Navigation Links
La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
Date:1/20/2013

SAN DIEGO (January 20th, 2013) A research team led by the La Jolla Institute for Allergy & Immunology has discovered the mechanism that enables CD4 helper T cells to assume the more aggressive role of killer T cells in mounting an immune attack against viruses, cancerous tumors and other damaged or infected cells. The finding, made in collaboration with researchers from the RIKEN Institute in Japan, could enable the development of more potent drugs for AIDS, cancer and many other diseases based on using this mechanism to trigger larger armies of killer T cells against infected or damaged cells.

CD4 helper T cells, which normally assist other cells of the immune system during an infection, and CD8 killer T cells, which directly attack and eliminate infected cells, are two of the body's most important immune cells for defending against diseases. Earlier research studies have shown that helper T cells can become killer cells in some instances. However, the specific mechanism of action that allowed this to occur was not known until now.

"We have identified the molecular switch that enables CD4 T cells to override their programming as helper cells and transform into cytolytic (killer) cells," said La Jolla Institute scientist and study co-leader Hilde Cheroutre, Ph.D. "Our team also showed that these transformed helper T cells represent a separate and distinct population of cells. They are not a subset of TH-1 helper cells as previously thought."

Jay A. Berzofsky, M.D., Ph.D., chief of the Vaccine Branch at the National Cancer Institute's Center for Cancer Research, called the finding "a major advance" that provides new understanding about the cell's lineage and basic mechanisms. Dr. Berzofsky was among the researchers whose work in the 1980s first demonstrated that helper cells could convert to killer cells. "Understanding how these cells derive and what causes them to switch from helper T cells to cytolytic T cells is an imp
'/>"/>

Contact: Bonnie Ward
contact@liai.org
619-303-3160
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. La Jolla Institute discovery could lead to new way to screen drugs for adverse reactions
2. La Jolla Institute scientist discovers key step in immune system-fueled inflammation
3. La Jolla institute identifies critical cell in fighting E. coli infection
4. Diabetes Research Institute develops oxygen-generating biomaterial
5. Space research institute honors Sen. Hutchison with Pioneer Award
6. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
7. Minneapolis Heart Institute selected to participate in Cardiovascular Cell Therapy Research Network
8. Cary Institute Hydrofracking Forum
9. Scripps Research Institute Professor Gerald F. Joyce elected to American Academy of Arts & Sciences
10. Scripps Research Institute scientists develop antidote for cocaine overdose
11. NJIT, Chinas Bengbu Glass Institute sign agreement for R&D, training
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Dec. 16, 2014 Research and ... the addition of the "Global Chemical Sensor ... http://photos.prnewswire.com/prnh/20130307/600769 ... the increasing demand for medical sensors in biomedical ... data for quick and correct diagnosis during surgical ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and ... the addition of the "Global Facial Recognition ... http://photos.prnewswire.com/prnh/20130307/600769 ... identification of individuals. Facial recognition system measures the ... nose, jaw edges, mouth, and the distance between ...
(Date:12/11/2014)... 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of ... report to their offering. One ... adoption of multimodal biometric systems. Multimodal biometric systems ... for verification and identification purposes. This helps to ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... down of their woody material, could be the key to ... researchers who add that the approach could also help turn ... major component of woody plant material, is woven in with ... gusts of wind and microbial attack. However, this protective barrier ...
... socioeconomic status and children,s educational environment. Nevertheless, some ... of high parental education and support for learning ... psychologists Angela Friend, John C. DeFries and Richard ... on reading disability, the most commonly identified learning ...
... 22, 2008, Cambridge, UK A new report demonstrates ... hand in seeking out bacteria in chronic infections. ... that can cause severe illness and death. Listeria ... infection is the third most common cause of bacterial ...
Cached Biology News:Modified plants may yield more biofuel 2The effect of parental education on the heritability of children's reading disability 2New research lights up chronic bacterial infection inside bone 2
(Date:12/17/2014)... Diego, CA (PRWEB) December 17, 2014 ... and activation agency and member of the Huntsworth Health ... Gonzales to its executive team. In her role, Gonzales ... , “We are incredibly honored to welcome a ... Agency Chief and CEO, Gaëtan Fraikin. “She is a ...
(Date:12/17/2014)... 2014  United Therapeutics Corporation (NASDAQ: UTHR ... as changes to Martine Rothblatt , Ph.D,s compensation ... United Therapeutics announced the promotion of Roger ... and David Zaccardelli , Pharm.D. to Executive Vice ... promotions, Dr. Rothblatt,s title will change from Chairman and ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)... 15, 2014 METTLER TOLEDO is ... tool, ParticleView V19 with PVM technology , ... particle vision and measurement tool continuously captures high-resolution ... ParticleView V19 then automatically prepares a report pairing ... size and concentration changes. This compelling blend of ...
Breaking Biology Technology:Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2
... ACCESS PHARMACEUTICALS, INC. (OTC Bulletin Board: ... proprietary polymer-based oral mucositis product has been launched ... countries by its European commercial partner, SpePharm, a ... of high medical value medicines in supportive and ...
... Micromet, Inc. (Nasdaq: MITI ), a ... of cancer, inflammation and autoimmune diseases, yesterday presented data ... Cancer Research (AACR) in Denver, Colorado, showing that its ... Cancer stem cells are thought to be responsible for ...
... Research and Manufacturers of America (PhRMA) and the national ... to promote three key policies designed to help achieve ... Families USA will work together and will reach out ... incorporated in the healthcare reform proposals to be considered ...
Cached Biology Technology:Access Pharmaceuticals Announces the European Launch of MuGard(TM) by its European Partner, SpePharm 2Access Pharmaceuticals Announces the European Launch of MuGard(TM) by its European Partner, SpePharm 3Micromet Presents Data at AACR Meeting Showing Elimination of Colorectal Cancer Stem Cells by BiTE Antibody MT110 2Micromet Presents Data at AACR Meeting Showing Elimination of Colorectal Cancer Stem Cells by BiTE Antibody MT110 3Micromet Presents Data at AACR Meeting Showing Elimination of Colorectal Cancer Stem Cells by BiTE Antibody MT110 4PhRMA, Families USA Jointly Promote Measures to Ensure Quality, Affordable Healthcare Coverage 2PhRMA, Families USA Jointly Promote Measures to Ensure Quality, Affordable Healthcare Coverage 3
...
...
... Mouse A-20 cells were cultured in RPMI ... the log phase of growth. In order ... cells were fixed in acetone-methanol. The cells ... coated slide, with each wells surface specifically treated ...
... proteases/caspases initiates apoptosis in mammalian cells. ... provides a simple and convenient means for ... in intact cells. The assay utilizes ... linked to rhodamine 110 (D2R), a reported ...
Biology Products: