Navigation Links
La Jolla Institute discovers novel tumor suppressor
Date:8/3/2009

SAN DIEGO (August 3, 2009) La Jolla Institute for Allergy & Immunology researchers studying an enzyme believed to play a role in allergy onset, instead have discovered its previously unknown role as a tumor suppressor that may be important in myeloproliferative diseases and some types of lymphoma and leukemia. Myeloproliferative diseases are a group of disorders characterized by an overproduction of blood cells by the bone marrow and include chronic myeloid leukemia. Lymphoma and leukemia are cancers of the blood.

"PLC-beta 3 is an enzyme, but the function we found was a completely different function that no one knew it had -- as a tumor suppressor," said the La Jolla Institute's Toshiaki Kawakami, M.D., Ph.D., who led the research team. The study, conducted in animal models, could eventually lead to the development of new therapies directed towards controlling this newly discovered cellular mechanism.

Tony Hunter, Ph.D., director of the Salk Institute Cancer Center and a professor in Salk's Molecular and Cell Biology Laboratory, called the finding an "important" step in advancing understanding of blood cancers. "It's very interesting that this molecule acts in this way independently of its enzyme activity," he said. "It's quite an unexpected finding and it definitely has the potential for helping the scientific community understand the mechanisms leading to some types of leukemia."

The findings are being published online today in the journal Cancer Cell in a paper entitled "Tumor Suppression by Phospholipase C- 3 via SHP-1-Mediated Dephosphorylation of STAT5." Researchers from UC San Diego Cancer Center, University of Alabama and the University of Western Ontario also contributed to the study.

Dr. Kawakami said he and his research team got their first inkling of something unexpected fairly early on in their experiments. "We wanted to better understand the PLC-beta 3 enzyme's possible role as a signalin
'/>"/>

Contact: Bonnie Ward
contact@liai.org
619-303-3160
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
2. Palm Beach County wants to establish a Max Planck Institute in Florida
3. Midlands Consortium delighted to be chosen to host £1 billion energy institute
4. $22 million gift from Alfred Taubman launches new biomedical research institute
5. 3 Columbia University Medical Center faculty elected to Institute of Medicine
6. Stowers Institutes Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
7. Weizmann Institute scientists discover: A risk distribution law for evolution
8. Ludwig Institute for Cancer Research to set up its first Asian branch in Singapore
9. Baker Institute finds increased domestic production wont make US self-sufficient in natural gas
10. Lupus Research Institute strategy delivers $30 million in national funding
11. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... the University of Texas Medical Branch at Galveston ... treated with radiation for cervical cancer should begin ... , The UTMB researchers, finding a high incidence ... treated with radiation, offer new recommendations that the ... screening about eight years after their initial cervical ...
(Date:4/17/2014)... led by the Australian National University (ANU), have ... and deep-sea temperature variability over the past 5.3 ... understand the climate surrounding ice ages over the ... the relationship between carbon dioxide levels, global temperatures ... University of Southampton (UoS) and the National Oceanography ...
(Date:4/16/2014)... 20-year assessment of Nicaragua,s legal, artisanal green sea turtle ... catch rates of turtles in what may have become ... Wildlife Conservation Society and University of Florida. , During ... 170,000 green turtles were killed between 1991 and 2011, ...
Breaking Biology News(10 mins):Radiation therapy for cervical cancer increases risk for colorectal cancer 2Ancient sea-levels give new clues on ice ages 2Declining catch rates in Caribbean green turtle fishery may be result of overfishing 2Declining catch rates in Caribbean green turtle fishery may be result of overfishing 3
... cancer cells that survive chemotherapy leaving the door ... Institute scientists developed an original method for imaging and ... how a chemotherapy drug affects each one. ... and Eran Eden in the lab of Prof. Uri ...
... Munich, Germany and Ann Arbor, MI, USA, Jan 28 ... has joined the Illumina-Connect program, linking them to the ... new tools and applications for Illumina-generated data. , ... Munich, Germany commented: "As the industry,s only provider of ...
... observe in another but have never actually experienced yourself? A ... answer this question. The research, published by Cell Press in ... provides insight into brain mechanisms involved in empathy. Brain-imaging ... feel their own emotions or observe the same emotions in ...
Cached Biology News:Weizmann Institute scientists discover how cancer cells survive a chemotherapy drug 2Genomatix joins Illumina-Connect program 2I feel your pain: Neural mechanisms of empathy 2
(Date:1/15/2014)... 2014  Bill Jacobs Automotive, a group of car dealerships headquartered ... the Heartland Blood Center and offering free oil change coupons ... place Saturday, Jan. 18 at the Bill Jacobs Cadillac and ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill Jacobs ...
(Date:1/15/2014)... JOSE, California , January 15, 2014 ... cancer, today announced the appointment of Thomas C Reynolds MD, ... 20 years, development experience gained in the biotechnology industry, most ... "I am delighted to welcome Tom at this transformative time ...
(Date:1/15/2014)... Two champions of science, technology, engineering, and ... annual competition for middle and high school students designed ... study. The competition presents students with real-world problems experienced ... Mathematics, and Sciences is a program administered by ...
(Date:1/15/2014)... 2014 AudioNotch is the internet's leading ... the treatment of tinnitus. Patients listen to sound therapy ... a period of weeks to months, their tinnitus volume decreases. ... forms: Notched Music and Notched White Noise. Now, AudioNotch is ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5
... Greg Schlicht and Dax Denman Join as Company ... Algenol Biofuels, developers of,DIRECT TO ETHANOL(TM), the ... continued growth of the company with the,appointments Greg ... General Counsel and Dax Denman as Senior Program ...
... Insmed Inc. (Nasdaq:,INSM) a developer of follow-on biologics ... of Insmed, will present at the,Biosimilars 2008 Conference ... Company,s perspective on the potential impact of follow-on ... a panel on this topic on,Tuesday, September 23, ...
... Study of More Than 60,000 Women Underscores Need for Better ... Implications and Risks Associated with Osteoporosis, MONTREAL, Sept. 15 ... (GLOW) showed that 55 percent of women,diagnosed with osteoporosis do ... their peers. This latest study from GLOW included more than,60,000 ...
Cached Biology Technology:Algenol Biofuels Further Strengthens Team With Key Appointments 2Insmed to Present at Biosimilars 2008 Conference 2Global Study Shows That Majority of Women with Osteoporosis Do Not Consider Themselves at Higher Risk for Fractures 2Global Study Shows That Majority of Women with Osteoporosis Do Not Consider Themselves at Higher Risk for Fractures 3
... Lauryl Ether 30% concentration ... Preservative. Surfactant. Clear Solution. ... is 1 mL of ... added to 400 mL ...
Mitotic Kinesin-Like Protein 1 (MKLP-1, KNSL5)...
... Contact Printing Kit contains choice of Printing Surface (3 ... over Ti adhesion layer, 1 silicon wafer coated with ... 3 plain glass slides) and PDMS Stamps (3 PDMS ... squares or 100 um x 10 mm or 200 ...
Mouse VEGF R1/Flt-1 Phycoerythrin MAb (Clone 141522) Keywords: Receptor Tyrosine Kinase, RTK, VEGFR1, VEGF Receptor 1 Protein Family: Receptor Tyrosine Kinases, VEGF/PDGF Family...
Biology Products: