In the area of biomechanics, Dr. Ley's work resulted in the development of a series of molecular contrast agents for use in ultrasound imaging that enables better and more comprehensive pictures for diagnostic purposes. With these images, physicians will be able to see cancerous cells, plaque formation, inflammation and other conditions more clearly and earlier on in their development, thus enabling earlier therapeutic treatments.

Regarding his methods work, Dr. Ley recently developed "dynamic footprinting," which marks a significant contribution to methods work in the vascular immunology field. The footprinting enables scientists to study neutrophil adhesion, a molecular process important in fighting bacterial infections, in unprecedented detail. As part of creating the dynamic footprinting method, Dr. Ley collaborated with Dr. Alex Groisman at UCSD to develop a microfluidic flow chamber 10,000 times smaller than the existing version. Using this flow chamber, scientists can see the surface structures and molecules involved in neutrophil adhesion with exceptional clarity. "The ability to understand what is actually occurring is significantly enhanced."

A native of Germany, Dr. Ley joined the La Jolla Institute in 2007 as Head of the Division of Inflammation Biology. Previously, he was director of the Robert M. Berne Cardiovascular Research Center at the University of Virginia. He has received many major awards, including the prestigious Marie T. Bonazinga Res
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Contact: Bonnie Ward
contact@liai.org
619-303-3160
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

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